WO2007067681A3 - Compositions et méthodes immunostimulatoires - Google Patents
Compositions et méthodes immunostimulatoires Download PDFInfo
- Publication number
- WO2007067681A3 WO2007067681A3 PCT/US2006/046662 US2006046662W WO2007067681A3 WO 2007067681 A3 WO2007067681 A3 WO 2007067681A3 US 2006046662 W US2006046662 W US 2006046662W WO 2007067681 A3 WO2007067681 A3 WO 2007067681A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- provides
- immune
- antigen
- useful
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000003308 immunostimulating effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 230000028993 immune response Effects 0.000 abstract 3
- 239000012678 infectious agent Substances 0.000 abstract 3
- 230000002708 enhancing effect Effects 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 210000002865 immune cell Anatomy 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/66—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
- A61K47/665—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells the pre-targeting system, clearing therapy or rescue therapy involving biotin-(strept) avidin systems
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0012—Cell encapsulation
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5152—Tumor cells
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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- A—HUMAN NECESSITIES
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
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- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/625—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier binding through the biotin-streptavidin system or similar
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2006321888A AU2006321888A1 (en) | 2005-12-08 | 2006-12-07 | Immunostimulatory compositions and methods |
JP2008544500A JP5564181B2 (ja) | 2005-12-08 | 2006-12-07 | 免疫刺激組成物および方法 |
CA2632663A CA2632663C (fr) | 2005-12-08 | 2006-12-07 | Compositions et methodes immunostimulatoires |
MX2008007292A MX2008007292A (es) | 2005-12-08 | 2006-12-07 | Composiciones inmunoestimuladoras y metodos. |
EP06848503A EP1976565A2 (fr) | 2005-12-08 | 2006-12-07 | Compositions et méthodes immunostimulatoires |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74817705P | 2005-12-08 | 2005-12-08 | |
US60/748,177 | 2005-12-08 | ||
US77117906P | 2006-02-06 | 2006-02-06 | |
US60/771,179 | 2006-02-06 | ||
US79964306P | 2006-05-12 | 2006-05-12 | |
US60/799,643 | 2006-05-12 | ||
US86317306P | 2006-10-27 | 2006-10-27 | |
US60/863,173 | 2006-10-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007067681A2 WO2007067681A2 (fr) | 2007-06-14 |
WO2007067681A3 true WO2007067681A3 (fr) | 2008-01-03 |
Family
ID=38123485
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/046662 WO2007067681A2 (fr) | 2005-12-08 | 2006-12-07 | Compositions et méthodes immunostimulatoires |
PCT/US2006/046663 WO2007067682A2 (fr) | 2005-12-08 | 2006-12-07 | Modification in vivo de surfaces cellulaires |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/046663 WO2007067682A2 (fr) | 2005-12-08 | 2006-12-07 | Modification in vivo de surfaces cellulaires |
Country Status (8)
Country | Link |
---|---|
US (5) | US7598345B2 (fr) |
EP (2) | EP1973572A2 (fr) |
JP (2) | JP2009518427A (fr) |
KR (2) | KR20080090411A (fr) |
