DK633289A - Retrovirale proteasehaemmere - Google Patents

Retrovirale proteasehaemmere Download PDF

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Publication number
DK633289A
DK633289A DK633289A DK633289A DK633289A DK 633289 A DK633289 A DK 633289A DK 633289 A DK633289 A DK 633289A DK 633289 A DK633289 A DK 633289A DK 633289 A DK633289 A DK 633289A
Authority
DK
Denmark
Prior art keywords
protease inhibitors
retroviral protease
retroviral
inhibitors
protease
Prior art date
Application number
DK633289A
Other languages
English (en)
Other versions
DK633289D0 (da
Inventor
Alexander Faessler
Ernst Hungerbuehler
Heinrich Rueeger
Peter Schneider
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK633289D0 publication Critical patent/DK633289D0/da
Publication of DK633289A publication Critical patent/DK633289A/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02Linear peptides containing at least one abnormal peptide link
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK633289A 1988-12-15 1989-12-14 Retrovirale proteasehaemmere DK633289A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH464088 1988-12-15

Publications (2)

Publication Number Publication Date
DK633289D0 DK633289D0 (da) 1989-12-14
DK633289A true DK633289A (da) 1990-06-16

Family

ID=4279903

Family Applications (1)

Application Number Title Priority Date Filing Date
DK633289A DK633289A (da) 1988-12-15 1989-12-14 Retrovirale proteasehaemmere

Country Status (15)

Country Link
EP (1) EP0374098A3 (da)
JP (1) JPH02300199A (da)
KR (1) KR900009692A (da)
AU (1) AU626361B2 (da)
CA (1) CA2005340A1 (da)
DD (1) DD290894A5 (da)
DK (1) DK633289A (da)
FI (1) FI895962A0 (da)
HU (1) HUT52525A (da)
IL (1) IL92672A0 (da)
MX (1) MX18736A (da)
NO (1) NO895026L (da)
NZ (1) NZ231750A (da)
PT (1) PT92554A (da)
ZA (1) ZA899558B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2010531A1 (en) * 1989-03-06 1990-09-06 Werner Neidhart Amino acid derivatives
AU7732691A (en) * 1990-06-01 1991-12-05 Ciba-Geigy Ag Hiv protease inhibitors and processes for their preparation
DE4126485A1 (de) * 1991-08-10 1993-02-11 Bayer Ag Trifluormethyl-haltige pseudopeptide
US5643878A (en) * 1991-09-12 1997-07-01 Ciba-Geigy Corporation 5-amino-4-hydroxyhexanoic acid derivatives
RU2126794C1 (ru) 1992-03-11 1999-02-27 Нархекс Лимитед Аминопроизводные оксо- или гидроксизамещенных гидразинов, способ их получения и фармацевтические композиции для ингибирования ретровирусной протеазы
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
DE69333270T2 (de) 1992-03-11 2004-08-05 Narhex Ltd. Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
TW217410B (da) * 1992-04-01 1993-12-11 Ciba Geigy
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
EP0626178A1 (de) * 1993-05-17 1994-11-30 Ciba-Geigy Ag Verwendung von Hemmstoffen von HIV-Aspartatproteasen zur Bekämpfung von Tumorerkrankungen
DE4332395A1 (de) * 1993-09-23 1995-04-13 Horst Dr Lindhofer Inhibitoren zur Hemmung der zymogenähnlichen Freispaltung der HIV-1 Protease
PL335484A1 (en) * 1997-02-26 2000-04-25 Pfizer Derivatives of heteroarylhexamide, their production and application as selective inhibitors of mip-1a being assimilated by its ccr1 receptor
JP2002538151A (ja) 1999-03-02 2002-11-12 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド カテプシンの可逆的インヒビターとして有用な化合物
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
JP2003522164A (ja) * 2000-02-04 2003-07-22 ファイザー・プロダクツ・インク ヘテロ環式アミド誘導体
EP1498417A1 (en) * 2000-02-04 2005-01-19 Pfizer Products Inc. Heterocyclic amide derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
WO1988003022A1 (en) * 1986-10-31 1988-05-05 Pfizer Inc. Relatively low molecular weight polypeptides as renin inhibitors

Also Published As

Publication number Publication date
PT92554A (pt) 1990-06-29
EP0374098A2 (de) 1990-06-20
AU4678489A (en) 1990-06-21
JPH02300199A (ja) 1990-12-12
NZ231750A (en) 1992-08-26
ZA899558B (en) 1990-08-29
HUT52525A (en) 1990-07-28
NO895026L (no) 1990-06-18
DD290894A5 (de) 1991-06-13
EP0374098A3 (de) 1991-05-02
MX18736A (es) 1994-02-28
IL92672A0 (en) 1990-09-17
DK633289D0 (da) 1989-12-14
AU626361B2 (en) 1992-07-30
FI895962A0 (fi) 1989-12-13
KR900009692A (ko) 1990-07-05
CA2005340A1 (en) 1990-06-15
NO895026D0 (no) 1989-12-14

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment