MX2016008013A - Conjugados de farmacos anticuerpo (adcs) con inhibidores de ksp. - Google Patents

Conjugados de farmacos anticuerpo (adcs) con inhibidores de ksp.

Info

Publication number
MX2016008013A
MX2016008013A MX2016008013A MX2016008013A MX2016008013A MX 2016008013 A MX2016008013 A MX 2016008013A MX 2016008013 A MX2016008013 A MX 2016008013A MX 2016008013 A MX2016008013 A MX 2016008013A MX 2016008013 A MX2016008013 A MX 2016008013A
Authority
MX
Mexico
Prior art keywords
adcs
drug conjugates
antibody drug
ksp
diseases
Prior art date
Application number
MX2016008013A
Other languages
English (en)
Other versions
MX380273B (es
Inventor
Hans Lerchen Georg
Wittrock Sven
Griebenow Nils
Ludwig Stelte Beatrix
Sommer Anette
Berndt Sandra
Mahlert Christoph
Lobell Mario
Terjung Carsten
Greven Simone
Cancho Grande Yolanda
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of MX2016008013A publication Critical patent/MX2016008013A/es
Publication of MX380273B publication Critical patent/MX380273B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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Abstract

La presente invención se refiere a novedosos conjugados de fármacos anticuerpo (ADC), con metabolitos activos de estos ADC, con procedimientos para preparar estos ADC, con la utilización de estos ADC para el tratamiento y/o profilaxis de enfermedades y con el uso de estos ADC para la preparación de medicamentos para el tratamiento y/o prevención de enfermedades, en particular trastornos hiperproliferativas y/o angiogénicos, tales como, por ejemplo, enfermedades de cáncer. Tales tratamientos pueden llevarse a cabo como monoterapia o bien en combinación con otros medicamentos o medidas terapéuticas adicionales.
MX2016008013A 2013-12-23 2014-12-10 Conjugados de farmacos anticuerpo (adcs) con inhibidores de ksp. MX380273B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13199358 2013-12-23
EP14170585 2014-05-30
PCT/EP2014/077144 WO2015096982A1 (de) 2013-12-23 2014-12-10 Binder-konjugate (adcs) mit ksp-inhibitoren

Publications (2)

Publication Number Publication Date
MX2016008013A true MX2016008013A (es) 2017-05-12
MX380273B MX380273B (es) 2025-04-01

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MX2016008013A MX380273B (es) 2013-12-23 2014-12-10 Conjugados de farmacos anticuerpo (adcs) con inhibidores de ksp.

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US (1) US10022453B2 (es)
EP (1) EP3086814B1 (es)
JP (1) JP6721507B2 (es)
KR (1) KR102329024B1 (es)
CN (1) CN106163568B (es)
AU (1) AU2014372833B2 (es)
BR (1) BR112016014830A2 (es)
CA (1) CA2934617A1 (es)
DK (1) DK3086814T3 (es)
ES (1) ES2815098T3 (es)
IL (1) IL246124B (es)
MX (1) MX380273B (es)
NZ (1) NZ720736A (es)
PE (1) PE20160996A1 (es)
PL (1) PL3086814T3 (es)
PT (1) PT3086814T (es)
RU (1) RU2698697C2 (es)
SA (1) SA516371381B1 (es)
SG (1) SG11201604758PA (es)
TW (1) TWI650136B (es)
WO (1) WO2015096982A1 (es)
ZA (1) ZA201603585B (es)

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