DK1819359T3 - Anti-integrin-immunokonjugater, fremgangsmåder til deres fremstilling og deres anvendelse - Google Patents
Anti-integrin-immunokonjugater, fremgangsmåder til deres fremstilling og deres anvendelse Download PDFInfo
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- DK1819359T3 DK1819359T3 DK05852484T DK05852484T DK1819359T3 DK 1819359 T3 DK1819359 T3 DK 1819359T3 DK 05852484 T DK05852484 T DK 05852484T DK 05852484 T DK05852484 T DK 05852484T DK 1819359 T3 DK1819359 T3 DK 1819359T3
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Claims (32)
1. Antistof-lægemiddel-konjugat omfattende: et antistof der binder til en alfaV-underenhed af en heterodimer human integrinreceptor konjugeret til et cytotoksisk middel med en IC50 på ΙΟ'9 M eller derunder, hvor antistof-lægemiddelkonjugatet udøver en cytotoksisk eller cytostatisk virkning på en alfaV-integrin-udtrykkende cancercelielinje, med formlen:
hvor antistoffet er et human alfaV integrin-underenhed specifikt antistof, hvor antistoffet er i stand ti! at blive internaliseret af cellen der udtrykker alfaV-underenhed; hvor maytansinol forestres ved C-3; Ri, R2, Xi og X2 er uafhængigt H, Me, C2H5, lineær alkyl eller alkenyl med fra 1 til 10 carbonatomer, forgrenet eller cyklisk a I kyl eller alkenyl med fra 3 til 10 carbonatomer, phenyl, substitueret phenyl, eller en heterocyklisk arylgruppe, eller en heterocycloalkylgruppe; n er 1 - 5; p er 1 - 5; og m er 1 ti! 10, og de farmaceutisk acceptable salte og estere deraf.
2. Antistof-lægemiddelkonjugat ifølge krav 1, hvor antistoffet konkurrerer om binding til humant alfaV-integrin med monoklonalt antistof CNTO 95 eller et fragment deraf.
3. Antistofkonjugat ifølge krav 1, hvor antistofmolekylet er det monoklonale antistof CNTO 95 eller et rekombinant antistof med mindst én af de komplementære bestemmende regioner (CDR'er) af CNTO 95 med aminosyresekvensen ifølge SEQ ID NO: 1-6 eller konservative substitutioner af den mindst ene CDR.
4. Antistofkonjugat ifølge krav 2, i hvilket det monoklonale antistof konkurrerer med MAb CNTO 95 der binder til levende celler der udtrykker humant aifaVbetaS-integrin.
5. Antistofkonjugat ifølge krav 1, hvor antistofmolekylet er specifikt for en epitop inde i aminosyresekvensen SEQ ID NO: 9.
6. Antistof-lægemiddelkonjugat ifølge krav 1, hvor antistoffet er et humant, humaniseret, eller kimært ancistof.
7. Konjugatet ifølge krav 1, hver gennemsnitstallet af cytotoksiske grupper bundet tii antistofmoiekylet er mellem 3 og 4-
8. Antistofkonjugat ifølge krav 1, hvor n= 2, Ri og R2 begge er methyl, Xi og X2 er H og p er 2,
9. Fremgangsmåde til fremstilling af et konjugat ifølge krav 1, omfattende trinnene: (a) indføre én eller flere frie eller beskyttede thiolgrupper i et antistofmolekyle der binder til en alfaV-underenhed af en heterodimer human integrinreceptor; (b) omsætte antistofmolekylet fra trin (a) med en forbindelse der er et cytotoksisk middel med en IC50 på 10~9 M eller derunder, hvilken forbindelse har én eller flere disulfid- eller thiolgrupper; og (c) genvinde det resulterende konjugat, hvor den toksiske forbindelse er et maytansinoid.
