FR2919804B1 - Composition et vaccin therapeutique anti-tumoral - Google Patents

Composition et vaccin therapeutique anti-tumoral

Info

Publication number
FR2919804B1
FR2919804B1 FR0705767A FR0705767A FR2919804B1 FR 2919804 B1 FR2919804 B1 FR 2919804B1 FR 0705767 A FR0705767 A FR 0705767A FR 0705767 A FR0705767 A FR 0705767A FR 2919804 B1 FR2919804 B1 FR 2919804B1
Authority
FR
France
Prior art keywords
red blood
blood cells
composition
cells
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR0705767A
Other languages
English (en)
Other versions
FR2919804A1 (fr
Inventor
Yann Godfrin
Alice Marchand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phaxiam Therapeutics SA
Original Assignee
Erytech Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0705767A priority Critical patent/FR2919804B1/fr
Application filed by Erytech Pharma SA filed Critical Erytech Pharma SA
Priority to KR1020107004794A priority patent/KR101666041B1/ko
Priority to PL08787072T priority patent/PL2185164T3/pl
Priority to ES08787072.1T priority patent/ES2649761T3/es
Priority to PCT/EP2008/060492 priority patent/WO2009019317A1/fr
Priority to CA2695478A priority patent/CA2695478C/fr
Priority to HUE08787072A priority patent/HUE035983T2/hu
Priority to CN200880110270.0A priority patent/CN101873862B/zh
Priority to PT87870721T priority patent/PT2185164T/pt
Priority to DK08787072.1T priority patent/DK2185164T3/da
Priority to NO08787072A priority patent/NO2185164T3/no
Priority to JP2010519476A priority patent/JP6077195B2/ja
Priority to AU2008285595A priority patent/AU2008285595B2/en
Priority to EP08787072.1A priority patent/EP2185164B1/fr
Priority to US12/672,094 priority patent/US9364504B2/en
Publication of FR2919804A1 publication Critical patent/FR2919804A1/fr
Priority to IL203714A priority patent/IL203714A/en
Publication of FR2919804B1 publication Critical patent/FR2919804B1/fr
Application granted granted Critical
Priority to HK11102915.5A priority patent/HK1148688A1/xx
Priority to US15/154,273 priority patent/US9950049B2/en
Priority to JP2016170936A priority patent/JP6352996B2/ja
Priority to HRP20171566TT priority patent/HRP20171566T1/hr
Priority to US15/961,226 priority patent/US10780151B2/en
Priority to US17/000,007 priority patent/US20210077602A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001122—Ephrin Receptors [Eph]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
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    • A61K39/001136—Cytokines
    • A61K39/001139—Colony stimulating factors [CSF]
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001148—Regulators of development
    • A61K39/001149—Cell cycle regulated proteins, e.g. cyclin, CDC, CDK or INK-CCR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001148—Regulators of development
    • A61K39/00115—Apoptosis related proteins, e.g. survivin or livin
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    • A61K39/0005—Vertebrate antigens
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    • A61K39/001148—Regulators of development
    • A61K39/00115—Apoptosis related proteins, e.g. survivin or livin
    • A61K39/001151—Apoptosis related proteins, e.g. survivin or livin p53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001152—Transcription factors, e.g. SOX or c-MYC
    • A61K39/001153—Wilms tumor 1 [WT1]
    • A—HUMAN NECESSITIES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A61K39/001156—Tyrosinase and tyrosinase related proteinases [TRP-1 or TRP-2]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
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    • A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K39/001186—MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K39/001188—NY-ESO
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K39/001189—PRAME
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00119—Melanoma antigens
    • A61K39/001191—Melan-A/MART
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
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    • A61K39/001192—Glycoprotein 100 [Gp100]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001196—Fusion proteins originating from gene translocation in cancer cells
    • A61K39/001197—Breakpoint cluster region-abelson tyrosine kinase [BCR-ABL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2806—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD2
    • A—HUMAN NECESSITIES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
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    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6056—Antibodies
FR0705767A 2007-08-08 2007-08-08 Composition et vaccin therapeutique anti-tumoral Active FR2919804B1 (fr)

Priority Applications (22)

