PE20080112A1 - Anticuerpo humanizado especifico para tslp (linfopoyetina estromal timica) y composiciones farmaceuticas - Google Patents
Anticuerpo humanizado especifico para tslp (linfopoyetina estromal timica) y composiciones farmaceuticasInfo
- Publication number
- PE20080112A1 PE20080112A1 PE2007000198A PE2007000198A PE20080112A1 PE 20080112 A1 PE20080112 A1 PE 20080112A1 PE 2007000198 A PE2007000198 A PE 2007000198A PE 2007000198 A PE2007000198 A PE 2007000198A PE 20080112 A1 PE20080112 A1 PE 20080112A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- tslp
- region selected
- humanized antibody
- stromal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Transplantation (AREA)
- Plant Pathology (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
SE REFIERE A UN ANTICUERPO HUMANIZADO AISLADO O UN FRAGMENTO FUNCIONAL QUE COMPRENDE UNA REGION DE ENLACE CON ANTIGENO QUE ES ESPECIFICA PARA TSLP (LIFOPOYETINA ESTROMAL TIMICA HUMANA) CON UNA KD DE 1x10-9 M O MENOS. DICHO ANTICUERPO COMPRENDE: A) UNA REGION L-CDR1 SELECCIONADA DE SEQ ID N0:38, UNA REGION L-CDR2 SELECCIONADA DE SEQ ID N0:47, UNA REGION L-CDR3 SELECCIONADA DE SEQ ID N0:60; B) UNA REGION H-CDR1 SELECCIONADA DE SEQ ID N0:3, UNA REGION H-CDR2 SELECCIONADA DE SEQ ID: 15, SEQ ID:17, SEQ ID:18, SEQ ID:19, SEQ ID:20 Y UNA REGION H-CDR3 SELECCIONADA DE SEQ ID:28 Y VARIANTES CONSERVADORAS DE LAS MISMAS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA CON EXCIPIENTES FARMACEUTICAMENTE ACEPTABLES. DICHO ANTICUERPO ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES TALES COMO EL ASMA, DERMATITIS ATOPICA, RINITIS ALERGICA, FIBROSIS, ENFERMEDAD INFLAMATORIA DEL INTESTINO Y EL LINFOMA DE HODKIN
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0603683.4A GB0603683D0 (en) | 2006-02-23 | 2006-02-23 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080112A1 true PE20080112A1 (es) | 2008-03-13 |
Family
ID=36178659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000198A PE20080112A1 (es) | 2006-02-23 | 2007-02-22 | Anticuerpo humanizado especifico para tslp (linfopoyetina estromal timica) y composiciones farmaceuticas |
Country Status (24)
Country | Link |
---|---|
US (2) | US8420787B2 (es) |
EP (2) | EP2341076A3 (es) |
JP (1) | JP2009527235A (es) |
KR (1) | KR20080099330A (es) |
CN (1) | CN101389657A (es) |
AR (1) | AR059867A1 (es) |
AU (1) | AU2007218165A1 (es) |
BR (1) | BRPI0708145A2 (es) |
CA (1) | CA2638851A1 (es) |
CL (1) | CL2007000478A1 (es) |
CR (1) | CR10184A (es) |
EC (1) | ECSP088690A (es) |
ES (1) | ES2404058T3 (es) |
GB (1) | GB0603683D0 (es) |
IL (1) | IL193229A0 (es) |
MA (1) | MA30274B1 (es) |
MX (1) | MX2008010807A (es) |
NO (1) | NO20083911L (es) |
PE (1) | PE20080112A1 (es) |
RU (1) | RU2008137531A (es) |
TN (1) | TNSN08333A1 (es) |
TW (1) | TW200813089A (es) |
WO (1) | WO2007096149A1 (es) |
ZA (1) | ZA200806490B (es) |
Families Citing this family (129)
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EP2860192B1 (en) * | 2005-10-12 | 2017-09-27 | MorphoSys AG | Generation and profiling of fully human HuCAL GOLD-derived therapeutic antibodies specific for human CD38 |
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
PL2500360T3 (pl) | 2005-10-31 | 2016-01-29 | Oncomed Pharm Inc | Kompozycje i sposoby diagnozowania i leczenia nowotworu |