10. Fremgangsmåden ifølge krav 9, hvor (2-pyridyl)-3-dithiopropansyre-N-hydroxysuccinimidester (SPDP), (2-pyridyl)-4-dithiopentansyre-N-hydroxysueinimidester (SPP), eller (2-pyridyi)~4~dithiobufansyre-N-hydroxysuccinimidester (SPDB) anvendes til at indføre de frie eller beskyttede thiolgrupper i antistofmolekylet.
11. Farmaceutisk sammensætning omfattende et konjugat ifølge et hvilket som helst af kravene 1 til 8 og en farmaceutisk acceptabel bærer, diluent, eller exipiens.
12. Konjugat ifølge et hvilket som helst af kravene 1 til 8 til anvendelse i medicin, fortrinsvis til anvendelse i behandlingen af cancer,
13. Konjugatet ifølge krav 12 til anvendelse i behandlingen af brystadenocarcinom, lungeadenocarcinom, bugspytkirteladenocarcinom, tyktarmsadenocarcinom, nyrecellecarcinom, eller maveadenocarcinom.
14. Konjugatet ifølge krav 12, til anvendelse i behandlingen af hoved- og hals-skvamøs cellecarcinom, skvamøs spiserørscellecarcinom, skvamøs lunge-cellecarcinom, skvamøs hudcellecarcinom, eller skvamøs livmoderhalscellecarcinom.
15. Konjugatet ifølge krav 12 ti! anvendelse i behandling eller forebyggelse af metastatisk spredning af cancer.
16. Monoklonalt antistofkonjugat ifølge et hvilket som helst af kravene 1-8 der forebygger CNTO 95 der binder til levende celler der udtrykker humant alfaVbetaS-integrin til anvendelse i medicin, fortrinsvis til anvendelse til inhibering af væksten af cancerceller hos et pattedyr.
17. Konjugatet til anvendelse ifølge krav 16, i hvilket antistofkonjugatet skal administreres intravenøst.
18. Konjugatet til anvendelse ifølge krav 17, i hvilket antistofkonjugatet skal administreres i en mængde på fra 0,05 mg/kg til 12,0 mg/kg legemsvægt.
19. Konjugatet til anvendelse ifølge krav 16, i hvilket pattedyret er en human patient.
20. Monoklonalt antistofkonjugat ifølge et hvilket som helst af kravene 1-8, der forebygger at CNTO 95 binder til levende celler der udtrykker humant alfaVbetaS-integrin til anvendelse i inhibering af angiogenese hos et pattedyr med en angiogenese-afhængig sygdom valgt fra gruppen bestående af cancermetastaser, angiom, angioflbrom, diabetisk retinopati, præmature spædbørn retinopati, neovaskuSær glaucom, hornhindesygdom induceret ved angiogenese, involutional makula, makular-degenerering, pterygium, retinal-degenerering, retrolentale fibroplasier, granulær konjunktivitis, psoriasis, telangiectasis, pyogenisk granulom, seborrheisk dermatitis, acne og arthritis.
21. Monoklonalt antistofkonjugat ifølge et hvilket som helst af kravene 1-8, der forebygger at CNTO 95 binder til levende celler der udtrykker humant alfaVbeta3-integrin til anvendelse i bedring af en inflammatorisk sygdom hos et pattedyr, hvor den inflammatoriske sygdom er valgt fra gruppen bestående af rheumatoid arthritis, makulær-degenerering, psoriasis, diabetisk retinopati.
22. Monoklonalt antistofkonjugat ifølge et hvilket som helst af kravene 1-8, der forebygger at CNTO 95 binder til levende celler der udtrykker humant alfaVbetaS-integrin til behandling af angiogene hudlidelser valgt fra gruppen bestående af psoriasis, venøse sår, acne, rosacea, vorter, eksem, hæmangiomer, og lymphangiogenese.
23. Monoklonalt antistofkonjugat ifølge et hvilket som helst af kravene 1-8, der forebygger at CNTO 95 binder til levende celler der udtrykker humant alfaVbetaS-integrin til behandling af lidelser der involverer hornhinde- eller nethindevaskularisering.
