PE20090321A1 - Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica - Google Patents

Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica

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Publication number
PE20090321A1
PE20090321A1 PE2008000929A PE2008000929A PE20090321A1 PE 20090321 A1 PE20090321 A1 PE 20090321A1 PE 2008000929 A PE2008000929 A PE 2008000929A PE 2008000929 A PE2008000929 A PE 2008000929A PE 20090321 A1 PE20090321 A1 PE 20090321A1
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PE
Peru
Prior art keywords
hvr
seq
notch1 nrr
preparation
sequence
Prior art date
Application number
PE2008000929A
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English (en)
Inventor
Yan Wu
Christian Siebel
Original Assignee
Genentech Inc
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39735560&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090321(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20090321A1 publication Critical patent/PE20090321A1/es

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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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Abstract

REFERIDA A ANTICUERPOS HUMANIZADOS anti-NOTCH1 NRR (REGION REGULADORA NEGATIVA), QUE SE CARACTERIZA POR SER INICIALMENTE AISLADO DE HUMANO O RATON; UNIRSE A UN RECEPTOR NOTCH1 NRR CON UN Kd DE 1X10-7 A MAS; Y QUE COMPRENDE: a)AL MENOS 1 A 5 SECUENCIAS DE LA REGION HIPERVARIABLE (HVR) SELECCIONADA DE; HVR-L1 QUE ES LA SECUENCIA RASQDVSTAVA (SEQ ID NO:7), HVR-L2 QUE ES LA SECUENCIA SASFLYS (SEQ ID NO:8), HVR-H3 QUE ES LA SECUENCIA ARGSGFRWVMDY (SEQ ID NO:6), ENTRE OTRAS; b)AL MENOS UNA VARIANTE DE HVR, DE ALMENOS UN RESIDUO DE LA SEQ ID NOS: 1 A 12. SE REFIERE TAMBIEN A UN POLINUCLEOTIDO CODIFICADOR, UN VECTOR DE EXPRESION, CELULAS HUESPED, UN METODO DE PREPARACION DEL INMUNOCONJUGADO Y COMPOSICION FARMACEUTICA. DICHOS ANTICUERPOS SON INICIALMENTE AISLADOS DE HUMANO O RATON Y DISMINUYEN LA SENALIZACION DE NOTCH1 LA CUAL ES IMPORTANTE EN EL CRECIMIENTO TUMORAL
PE2008000929A 2007-06-04 2008-06-02 Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica PE20090321A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93307207P 2007-06-04 2007-06-04
US99464607P 2007-09-20 2007-09-20

Publications (1)

Publication Number Publication Date
PE20090321A1 true PE20090321A1 (es) 2009-04-20

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ID=39735560

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PE2008000929A PE20090321A1 (es) 2007-06-04 2008-06-02 Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica

Country Status (29)

Country Link
US (5) US8846871B2 (es)
EP (1) EP2152748B1 (es)
JP (4) JP5623272B2 (es)
KR (2) KR20160043128A (es)
CN (1) CN101796074B (es)
AR (1) AR066846A1 (es)
BR (1) BRPI0811382A2 (es)
CA (1) CA2687866C (es)
CL (1) CL2008001634A1 (es)
CO (1) CO6150200A2 (es)
CR (2) CR11139A (es)
CY (1) CY1114690T1 (es)
DK (1) DK2152748T3 (es)
EC (1) ECSP099785A (es)
ES (1) ES2432798T3 (es)
HK (1) HK1141040A1 (es)
HR (1) HRP20131107T1 (es)
IL (3) IL202183A0 (es)
MA (1) MA31502B1 (es)
MX (1) MX2009013199A (es)
NZ (1) NZ581303A (es)
PE (1) PE20090321A1 (es)
PH (1) PH12015500550A1 (es)
PL (1) PL2152748T3 (es)
PT (1) PT2152748E (es)
RU (1) RU2476443C2 (es)
SI (1) SI2152748T1 (es)
TW (1) TWI458737B (es)
WO (1) WO2008150525A1 (es)

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