LT2014112A - Iš normalių audinių gautos ksenogeninės vakcinos, skirtos pažeisti imuninės sistemos su navikais susijusių antigenų toleravimą - Google Patents
Iš normalių audinių gautos ksenogeninės vakcinos, skirtos pažeisti imuninės sistemos su navikais susijusių antigenų toleravimąInfo
- Publication number
- LT2014112A LT2014112A LT2014112A LT2014112A LT2014112A LT 2014112 A LT2014112 A LT 2014112A LT 2014112 A LT2014112 A LT 2014112A LT 2014112 A LT2014112 A LT 2014112A LT 2014112 A LT2014112 A LT 2014112A
- Authority
- LT
- Lithuania
- Prior art keywords
- xenogenic
- tumor
- breaking
- normal tissue
- associated antigens
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 230000006058 immune tolerance Effects 0.000 title 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 241001494479 Pecora Species 0.000 abstract 1
- 230000001605 fetal effect Effects 0.000 abstract 1
- 210000003754 fetus Anatomy 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- 230000002381 testicular Effects 0.000 abstract 1
- 210000001550 testis Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00118—Cancer antigens from embryonic or fetal origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Developmental Biology & Embryology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Aprašoma priešnavikinė vakcina, apimanti sėklidžių ir iš fetalinių audinių kilusius komponentus. Ląstelių preparatai yra ruošiami iš normalių audinių, paimtų tiesiogiai iš gyvūnų. Tokios vakcinos gali būti naudojamos įvairių vėžio tipų gydymui ir prevencijai. Pavyzdžiui, buvo nustatyta, kad vakcina, susidedanti iš gliutaraldehidu paveiktų ląstelių, paruoštų iš avies sėklidžių ir fetalinių plaučių, yra efektyvi sukeliant priešnavikines ląstelines reakcijas bei pailginant plaučių vėžį turinčių pelių išgyvenimo trukmę.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LT2014112A LT6313B (lt) | 2014-09-26 | 2014-09-26 | Iš normalių audinių gautos ksenogeninės vakcinos, skirtos pažeisti imuninės sistemos su navikais susijusių antigenų toleravimą |
EA201790709A EA037056B1 (ru) | 2014-09-26 | 2015-04-15 | Ксеногенные вакцины, полученные из здоровых тканей, для преодоления иммунной толерантности в отношении опухолеассоциированных антигенов |
US15/514,100 US10695408B2 (en) | 2014-09-26 | 2015-04-15 | Xenogenic normal tissue-derived vaccines for breaking the immune tolerance to tumor-associated, antigens |
PCT/IB2015/052738 WO2016046651A1 (en) | 2014-09-26 | 2015-04-15 | Xenogenic normal tissue-derived vaccines for breaking the immune tolerance to tumor-associated, antigens |
EP15727068.7A EP3197484A1 (en) | 2014-09-26 | 2015-04-15 | Xenogenic normal tissue-derived vaccines for breaking the immune tolerance to tumor-associated, antigens |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LT2014112A LT6313B (lt) | 2014-09-26 | 2014-09-26 | Iš normalių audinių gautos ksenogeninės vakcinos, skirtos pažeisti imuninės sistemos su navikais susijusių antigenų toleravimą |
Publications (2)
Publication Number | Publication Date |
---|---|
LT2014112A true LT2014112A (lt) | 2016-04-25 |
LT6313B LT6313B (lt) | 2016-09-12 |
Family
ID=53284311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LT2014112A LT6313B (lt) | 2014-09-26 | 2014-09-26 | Iš normalių audinių gautos ksenogeninės vakcinos, skirtos pažeisti imuninės sistemos su navikais susijusių antigenų toleravimą |
Country Status (5)
Country | Link |
---|---|
US (1) | US10695408B2 (lt) |
EP (1) | EP3197484A1 (lt) |
EA (1) | EA037056B1 (lt) |
LT (1) | LT6313B (lt) |
WO (1) | WO2016046651A1 (lt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020030634A1 (en) * | 2018-08-06 | 2020-02-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating cancers |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2192884C2 (ru) | 2000-11-09 | 2002-11-20 | Государственное учреждение Научно-исследовательский институт клинической иммунологии СО РАМН | Вакцина для стимуляции противоопухолевого иммунитета |
WO2007106576A2 (en) * | 2006-03-15 | 2007-09-20 | University Of Louisville Research Foundation, Inc. | Methods and materials for immunization against cancer |
-
2014
- 2014-09-26 LT LT2014112A patent/LT6313B/lt unknown
-
2015
- 2015-04-15 WO PCT/IB2015/052738 patent/WO2016046651A1/en active Application Filing
- 2015-04-15 EA EA201790709A patent/EA037056B1/ru unknown
- 2015-04-15 EP EP15727068.7A patent/EP3197484A1/en active Pending
- 2015-04-15 US US15/514,100 patent/US10695408B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP3197484A1 (en) | 2017-08-02 |
US20170296642A1 (en) | 2017-10-19 |
EA037056B1 (ru) | 2021-01-29 |
LT6313B (lt) | 2016-09-12 |
US10695408B2 (en) | 2020-06-30 |
WO2016046651A1 (en) | 2016-03-31 |
EA201790709A1 (ru) | 2017-10-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB1A | Patent application published |
Effective date: 20160425 |
|
FG9A | Patent granted |
Effective date: 20160912 |