DK1915620T3 - Diagnose, behandling og prævention af vaskulære sygdomme ved hjælp af IL-1alpha-autoantistoffer - Google Patents
Diagnose, behandling og prævention af vaskulære sygdomme ved hjælp af IL-1alpha-autoantistofferInfo
- Publication number
- DK1915620T3 DK1915620T3 DK06795161.6T DK06795161T DK1915620T3 DK 1915620 T3 DK1915620 T3 DK 1915620T3 DK 06795161 T DK06795161 T DK 06795161T DK 1915620 T3 DK1915620 T3 DK 1915620T3
- Authority
- DK
- Denmark
- Prior art keywords
- autoantibodies
- vascular diseases
- 1alpha
- contraception
- diagnosis
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70445005P | 2005-08-02 | 2005-08-02 | |
PCT/IB2006/002038 WO2007015128A1 (en) | 2005-08-02 | 2006-07-26 | DIAGNOSIS, TREATMENT, AND PREVENTION OF VASCULAR DISORDERS USING IL-1α AUTOANTIBODIES |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1915620T3 true DK1915620T3 (da) | 2010-10-04 |
Family
ID=37442093
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06795161.6T DK1915620T3 (da) | 2005-08-02 | 2006-07-26 | Diagnose, behandling og prævention af vaskulære sygdomme ved hjælp af IL-1alpha-autoantistoffer |
Country Status (11)
Country | Link |
---|---|
US (2) | US8187817B2 (da) |
EP (2) | EP1915620B1 (da) |
JP (2) | JP5645361B2 (da) |
CN (2) | CN101253409A (da) |
AT (1) | ATE470151T1 (da) |
AU (1) | AU2006274698B2 (da) |
CA (1) | CA2617637C (da) |
DE (1) | DE602006014691D1 (da) |
DK (1) | DK1915620T3 (da) |
ES (1) | ES2346691T3 (da) |
WO (1) | WO2007015128A1 (da) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2346691T3 (es) * | 2005-08-02 | 2010-10-19 | Xbiotech, Inc | Diagnostico, tratamiento y prevencion de trastornos vasculares usando autoanticuerpos il-1alfa. |
US20110008282A1 (en) * | 2006-05-15 | 2011-01-13 | Xbiotech, Inc. | IL-1alpha immunization induces autoantibodies protective against atherosclerosis |
CA2652274A1 (en) * | 2006-05-15 | 2007-11-22 | Xbiotech Inc. | Il-1.alpha. immunization induces autoantibodies protective against atherosclerosis |
ES2374845T3 (es) * | 2006-05-22 | 2012-02-22 | Xbiotech, Inc | Tratamiento de cáncer con anticuerpos anti-il-1. |
ES2576681T3 (es) * | 2008-05-30 | 2016-07-08 | Xbiotech, Inc | Anticuerpos IL-1 alfa |
US8242074B2 (en) | 2008-09-12 | 2012-08-14 | Xbiotech, Inc. | Modulation of the amount or function of pathogenic CD14+CD16+ monocytes |
US20130231257A1 (en) | 2010-05-12 | 2013-09-05 | The University Of Birmingham | Biomarker |
EP2571532B1 (en) | 2010-05-14 | 2017-05-03 | Abbvie Inc. | Il-1 binding proteins |
JP6324720B2 (ja) | 2010-06-18 | 2018-05-16 | エックスバイオテク, インコーポレイテッドXbiotech, Inc. | 関節炎治療 |
EP3443985B1 (en) | 2010-08-23 | 2020-12-16 | XBiotech, Inc | Treatment for neoplastic diseases |
WO2012067165A1 (ja) * | 2010-11-17 | 2012-05-24 | 国立大学法人愛媛大学 | 自己免疫疾患に関与するタンパク質の解析方法及び該疾患の検査方法 |
US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
WO2013043973A2 (en) | 2011-09-23 | 2013-03-28 | Xbiotech, Inc. | Cachexia treatment |
US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
CA3053231A1 (en) | 2017-02-16 | 2018-08-23 | Xbiotech Inc. | Treatment of hidradenitis suppurativa |
SG11202008718UA (en) * | 2018-03-09 | 2020-10-29 | Brigham & Womens Hospital Inc | Combination therapy for cardiovascular diseases |
US10975146B2 (en) | 2018-06-29 | 2021-04-13 | Cedars-Sinai Medical Center | Interleukin-1 inhibition for combination treatment of pancreatic cancer |
Family Cites Families (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH652145A5 (de) | 1982-01-22 | 1985-10-31 | Sandoz Ag | Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen. |