AU (2) | AU2006321888A1 (fr) |
CA (2) | CA2632663C (fr) |
MX (2) | MX2008007292A (fr) |
WO (2) | WO2007067681A2 (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7989173B2 (en) | 2006-12-27 | 2011-08-02 | The Johns Hopkins University | Detection and diagnosis of inflammatory disorders |
US9005616B2 (en) | 2009-08-31 | 2015-04-14 | Amplimmune, Inc. | Methods and compositions for the inhibition of transplant rejection |
US9296822B2 (en) | 2005-12-08 | 2016-03-29 | E.R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to O8E |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7030219B2 (en) | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
ATE531789T1 (de) | 2000-06-30 | 2011-11-15 | Univ Louisville Res Found | Zellmembranenveränderung |
EP3130350A1 (fr) | 2005-06-08 | 2017-02-15 | Dana-Farber Cancer Institute, Inc. | Procédés et compositions pour le traitement du cancer et d'infections pérsistantes en inhibant la voie de la mort céllulaire programmée (pd-1) |
WO2007067681A2 (fr) * | 2005-12-08 | 2007-06-14 | University Of Louisville Research Foundation, Inc. | Compositions et méthodes immunostimulatoires |
AU2006321890A1 (en) * | 2005-12-08 | 2007-06-14 | University Of Louisville Research Foundation, Inc. | Methods and compositions for expanding T regulatory cells |
JP5601836B2 (ja) * | 2006-11-08 | 2014-10-08 | マクロジェニックス ウエスト, インコーポレイテッド | Tes7およびtes7に結合する抗体 |
CN105056226A (zh) * | 2006-12-27 | 2015-11-18 | 埃默里大学 | 用于治疗传染病和肿瘤的组合物和方法 |
US8658180B2 (en) | 2008-08-15 | 2014-02-25 | Mark A. Miller | Vaccines against influenza virus |
DK2350129T3 (en) | 2008-08-25 | 2015-08-31 | Amplimmune Inc | PREPARATIONS WITH PD-1 ANTAGONISTS AND PROCEDURES FOR USE THEREOF |
KR20110074850A (ko) * | 2008-08-25 | 2011-07-04 | 앰플리뮨, 인크. | Pd-1 길항제 및 그의 사용 방법 |
DK2370593T3 (en) * | 2008-11-28 | 2016-07-04 | Univ Emory | A method for determining the effect of PD-1 Antagonists |
SG10201708690SA (en) * | 2008-12-09 | 2017-12-28 | Genentech Inc | Anti-pd-l1 antibodies and their use to enhance t-cell function |
US8580274B2 (en) | 2009-02-10 | 2013-11-12 | University Of The Ryukyus | Drug transporter, and adjuvant and vaccine each utilizing same |
WO2010102278A1 (fr) * | 2009-03-06 | 2010-09-10 | President And Fellows Of Harvard College | Procédés et compositions permettant de générer et de maintenir des cellules t de régulation |
JP5550132B2 (ja) * | 2009-10-30 | 2014-07-16 | 学校法人東京理科大学 | 抗原特異的b細胞集団の製造方法 |
EP2335721A1 (fr) * | 2009-12-21 | 2011-06-22 | Institut Pasteur | Système d'administration pour antigène contenant streptavidin et biotin |
US8981057B2 (en) | 2010-03-05 | 2015-03-17 | Academisch Medisch Centrum Bij De Universiteit Van Amsterdam | B-cell stimulating fusion proteins of an antigen with BAFF or APRIL |
WO2012020842A1 (fr) * | 2010-08-13 | 2012-02-16 | 独立行政法人理化学研究所 | Complexe ayant un effet de vaccin antitumoral et son utilisation |
US9233125B2 (en) * | 2010-12-14 | 2016-01-12 | University Of Maryland, Baltimore | Universal anti-tag chimeric antigen receptor-expressing T cells and methods of treating cancer |
CA2826582A1 (fr) * | 2011-02-10 | 2012-08-16 | University Of Louisville Research Foundation, Inc. | Compositions d'adjuvant avec 4-1bbl |
ES2864765T3 (es) | 2011-05-11 | 2021-10-14 | Childrens Medical Center | Proteína de unión a biotina modificada, proteínas de fusión de la misma y aplicaciones |
