ATE528014T1 - Polypeptid mit modifizierten kunitz domains - Google Patents
Polypeptid mit modifizierten kunitz domainsInfo
- Publication number
- ATE528014T1 ATE528014T1 AT07023364T AT07023364T ATE528014T1 AT E528014 T1 ATE528014 T1 AT E528014T1 AT 07023364 T AT07023364 T AT 07023364T AT 07023364 T AT07023364 T AT 07023364T AT E528014 T1 ATE528014 T1 AT E528014T1
- Authority
- AT
- Austria
- Prior art keywords
- phe
- cys
- glu
- ala
- polypeptide
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 150000001413 amino acids Chemical group 0.000 abstract 2
- WQVFQXXBNHHPLX-ZKWXMUAHSA-N Ala-Ala-His Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(O)=O WQVFQXXBNHHPLX-ZKWXMUAHSA-N 0.000 abstract 1
- BGDILZXXDJCKPF-CIUDSAMLSA-N Arg-Gln-Cys Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(O)=O BGDILZXXDJCKPF-CIUDSAMLSA-N 0.000 abstract 1
- HUZGPXBILPMCHM-IHRRRGAJSA-N Asn-Arg-Phe Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O HUZGPXBILPMCHM-IHRRRGAJSA-N 0.000 abstract 1
- FANQWNCPNFEPGZ-WHFBIAKZSA-N Asp-Asp-Gly Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(O)=O FANQWNCPNFEPGZ-WHFBIAKZSA-N 0.000 abstract 1
- YWEHYKGJWHPGPY-XGEHTFHBSA-N Cys-Thr-Arg Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CS)N)O YWEHYKGJWHPGPY-XGEHTFHBSA-N 0.000 abstract 1
- NUSWUSKZRCGFEX-FXQIFTODSA-N Glu-Glu-Cys Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(O)=O NUSWUSKZRCGFEX-FXQIFTODSA-N 0.000 abstract 1
- YLJHCWNDBKKOEB-IHRRRGAJSA-N Glu-Glu-Phe Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O YLJHCWNDBKKOEB-IHRRRGAJSA-N 0.000 abstract 1
- IDEODOAVGCMUQV-GUBZILKMSA-N Glu-Ser-Leu Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O IDEODOAVGCMUQV-GUBZILKMSA-N 0.000 abstract 1
- XXGQRGQPGFYECI-WDSKDSINSA-N Gly-Cys-Glu Chemical compound NCC(=O)N[C@@H](CS)C(=O)N[C@H](C(O)=O)CCC(O)=O XXGQRGQPGFYECI-WDSKDSINSA-N 0.000 abstract 1
- VEPIBPGLTLPBDW-URLPEUOOSA-N Ile-Phe-Thr Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)N VEPIBPGLTLPBDW-URLPEUOOSA-N 0.000 abstract 1
- PRTZQMBYUZFSFA-XEGUGMAKSA-N Ile-Tyr-Gly Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)NCC(=O)O)N PRTZQMBYUZFSFA-XEGUGMAKSA-N 0.000 abstract 1
- 102000001399 Kallikrein Human genes 0.000 abstract 1
- 108060005987 Kallikrein Proteins 0.000 abstract 1
- KJIXWRWPOCKYLD-IHRRRGAJSA-N Lys-Lys-Met Chemical compound CSCC[C@@H](C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)N KJIXWRWPOCKYLD-IHRRRGAJSA-N 0.000 abstract 1
- BKIFWLQFOOKUCA-DCAQKATOSA-N Met-His-Ser Chemical compound CSCC[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CO)C(=O)O)N BKIFWLQFOOKUCA-DCAQKATOSA-N 0.000 abstract 1
- KZNQNBZMBZJQJO-UHFFFAOYSA-N N-glycyl-L-proline Natural products NCC(=O)N1CCCC1C(O)=O KZNQNBZMBZJQJO-UHFFFAOYSA-N 0.000 abstract 1
- UEHNWRNADDPYNK-DLOVCJGASA-N Phe-Cys-Ala Chemical compound C[C@@H](C(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](CC1=CC=CC=C1)N UEHNWRNADDPYNK-DLOVCJGASA-N 0.000 abstract 1
- DNAXXTQSTKOHFO-QEJZJMRPSA-N Phe-Lys-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC1=CC=CC=C1 DNAXXTQSTKOHFO-QEJZJMRPSA-N 0.000 abstract 1
- OWSLLRKCHLTUND-BZSNNMDCSA-N Phe-Phe-Asn Chemical compound C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC(=O)N)C(=O)O)N OWSLLRKCHLTUND-BZSNNMDCSA-N 0.000 abstract 1
- NUZHSNLQJDYSRW-BZSNNMDCSA-N Pro-Arg-Trp Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O NUZHSNLQJDYSRW-BZSNNMDCSA-N 0.000 abstract 1
- AIZVVCMAFRREQS-GUBZILKMSA-N Pro-Cys-Arg Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O AIZVVCMAFRREQS-GUBZILKMSA-N 0.000 abstract 1
- 108010041407 alanylaspartic acid Proteins 0.000 abstract 1
- 108010084264 glycyl-glycyl-cysteine Proteins 0.000 abstract 1
- 108010012581 phenylalanylglutamate Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38723902P | 2002-06-07 | 2002-06-07 | |
| US40700302P | 2002-08-28 | 2002-08-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE528014T1 true ATE528014T1 (de) | 2011-10-15 |
Family
ID=29739936
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07023364T ATE528014T1 (de) | 2002-06-07 | 2003-06-06 | Polypeptid mit modifizierten kunitz domains |
| AT03757339T ATE477020T1 (de) | 2002-06-07 | 2003-06-06 | Prevention und verringerung von ischemia |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03757339T ATE477020T1 (de) | 2002-06-07 | 2003-06-06 | Prevention und verringerung von ischemia |
Country Status (12)
| Country | Link |
|---|---|
| US (13) | US7064107B2 (de) |
| EP (4) | EP1941867B1 (de) |
| JP (3) | JP2005534647A (de) |
| AT (2) | ATE528014T1 (de) |
| AU (3) | AU2003243394B2 (de) |
| CA (1) | CA2488558C (de) |
| CY (1) | CY1112228T1 (de) |
| DE (1) | DE60333758D1 (de) |
| DK (4) | DK2298278T3 (de) |
| ES (4) | ES2372978T3 (de) |
| PT (4) | PT2311432E (de) |
| WO (1) | WO2003103475A2 (de) |
Families Citing this family (106)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE529444T1 (de) | 1994-01-11 | 2011-11-15 | Dyax Corp | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
| US6057287A (en) * | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| AU2001279203A1 (en) | 2000-07-31 | 2002-02-13 | Harman International Industries Inc. | Loudspeaker coil suspension system |
| US20050222023A1 (en) * | 2002-02-07 | 2005-10-06 | Hans-Peter Hauser | Albumin-fused kunitz domain peptides |
| CA2488558C (en) | 2002-06-07 | 2013-08-20 | Dyax Corp. | Prevention and reduction of blood loss |
| US7153829B2 (en) * | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| WO2004019968A1 (en) * | 2002-08-28 | 2004-03-11 | Dyax Corp. | Methods for preserving organs and tissues |
| US6989369B2 (en) * | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
| AU2004268145B2 (en) * | 2003-08-29 | 2010-09-16 | Takeda Pharmaceutical Company Limited | Poly-PEGylated protease inhibitors |
| EP1667623B1 (de) * | 2003-09-12 | 2010-11-24 | Z-Medica Corporation | Teilweise hydriertes hämostatisches mittel |
| US20060177971A1 (en) * | 2004-01-13 | 2006-08-10 | Jsr Corporation | Anisotropically conductive connector, production process thereof and application product thereof |