24. Konjugat til anvendelse ifølge krav 22 eller 23, hvor antistofkonjugatet administreres i kombination med et andet terapeutisk eller profylaktisk middel eller modalitet.
25. Artikel til fremstilling omfattende konjugatsammensætningen ifølge et hvilket som helst af kravene 1-8 og en beholder, og yderligere omfattende en pakkeinformation eller label der indikerer at sammensætningen kan anvendes til at behandle en sygdom kendetegnet ved celler der udtrykker alfaV-underenheden integrin.
26. Artikel til fremstilling ifølge krav 25, hvor pakkeinformationen indikerer at sammensætningen kan anvendes til at behandle cancer,
27. Antistofkonjugat ifølge krav 1, hvor n=2, Ri og R2 begge er methyl
28. Antistofkonjugat ifølge krav 1, hvor antistoffet omfatter (i) hele den tung-kædede komplementært bestemmende region's (CDR) aminosyresekvenser af CNTO 95 som vist i SEQ ID NO: 1, 2, og 3, og (ii) alle de let-kædede CDR- aminosyresekvenser af CNTO 95 som vist i SEQ ID NO: 4, 5, og 6.
29. Antistofkonjugat ifølge krav 28, hvor mindst én af de tung-kædede variable regionsekvenser omfatter den tung-kædede variable regionsekvens af CNTO 95 som vist i SEQ ID NO: 7.
30. Antistofkonjugat ifølge krav 28, hvor mindst én af de let-kædede variable regionsekvenser omfatter den let-kædede variable regionsekvens af CNTO 95 som vist i SEQ ID NO: 8.
31. Antistofkonjugat ifølge krav 1, hvor antistoffet omfatter en tung-kæde variabel region af CNTO 95 som vist i SEQ ID NO: 7 og en I et-kæde variabel region af CNTO 95 som vist i SEQ ID NO: 8.
32. Antistofkonjugat ifølge krav 1, hvor antistoffet er monoklonalt antistof CNTO 95.
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US63444504P | 2004-12-09 | 2004-12-09 | |
PCT/US2005/043250 WO2006062779A2 (en) | 2004-12-09 | 2005-11-30 | Anti-integrin immunoconjugates, methods and uses |
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Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2325344B1 (es) * | 2004-11-02 | 2010-06-09 | Univ Madrid Autonoma | Inhibidores de angiogenesis multifuncionales y multivalentes. |
PT1819359E (pt) * | 2004-12-09 | 2015-05-28 | Janssen Biotech Inc | Imunoconjugados anti-integrina, métodos para a sua produção e sua utilização |
AU2006274698B2 (en) | 2005-08-02 | 2011-06-09 | Xbiotech, Inc. | Diagnosis, treatment, and prevention of vascular disorders using IL-1a autoantibodies |
BRPI0709338A2 (pt) * | 2006-03-21 | 2011-07-12 | Genentech Inc | anticorpo, molécula de ácido nucleico isolada, célula, composições, método de detecção da proteìna alfa5beta1, uso de anticorpo, métodos de tratamento, kit, uso de uma composição, uso de uma antagonista de alfa5beta e uso de uma antagonista de vegf |
AU2007348941B2 (en) * | 2006-08-03 | 2011-08-04 | Medimmune Limited | Antibodies directed to alphaVbeta6 and uses thereof |
US20080081041A1 (en) * | 2006-09-29 | 2008-04-03 | Jeffrey Nemeth | Method of Using IL6 Antagonists with Mitoxantrone for Prostate Cancer |
WO2008141276A1 (en) * | 2007-05-11 | 2008-11-20 | Centocor, Inc. | Anti-alpha-v immunoliposome composition, methods and uses |
US20090175784A1 (en) * | 2007-05-11 | 2009-07-09 | Joshua Goldstein | Anti-Alpha V Immunoliposome Composition, Methods, and Uses |