JP6120848B2 (ja) | 2011-08-15 | 2017-04-26 | メディミューン,エルエルシー | 抗b7−h4抗体およびその使用 |
HRP20230424T1 (hr) | 2012-06-28 | 2023-07-07 | University Of Central Florida Research Foundation Incorporated | Postupci i pripravci za prirodnoubilačke stanice |
WO2014076703A1 (fr) * | 2012-11-14 | 2014-05-22 | Silenseed Ltd. | Procédés et compositions destinés au traitement du cancer |
BR112015014063A2 (pt) | 2012-12-19 | 2018-10-30 | Amplimmune Inc | anticorpos anti-b7-h4 humano e seus usos. |
EP2951209A4 (fr) | 2013-01-31 | 2016-06-22 | Univ Jefferson | Protéine de fusion agoniste des cd40 ox40 et ses utilisations |
AU2014214844B2 (en) | 2013-02-07 | 2017-12-14 | Children's Medical Center Corporation | Protein antigens that provide protection against pneumococcal colonization and/or disease |
WO2014145355A1 (fr) * | 2013-03-15 | 2014-09-18 | Stone Geoffrey W | Composition composée d'un antigène lié à un ligand de la superfamille des tnf |
AU2014337367B2 (en) | 2013-10-15 | 2020-04-30 | The Scripps Research Institute | Peptidic chimeric antigen receptor T cell switches and uses thereof |
CN103966312B (zh) * | 2014-03-19 | 2016-01-13 | 新乡学院 | 猪外周血单核淋巴细胞pd-l2重组质粒的构建、基因丰度实时检测方法及其应用 |
EP3148573A4 (fr) * | 2014-05-29 | 2017-11-15 | Medimmune, LLC | Protéines de fusion ox40l et leurs utilisations |
GB201410031D0 (en) * | 2014-06-05 | 2014-07-16 | Isis Innovation | Polypeptides and uses thereof |
WO2016154621A1 (fr) | 2015-03-26 | 2016-09-29 | The California Institute For Biomedical Research | Récepteurs chimériques non-scfv commutables, commutateurs, et leurs utilisations |
CN107708725A (zh) * | 2015-04-02 | 2018-02-16 | 坎库雷有限公司 | 用于引发免疫应答的剂和组合物 |
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US9296822B2 (en) | 2005-12-08 | 2016-03-29 | E.R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to O8E |
US7989173B2 (en) | 2006-12-27 | 2011-08-02 | The Johns Hopkins University | Detection and diagnosis of inflammatory disorders |
US9134321B2 (en) | 2006-12-27 | 2015-09-15 | The Johns Hopkins University | Detection and diagnosis of inflammatory disorders |
US9005616B2 (en) | 2009-08-31 | 2015-04-14 | Amplimmune, Inc. | Methods and compositions for the inhibition of transplant rejection |
US9011853B2 (en) | 2009-08-31 | 2015-04-21 | Amplimmune, Inc. | B7-H4 fusion proteins and methods of use thereof |
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US20120171240A1 (en) | 2012-07-05 |
US9079976B2 (en) | 2015-07-14 |
MX2008007286A (es) | 2008-10-21 |
EP1976565A2 (fr) | 2008-10-08 |
US20070172504A1 (en) | 2007-07-26 |
US7598345B2 (en) | 2009-10-06 |
JP2009518426A (ja) | 2009-05-07 |
US8017582B2 (en) | 2011-09-13 |
AU2006321889A1 (en) | 2007-06-14 |
WO2007067681A2 (fr) | 2007-06-14 |
KR20080090412A (ko) | 2008-10-08 |
CA2632682A1 (fr) | 2007-06-14 |
JP5564181B2 (ja) | 2014-07-30 |
EP1973572A2 (fr) | 2008-10-01 |
KR20080090411A (ko) | 2008-10-08 |
WO2007067682A3 (fr) | 2007-11-15 |
US20100240585A1 (en) | 2010-09-23 |
MX2008007292A (es) | 2008-10-17 |
US20070184473A1 (en) | 2007-08-09 |
CA2632663C (fr) | 2015-08-18 |
US20100158936A1 (en) | 2010-06-24 |
WO2007067682A2 (fr) | 2007-06-14 |
JP2009518427A (ja) | 2009-05-07 |
CA2632663A1 (fr) | 2007-06-14 |
AU2006321888A1 (en) | 2007-06-14 |
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