ZA899558B - Retroviral protease inhibitors - Google Patents

Retroviral protease inhibitors

Info

Publication number
ZA899558B
ZA899558B ZA899558A ZA899558A ZA899558B ZA 899558 B ZA899558 B ZA 899558B ZA 899558 A ZA899558 A ZA 899558A ZA 899558 A ZA899558 A ZA 899558A ZA 899558 B ZA899558 B ZA 899558B
Authority
ZA
South Africa
Prior art keywords
protease inhibitors
retroviral protease
retroviral
inhibitors
protease
Prior art date
Application number
ZA899558A
Other languages
English (en)
Inventor
Alexander Faessler
Faessler Alexander
Ernst Hungerbuehler
Hungerbuehler Ernst
Heinrich Rueeger
Rueeger Heinrich
Peter Schneider
Schneider Peter
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of ZA899558B publication Critical patent/ZA899558B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02Linear peptides containing at least one abnormal peptide link
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA899558A 1988-12-15 1989-12-14 Retroviral protease inhibitors ZA899558B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH464088 1988-12-15

Publications (1)

Publication Number Publication Date
ZA899558B true ZA899558B (en) 1990-08-29

Family

ID=4279903

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA899558A ZA899558B (en) 1988-12-15 1989-12-14 Retroviral protease inhibitors

Country Status (15)

Country Link
EP (1) EP0374098A3 (xx)
JP (1) JPH02300199A (xx)
KR (1) KR900009692A (xx)
AU (1) AU626361B2 (xx)
CA (1) CA2005340A1 (xx)
DD (1) DD290894A5 (xx)
DK (1) DK633289A (xx)
FI (1) FI895962A0 (xx)
HU (1) HUT52525A (xx)
IL (1) IL92672A0 (xx)
MX (1) MX18736A (xx)
NO (1) NO895026L (xx)
NZ (1) NZ231750A (xx)
PT (1) PT92554A (xx)
ZA (1) ZA899558B (xx)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5409927A (en) * 1992-04-01 1995-04-25 Ciba-Geigy Corporation Morpholin- and thiomorpholin-4-ylamides
US5643878A (en) * 1991-09-12 1997-07-01 Ciba-Geigy Corporation 5-amino-4-hydroxyhexanoic acid derivatives
US5663168A (en) * 1993-05-17 1997-09-02 Ciba-Geigy Corporation Use of compositions for combating tumour diseases

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2010531A1 (en) * 1989-03-06 1990-09-06 Werner Neidhart Amino acid derivatives
AU7732691A (en) * 1990-06-01 1991-12-05 Ciba-Geigy Ag Hiv protease inhibitors and processes for their preparation
DE4126485A1 (de) * 1991-08-10 1993-02-11 Bayer Ag Trifluormethyl-haltige pseudopeptide
NZ249789A (en) 1992-03-11 1997-07-27 Narhex Ltd Hydrazine, carbazate and 1,2-diazacyclic derivatives and pharmaceutical compositions
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
DE69333270T2 (de) 1992-03-11 2004-08-05 Narhex Ltd. Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
DE4332395A1 (de) * 1993-09-23 1995-04-13 Horst Dr Lindhofer Inhibitoren zur Hemmung der zymogenähnlichen Freispaltung der HIV-1 Protease
PL335484A1 (en) 1997-02-26 2000-04-25 Pfizer Derivatives of heteroarylhexamide, their production and application as selective inhibitors of mip-1a being assimilated by its ccr1 receptor
WO2000051998A1 (en) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
EP1498417A1 (en) * 2000-02-04 2005-01-19 Pfizer Products Inc. Heterocyclic amide derivatives
EA005320B1 (ru) 2000-02-04 2005-02-24 Пфайзер Продактс Инк. Производные гетероциклического амида

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
HU204285B (en) * 1986-10-31 1991-12-30 Pfizer Process for producing renin-inhibiting polypeptides of small molecule mass and pharmaceutical compositions containing them

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643878A (en) * 1991-09-12 1997-07-01 Ciba-Geigy Corporation 5-amino-4-hydroxyhexanoic acid derivatives
US5409927A (en) * 1992-04-01 1995-04-25 Ciba-Geigy Corporation Morpholin- and thiomorpholin-4-ylamides
US5663168A (en) * 1993-05-17 1997-09-02 Ciba-Geigy Corporation Use of compositions for combating tumour diseases

Also Published As

Publication number Publication date
DD290894A5 (de) 1991-06-13
EP0374098A3 (de) 1991-05-02
NO895026L (no) 1990-06-18
NO895026D0 (no) 1989-12-14
MX18736A (es) 1994-02-28
PT92554A (pt) 1990-06-29
DK633289A (da) 1990-06-16
JPH02300199A (ja) 1990-12-12
FI895962A0 (fi) 1989-12-13
IL92672A0 (en) 1990-09-17
AU4678489A (en) 1990-06-21
EP0374098A2 (de) 1990-06-20
HUT52525A (en) 1990-07-28
DK633289D0 (da) 1989-12-14
CA2005340A1 (en) 1990-06-15
NZ231750A (en) 1992-08-26
KR900009692A (ko) 1990-07-05
AU626361B2 (en) 1992-07-30

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