US5672347A (en) | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
US4965198A (en) | 1985-12-24 | 1990-10-23 | Konica Corporation | Monoclonal antibody and method of manufacturing hybridoma producing the same |
DE3631229A1 (de) | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
DK590387A (da) | 1986-11-13 | 1988-05-14 | Otsuka Pharma Co Ltd | Antistoffer mod interleukin-1 |
US5034316A (en) | 1987-03-30 | 1991-07-23 | The Regents Of The University Of California | In vitro human monoclonal IgG rheumatoid factor autoantibody |
FR2640146B1 (fr) | 1988-12-08 | 1993-12-24 | Commissariat A Energie Atomique | Anticorps monoclonaux anti-interleukines 1(alpha) et 1(beta), leur procede de production et applications desdits anticorps a la detection des interleukines 1(alpha) et 1(beta) et en therapeutique |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
EP0434879A1 (en) | 1989-12-14 | 1991-07-03 | Schering-Plough | Method of making factor dependent human B cell lines |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
DK0585287T3 (da) | 1990-07-10 | 2000-04-17 | Cambridge Antibody Tech | Fremgangsmåde til fremstilling af specifikke bindingsparelementer |
CA2405246A1 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with alterred binding properties |
DK1471142T3 (da) | 1991-04-10 | 2009-03-09 | Scripps Research Inst | Heterodimere receptor-biblioteker under anvendelse af fagemider |
DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
ES2140469T3 (es) | 1992-10-14 | 2000-03-01 | Nycomed Imaging As | Composiciones y metodos terapeuticos y de diagnostico por obtencion de imagenes. |
ATE204299T1 (de) | 1993-03-05 | 2001-09-15 | Bayer Ag | Humane monoklonale anti-tnf alpha antikörper |
EP0659766A1 (en) | 1993-11-23 | 1995-06-28 | Schering-Plough | Human monoclonal antibodies against human cytokines and methods of making and using such antibodies |
US5959085A (en) | 1993-11-23 | 1999-09-28 | Schering Corporation | Human monoclonal antibodies against human cytokines and methods of making and using such antibodies |
GB9509620D0 (en) | 1995-05-12 | 1995-07-05 | Nat Blood Authority | Transepithelial transport of molecular species |
US6140470A (en) | 1995-06-30 | 2000-10-31 | Yale University | Human monoclonal anti-tumor antibodies |
US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
US6524795B1 (en) * | 1997-03-10 | 2003-02-25 | Interleukin Genetics, Inc. | Diagnostics for cardiovascular disorders |
SE9802402D0 (sv) | 1998-07-03 | 1998-07-03 | Karolinska Innovations Ab | Method of diagnosing cardiovascular disease and early atherosclerosis |
US20030040617A9 (en) | 1999-03-12 | 2003-02-27 | Rosen Craig A. | Nucleic acids, proteins and antibodies |
US6914128B1 (en) | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
US20030232054A1 (en) | 2000-01-25 | 2003-12-18 | Tang Y. Tom | Novel nucleic acids and polypeptides |
US20020131954A1 (en) | 2000-05-02 | 2002-09-19 | Tobinick Edward L. | Interleukin antagonists for the treatment of neurological, retinal and muscular disorders |
WO2002033408A1 (en) * | 2000-10-17 | 2002-04-25 | Besst-Test Aps | Assay for directly detecting an inflammatory indicator in a body fluid sample |
US20030026806A1 (en) | 2000-10-27 | 2003-02-06 | Amgen Inc. | Antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof |
JP2005510524A (ja) | 2001-11-16 | 2005-04-21 | アルス・セラピー・デベロツプメント・フアンデーシヨン・インコーポレーテツド | ポリアミン経路の調節による神経変性障害の治療 |