| US7235530B2 (en) * | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| MX2007006997A (es) * | 2004-12-23 | 2007-10-10 | Csl Behring Gmbh | Prevencion de formacion y/o estabilizacion de trombo. |
| US20060178609A1 (en) * | 2005-02-09 | 2006-08-10 | Z-Medica, Llc | Devices and methods for the delivery of molecular sieve materials for the formation of blood clots |
| EP1853326B1 (de) | 2005-02-15 | 2016-06-15 | Virginia Commonwealth University | Mineraltechnologien (mt) für akute hämostase und zur behandlung akuter wunden und chronischer geschwüre |
| JP4976412B2 (ja) | 2005-12-01 | 2012-07-18 | ベー・エル・アー・ハー・エム・エス・ゲーエムベーハー | エンドセリン、エンドセリンアゴニスト及びアドレノメジュリンアンタゴニストによる危篤患者の診断及び治療のための方法 |
| US20070213275A1 (en) * | 2006-03-10 | 2007-09-13 | Dyax Corp. | Formulations for ecallantide |
| PT1854477T (pt) * | 2006-03-16 | 2016-11-10 | Dyax Corp | Inibidores peptidicos da calicreína plasmática e sua utilização no tratamento de doenças oftalmológicas |
| PL2374472T3 (pl) * | 2006-03-16 | 2018-11-30 | Dyax Corp. | Kompozycje i sposoby leczenia zaburzeń okulistycznych |
| US8938898B2 (en) * | 2006-04-27 | 2015-01-27 | Z-Medica, Llc | Devices for the identification of medical products |
| US8202532B2 (en) | 2006-05-26 | 2012-06-19 | Z-Medica Corporation | Clay-based hemostatic agents and devices for the delivery thereof |
| US7968114B2 (en) * | 2006-05-26 | 2011-06-28 | Z-Medica Corporation | Clay-based hemostatic agents and devices for the delivery thereof |
| US7604819B2 (en) | 2006-05-26 | 2009-10-20 | Z-Medica Corporation | Clay-based hemostatic agents and devices for the delivery thereof |
| US20080085300A1 (en) * | 2006-10-06 | 2008-04-10 | Z-Medica Corporation | Hemostatic compositions and method of manufacture |
| US9345457B2 (en) | 2006-12-13 | 2016-05-24 | Devicor Medical Products, Inc. | Presentation of biopsy sample by biopsy device |
| AU2008289005A1 (en) * | 2007-08-21 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
| US20090105142A1 (en) * | 2007-08-23 | 2009-04-23 | Genzyme Corporation | Treatment with kallikrein inhibitors |
| WO2009032884A1 (en) * | 2007-09-05 | 2009-03-12 | Z-Medica Corporation | Wound healing with zeolite-based hemostatic devices |
| WO2010080833A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| HUE057244T2 (hu) | 2010-01-06 | 2022-04-28 | Takeda Pharmaceuticals Co | Plazma kallikreint kötõ fehérjék |
| EP2347778A1 (de) | 2010-01-25 | 2011-07-27 | ECP Entwicklungsgesellschaft mbH | Fluidpumpe mit einem radial komprimierbaren Rotor |
| US8858969B2 (en) | 2010-09-22 | 2014-10-14 | Z-Medica, Llc | Hemostatic compositions, devices, and methods |
| AU2012204202A1 (en) | 2011-01-06 | 2013-07-11 | Dyax Corp. | Plasma kallikrein binding proteins |
| EP2717923B1 (de) | 2011-06-10 | 2017-09-27 | Ionis Pharmaceuticals, Inc. | Verfahren zur modulierung der kallikrein (klkb1)-expression |
| US9322021B2 (en) | 2011-06-29 | 2016-04-26 | Ionis Pharmaceuticals, Inc. | Methods for modulating kallikrein (KLKB1) expression |
| EP2780371B1 (de) | 2011-11-16 | 2018-10-24 | AdrenoMed AG | Anti-adrenomedullin (adm)-antikörper oder anti-adm-antikörperfragment oder anti-adm-non-ig-gerüst zur regulierung des flüssigkeitsgleichgewichts bei einem patienten mit einer chronischen oder akuten erkrankung |
| CA2856142A1 (en) | 2011-11-16 | 2013-05-23 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in therapy of an acute disease or acute condition of a patient for stabilizing the circulation |
| PT2594587E (pt) | 2011-11-16 | 2014-08-27 | Adrenomed Ag | Anticorpo anti-adrenomedulina (adm) ou fragmento de anticorpo anti-adm ou andaime proteico não ig anti-adm para diminuir o risco de mortalidade num paciente com uma doença aguda ou crónica ou num estado agudo |
| WO2013072512A1 (en) | 2011-11-16 | 2013-05-23 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or an anti-adm non-ig scaffold for use in therapy |
| JP6193871B2 (ja) | 2011-11-16 | 2017-09-06 | アドレノメト アクチェンゲゼルシャフト | 慢性若しくは急性疾患又は急性病態に罹患している患者の臓器機能障害又は臓器不全を予防又は軽減するための、抗アドレノメデュリン（ＡＤＭ）抗体、抗ＡＤＭ抗体フラグメント又は抗ＡＤＭ非Ｉｇ足場 |
| RS55804B1 (sr) | 2011-11-16 | 2017-08-31 | Sphingotec Gmbh | Testovi za adrenomedulin i metodi za određivanje zrelog adrenomedulina |
| CN103308670B (zh) | 2012-03-08 | 2017-06-09 | 思芬构技术有限公司 | 用于预测对象患糖尿病和/或代谢综合征的风险的方法 |
| CN103308673B (zh) | 2012-03-08 | 2017-05-31 | 思芬构技术有限公司 | 用于预测雌性对象中发生心血管事件的风险的方法 |
| CN103308689B (zh) | 2012-03-08 | 2017-04-12 | 思芬构技术有限公司 | 用于预测雌性对象中患上癌症的风险或诊断癌症的方法 |
| MX376779B (es) | 2012-06-22 | 2025-03-07 | Teleflex Tech Llc | Dispositivos hemostaticos. |
| CN104769433B (zh) | 2012-10-02 | 2018-07-27 | 斯弗因高泰克有限公司 | 诊断或监测肾功能或者诊断肾功能异常的方法 |
| RU2677895C2 (ru) | 2013-01-08 | 2019-01-22 | Сфинготек Гмбх | Уровни гормона роста натощак в качестве прогностического маркера сердечно-сосудистого риска |
| HUE044285T2 (hu) | 2013-01-20 | 2019-10-28 | Dyax Corp | PKal-mediálta rendellenességek értékelése, vizsgálata és kezelése |
| KR102523810B1 (ko) | 2013-01-20 | 2023-04-21 | 다케다 파머수티컬 컴패니 리미티드 | 브래디키닌 매개 장애의 평가 및 치료 |
| CA2907467C (en) | 2013-03-20 | 2024-09-10 | Sphingotec Gmbh | Adrenomedulline to guide blood pressure-lowering therapy |
| WO2015031679A2 (en) | 2013-08-28 | 2015-03-05 | Isis Pharmaceuticals, Inc. | Modulation of prekallikrein (pkk) expression |
| KR20230054745A (ko) | 2013-10-21 | 2023-04-25 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 시스템 바이오마커를 결정하기 위한 검정법 |
| KR102295623B1 (ko) | 2013-10-21 | 2021-08-31 | 다이액스 코포레이션 | 자가면역 질환의 진단 및 치료 |
| KR102903403B1 (ko) | 2014-01-21 | 2025-12-24 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 결합 단백질 및 유전성 혈관부종을 치료하는 데 있어서의 이의 용도 |
| US10428158B2 (en) | 2014-03-27 | 2019-10-01 | Dyax Corp. | Compositions and methods for treatment of diabetic macular edema |
| HUE052709T2 (hu) | 2014-05-01 | 2021-05-28 | Ionis Pharmaceuticals Inc | Módosított antiszensz oligonukleotidok konjugátumai és azok alkalmazása PKK expressziójának módosítására |
| EP3002589A1 (de) | 2014-10-01 | 2016-04-06 | sphingotec GmbH | Verfahren zur stratifizierung einer frau zur hormonersatztherapie |