MX2010003325A (es) | 2007-09-26 | 2010-04-09 | Genentech Inc | Anticuepos novedosos. |
CN104524590B (zh) | 2008-04-30 | 2019-06-21 | 伊缪诺金公司 | 交联剂和它们的用途 |
PL3085773T3 (pl) | 2008-05-30 | 2021-01-11 | Xbiotech, Inc | Zastosowanie przeciwciał il-1 alfa |
CA2731384C (en) * | 2008-07-21 | 2015-03-10 | The Brigham And Women's Hospital, Inc. | Methods and compositions relating to synthetic beta-1,6 glucosamine oligosaccharides |
JP5976319B2 (ja) | 2008-09-12 | 2016-08-23 | エックスバイオテク,インコーポレイテッドXbiotech,Inc. | 病原性単球の標的化 |
CN102216779B (zh) * | 2008-10-13 | 2013-11-27 | 泽普塔根股份公司 | 免疫缀合物的制备方法及其应用 |
PE20120770A1 (es) | 2009-03-25 | 2012-07-10 | Genentech Inc | ANTICUERPOS ANTI alfa5ß1 CON ACTIVIDAD SOBRE GLIOBLASTOMAS |
SI2437790T1 (sl) | 2009-06-03 | 2019-07-31 | Immunogen, Inc. | Konjugacijske metode |
FR2947269B1 (fr) * | 2009-06-29 | 2013-01-18 | Sanofi Aventis | Nouveaux composes anticancereux |
CA2676946A1 (en) * | 2009-08-28 | 2011-02-28 | Lucie Peduto | Adam12 inhibitors and their use against inflammation-induced fibrosis |
IN2012DN02780A (da) | 2009-10-06 | 2015-09-18 | Immunogen Inc | |
AR080154A1 (es) | 2010-02-10 | 2012-03-14 | Immunogen Inc | Anticuerpos cd20 y su utilizacion |
WO2011162933A1 (en) * | 2010-06-04 | 2011-12-29 | Immunogen, Inc. | Anti-integrin immunoconjugate dosing regimens |
KR102167261B1 (ko) | 2010-06-18 | 2020-10-20 | 엑스바이오테크, 인크. | 관절염 치료 |
AU2011293554B9 (en) | 2010-08-23 | 2015-03-19 | Xbiotech Inc. | Treatment for neoplastic diseases |
US9328160B2 (en) * | 2010-10-29 | 2016-05-03 | Perseus Proteomics Inc. | Anti-CDH3 antibody having high internalization capacity |
EA201991268A3 (ru) | 2011-03-29 | 2020-01-31 | Иммуноджен, Инк. | Получение конъюгатов "майтансиноид-антитело" одностадийным способом |
SG193996A1 (en) | 2011-03-29 | 2013-11-29 | Immunogen Inc | Preparation of maytansinoid antibody conjugates by a one-step process |
US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
JP2014515753A (ja) | 2011-04-21 | 2014-07-03 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 新規な結合剤−薬物複合体(adc)およびそれらの使用 |
MX2013013104A (es) * | 2011-05-09 | 2014-10-15 | Univ Virginia Patent Found | Composiciones y metodos para el tratamiento de cancer. |
MX356808B (es) | 2011-09-23 | 2018-06-14 | Xbiotech Inc | Uso de una composición farmacéutica que comprende un anticuerpo anti-il-1a para el tratamiento de la caquexia. |
WO2013110578A1 (en) * | 2012-01-27 | 2013-08-01 | F. Hoffmann-La Roche Ag | Integrin antagonist conjugates for targeted delivery to cells expressing alpha-v-beta-3 |
EA031069B1 (ru) * | 2012-02-17 | 2018-11-30 | Сиэтл Дженетикс, Инк. | АНТИТЕЛА ПРОТИВ ИНТЕГРИНОВ αVβ6 И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ ЗЛОКАЧЕСТВЕННЫХ НОВООБРАЗОВАНИЙ |
US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
CN104768955B (zh) * | 2012-09-26 | 2018-04-27 | 伊缪诺金公司 | 用于美登醇酰化的改进的方法 |
RU2661083C2 (ru) | 2012-10-04 | 2018-07-11 | Иммуноджен, Инк. | Использование пвдф-мембраны для очистки конъюгатов клеточно-связывающий агент - цитотоксический агент |
EP2911701A4 (en) * | 2012-10-23 | 2016-06-08 | Univ Johns Hopkins | Novel self-assembling drug amphiphiles and methods for synthesis and application |
CA2898239A1 (en) | 2013-01-23 | 2014-07-31 | Syddansk Universitet | Mfap4 binding antibodies blocking the interaction between mfap4 and integrin receptors |
EP2777714A1 (en) | 2013-03-15 | 2014-09-17 | NBE-Therapeutics LLC | Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme |
WO2015009948A1 (en) * | 2013-07-19 | 2015-01-22 | Regents Of The University Of California | Milk fat globule epidermal growth factor 8 regulates fatty acid uptake |
BR112016004023A2 (pt) | 2013-08-26 | 2022-11-16 | Regeneron Pharma | Composição, métodos para preparar uma composição e para tratar uma doença, e, composto |
MX2016008013A (es) | 2013-12-23 | 2017-05-12 | Bayer Pharma AG | Conjugados de farmacos anticuerpo (adcs) con inhibidores de ksp. |
RU2741470C9 (ru) | 2014-09-02 | 2021-04-27 | Иммьюноджен, Инк. | Способы составления композиций конъюгата антитело-лекарственное средство |
JP2018505128A (ja) | 2014-11-19 | 2018-02-22 | イミュノジェン・インコーポレーテッド | 細胞結合剤−細胞毒性剤コンジュゲートを調製するためのプロセス |
BR112017011773A2 (pt) | 2014-12-04 | 2018-02-20 | Celgene Corporation | composto isolado, conjugados isolados, composiçôes farmacêuticas, e métodos de tratamento de um distúrbio em um mamífero |
US10188745B2 (en) | 2014-12-23 | 2019-01-29 | Nbe-Therapeutics Ag | Binding protein drug conjugates comprising anthracycline derivatives |
SG11201710639YA (en) | 2015-06-22 | 2018-01-30 | Bayer Pharma AG | Antibody drug conjugates (adcs) and antibody prodrug conjugates (apdcs) with enzymatically cleavable groups |
WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
AU2017213858A1 (en) | 2016-02-05 | 2018-08-16 | Immunogen, Inc. | Efficient process for preparing cell-binding agent-cytotoxic agent conjugates |
GB201602356D0 (en) * | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
SG10202008909VA (en) | 2016-03-24 | 2020-10-29 | Bayer Pharma AG | Prodrugs of cytotoxic active agents having enzymatically cleavable groups |
EP3919518A1 (en) | 2016-06-15 | 2021-12-08 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies |
JP7066714B2 (ja) | 2016-12-21 | 2022-05-13 | バイエル・ファルマ・アクティエンゲゼルシャフト | 酵素的に切断可能な基を有する抗体薬物コンジュゲート(adc) |
US11433140B2 (en) | 2016-12-21 | 2022-09-06 | Bayer Pharma Aktiengesellschaft | Specific antibody drug conjugates (ADCs) having KSP inhibitors |
US20190351066A1 (en) | 2016-12-21 | 2019-11-21 | Bayer Aktiengesellschaft | Prodrugs of cytotoxic active agents having enzymatically cleavable groups |
WO2018150265A1 (en) | 2017-02-16 | 2018-08-23 | Xbiotech, Inc. | Treatment of hidradenitis suppurativa |
US10639382B2 (en) | 2017-04-13 | 2020-05-05 | National Guard Health Affairs | Method for treating leukemia |
EP3630185A4 (en) * | 2017-05-30 | 2020-06-17 | The Board of Trustees of the Leland Stanford Junior University | TREATMENT OF NEURO-INFLAMMATORY DISEASE |
AU2018279105A1 (en) * | 2017-06-07 | 2019-12-19 | Silverback Therapeutics, Inc. | Antibody conjugates of immune-modulatory compounds and uses thereof |
US20200046737A1 (en) | 2018-08-09 | 2020-02-13 | Notable Labs, Inc. | Methods for treating cancer, and compositions therefor |