DK2213685T3 (da) | 2002-09-06 | 2014-03-03 | Medarex Llc | Terapeutisk anti-IL-1R1-monoklonalt antistof |
WO2004100987A2 (en) | 2003-05-06 | 2004-11-25 | Regeneron Pharmaceuticals, Inc. | Methods of using il-1 antagonists to treat neointimal hyperplasia |
HN2004000285A (es) | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTICUERPOS DIRIGIDOS A c-MET |
US7799327B2 (en) | 2003-12-24 | 2010-09-21 | Henry John Smith | Autoantibodies utilized as carrier agents for pharmaceutical compounds used in cancer treatment |
US7105183B2 (en) | 2004-02-03 | 2006-09-12 | The Regents Of The University Of California | Chlorite in the treatment of neurodegenerative disease |
US20050276807A1 (en) | 2004-06-15 | 2005-12-15 | Advanced Biotherapy, Inc. | Treatment of acne |
US7718674B2 (en) | 2004-09-27 | 2010-05-18 | Bridge Pharma, Inc. | Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine |
DK1819359T3 (da) | 2004-12-09 | 2015-04-20 | Janssen Biotech Inc | Anti-integrin-immunokonjugater, fremgangsmåder til deres fremstilling og deres anvendelse |
ES2346691T3 (es) * | 2005-08-02 | 2010-10-19 | Xbiotech, Inc | Diagnostico, tratamiento y prevencion de trastornos vasculares usando autoanticuerpos il-1alfa. |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
CN101267834B (zh) | 2005-09-28 | 2013-06-05 | 赛托斯生物技术公司 | 白介素-1偶联物及其用途 |
CA2652274A1 (en) | 2006-05-15 | 2007-11-22 | Xbiotech Inc. | Il-1.alpha. immunization induces autoantibodies protective against atherosclerosis |
US20110008282A1 (en) | 2006-05-15 | 2011-01-13 | Xbiotech, Inc. | IL-1alpha immunization induces autoantibodies protective against atherosclerosis |
ES2374845T3 (es) | 2006-05-22 | 2012-02-22 | Xbiotech, Inc | Tratamiento de cáncer con anticuerpos anti-il-1. |
PL2446904T3 (pl) | 2006-05-30 | 2015-10-30 | Genentech Inc | Przeciwciała anty-CD22, ich immunokoniugaty oraz ich zastosowania |
US8324350B2 (en) | 2006-12-29 | 2012-12-04 | Abbott Laboratories | Dual-specific IL-1α/IL-1β antibodies |
CN102056485A (zh) | 2008-04-15 | 2011-05-11 | 萨可德公司 | 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 |
ES2576681T3 (es) | 2008-05-30 | 2016-07-08 | Xbiotech, Inc | Anticuerpos IL-1 alfa |
US8242074B2 (en) | 2008-09-12 | 2012-08-14 | Xbiotech, Inc. | Modulation of the amount or function of pathogenic CD14+CD16+ monocytes |
CA2749966A1 (en) | 2009-01-29 | 2010-08-05 | Abbott Laboratories | Il-1 binding proteins |
-
2006
- 2006-07-26 ES ES06795161T patent/ES2346691T3/es active Active
- 2006-07-26 WO PCT/IB2006/002038 patent/WO2007015128A1/en active Application Filing
- 2006-07-26 JP JP2008524607A patent/JP5645361B2/ja active Active
- 2006-07-26 DK DK06795161.6T patent/DK1915620T3/da active
- 2006-07-26 CN CNA2006800319580A patent/CN101253409A/zh active Pending
- 2006-07-26 CA CA2617637A patent/CA2617637C/en active Active
- 2006-07-26 DE DE602006014691T patent/DE602006014691D1/de active Active
- 2006-07-26 US US11/997,496 patent/US8187817B2/en active Active
- 2006-07-26 CN CN201811136397.1A patent/CN109187944A/zh active Pending
- 2006-07-26 EP EP06795161A patent/EP1915620B1/en active Active
- 2006-07-26 EP EP10164642A patent/EP2216653A1/en not_active Withdrawn
- 2006-07-26 AU AU2006274698A patent/AU2006274698B2/en active Active
- 2006-07-26 AT AT06795161T patent/ATE470151T1/de active
-
2012
- 2012-05-17 US US13/473,939 patent/US8865175B2/en active Active
- 2012-12-27 JP JP2012283791A patent/JP5717256B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
JP2013127469A (ja) | 2013-06-27 |