| EP3916020A1 (de) | 2015-03-30 | 2021-12-01 | Dyax Corp. | Plasma-kallikrein-inhibitoren und verwendungen davon zur verhinderung des angriffs durch hereditäres angioödem |
| CA2983542A1 (en) | 2015-04-24 | 2016-10-27 | Sphingotec Gmbh | A method for predicting the risk of incidence of chronic kidney disease |
| CN108291917B (zh) | 2015-10-19 | 2021-08-27 | 武田药品工业株式会社 | 检测裂解的高分子量激肽原的免疫测定方法 |
| JP7003354B2 (ja) | 2015-12-11 | 2022-03-04 | 武田薬品工業株式会社 | 遺伝性血管性浮腫の発作を治療するための血漿カリクレイン阻害薬およびその用途 |
| EP4417217A3 (de) | 2016-04-21 | 2024-11-13 | 4TEEN4 Pharmaceuticals GmbH | Verfahren zur bestimmung von dpp3 und therapeutische verfahren |
| MA45493A (fr) | 2016-06-27 | 2019-05-01 | Aicuris Anti Infective Cures Gmbh | Inhibiteurs d'entrée de hcmv. |
| AU2017294549C1 (en) | 2016-07-08 | 2023-10-26 | Sphingotec Gmbh | Adrenomedullin for assessing congestion in a subject with acute heart failure |
| KR20250030022A (ko) | 2016-09-16 | 2025-03-05 | 다케다 파머수티컬 컴패니 리미티드 | 접촉 활성화 시스템과 연관된 질환을 위한 대사물질 바이오마커 |
| EP3513196B1 (de) | 2016-09-16 | 2026-02-25 | Takeda Pharmaceutical Company Limited | Proteinbiomarker für krankheiten, die mit dem kontaktaktivierungssystem verbunden sind |
| JP7319916B2 (ja) | 2016-09-16 | 2023-08-02 | 武田薬品工業株式会社 | 遺伝性血管性浮腫のｒｎａバイオマーカー |
| EP3309550A1 (de) | 2016-10-12 | 2018-04-18 | sphingotec GmbH | Verfahren zum nachweis von apolipoprotein e4 |
| RU2762059C2 (ru) | 2016-12-16 | 2021-12-15 | Адреномед Аг | Антитело против адреномедуллина (adm), или фрагмент анти-adm антитела, или анти-adm не-ig каркас для применения при вмешательстве и терапии гиперемии у пациента |
| EP3339324A1 (de) | 2016-12-22 | 2018-06-27 | sphingotec GmbH | Anti-adrenomedullin (adm)-antikörper oder anti-adm antikörperfragment oder anti-adm-nicht-ig-gerüst zur verwendung in einer intervention und therapie von verstopfung bei einem darauf angewiesenen patienten |
| AU2018276361A1 (en) | 2017-05-30 | 2019-12-05 | Sphingotec Gmbh | A method for diagnosing or monitoring kidney function or diagnosing kidney dysfunction |
| MY204700A (en) | 2017-09-25 | 2024-09-10 | Adrenomed Ag | Anti-adrenomedullin (adm) binder for use in therapy or prevention of symptoms of illness |
| CA3079112A1 (en) | 2017-10-18 | 2019-04-25 | Adrenomed Ag | Therapy monitoring under treatment with an anti-adrenomedullin (adm) binder |
| CA3079931A1 (en) | 2017-10-24 | 2019-05-02 | Sphingotec Gmbh | Selenoprotein p for prediction of a first cardiovascular event |
| MX2020004271A (es) | 2017-10-25 | 2020-07-29 | 4TEEN4 Pharmaceuticals GmbH | Aglutinante de dpp3 dirigido a y que se une a epitopes de dpp3 especificos y su uso en la prevencion o tratamiento de enfermedades/condiciones agudas que estan asociadas con estres oxidativo. |
| EP3569614A1 (de) | 2018-05-18 | 2019-11-20 | Julius-Maximilians-Universität Würzburg | Verbindungen und verfahren zur immobilisierung von myostatin-inhibitoren auf der extrazellulären matrix durch transglutaminase |
| EP3586865A1 (de) | 2018-06-21 | 2020-01-01 | Charité - Universitätsmedizin Berlin | Ergänzende anaphylatoxinbindemittel und deren verwendung in der behandlung einer person mit okularer wunde und/oder fibrose |
| BR112021003789A2 (pt) | 2018-08-30 | 2021-05-18 | Dyax Corp. | método para tratar ataque de angioedema hereditário (hae) ou reduzir a taxa de ataque de hae |
| BR112021010069A2 (pt) | 2018-12-20 | 2021-11-23 | Sphingotec Gmbh | Selenoproteína p em insuficiência cardíaca |
| CN113557031A (zh) | 2018-12-21 | 2021-10-26 | 4Teen4制药有限公司 | 使用血管紧张肽受体激动剂和/或其前体的治疗的疗法指导和/或疗法监测 |
| US20200317815A1 (en) | 2019-03-14 | 2020-10-08 | Dyax Corp. | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
| US20220291234A1 (en) | 2019-08-15 | 2022-09-15 | Sphingotec Gmbh | A method for diagnosing or monitoring kidney function or diagnosing kidney dysfunction in pediatric patients |
| RU2712629C1 (ru) * | 2019-08-27 | 2020-01-30 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Астраханский ГМУ Минздрава России) | Способ прогнозирования сердечно-сосудистых осложнений у больных ишемической болезнью сердца в сочетании с постинфарктной аневризмой левого желудочка |
| JP2022546061A (ja) | 2019-08-30 | 2022-11-02 | ４ティーン４ ファーマシューティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | ショック症治療のための治療法の誘導および／または治療法の監視 |
| WO2021146160A1 (en) | 2020-01-13 | 2021-07-22 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack |
| EP3871689A1 (de) | 2020-02-26 | 2021-09-01 | sphingotec GmbH | Anti-adm-antikörper, die an den freien n-terminus binden, für einen beschleunigten übergang von adm-gly zu bio-adm bei patienten mit einem adm-gly/bio-adm-verhältnis über einem schwellenwert und kombination mit vitamin c |
| CA3172349A1 (en) | 2020-02-27 | 2021-09-02 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 for therapy guidance, monitoring and stratification of nt-adm antibodies in patients with shock |
| KR20220145898A (ko) | 2020-02-27 | 2022-10-31 | 아드레노메드 아게 | 쇼크 환자의 치료에 사용하기 위한 항-아드레노메둘린 (adm) 결합제 |
| KR20220145897A (ko) | 2020-02-27 | 2022-10-31 | 아드레노메드 아게 | 쇼크의 치료 또는 예방에 사용하기 위한 항-아드레노메둘린 (adm) 항체 또는 항-adm 항체 단편 또는 항-adm 비-ig 스캐폴드 |
| MX2022011577A (es) | 2020-03-16 | 2022-10-18 | Sphingotec Gmbh | Proadrenomedulina o fragmento de la misma en pacientes infectados con coronavirus y tratamientos con aglutinante contra la adrenomedulina. |
| EP3922993A1 (de) | 2020-06-12 | 2021-12-15 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 bei patienten, die mit coronavirus infiziert sind |
| CN115769076A (zh) | 2020-03-16 | 2023-03-07 | 4Teen4制药有限公司 | 感染冠状病毒的患者中的dpp3 |
| EP4126219A2 (de) | 2020-04-04 | 2023-02-08 | Takeda Pharmaceutical Company Limited | Plasmakallikreinhemmer und verwendungen davon zur behandlung von akutem atemnotsyndrom |
| EP4023218A1 (de) | 2020-12-02 | 2022-07-06 | S-Form Pharma | Kombinationstherapie für patienten mit akuter und/oder anhaltender dyspnoe |
| CN117529664A (zh) | 2021-06-18 | 2024-02-06 | 思芬构技术有限公司 | 用于预测脓毒症和脓毒性休克的方法 |