MX2022000449A (es) | 2019-07-10 | 2022-04-25 | Cybrexa 2 Inc | Conjugados peptídicos de citotoxinas como terapéuticos. |
EP3996749A1 (en) | 2019-07-10 | 2022-05-18 | Cybrexa 3, Inc. | Peptide conjugates of microtubule-targeting agents as therapeutics |
WO2024001669A1 (zh) * | 2022-06-27 | 2024-01-04 | 昱言科技(北京)有限公司 | 靶向itga2的抗体和包含此抗体的抗体药物缀合物 |
CN115350187B (zh) * | 2022-08-30 | 2023-08-29 | 中山大学 | 异丙托溴铵在抑制肺癌骨转移中的应用 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3896111A (en) | 1973-02-20 | 1975-07-22 | Research Corp | Ansa macrolides |
SE430062B (sv) | 1977-03-04 | 1983-10-17 | Pharmacia Fine Chemicals Ab | Kopplings- eller tioleringsreagens |
US4151042A (en) | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
CA2026147C (en) * | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
CA2131528C (en) | 1992-03-05 | 2004-07-13 | Philip E. Thorpe | Methods and compositions for targeting the vasculature of solid tumors |
JP3161490B2 (ja) | 1993-07-30 | 2001-04-25 | 松下電器産業株式会社 | 金型装置 |
US6160099A (en) | 1998-11-24 | 2000-12-12 | Jonak; Zdenka Ludmila | Anti-human αv β3 and αv β5 antibodies |
GB9909392D0 (en) | 1999-04-24 | 1999-06-23 | Imp Cancer Res Tech | Treatment, imaging and diagnosis of disease |
HU230586B1 (hu) | 1999-06-25 | 2017-02-28 | Genentech, Inc. | Anti-ErbB antitest/maytansinoid konjugátumok alkalmazása rákos betegségek kezelésére szolgáló gyógyszer előállítására |
US7288390B2 (en) | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
US7163681B2 (en) | 2000-08-07 | 2007-01-16 | Centocor, Inc. | Anti-integrin antibodies, compositions, methods and uses |
AR030612A1 (es) | 2000-09-12 | 2003-08-27 | Smithkline Beecham Corp | Procedimiento e intermedios |
EP1389090A2 (en) * | 2001-04-26 | 2004-02-18 | Board of Regents, The University of Texas System | Diagnostic imaging compositions, their methods of synthesis and use |
US20030103985A1 (en) * | 2001-05-18 | 2003-06-05 | Boehringer Ingelheim International Gmbh | Cytotoxic CD44 antibody immunoconjugates |
EP1258255A1 (en) | 2001-05-18 | 2002-11-20 | Boehringer Ingelheim International GmbH | Conjugates of an antibody to CD44 and a maytansinoid |
US6441163B1 (en) * | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
AU2003228998A1 (en) | 2002-05-13 | 2003-12-02 | Smithkline Beecham Corporation | Process for preparing maytansinol |
AU2003259163B2 (en) | 2002-08-16 | 2008-07-03 | Immunogen, Inc. | Cross-linkers with high reactivity and solubility and their use in the preparation of conjugates for targeted delivery of small molecule drugs |
KR101441358B1 (ko) * | 2003-05-14 | 2014-09-24 | 이뮤노젠 아이엔씨 | 약물 콘쥬게이트 조성물 |
US7276497B2 (en) * | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
ES2559670T3 (es) | 2003-05-20 | 2016-02-15 | Immunogen, Inc. | Agentes citotóxicos mejorados que comprenden nuevos maitansinoides |
PT1819359E (pt) * | 2004-12-09 | 2015-05-28 | Janssen Biotech Inc | Imunoconjugados anti-integrina, métodos para a sua produção e sua utilização |
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- 2005-11-30 WO PCT/US2005/043250 patent/WO2006062779A2/en active Application Filing
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