MX2018007295A - Interleucina 10 en la produccion de linfocitos t cd8+especificos para el antigeno y metodos de uso de estos. - Google Patents

Interleucina 10 en la produccion de linfocitos t cd8+especificos para el antigeno y metodos de uso de estos.

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Publication number
MX2018007295A
MX2018007295A MX2018007295A MX2018007295A MX2018007295A MX 2018007295 A MX2018007295 A MX 2018007295A MX 2018007295 A MX2018007295 A MX 2018007295A MX 2018007295 A MX2018007295 A MX 2018007295A MX 2018007295 A MX2018007295 A MX 2018007295A
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Mexico
Prior art keywords
specific
cells
antigen
disease antigen
disease
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MX2018007295A
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English (en)
Inventor
Mccauley Scott
Brian MUMM John
Ho CHAN Ivan
Oft Martin
Ogg Scott
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Armo Biosciences Inc
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Application filed by Armo Biosciences Inc filed Critical Armo Biosciences Inc
Publication of MX2018007295A publication Critical patent/MX2018007295A/es

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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Abstract

La presente descripción proporciona métodos y composiciones que se relacionan con linfocitos T CD8+ aislados que expresan un receptor de linfocitos T especifico del antígeno de una enfermedad, así como ácidos nucleicos que codifican los pares de polipéptidos Va y V13 de los receptores de linfocitos T (TCR) de tales linfocitos T específicos del antígeno de la enfermedad. Tales linfocitos T CD8+ específicos del antígeno de la enfermedad se pueden obtener de la periferia (por ejemplo, la sangre) de un sujeto que padece una enfermedad susceptible de tratamiento con un agente de 1L-10. La presente descripción también contempla métodos terapéuticos y composiciones que se relacionan con la administración de linfocitos T CD8+ específicos del antígeno de la enfermedad aislados a un sujeto, así como métodos terapéuticos y composiciones relacionadas con linfocitos T CD8+ modificados genéticamente para expresar un TCP especifico del antígeno de la enfermedad y/o el receptor del antígeno quimérico.
MX2018007295A 2016-01-11 2017-01-10 Interleucina 10 en la produccion de linfocitos t cd8+especificos para el antigeno y metodos de uso de estos. MX2018007295A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662277442P 2016-01-11 2016-01-11
PCT/US2017/012882 WO2017123557A1 (en) 2016-01-11 2017-01-10 Interleukin-10 in production of antigen-specific cd8+ t cells and methods of use of same

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MX2018007295A true MX2018007295A (es) 2019-03-28

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US (1) US11814679B2 (es)
EP (1) EP3402512A4 (es)
JP (1) JP7082051B2 (es)
KR (1) KR20180101417A (es)
CN (1) CN108697776A (es)
AU (1) AU2017207282A1 (es)
CA (1) CA3008287A1 (es)
MX (1) MX2018007295A (es)
WO (1) WO2017123557A1 (es)

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