| KR20240041912A (ko) | 2021-06-29 | 2024-04-01 | 베리솔 게엠베하 | 체액내 셀레늄 결핍을 식별하기 위한 복합 바이오마커 |
| WO2024003617A2 (en) | 2022-06-30 | 2024-01-04 | Takeda Pharmaceutical Company Limited | Protein biomarkers for lanadelumab treatment |
| JP2025525059A (ja) | 2022-07-29 | 2025-08-01 | アドレノメト アクチェンゲゼルシャフト | ショックの治療又は予防に使用するための抗アドレノメデュリン（ＡＤＭ）抗体若しくは抗ＡＤＭ抗体フラグメント又は抗ＡＤＭ非Ｉｇ足場 |
| AU2023315168A1 (en) | 2022-07-29 | 2025-02-13 | 4TEEN4 Pharmaceuticals GmbH | Prediction of an increase of dpp3 in a patient with septic shock |
| JP2025541138A (ja) | 2022-12-15 | 2025-12-18 | ４ティーン４ ファーマシューティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 重篤な患者における肺機能の改善のためのｄｐｐ３阻害剤 |
| EP4680966A1 (de) | 2023-03-17 | 2026-01-21 | PAM Theragnostics GmbH | Verfahren zur bestimmung der peptidylglycin-alpha-amidierenden monooxygenase (pam) und deren verwendung für diagnostische zwecke |
| WO2024200862A1 (en) | 2023-03-29 | 2024-10-03 | 4TEEN4 Pharmaceuticals GmbH | Dpp3 inhibitor for myocardial protection and prevention of myocardial injury in critically ill patients with blood pressure decline |
| WO2025068313A1 (en) | 2023-09-25 | 2025-04-03 | Sphingotec Gmbh | A method for early diagnosis, early prediction, monitoring or prediction of severity of reduced graft function in a kidney transplantation patient |
| WO2025229075A1 (en) | 2024-05-03 | 2025-11-06 | Sphingotec Gmbh | A method for the specific determination of proenkephalin fragment 119-159 |
| WO2025248139A1 (en) | 2024-05-31 | 2025-12-04 | 4TEEN4 Pharmaceuticals GmbH | Use of adrenomedullin or fragments thereof in the treatment of a patient in need thereof |
| EP4675277A1 (de) | 2024-07-05 | 2026-01-07 | Predemtec AG | Verfahren zur diagnose von morbus alzheimer oder zur bestimmung des risikos des leidens an morbus alzheimer |
Family Cites Families (211)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT275583B (de) | 1964-03-04 | 1969-10-27 | Plasser Bahnbaumasch Franz | Profilfreie Maschine zum Reinigen des Eisenbahnbettungsschotters |
| BR6915369D0 (pt) | 1969-02-27 | 1973-03-13 | Bayer Ag | Emprego de inibidores biologicos de proteases para conservacao de orgaos tecidos e alimentos |
| US3691016A (en) | 1970-04-17 | 1972-09-12 | Monsanto Co | Process for the preparation of insoluble enzymes |
| CA1023287A (en) | 1972-12-08 | 1977-12-27 | Boehringer Mannheim G.M.B.H. | Process for the preparation of carrier-bound proteins |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| DE2619246A1 (de) | 1976-04-30 | 1977-11-10 | Bayer Ag | Desamino-derivate des kallikrein- trypsin-inhibitors, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4195128A (en) | 1976-05-03 | 1980-03-25 | Bayer Aktiengesellschaft | Polymeric carrier bound ligands |
| DE2654124A1 (de) | 1976-11-29 | 1978-06-01 | Bayer Ag | Derivate des trypsin-kallikrein-inhibitors aus rinderorganen (bpti) mit proteasenhemmwirkung und antiphlogistischer wirkung, ihre herstellung und ihre verwendung als arzneimittel |
| US4330440A (en) | 1977-02-08 | 1982-05-18 | Development Finance Corporation Of New Zealand | Activated matrix and method of activation |
| CA1093991A (en) | 1977-02-17 | 1981-01-20 | Hideo Hirohara | Enzyme immobilization with pullulan gel |
| CA1113397A (en) * | 1977-11-09 | 1981-12-01 | Peter F.R. Lunn | Aqueous persulphate and percarbonate composition for bleaching hair |
| US4229537A (en) | 1978-02-09 | 1980-10-21 | New York University | Preparation of trichloro-s-triazine activated supports for coupling ligands |
| AT359653B (de) | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
| US4299537A (en) * | 1979-06-19 | 1981-11-10 | Evans Frederick C | Interlinked variable-pitch blades for windmills and turbines |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
| AU560584B2 (en) | 1983-07-28 | 1987-04-09 | Bayer Aktiengesellschaft | Homologues of aprotinin |
| US4657893A (en) | 1984-05-09 | 1987-04-14 | Syntex (U.S.A.) Inc. | 4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors |
| US4845242A (en) | 1987-04-28 | 1989-07-04 | Georgia Tech Research Corporation | Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents |
| US4609725A (en) | 1984-10-09 | 1986-09-02 | Merck & Co., Inc. | Cardiac atrial peptides |
| US4931385A (en) | 1985-06-24 | 1990-06-05 | Hygeia Sciences, Incorporated | Enzyme immunoassays and immunologic reagents |
| US5444156A (en) * | 1985-07-12 | 1995-08-22 | Temple University-Of The Commonwealth System Of Higher Education | Monoclonal antibodies to human plasma prekallikrein |
| JPH0623113B2 (ja) | 1986-01-31 | 1994-03-30 | 浩 前田 | 癌性胸・腹水貯留抑制剤 |
| EP0255011A3 (de) | 1986-07-29 | 1988-11-23 | Miles Inc. | Menschliches Inter-alpha-trypsin-Inhibitorgen |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US4881175A (en) | 1986-09-02 | 1989-11-14 | Genex Corporation | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
| US5187153A (en) | 1986-11-17 | 1993-02-16 | Scios Nova Inc. | Methods of treatment using Alzheimer's amyloid polypeptide derivatives |
| DE3752253T2 (de) | 1986-11-17 | 1999-05-27 | Scios Inc | Rekombiniertes Alzheimer Amyloid-Protein. |
| EP0285123A3 (de) | 1987-04-03 | 1989-02-01 | Stabra AG | Verfahren zur vollständigen Mutagenese von Nucleinsäuren |
| IL87172A (en) * | 1987-07-23 | 1994-12-29 | Univ Washington | Method of isolating highly purified tissue factor inhibitor |
| US4966852A (en) * | 1987-07-23 | 1990-10-30 | Monsanto Company | DNA clone of human tissue factor inhibitor |
| US5106833A (en) * | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
| GB2208511A (en) | 1987-08-07 | 1989-04-05 | Bayer Ag | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
| DK225488D0 (da) | 1988-04-26 | 1988-04-26 | Novo Industri As | Polypeptid |
| IL87171A (en) | 1987-11-23 | 1995-08-31 | Monsanto Co | cDNA of human tissue factor inhibitor |
| ATE151110T1 (de) | 1988-09-02 | 1997-04-15 | Protein Eng Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
| US5663143A (en) | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| US7078383B2 (en) * | 1988-09-02 | 2006-07-18 | Dyax Corp. | ITI-D1 Kunitz domain mutants as HNE inhibitors |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5372933A (en) * | 1988-10-03 | 1994-12-13 | The Scripps Research Institute | Polypeptides that mimic receptor-induced binding sites, and methods of using same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| ATE114332T1 (de) | 1989-05-13 | 1994-12-15 | Bayer Ag | Proteinaseninhibitoren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel. |
| DK408089D0 (da) * | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
| US5378614A (en) * | 1989-08-18 | 1995-01-03 | Novo Nordisk A/S | Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast |
| US5278285A (en) * | 1990-02-01 | 1994-01-11 | Bayer Aktiengesellschaft | Variant of Kunitz-type inhibitor derived from the α3-chain of human type VI collagen produced by recombinant DNA technology |
| US5583107A (en) * | 1990-09-04 | 1996-12-10 | Cor Therapeutics, Inc. | Agents affecting thrombosis and hemostasis |
| US5278144A (en) * | 1990-09-04 | 1994-01-11 | Cor Therapeutics, Inc. | Antithrombosis agents |
| IL99585A0 (en) | 1990-10-01 | 1992-08-18 | Novo Nordisk As | Aprotinin analogues,their production and pharmaceutical compositions containing them |
| US5409895A (en) | 1990-11-13 | 1995-04-25 | Mochida Pharmaceutical Co., Ltd. | Protease inhibitory polypeptides derived from urinary trypsin inhibitor and compositions thereof |
| US20030223977A1 (en) * | 1991-03-01 | 2003-12-04 | Ley Arthur Charles | Kunitz domain mutants as cathepsin G inhibitors |
| US5166133A (en) * | 1991-04-17 | 1992-11-24 | Cetus Corporation | Method for inhibing adhesion of white blood cells to endothelial cells |
| AU675916B2 (en) | 1991-06-14 | 1997-02-27 | Genentech Inc. | Method for making humanized antibodies |
| AU3061092A (en) | 1991-10-31 | 1993-06-07 | Salk Institute Biotechnology/Industrial Associates, Inc., The | Recombinant amyloid precursor protein inhibitor domain and treatment of various disease states |
| IL104324A0 (en) | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
| IL104327A0 (en) * | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
| IL104314A0 (en) * | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them |
| IL104326A0 (en) | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
| IL104325A (en) | 1992-01-07 | 2000-10-31 | Novo Nordisk As | Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above |
| US5212091A (en) * | 1992-03-02 | 1993-05-18 | Monsanto Company | Method of producing tissue factor pathway inhibitor |
| US6063764A (en) * | 1992-06-01 | 2000-05-16 | Washington University & Chiron Corp. | Method for using lipoprotein associated coagulation inhibitor to treat sepsis |
| EP0651766A4 (de) * | 1992-07-13 | 1996-07-31 | Corvas Int Inc | INHIBITOREN VON FAKTOR Xa, DIE SICH VOM INHIBITOR DES PANKREATISCHEN TRYPSON AUS RIND ABLEITEN. |
| US5436153A (en) * | 1992-12-02 | 1995-07-25 | Sprecher; Cindy A. | Human amyloid protein precursor homolog and Kunitz-type inhibitor |
| EP0740702A1 (de) | 1992-12-02 | 1996-11-06 | Zymogenetics, Inc. | Neuer menschlicher Amyloid - Protein - Vorläufer und Kunitztyp - Inhibitor |
| US5426224A (en) | 1993-03-18 | 1995-06-20 | The University Of North Carolina At Chapel Hill | Mammalian DNA topoisomerase II inhibitor and method |
| JP3929484B2 (ja) * | 1993-09-14 | 2007-06-13 | ジェネンテック・インコーポレーテッド | エコチンおよびその同族体を含む医薬的組成物 |
| US5455338A (en) * | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
| US5951974A (en) | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
| US5446090A (en) * | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| US5759548A (en) | 1993-11-30 | 1998-06-02 | Lxr Biotechnology Inc. | Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| ATE529444T1 (de) | 1994-01-11 | 2011-11-15 | Dyax Corp | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
| JP3805785B2 (ja) * | 1994-01-11 | 2006-08-09 | ダイアックス コープ． | カリクレイン阻害クニッツドメイン蛋白質およびその相同体 |
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| US5795954A (en) * | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
| EP0763055B1 (de) * | 1994-06-02 | 1999-11-03 | Merrell Pharmaceuticals Inc. | Perfluoroalkyll ketone, inhibitoren von elastase und prozess zur deren herstellung |
| US5589359A (en) * | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
| ATE226249T1 (de) * | 1994-08-05 | 2002-11-15 | Chiron Corp | Herstellung des inhibitors fuer die komplexbildung des gewebefaktors |
| US5648331A (en) * | 1994-08-26 | 1997-07-15 | G.D. Searle & Co. | Method of inhibiting tissue ischemia and reperfusion injury |
| JP3811186B2 (ja) * | 1994-10-18 | 2006-08-16 | コーバス インターナショナル， インコーポレイテッド | 線虫から抽出されるセリンプロテアーゼ阻害剤および抗凝固性タンパク質 |
| US6159938A (en) * | 1994-11-21 | 2000-12-12 | Cortech, Inc. | Serine protease inhibitors comprising α-keto heterocycles |
| JPH10510540A (ja) * | 1994-12-12 | 1998-10-13 | オメロス メディカル システムズ，インコーポレーテッド | 灌注用溶液並びに疼痛、炎症及びけいれんの抑制法 |
| RU2180852C2 (ru) * | 1994-12-12 | 2002-03-27 | Омерос Медикл Системс, Инк. | Ингибирующий раствор и способ подавления боли, воспаления или спазма |
| US5914316A (en) * | 1994-12-16 | 1999-06-22 | Washington University | Method of inhibiting intimal hyperplasia |
| US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| AU707323B2 (en) * | 1995-03-10 | 1999-07-08 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
| US5695760A (en) * | 1995-04-24 | 1997-12-09 | Boehringer Inglehiem Pharmaceuticals, Inc. | Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation |
| US5804376A (en) * | 1995-05-02 | 1998-09-08 | Incyte Pharmaceuticals, Inc. | Pancreas-derived serpin |
| ZA963619B (en) * | 1995-05-08 | 1996-11-22 | Scios Inc | Protease inhibitor peptides |
| EP0827539A2 (de) | 1995-05-08 | 1998-03-11 | Scios Inc. | Protease inhibitoren vom kunitz-type |
| US5780265A (en) * | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
| US5786328A (en) * | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
| US6242414B1 (en) * | 1995-06-07 | 2001-06-05 | Chiron Corporation | Regulation of cytokine synthesis and release |