EP3170401B1 (en) | 2006-10-25 | 2019-06-05 | Revalesio Corporation | Ionic aqueous fluid composition containing oxygen microbubbles |
US8445546B2 (en) | 2006-10-25 | 2013-05-21 | Revalesio Corporation | Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures |
WO2008052145A2 (en) | 2006-10-25 | 2008-05-02 | Revalesio Corporation | Methods of therapeutic treatment of eyes and other human tissues using an oxygen-enriched solution |
CN101605814B (zh) | 2006-12-14 | 2014-02-19 | 默沙东公司 | 经工程改造的抗tslp抗体 |
EP3424529A1 (en) | 2007-07-02 | 2019-01-09 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for treating and diagnosing cancer |
US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
WO2009023184A2 (en) * | 2007-08-10 | 2009-02-19 | Protelix, Inc. | Universal fibronectin type iii binding-domain libraries |
US7982016B2 (en) * | 2007-09-10 | 2011-07-19 | Amgen Inc. | Antigen binding proteins capable of binding thymic stromal lymphopoietin |
US9523090B2 (en) | 2007-10-25 | 2016-12-20 | Revalesio Corporation | Compositions and methods for treating inflammation |
US20090227018A1 (en) * | 2007-10-25 | 2009-09-10 | Revalesio Corporation | Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction |
MX2010004563A (es) * | 2007-10-25 | 2010-07-28 | Revalesio Corp | Composiciones y métodos para modular la transducción de la señal intracelular mediada por la membrana celular. |
US10125359B2 (en) | 2007-10-25 | 2018-11-13 | Revalesio Corporation | Compositions and methods for treating inflammation |
US9745567B2 (en) | 2008-04-28 | 2017-08-29 | Revalesio Corporation | Compositions and methods for treating multiple sclerosis |
BRPI0911757A2 (pt) | 2008-05-01 | 2013-09-17 | Revalesio Corp | composiÇÕes e mÉtodos para tratar distérbios digestivos. |
JP5792621B2 (ja) | 2008-09-26 | 2015-10-14 | オンコメッド ファーマシューティカルズ インコーポレイテッド | frizzled結合剤およびその使用 |
EP2213682A1 (en) | 2009-01-30 | 2010-08-04 | Institut Curie | TSLP promotes immune evasion and persistence of viruses |
US8815292B2 (en) | 2009-04-27 | 2014-08-26 | Revalesio Corporation | Compositions and methods for treating insulin resistance and diabetes mellitus |
US8637019B2 (en) * | 2009-11-04 | 2014-01-28 | Merck Sharp & Dohme Corp. | Engineered anti-TSLP antibody |
TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
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GB0603683D0 (en) | 2006-04-05 |
CN101389657A (zh) | 2009-03-18 |
TW200813089A (en) | 2008-03-16 |
ES2404058T3 (es) | 2013-05-23 |
WO2007096149A1 (en) | 2007-08-30 |
US20090186022A1 (en) | 2009-07-23 |
RU2008137531A (ru) | 2010-03-27 |
CL2007000478A1 (es) | 2008-03-14 |
EP1991583B1 (en) | 2012-12-19 |
ZA200806490B (en) | 2009-06-24 |
TNSN08333A1 (en) | 2009-12-29 |
US20130323237A1 (en) | 2013-12-05 |
NO20083911L (no) | 2008-11-05 |
MA30274B1 (fr) | 2009-03-02 |
KR20080099330A (ko) | 2008-11-12 |
AU2007218165A1 (en) | 2007-08-30 |
BRPI0708145A2 (pt) | 2011-05-17 |
AR059867A1 (es) | 2008-05-07 |
ECSP088690A (es) | 2008-09-29 |
US8420787B2 (en) | 2013-04-16 |
JP2009527235A (ja) | 2009-07-30 |
EP1991583A1 (en) | 2008-11-19 |
IL193229A0 (en) | 2009-02-11 |
EP2341076A2 (en) | 2011-07-06 |
CR10184A (es) | 2008-12-03 |
EP2341076A3 (en) | 2011-08-24 |
CA2638851A1 (en) | 2007-08-30 |
MX2008010807A (es) | 2008-09-01 |
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