DE602006014691D1 (de) | 2010-07-15 |
CA2617637C (en) | 2017-07-18 |
AU2006274698A2 (en) | 2008-03-06 |
AU2006274698B2 (en) | 2011-06-09 |
ATE470151T1 (de) | 2010-06-15 |
CN101253409A (zh) | 2008-08-27 |
JP5645361B2 (ja) | 2014-12-24 |
US8865175B2 (en) | 2014-10-21 |
JP2009503529A (ja) | 2009-01-29 |
CA2617637A1 (en) | 2007-02-08 |
JP5717256B2 (ja) | 2015-05-13 |
EP1915620A1 (en) | 2008-04-30 |
WO2007015128A1 (en) | 2007-02-08 |
US8187817B2 (en) | 2012-05-29 |
AU2006274698A1 (en) | 2007-02-08 |
EP1915620B1 (en) | 2010-06-02 |
ES2346691T3 (es) | 2010-10-19 |
EP2216653A1 (en) | 2010-08-11 |
CN109187944A (zh) | 2019-01-11 |
US20120231012A1 (en) | 2012-09-13 |
US20090123415A1 (en) | 2009-05-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1915620T3 (da) | Diagnose, behandling og prævention af vaskulære sygdomme ved hjælp af IL-1alpha-autoantistoffer | |
NO20074999L (no) | Metode og preparat for behandling av perifere vaskulaere sykdommer | |
LTPA2017009I1 (lt) | Brutono tirozinkinazės inhibitoriai | |
BRPI0814339A2 (pt) | composição farmacêutica, kit para a preparação da composição farmacêutica, conjugado, e, métodos de formação de imagem óptica in vivo do corpo de mamíferos, e de detecção, estabilização, diagnóstico, monitoramento do progresso da doença ou monitoramento do tratamento de um estado doentio do corpon dos mamíferos | |
EA200870254A1 (ru) | Способ лечения воспалительных заболеваний | |
LTC1781298I2 (lt) | Farmacinės kompozicijos, turinčios benzoksazino, skirtos respiracinių ligų gydymui | |
BRPI0416628A (pt) | uso de compostos orgánicos | |
EA201000644A1 (ru) | Антитела для лечения и профилактики болезни альцгеймера и их применение | |
EA200870325A1 (ru) | Лекарственные формы для введения комбинаций лекарственных средств | |
HK1117083A1 (en) | Compositions and methods for treatment of eye disorders | |
NO20073816L (no) | Kombinasjonsterapi for behandling av diabetes og tilstander relatert dertil og for behandling av tilstanden som er bedret ved a oke blod GLP-1 nivaet | |
ME02414B (me) | Tretman kronove bolesti lakvinimodom | |
CO6390078A2 (es) | Inihibidores de syk de imidazopirazina | |
EA201290078A1 (ru) | Гетероциклические соединения для ингибирования pask | |
BRPI0821895A2 (pt) | Composiçao farmacêutica, método de tratamento ou prevenção de uma doença, uma condição e sintomas das mesmas em animais de sangue quente, incluindo seres humanos, método de preparação da composição farmacêutica e método para diagnosticar uma doença, condição, síndrome. | |
BRPI0717741A2 (pt) | Compostos e respectivos método de preparação, método de redução de composto de sulfonil substituído, composição farmacêutica método de tratamento ou prevenção de doença | |
NO20076405L (no) | Anvendelse av 24-nor-UDCA | |
WO2007069073A3 (en) | Pharmaceutical formulations of amyloid inhibiting compounds | |
DK1670903T3 (da) | Behandling af neurodegenerative sygdomme | |
DK1778837T3 (da) | Behandling af neurodegenerative sygdomme ved anvendelse af SCD4-inhibitorer | |
FR2864903B1 (fr) | Appareil de traitement notamment par laser d'un cancer ou d'un etat precancereux | |
BRPI0607851A2 (pt) | compostos e usos dos mesmos | |
ATE495271T1 (de) | Zusammensetzungen und verfahren zum nachweis von störungen in verbindung mit histamin | |
ATE495750T1 (de) | Sulfatide zur behandlung von autoimmunkrankheiten | |
EA200900923A1 (ru) | Применение нейропротективных соединений в получении лекарственных средств, предназначенных для лечения нейродегенеративных заболеваний |