| US6126933A (en) * | 1995-06-27 | 2000-10-03 | Genetics Institute | Methods of treating inflammatory bowel diseases by administering IL-11 |
| US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| JPH0959838A (ja) | 1995-08-24 | 1997-03-04 | Kuraray Co Ltd | 紡績糸 |
| WO1997009989A1 (en) | 1995-09-14 | 1997-03-20 | Lxr Biotechnology Inc. | Compositions with anti-apoptotic activity, containing a mixture of phospholipids |
| US5853723A (en) * | 1995-09-21 | 1998-12-29 | University Of Utah Research Foundation | Targeting of peg antibody conjugates to islet cells |
| US5824870A (en) | 1995-11-06 | 1998-10-20 | Baszczynski; Chris | Commercial production of aprotinin in plants |
| US5736364A (en) * | 1995-12-04 | 1998-04-07 | Genentech, Inc. | Factor viia inhibitors |
| WO1997033996A2 (en) | 1996-03-11 | 1997-09-18 | Bayer Corporation | Human bikunin |
| US6013763A (en) * | 1996-06-04 | 2000-01-11 | Genentech, Inc. | Peptide variants of protein A |
| JP3657700B2 (ja) * | 1996-06-18 | 2005-06-08 | 新日本石油化学株式会社 | カサ高性不織布の製造方法 |
| US5869637A (en) * | 1996-07-22 | 1999-02-09 | Incyte Pharmaceuticals, Inc. | Human Kallikrein |
| US6214966B1 (en) * | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
| US6255455B1 (en) | 1996-10-11 | 2001-07-03 | The Trustees Of The University Of Pennsylvania | Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof |
| US6258351B1 (en) * | 1996-11-06 | 2001-07-10 | Shearwater Corporation | Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels |
| WO1998033920A2 (en) * | 1997-01-31 | 1998-08-06 | Human Genome Sciences, Inc. | Tissue factor pathway inhibitor-3 |
| US5786238A (en) * | 1997-02-13 | 1998-07-28 | Generyal Dynamics Information Systems, Inc. | Laminated multilayer substrates |
| US5962300A (en) * | 1997-03-26 | 1999-10-05 | Incyte Pharmaceuticals, Inc. | Human kallikrein |
| AU736549B2 (en) | 1997-05-21 | 2001-08-02 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Method for the production of non-immunogenic proteins |
| US5990237A (en) * | 1997-05-21 | 1999-11-23 | Shearwater Polymers, Inc. | Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines |
| EP1027054A4 (de) | 1997-10-28 | 2002-11-04 | Vivus Inc | Lokale anwendung von phosphodiesterase inhibitoren zur behandlung der erektilen dysfunktion |
| AU755051B2 (en) * | 1998-01-07 | 2002-12-05 | Debio Recherche Pharmaceutique S.A. | Degradable heterobifunctional poly(ethylene glycol) acrylates and gels and conjugates derived therefrom |
| DK1061954T3 (da) * | 1998-03-12 | 2004-10-18 | Nektar Therapeutics Al Corp | Polyethylenglycolderivater med proximale reaktive grupper |
| EP0985697B1 (de) * | 1998-03-24 | 2006-01-04 | Nof Corporation | Oximanderivate und verfahren zu ihrer herstellung |
| US6017723A (en) * | 1998-03-27 | 2000-01-25 | Long Island Jewish Medical Center | Method for isolating inhibitors of protease activity |
| US6001596A (en) * | 1998-05-07 | 1999-12-14 | Incyte Pharmaceuticals, Inc. | Growth-associated protease inhibitor heavy chain precursor |
| US6087473A (en) * | 1999-05-26 | 2000-07-11 | Zymogenetics, Inc. | Kunitz domain polypeptide and materials and methods for making it |
| JP2002517197A (ja) * | 1998-06-03 | 2002-06-18 | サイオス，インコーポレーテッド | プロテアーゼインヒビターペプチド |
| US6783965B1 (en) * | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| CA2338665C (en) * | 1998-08-06 | 2011-01-18 | Mountain View Pharmaceuticals, Inc. | Peg-urate oxidase conjugates and use thereof |
| EP1108029A1 (de) | 1998-09-03 | 2001-06-20 | ZymoGenetics | Kunitzdomäne-polypeptide zkun6 |
| US7067144B2 (en) | 1998-10-20 | 2006-06-27 | Omeros Corporation | Compositions and methods for systemic inhibition of cartilage degradation |
| US6565874B1 (en) | 1998-10-28 | 2003-05-20 | Atrix Laboratories | Polymeric delivery formulations of leuprolide with improved efficacy |
| WO2000032772A2 (en) * | 1998-11-30 | 2000-06-08 | Eli Lilly And Company | Erythropoietic compounds |
| DE69934967T2 (de) | 1998-12-08 | 2007-12-06 | Biovation Ltd. | Verfahren zur verminderung der immunogenität von proteinen |
| US20030012969A1 (en) * | 1999-04-06 | 2003-01-16 | Clark Bert Thomas | Soluble membrane strengthened paper products |
| CN1550235A (zh) | 1999-04-29 | 2004-12-01 | ŵ��Ų�ڿ˹�˾ | 结合肝素的拮抗剂在缓激肽释放的抑制中的应用 |
| US6605316B1 (en) | 1999-07-31 | 2003-08-12 | The Regents Of The University Of California | Structures and fabrication techniques for solid state electrochemical devices |
| US6180607B1 (en) * | 1999-08-05 | 2001-01-30 | Christopher Davies | Protein having proteinase inhibitor activity |
| EP1212422B1 (de) | 1999-08-24 | 2007-02-21 | Medarex, Inc. | Humane antikörper gegen ctla-4 und deren verwendungen |
| HRP20020387A2 (en) * | 1999-11-12 | 2005-10-31 | Maxygen Holdings Ltd. | Interferon gamma conjugates |
| US6348558B1 (en) * | 1999-12-10 | 2002-02-19 | Shearwater Corporation | Hydrolytically degradable polymers and hydrogels made therefrom |
| JP5095061B2 (ja) * | 1999-12-22 | 2012-12-12 | ネクター セラピューティックス | ポリ（エチレングリコール）の１−ベンゾトリアゾリル炭酸エステルの調製のための方法 |
| US6544760B2 (en) * | 1999-12-22 | 2003-04-08 | Zymogenetics, Inc. | Kunitz domain polypeptide Zkun11 |
| US6413507B1 (en) * | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
| US20020102703A1 (en) * | 1999-12-29 | 2002-08-01 | Sheppard Paul O. | Kunitz domain polypeptide zkun10 |
| GB9930882D0 (en) * | 1999-12-30 | 2000-02-23 | Nps Allelix Corp | GLP-2 formulations |
| WO2001068707A1 (en) | 2000-03-13 | 2001-09-20 | Eli Lilly And Company | Human hepatocyte growth factor activator inhibitor homologue |
| EP2298355A3 (de) | 2000-04-12 | 2011-06-29 | Human Genome Sciences, Inc. | Albuminfusionsproteine |
| CN1331213A (zh) | 2000-06-30 | 2002-01-16 | 上海博德基因开发有限公司 | 一种新的多肽——人大蛋白10.01和编码这种多肽的多核苷酸 |
| DE10034357C1 (de) | 2000-07-14 | 2001-12-13 | Elotherm Gmbh | Verfahren und Vorrichtung zum Härten von Flächen an Bauteilen |
| JP2004509617A (ja) | 2000-09-08 | 2004-04-02 | シェーリング コーポレイション | 哺乳動物遺伝子；関連試薬および方法 |
