PE20061152A1 - Anticuerpos humanizados que reconocen el peptido beta amiloideo - Google Patents

Anticuerpos humanizados que reconocen el peptido beta amiloideo

Info

Publication number
PE20061152A1
PE20061152A1 PE2005001470A PE2005001470A PE20061152A1 PE 20061152 A1 PE20061152 A1 PE 20061152A1 PE 2005001470 A PE2005001470 A PE 2005001470A PE 2005001470 A PE2005001470 A PE 2005001470A PE 20061152 A1 PE20061152 A1 PE 20061152A1
Authority
PE
Peru
Prior art keywords
waste
light chain
sequence
variable region
cdr
Prior art date
Application number
PE2005001470A
Other languages
English (en)
Inventor
Guriq Basi
Jack Steven Jacobsen
Original Assignee
Neuralab Ltd
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36588573&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20061152(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Neuralab Ltd, Wyeth Corp filed Critical Neuralab Ltd
Publication of PE20061152A1 publication Critical patent/PE20061152A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

REFERIDA A UNA CADENA LIGERA DE INMUNOGLOBULINA HUMANIZADA QUE COMPRENDE (i) REGIONES DE DETERMINACION DE COMPLEMENTARIEDAD DE REGION VARIABLE (CDRs) A PARTIR DE LA SECUENCIA DE REGION VARIABLE DE LA CADENA LIGERA DE LA INMUNOGLOBULINA 15C11 COMO SE PRESENTA EN SEQ ID NO:2, Y (ii) REGION DE MARCO VARIABLE DE UNA SECUENCIA DE CADENA LIGERA DE INMUNOGLOBULINA DEL RECEPTOR HUMANO, QUE OPCIONALMENTE TIENE AL MENOS UN RESIDUO DE MARCO SUSTITUIDO CON EL CORRESPONDIENTE RESIDUO AMINOACIDO DE LA SECUENCIA DE REGION VARIABLE DE LA CADENA LIGERA DEL 15C11 DE RATON, DONDE EL RESIDUO DE MARCO SE SELECCIONA DEL GRUPO QUE CONSTA DE: a) UN RESIDUO QUE DE MANERA NO COVALENTE SE UNA AL ANTIGENO DIRECTAMENTE, b) UN RESIDUO ADYACENTE A UNA CDR, c) UN RESIDUO QUE INTERACTUA CON LA CDR, Y d) UN RESIDUO QUE PARTICIPA EN LA INTERFASE VL-VH. ESTOS REAGENTES INMUNOLOGICOS IDENTIFICAN Y CARACTERIZAN ANTICUERPOS MONOCLONALES TALES COMO 15C11 Y 9G8, QUE SE UNEN ESPECIFICAMENTE AL PEPTIDO BETA AMILOIDEO Y SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES AMILOIDEAS TALES COMO LA ENFERMEDAD DE ALZHEIMER
PE2005001470A 2004-12-15 2005-12-15 Anticuerpos humanizados que reconocen el peptido beta amiloideo PE20061152A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63668404P 2004-12-15 2004-12-15

Publications (1)

Publication Number Publication Date
PE20061152A1 true PE20061152A1 (es) 2006-10-13

Family

ID=36588573

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005001470A PE20061152A1 (es) 2004-12-15 2005-12-15 Anticuerpos humanizados que reconocen el peptido beta amiloideo

Country Status (8)

Country Link
US (1) US7625560B2 (es)
EP (1) EP1838854B1 (es)
AR (1) AR051528A1 (es)
ES (1) ES2396555T3 (es)
PE (1) PE20061152A1 (es)
TW (1) TW200636066A (es)
UY (1) UY29282A1 (es)
WO (1) WO2006066049A2 (es)

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