AR080154A1 - Anticuerpos cd20 y su utilizacion - Google Patents

Anticuerpos cd20 y su utilizacion

Info

Publication number
AR080154A1
AR080154A1 ARP110100412A ARP110100412A AR080154A1 AR 080154 A1 AR080154 A1 AR 080154A1 AR P110100412 A ARP110100412 A AR P110100412A AR P110100412 A ARP110100412 A AR P110100412A AR 080154 A1 AR080154 A1 AR 080154A1
Authority
AR
Argentina
Prior art keywords
cells
cd2o
cell
pta
hybridoma
Prior art date
Application number
ARP110100412A
Other languages
English (en)
Inventor
Jutta Deckert
Weston Rui
Peter U Park
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of AR080154A1 publication Critical patent/AR080154A1/es

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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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Abstract

El CD2O es una proteína transmembrana de la familia de las tetraspaninas que se expresan en la superficie de las células B y que se ha encontrado tanto en las células B de la sangre periférica como en los tejidos linfoides. La expresion de CD2O persiste desde la etapa temprana del desarrollo de las células pre-B hasta la fase de diferenciacion del desarrollo de las células plasmáticas. Contrariamente, no se encuentra en las células madre hematopoyéticas, las células pro-B, las células diferenciadas del plasma o los tejidos no linfoides. Además de la expresion en las células B normales, el CD2O se expresa en las neoplasias malignas derivadas de la célula B, tal como en el linfoma no-Hodgkin (NHL) y la leucemia linfocítica cronica (CLL) de células B. Se conoce que las células que expresan CD2O juegan un rol en otras enfermedades o trastornos, entre los que se incluyen la inflamacion. La presente incluye anticuerpos anti-CD2O, formas y fragmentos, que poseen propiedades físicas y funcionales superiores, inmunoconjugados, composiciones, reactivos para el diagnostico, métodos para inhibir el crecimiento, métodos terapéuticos, anticuerpos mejorados y líneas celulares; y polinucleotidos, vectores y construcciones genéticas que los codifican. Reivindicacion 4:Un anticuerpo o fragmento del mismo de la reivindicacion 1 producido mediante el hibridoma (N° de acceso ATCC PTA- 10486) o el hibridoma (N° De Acceso ATCC PTA-10487).
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US20110195021A1 (en) 2011-08-11
WO2011100403A1 (en) 2011-08-18
US20160108126A1 (en) 2016-04-21
BR112012020102A2 (pt) 2016-11-29
JP5841072B2 (ja) 2016-01-06
US9173961B2 (en) 2015-11-03
HK1216540A1 (zh) 2016-11-18
CN102933231B (zh) 2015-07-29
EP2533810A1 (en) 2012-12-19

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