| AU2002217014B2 (en) * | 2000-10-31 | 2006-11-02 | Debiopharm S.A. | Suspension of an EPI-hNE protein, process of preparation thereof, dry powder aerosol derived therefrom, pharmaceutical compositions containing said suspension or aerosol, and their uses |
| US20030113726A1 (en) | 2000-12-04 | 2003-06-19 | Zenta Tsuchihashi | Human single nucleotide polymorphisms |
| TW593427B (en) * | 2000-12-18 | 2004-06-21 | Nektar Therapeutics Al Corp | Synthesis of high molecular weight non-peptidic polymer derivatives |
| WO2002092147A2 (en) | 2001-05-11 | 2002-11-21 | Aradigm Corporation | Optimization of the molecular properties and formulation of proteins delivered by inhalation |
| TR200400295T2 (tr) | 2001-05-21 | 2005-04-21 | Nektar Therapeutics | Kimyasal olarak modifiye edilmiş ensülin'in akçiğer yoluyla verilmesi |
| US20040152633A1 (en) * | 2001-05-31 | 2004-08-05 | Jorgensen Marianne Ulrich | Kunitz-type sequences and polypeptides |
| US6926250B1 (en) | 2001-07-10 | 2005-08-09 | Sankyo Seiki Mfg. Co., Ltd. | Valve driving device |
| EP1406652A2 (de) | 2001-07-10 | 2004-04-14 | Omnio AB | Neue arzneimittelziele für arthritis |
| US20050222023A1 (en) | 2002-02-07 | 2005-10-06 | Hans-Peter Hauser | Albumin-fused kunitz domain peptides |
| KR20050002823A (ko) | 2002-02-07 | 2005-01-10 | 델타 바이오테크놀로지 리미티드 | 알부민-융합 쿠니츠 도메인 펩타이드 |
| WO2003101941A2 (en) | 2002-05-31 | 2003-12-11 | Genzyme Corporation | Alpha acyloxyacetamides for kallikrein and urokinase inhibition |
| CA2488558C (en) | 2002-06-07 | 2013-08-20 | Dyax Corp. | Prevention and reduction of blood loss |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| PL375254A1 (en) * | 2002-07-24 | 2005-11-28 | F.Hoffmann-La Roche Ag | Pegylated t20 polypeptide |
| CN100337689C (zh) * | 2002-07-24 | 2007-09-19 | 弗·哈夫曼-拉罗切有限公司 | 聚亚烷基二醇酸加合物 |
| WO2004019968A1 (en) * | 2002-08-28 | 2004-03-11 | Dyax Corp. | Methods for preserving organs and tissues |
| US20040062748A1 (en) * | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| US8129330B2 (en) * | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| US7314613B2 (en) * | 2002-11-18 | 2008-01-01 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
| EP1667708B9 (de) * | 2002-12-26 | 2012-10-31 | Mountain View Pharmaceuticals, Inc. | INTERFERON-BETA-1b POLYETHYLENEGLYKOL-KONJUGATE MIT ERHÖHTER IN VITRO BIOLOGISCHER WIRKSAMKEIT |
| ATE500345T1 (de) * | 2003-01-07 | 2011-03-15 | Dyax Corp | Kunitz-domäne-bibliothek |
| DE602004015725D1 (de) | 2003-01-08 | 2008-09-25 | Novartis Vaccines & Diagnostic | Stabilisierte lyophilisierte zubereitungen mit gewebefaktor-inhibitor (tfpi) oder varianten des gewebefaktor-inhibitors |
| US20040224886A1 (en) | 2003-01-08 | 2004-11-11 | Chiron Corporation | Stabilized compositions comprising tissue factor pathway inhibitor protein or tissue factor pathway inhibitor variant proteins |
| DE10301300B4 (de) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
| US6989369B2 (en) * | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
| WO2005003150A2 (en) | 2003-07-02 | 2005-01-13 | Emory University | Compositions and methods for use of a protease inhibitor and adenosine for preventing organ ischemia and reperfusion injury |
| WO2005019270A2 (en) * | 2003-08-14 | 2005-03-03 | Dyax Corp. | Endotheliase-2 ligands |
| AU2004268145B2 (en) | 2003-08-29 | 2010-09-16 | Takeda Pharmaceutical Company Limited | Poly-PEGylated protease inhibitors |
| AU2004268144A1 (en) * | 2003-08-29 | 2005-03-10 | Dyax Corp. | Modified protease inhibitors |
| WO2005027753A1 (en) | 2003-09-19 | 2005-03-31 | St. Jude Medical, Inc. | Apparatus and methods for tissue gathering and securing |
| US7268109B2 (en) | 2003-10-02 | 2007-09-11 | Elan Pharmaceuticals, Inc. | Method for reducing pain |
| US20060228331A1 (en) * | 2003-10-10 | 2006-10-12 | Novo Nordisk A/S | IL-21 Derivatives and variants |
| WO2005041631A2 (en) * | 2003-10-21 | 2005-05-12 | Dyax Corp. | Endotheliase-1 ligands |
| EP1713929A2 (de) * | 2004-02-03 | 2006-10-25 | Bayer HealthCare AG | Diagnostika und therapeutika für mit plasma-kallikrein (klkb1) assoziierten krankheiten |
| WO2005095327A1 (ja) | 2004-03-31 | 2005-10-13 | Ajinomoto Co., Inc. | アニリン誘導体 |
| EP1807451A2 (de) | 2004-08-03 | 2007-07-18 | Dyax Corporation | Hk1-bindende proteine |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| JP2008520729A (ja) | 2004-11-22 | 2008-06-19 | ダイアックス コーポレーション | プラスミン阻害療法 |
| ITMI20042442A1 (it) | 2004-12-21 | 2005-03-21 | Aliveris S R L | Paste alimentari con migliorate caratteristiche di digeribilita' |
| MX2007006997A (es) | 2004-12-23 | 2007-10-10 | Csl Behring Gmbh | Prevencion de formacion y/o estabilizacion de trombo. |
| WO2006089005A2 (en) | 2005-02-17 | 2006-08-24 | Bristol-Myers Squibb Company | Combination of selective factor viia and/or xia and plasma kallikrein inhibitors |
| EP1858542A4 (de) | 2005-02-24 | 2009-08-19 | Joslin Diabetes Center Inc | Zusammensetzungen und verfahren zur behandlung von gefässpermeabilität |
| WO2006117565A2 (en) | 2005-05-04 | 2006-11-09 | Zealand Pharma A/S | Glucagon-like-peptide-2 (glp-2) analogues |
| US20070079096A1 (en) | 2005-09-30 | 2007-04-05 | Chih-Wei Chen | Data storage unit access authorization table automatic rebuilding method and system |
| US7583040B2 (en) | 2005-09-30 | 2009-09-01 | 9141-0720 Quebec Inc. | Motorized closure operating device with electronic control system |
| US8828703B2 (en) * | 2005-12-29 | 2014-09-09 | Dyax Corp. | Protease inhibition |
| US7276480B1 (en) * | 2005-12-30 | 2007-10-02 | Dyax Corp. | Prevention and reduction of blood loss |
| US20070213275A1 (en) * | 2006-03-10 | 2007-09-13 | Dyax Corp. | Formulations for ecallantide |
| PT1854477T (pt) | 2006-03-16 | 2016-11-10 | Dyax Corp | Inibidores peptidicos da calicreína plasmática e sua utilização no tratamento de doenças oftalmológicas |
| US20080031426A1 (en) | 2006-06-27 | 2008-02-07 | Weeks Walter L | Audio, video, and navigational law enforcement system and method |
| EP1873344A1 (de) | 2006-06-30 | 2008-01-02 | Sika Technology AG | Mittels Silikon agedichtete Verklebung |
