AU4678489A - Retroviral protease inhibitors - Google Patents

Retroviral protease inhibitors

Info

Publication number
AU4678489A
AU4678489A AU46784/89A AU4678489A AU4678489A AU 4678489 A AU4678489 A AU 4678489A AU 46784/89 A AU46784/89 A AU 46784/89A AU 4678489 A AU4678489 A AU 4678489A AU 4678489 A AU4678489 A AU 4678489A
Authority
AU
Australia
Prior art keywords
protease inhibitors
retroviral protease
retroviral
inhibitors
protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU46784/89A
Other versions
AU626361B2 (en
Inventor
Alexander Fassler
Ernst Hungerbuhler
Heinrich Rueger
Peter Schneider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of AU4678489A publication Critical patent/AU4678489A/en
Application granted granted Critical
Publication of AU626361B2 publication Critical patent/AU626361B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02Linear peptides containing at least one abnormal peptide link
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU46784/89A 1988-12-15 1989-12-14 Retroviral protease inhibitors Ceased AU626361B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH4640/88 1988-12-15
CH464088 1988-12-15

Publications (2)

Publication Number Publication Date
AU4678489A true AU4678489A (en) 1990-06-21
AU626361B2 AU626361B2 (en) 1992-07-30

Family

ID=4279903

Family Applications (1)

Application Number Title Priority Date Filing Date
AU46784/89A Ceased AU626361B2 (en) 1988-12-15 1989-12-14 Retroviral protease inhibitors

Country Status (15)

Country Link
EP (1) EP0374098A3 (en)
JP (1) JPH02300199A (en)
KR (1) KR900009692A (en)
AU (1) AU626361B2 (en)
CA (1) CA2005340A1 (en)
DD (1) DD290894A5 (en)
DK (1) DK633289A (en)
FI (1) FI895962A0 (en)
HU (1) HUT52525A (en)
IL (1) IL92672A0 (en)
MX (1) MX18736A (en)
NO (1) NO895026L (en)
NZ (1) NZ231750A (en)
PT (1) PT92554A (en)
ZA (1) ZA899558B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2010531A1 (en) * 1989-03-06 1990-09-06 Werner Neidhart Amino acid derivatives
AU7732691A (en) * 1990-06-01 1991-12-05 Ciba-Geigy Ag Hiv protease inhibitors and processes for their preparation
DE4126485A1 (en) * 1991-08-10 1993-02-11 Bayer Ag TRIFLUOROMETHYL-CONTAINING PSEUDOPEPTIDE
US5643878A (en) * 1991-09-12 1997-07-01 Ciba-Geigy Corporation 5-amino-4-hydroxyhexanoic acid derivatives
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
MXPA93002392A (en) 1992-03-11 2005-02-04 Narhex Ltd Amine derivatives of oxo- and hydroxy-substitued hydrocarbons.
EP0633881B1 (en) 1992-03-11 2003-10-29 Narhex Limited Amine derivatives of oxo- and hydroxy-substitued hydrocarbons
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
TW217410B (en) * 1992-04-01 1993-12-11 Ciba Geigy
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
EP0626178A1 (en) * 1993-05-17 1994-11-30 Ciba-Geigy Ag Use of inhibitors of HIV-protease for the treatment of tumorous diseases
DE4332395A1 (en) * 1993-09-23 1995-04-13 Horst Dr Lindhofer Inhibitors for the zymogen-like liberation cleavage of HIV-1 protease
WO1998038167A1 (en) * 1997-02-26 1998-09-03 Pfizer Inc. Heteroaryl-hexanoic acid amide derivatives, their preparation and their use as selective inhibitors of mip-1-alpha binding to its ccr1 receptor
WO2000051998A1 (en) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
EP1498417A1 (en) * 2000-02-04 2005-01-19 Pfizer Products Inc. Heterocyclic amide derivatives
SK10882002A3 (en) * 2000-02-04 2003-10-07 Pfizer Products Inc. Heterocyclic amide derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
HU204285B (en) * 1986-10-31 1991-12-30 Pfizer Process for producing renin-inhibiting polypeptides of small molecule mass and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DK633289A (en) 1990-06-16
JPH02300199A (en) 1990-12-12
DD290894A5 (en) 1991-06-13
EP0374098A3 (en) 1991-05-02
HUT52525A (en) 1990-07-28
DK633289D0 (en) 1989-12-14
IL92672A0 (en) 1990-09-17
PT92554A (en) 1990-06-29
AU626361B2 (en) 1992-07-30
EP0374098A2 (en) 1990-06-20
FI895962A0 (en) 1989-12-13
NO895026D0 (en) 1989-12-14
NO895026L (en) 1990-06-18
CA2005340A1 (en) 1990-06-15
KR900009692A (en) 1990-07-05
NZ231750A (en) 1992-08-26
MX18736A (en) 1994-02-28
ZA899558B (en) 1990-08-29

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