MX2009005743A - Nuevos anticuerpos monoclonales de globulomero anti-ab selectivos del conformero ab. - Google Patents

Nuevos anticuerpos monoclonales de globulomero anti-ab selectivos del conformero ab.

Info

Publication number
MX2009005743A
MX2009005743A MX2009005743A MX2009005743A MX2009005743A MX 2009005743 A MX2009005743 A MX 2009005743A MX 2009005743 A MX2009005743 A MX 2009005743A MX 2009005743 A MX2009005743 A MX 2009005743A MX 2009005743 A MX2009005743 A MX 2009005743A
Authority
MX
Mexico
Prior art keywords
abeta
monoclonal antibodies
new
selective anti
conformer
Prior art date
Application number
MX2009005743A
Other languages
English (en)
Inventor
Boris Labkovsky
Heinz Hillen
Patrick Keller
Stefan Barghorn
Ulrich Ebert
Andreas R Striebinger
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of MX2009005743A publication Critical patent/MX2009005743A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Abstract

La presente invención se refiere a anticuerpos monoclonales que pueden ser usados en el tratamiento y el diagnóstico del mal de Alzheimer. En particular, la presente invención se refiere a anticuerpos monoclonales, denominados 10F4 y 3C5, y a otros anticuerpos monoclonales (por ejemplo humanos o humanizados de múrido) que tienen propiedades similares a ellos.
MX2009005743A 2006-11-30 2007-11-29 Nuevos anticuerpos monoclonales de globulomero anti-ab selectivos del conformero ab. MX2009005743A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87215606P 2006-11-30 2006-11-30
PCT/US2007/085932 WO2008067464A2 (en) 2006-11-30 2007-11-29 NEW Aβ CONFORMER SELECTIVE ANTI-Aβ GLOBULOMER MONOCLONAL ANTIBODIES

Publications (1)

Publication Number Publication Date
MX2009005743A true MX2009005743A (es) 2010-02-24

Family

ID=39468719

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005743A MX2009005743A (es) 2006-11-30 2007-11-29 Nuevos anticuerpos monoclonales de globulomero anti-ab selectivos del conformero ab.

Country Status (8)

Country Link
US (5) US8455626B2 (es)
EP (1) EP2097104A4 (es)
JP (1) JP2010511386A (es)
CN (1) CN101652146A (es)
CA (1) CA2671217A1 (es)
MX (1) MX2009005743A (es)
TW (1) TW200840592A (es)
WO (1) WO2008067464A2 (es)

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