| EP2051707B1 (de) | 2006-07-31 | 2013-07-17 | Activesite Pharmaceuticals, Inc. | Plasma-kallikrein-hemmer |
| US20080299050A1 (en) | 2006-10-05 | 2008-12-04 | Drugtech Corporation | Topical therapies for oral mucositis and other conditions |
| AU2008289005A1 (en) | 2007-08-21 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
| US20090105142A1 (en) | 2007-08-23 | 2009-04-23 | Genzyme Corporation | Treatment with kallikrein inhibitors |
| US20090215119A1 (en) | 2008-02-13 | 2009-08-27 | Dyax Corp. | Methods for producing specific binding pairs |
| DE102008027574A1 (de) | 2008-06-10 | 2009-12-17 | Merck Patent Gmbh | Neue Pyrrolidinderivate als MetAP-2 Inhibitoren |
| DE102008033095A1 (de) | 2008-07-15 | 2010-01-28 | Uhde Gmbh | Vorrichtung zur Schlackeabführung aus einem Kohlevergasungsreaktor |
| WO2010080833A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| HUE057244T2 (hu) | 2010-01-06 | 2022-04-28 | Takeda Pharmaceuticals Co | Plazma kallikreint kötõ fehérjék |
| AU2012204202A1 (en) | 2011-01-06 | 2013-07-11 | Dyax Corp. | Plasma kallikrein binding proteins |
| US8691861B2 (en) | 2011-04-13 | 2014-04-08 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
| HUE044285T2 (hu) | 2013-01-20 | 2019-10-28 | Dyax Corp | PKal-mediálta rendellenességek értékelése, vizsgálata és kezelése |
| US10428158B2 (en) | 2014-03-27 | 2019-10-01 | Dyax Corp. | Compositions and methods for treatment of diabetic macular edema |
-
2003
- 2003-06-06 CA CA2488558A patent/CA2488558C/en not_active Expired - Lifetime
- 2003-06-06 ES ES07023364T patent/ES2372978T3/es not_active Expired - Lifetime
- 2003-06-06 PT PT101804847T patent/PT2311432E/pt unknown
- 2003-06-06 DK DK10180486.2T patent/DK2298278T3/en active
- 2003-06-06 US US10/456,986 patent/US7064107B2/en not_active Expired - Lifetime
- 2003-06-06 EP EP07023364A patent/EP1941867B1/de not_active Expired - Lifetime
- 2003-06-06 ES ES10180484.7T patent/ES2528254T3/es not_active Expired - Lifetime
- 2003-06-06 PT PT03757339T patent/PT1531791E/pt unknown
- 2003-06-06 PT PT101804862T patent/PT2298278E/pt unknown
- 2003-06-06 ES ES03757339T patent/ES2348230T3/es not_active Expired - Lifetime
- 2003-06-06 DK DK03757339.1T patent/DK1531791T3/da active
- 2003-06-06 EP EP10180484.7A patent/EP2311432B1/de not_active Expired - Lifetime
- 2003-06-06 AT AT07023364T patent/ATE528014T1/de active
- 2003-06-06 EP EP03757339A patent/EP1531791B1/de not_active Expired - Lifetime
- 2003-06-06 ES ES10180486.2T patent/ES2559927T3/es not_active Expired - Lifetime
- 2003-06-06 AT AT03757339T patent/ATE477020T1/de active
- 2003-06-06 PT PT07023364T patent/PT1941867E/pt unknown
- 2003-06-06 WO PCT/US2003/017665 patent/WO2003103475A2/en not_active Ceased
- 2003-06-06 JP JP2004510605A patent/JP2005534647A/ja active Pending
- 2003-06-06 DE DE60333758T patent/DE60333758D1/de not_active Expired - Lifetime
- 2003-06-06 DK DK07023364.8T patent/DK1941867T3/da active
- 2003-06-06 DK DK10180484.7T patent/DK2311432T3/en active
- 2003-06-06 EP EP10180486.2A patent/EP2298278B1/de not_active Expired - Lifetime
- 2003-06-06 AU AU2003243394A patent/AU2003243394B2/en not_active Expired
-
2005
- 2005-12-30 US US11/322,960 patent/US20060194727A1/en not_active Abandoned
-
2007
- 2007-04-27 US US11/796,272 patent/US20080064637A1/en not_active Abandoned
- 2007-10-30 US US11/929,729 patent/US8124586B2/en not_active Expired - Lifetime
- 2007-10-30 US US11/930,018 patent/US20080131426A1/en not_active Abandoned
- 2007-10-30 US US11/930,012 patent/US7811991B2/en not_active Expired - Lifetime
- 2007-10-31 US US11/931,635 patent/US20080152656A1/en not_active Abandoned
- 2007-10-31 US US11/931,373 patent/US7851442B2/en not_active Expired - Lifetime
- 2007-11-02 US US11/934,181 patent/US20080260752A1/en not_active Abandoned
-
2008
- 2008-05-29 AU AU2008202377A patent/AU2008202377B2/en not_active Expired
-
2010
- 2010-01-12 JP JP2010004265A patent/JP5249251B2/ja not_active Expired - Lifetime
- 2010-11-22 US US12/951,543 patent/US8710007B2/en not_active Expired - Lifetime
-
2011
- 2011-04-20 AU AU2011201811A patent/AU2011201811A1/en not_active Abandoned
-
2012
- 2012-01-11 CY CY20121100027T patent/CY1112228T1/el unknown
- 2012-11-01 JP JP2012242083A patent/JP2013049698A/ja active Pending
-
2014
- 2014-04-28 US US14/263,764 patent/US9480733B2/en not_active Expired - Lifetime
-
2016
- 2016-06-07 US US15/175,644 patent/US10245307B2/en not_active Expired - Lifetime
-
2019
- 2019-02-21 US US16/281,276 patent/US11344610B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE528014T1 (de) | Polypeptid mit modifizierten kunitz domains | |
| NO942553D0 (no) | Ny humanproteaseinhibitor av Kunitz-type og varianter derav | |
| DE69942035D1 (de) | Menschliches parathyroidhormon, modifikationen, herstellung und verwendung | |
| NL300013I1 (nl) | Nieuwe protein met TNF-remmende werking en hun ber | |
| WO2002002597A3 (en) | Peptide extended glycosylated polypeptides | |
| DE69128664D1 (de) | CNP-Gen und Vorläuferprotein aus Schwein | |
| WO2001005810A3 (de) | CYCLISCHE PEPTIDDERIVATE ALS INHIBITOREN DES INTEGRINS αvβ¿6? | |
| DK1519951T3 (da) | Kationiske ligekædede peptider med antifungale egenskaber | |
| DE3751398D1 (de) | Substrat-Peptide. | |
| ES2171157T3 (es) | Gen recombinante codificante para una proteina con actividad endoquitinasa. | |
| CY1115911T1 (el) | Τροποποιημενα πολυπεπτιδια περιοχης kunitz και η χρηση τους στην μειωση της ισχαιμιας ή της εκκινησης μιας συστημικης φλεγμονωδους ανταποκρισης που σχετιζεται με μια χειρουργικη επεμβαση | |
| ATE388965T1 (de) | Menschliche antithrombin-varianten | |
| FR2787454B1 (fr) | Inhibiteur de la topoisomerase ii | |
| ATE432985T1 (de) | Polypeptide mit aktivität der stimulierung von neutrophilen | |
| CO4340568A1 (es) | Familia de peptidos con 51 aminoacidos en longitud, secuen- cias de definicion, la planta transgenica comprendida, el vector de expresion recombinante y el metodo para su pro- duccion. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1941867 Country of ref document: EP |