MX2016006603A - Compuestos piperidinicos con actividad multimodal contra el dolor. - Google Patents

Compuestos piperidinicos con actividad multimodal contra el dolor.

Info

Publication number
MX2016006603A
MX2016006603A MX2016006603A MX2016006603A MX2016006603A MX 2016006603 A MX2016006603 A MX 2016006603A MX 2016006603 A MX2016006603 A MX 2016006603A MX 2016006603 A MX2016006603 A MX 2016006603A MX 2016006603 A MX2016006603 A MX 2016006603A
Authority
MX
Mexico
Prior art keywords
activity against
piperidine compounds
compounds
against pain
multimodal activity
Prior art date
Application number
MX2016006603A
Other languages
English (en)
Inventor
Almansa-Rosales Carmen
Cuevas Cordobes Felix
Maria AYET GALCERA Eva
Teresa SERAFINI CABANES Maria
Garcia Lopez Monica
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of MX2016006603A publication Critical patent/MX2016006603A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos con actividad farmacológica dual contra tanto el receptor sigma (s) como el receptor opioide µ y más particularmente a compuestos piperidínicos que presentan esta actividad farmacológica, a procesos para preparar tales compuestos, a composiciones farmacéuticas que los comprenden y a su uso en terapia, en particular para el tratamiento del dolor.
MX2016006603A 2013-12-20 2014-12-19 Compuestos piperidinicos con actividad multimodal contra el dolor. MX2016006603A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13384005 2013-12-20
PCT/EP2014/078811 WO2015091988A1 (en) 2013-12-20 2014-12-19 Piperidine compounds having multimodal activity against pain

Publications (1)

Publication Number Publication Date
MX2016006603A true MX2016006603A (es) 2016-09-06

Family

ID=49998041

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016006603A MX2016006603A (es) 2013-12-20 2014-12-19 Compuestos piperidinicos con actividad multimodal contra el dolor.

Country Status (8)

Country Link
US (1) US9902711B2 (es)
EP (1) EP3083595B1 (es)
JP (1) JP6498672B2 (es)
CN (1) CN105829297B (es)
CA (1) CA2931219A1 (es)
ES (1) ES2806408T3 (es)
MX (1) MX2016006603A (es)
WO (1) WO2015091988A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2016006604A (es) 2013-12-20 2016-09-08 Esteve Labor Dr Derivados de piperidina con actividad multimodal contra el dolor.
WO2016078771A1 (en) * 2014-11-21 2016-05-26 Laboratorios Del Dr. Esteve, S.A. 1,9-diazaspiro undecane compounds having multimodal activity against pain
AR105522A1 (es) 2015-07-29 2017-10-11 Esteve Labor Dr Derivados de amida sustituida que tienen actividad multimodal contra el dolor
CN108137569B (zh) * 2015-10-23 2022-03-15 埃斯蒂文制药股份有限公司 具有抗疼痛活性的取代的吗啉衍生物
TW202304448A (zh) * 2021-04-07 2023-02-01 西班牙商塔拉森斯調節公司 作為西格瑪配位基的新（高）哌啶基雜環
WO2024105225A1 (en) 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2083476B (en) * 1980-09-12 1984-02-08 Wyeth John & Brother Ltd Heterocyclic compounds
US4772604A (en) * 1986-02-27 1988-09-20 Duphar International Research B.V. Phenyl-substituted (N-piperazinyl) methylazoles for treating affections in the central nervous system
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
DE4321366A1 (de) * 1993-06-26 1995-01-05 Merck Patent Gmbh Piperidine und Piperazine
WO1999038864A1 (en) * 1998-02-03 1999-08-05 American Home Products Corporation Oxazole derivatives as serotonin-1a receptor agonists
US6248755B1 (en) * 1999-04-06 2001-06-19 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
GB9912411D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912415D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912410D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
JP3893960B2 (ja) * 2001-01-12 2007-03-14 トヨタ自動車株式会社 動力伝達装置
JP2009513513A (ja) * 2003-07-04 2009-04-02 グラクソスミスクライン・ソシエタ・ペル・アチオニ Ｏｒｌ−１受容体リガンドとしての置換インドール
JP4761756B2 (ja) * 2003-10-31 2011-08-31 大塚製薬株式会社 ２，３−ジヒドロイミダゾ［２，１−ｂ］オキサゾ−ル化合物
US7842696B2 (en) 2007-06-21 2010-11-30 Forest Laboratories Holdings Limited Piperazine derivatives as inhibitors of stearoyl-CoA desaturase
WO2010046780A2 (en) 2008-10-22 2010-04-29 Institut Pasteur Korea Anti viral compounds
WO2010080864A1 (en) 2009-01-12 2010-07-15 Array Biopharma Inc. Piperidine-containing compounds and use thereof
EP2521724B1 (en) * 2009-12-11 2016-11-23 Nono Inc. Agents and methods for treating ischemic and other diseases
AU2011214057B2 (en) 2010-02-12 2016-11-17 Pharmascience Inc. IAP BIR domain binding compounds
US8859777B2 (en) * 2010-04-30 2014-10-14 Kinentia Biosciences Llc 4-fluoro-4-arylpiperdin-1-yl derivatives as mu opioid function moderators
JP2013189395A (ja) * 2012-03-14 2013-09-26 Dainippon Sumitomo Pharma Co Ltd ジヒドロピロロピラジノン誘導体
JP2016028016A (ja) * 2012-12-12 2016-02-25 大日本住友製薬株式会社 オキサジアゾール誘導体とその医薬用途

Also Published As

Publication number Publication date
JP2016540793A (ja) 2016-12-28
US9902711B2 (en) 2018-02-27
US20170001979A1 (en) 2017-01-05
JP6498672B2 (ja) 2019-04-10
ES2806408T3 (es) 2021-02-17
WO2015091988A1 (en) 2015-06-25
EP3083595A1 (en) 2016-10-26
EP3083595B1 (en) 2020-05-27
CN105829297B (zh) 2019-08-09
CA2931219A1 (en) 2015-06-25
CN105829297A (zh) 2016-08-03

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