Application Number Priority Date Filing Date Title
FR0705767A FR2919804B1 (fr) 2007-08-08 2007-08-08 Composition et vaccin therapeutique anti-tumoral
US12/672,094 US9364504B2 (en) 2007-08-08 2008-08-08 Compostition and therapeutic anti-tumour vaccine
PL08787072T PL2185164T3 (pl) 2007-08-08 2008-08-08 Kompozycja i terapeutyczna szczepionka przeciwnowotworowa
EP08787072.1A EP2185164B1 (fr) 2007-08-08 2008-08-08 Composition et vaccin anti-tumoral thérapeutique
CA2695478A CA2695478C (fr) 2007-08-08 2008-08-08 Composition et vaccin anti-tumoral therapeutique
HUE08787072A HUE035983T2 (hu) 2007-08-08 2008-08-08 Készítmény és terápiás tumorellenes oltóanyag
CN200880110270.0A CN101873862B (zh) 2007-08-08 2008-08-08 组合物和治疗性抗肿瘤疫苗
PT87870721T PT2185164T (pt) 2007-08-08 2008-08-08 Composição e vacina anti-tumoral terapêutica
DK08787072.1T DK2185164T3 (da) 2007-08-08 2008-08-08 Sammensætning og terapeutisk antitumorvaccine
NO08787072A NO2185164T3 (fr) 2007-08-08 2008-08-08
JP2010519476A JP6077195B2 (ja) 2007-08-08 2008-08-08 組成物と治療用抗腫瘍ワクチン
AU2008285595A AU2008285595B2 (en) 2007-08-08 2008-08-08 Composition and therapeutic anti-tumour vaccine
KR1020107004794A KR101666041B1 (ko) 2007-08-08 2008-08-08 조성물 및 치료용 항종양 백신
ES08787072.1T ES2649761T3 (es) 2007-08-08 2008-08-08 Composición y vacuna antitumoral terapéutica
PCT/EP2008/060492 WO2009019317A1 (fr) 2007-08-08 2008-08-08 Composition et vaccin anti-tumoral thérapeutique
IL203714A IL203714A (en) 2007-08-08 2010-02-04 A drug containing red blood cell remedy, anti-tumor vaccine containing it and its uses
HK11102915.5A HK1148688A1 (en) 2007-08-08 2011-03-23 Composition and therapeutic anti-tumour vaccine
US15/154,273 US9950049B2 (en) 2007-08-08 2016-05-13 Composition and therapeutic anti-tumour vaccine
JP2016170936A JP6352996B2 (ja) 2007-08-08 2016-09-01 組成物と治療用抗腫瘍ワクチン
HRP20171566TT HRP20171566T1 (hr) 2007-08-08 2017-10-16 Pripravak i terapeutsko anti-tumorsko cjepivo
US15/961,226 US10780151B2 (en) 2007-08-08 2018-04-24 Composition and therapeutic anti-tumour vaccine
US17/000,007 US20210077602A1 (en) 2007-08-08 2020-08-21 Composition and therapeutic anti-tumour vaccine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0705767A FR2919804B1 (fr) 2007-08-08 2007-08-08 Composition et vaccin therapeutique anti-tumoral

Publications (2)

Publication Number Publication Date
FR2919804A1 FR2919804A1 (fr) 2009-02-13
FR2919804B1 true FR2919804B1 (fr) 2010-08-27

Family

ID=38982501

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0705767A Active FR2919804B1 (fr) 2007-08-08 2007-08-08 Composition et vaccin therapeutique anti-tumoral

Country Status (18)

Country Link
US (4) US9364504B2 (fr)
EP (1) EP2185164B1 (fr)
JP (2) JP6077195B2 (fr)
KR (1) KR101666041B1 (fr)
CN (1) CN101873862B (fr)
AU (1) AU2008285595B2 (fr)
CA (1) CA2695478C (fr)
DK (1) DK2185164T3 (fr)
ES (1) ES2649761T3 (fr)
FR (1) FR2919804B1 (fr)
HK (1) HK1148688A1 (fr)
HR (1) HRP20171566T1 (fr)
HU (1) HUE035983T2 (fr)
IL (1) IL203714A (fr)
NO (1) NO2185164T3 (fr)
PL (1) PL2185164T3 (fr)
PT (1) PT2185164T (fr)
WO (1) WO2009019317A1 (fr)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2919804B1 (fr) 2007-08-08 2010-08-27 Erytech Pharma Composition et vaccin therapeutique anti-tumoral
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