SI1711530T1 - Imunoglobulini, ki nevtralizirajo NogoA, za zdravljenje nevroloških bolezni - Google Patents

Imunoglobulini, ki nevtralizirajo NogoA, za zdravljenje nevroloških bolezni

Info

Publication number
SI1711530T1
SI1711530T1 SI200431272T SI200431272T SI1711530T1 SI 1711530 T1 SI1711530 T1 SI 1711530T1 SI 200431272 T SI200431272 T SI 200431272T SI 200431272 T SI200431272 T SI 200431272T SI 1711530 T1 SI1711530 T1 SI 1711530T1
Authority
SI
Slovenia
Prior art keywords
nogo
neutralising
immunoglobulins
treatment
neurological diseases
Prior art date
Application number
SI200431272T
Other languages
English (en)
Inventor
Jonathan Henry Ellis
Alexandre Eon-Duval
Robert Ian Grundy
Farhana Hussain
Ruth Mcadam
Christopher Plumpton
Rabinder Kumar Prinjha
Paul Alexander Wilson
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0329711A external-priority patent/GB0329711D0/en
Priority claimed from GB0329684A external-priority patent/GB0329684D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of SI1711530T1 publication Critical patent/SI1711530T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70Enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998Proteins not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI200431272T 2003-12-22 2004-12-20 Imunoglobulini, ki nevtralizirajo NogoA, za zdravljenje nevroloških bolezni SI1711530T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0329711A GB0329711D0 (en) 2003-12-22 2003-12-22 Antibodies
GB0329684A GB0329684D0 (en) 2003-12-22 2003-12-22 Method
EP04806128A EP1711530B1 (en) 2003-12-22 2004-12-20 Nogo-a neutralising immunoglobulins for treatment of neurological diseases
PCT/GB2004/005325 WO2005061544A2 (en) 2003-12-22 2004-12-20 Nogo-a neutralising immunoglobulins for treatment of neurological diseases

Publications (1)

Publication Number Publication Date
SI1711530T1 true SI1711530T1 (sl) 2010-01-29

Family

ID=34712703

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200431272T SI1711530T1 (sl) 2003-12-22 2004-12-20 Imunoglobulini, ki nevtralizirajo NogoA, za zdravljenje nevroloških bolezni

Country Status (28)

Country Link
US (4) US7988964B2 (sl)
EP (3) EP2213684A3 (sl)
JP (2) JP2007537145A (sl)
KR (1) KR101150548B1 (sl)
AR (1) AR048912A1 (sl)
AT (1) ATE440866T1 (sl)
AU (1) AU2004303585B2 (sl)
BR (1) BRPI0417959A (sl)
CA (1) CA2549956C (sl)
CY (1) CY1110530T1 (sl)
DE (1) DE602004022871D1 (sl)
DK (1) DK1711530T3 (sl)
ES (1) ES2330444T3 (sl)
HK (1) HK1100144A1 (sl)
HR (1) HRP20090527T1 (sl)
IL (1) IL176206A (sl)
IS (1) IS2739B (sl)
MA (1) MA28289A1 (sl)
MX (1) MXPA06007190A (sl)
MY (1) MY144612A (sl)
NO (1) NO20062767L (sl)
NZ (1) NZ548013A (sl)
PL (1) PL1711530T3 (sl)
PT (1) PT1711530E (sl)
RU (1) RU2362780C2 (sl)
SI (1) SI1711530T1 (sl)
TW (1) TWI329649B (sl)
WO (2) WO2005061544A2 (sl)

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DK1711530T3 (da) 2003-12-22 2009-12-14 Glaxo Group Ltd Nogo-A-neutraliserende immunoglobuliner til behandling af neurologiske sygdomme
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PL1954718T3 (pl) 2005-11-30 2015-04-30 Abbvie Inc Przeciwciała skierowane przeciwko A globulomerowi, ich reszty wiążące antygeny, odpowiednie hybrydomy, kwasy nukleinowe, wektory, komórki gospodarze, sposoby wytwarzania tych przeciwciał, kompozycje zawierające te przeciwciała, zastosowania tych przeciwciał i sposoby stosowania tych przeciwciał
JP5486808B2 (ja) 2005-11-30 2014-05-07 アッヴィ・インコーポレイテッド アミロイドベータタンパク質に対するモノクローナル抗体及びその使用
GB0525662D0 (en) * 2005-12-16 2006-01-25 Glaxo Group Ltd Immunoglobulins
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WO2009124281A2 (en) * 2008-04-04 2009-10-08 The Regents Of The University Of California Novel antibodies against cancer target block tumor growth, angiogenesis and metastasis
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JP2011527317A (ja) * 2008-07-11 2011-10-27 グラクソ グループ リミテッド Nogo−aアンタゴニストによる筋萎縮性側索硬化症の治療
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CN104744591B (zh) 2010-04-15 2022-09-27 Abbvie德国有限责任两合公司 β淀粉样蛋白结合蛋白
WO2012004773A1 (en) 2010-07-09 2012-01-12 Universite De Geneve New uses of nogo-a inhibitors and related methods
CN105348387B (zh) 2010-08-14 2020-08-25 Abbvie 公司 β淀粉样蛋白结合蛋白
EP2627357B1 (en) * 2010-10-15 2017-05-03 The Board of Regents of The University of Texas System Antibodies that bind amyloid oligomers
BR112013010569A2 (pt) 2010-10-29 2017-07-04 Immunogen Inc moléculas de ligação de egfr não antagonísticas e imunoconjugados das mesma
AU2011320314B2 (en) 2010-10-29 2015-08-06 Immunogen, Inc. Novel EGFR-binding molecules and immunoconjugates thereof
KR20140105765A (ko) 2011-11-21 2014-09-02 이뮤노젠 아이엔씨 EGfr 항체 세포독성제 접합체에 의한 EGfr 치료에 내성을 나타내는 종양의 치료 방법
AU2013208003B2 (en) 2012-01-09 2017-12-14 The Scripps Research Institute Ultralong complementarity determining regions and uses thereof
MX352772B (es) 2012-01-27 2017-12-07 Abbvie Deutschland Composición y método para el diagnóstico y tratamiento de enfermedades asociadas con la degeneración de neuritas.
EP2870177A1 (en) 2012-07-05 2015-05-13 Glaxo Group Limited Optimum dose regime of an anti-nogo-a antibody in the treatment of amyotrophic lateral sclerosis
HUE049866T2 (hu) 2015-05-04 2020-11-30 Cytomx Therapeutics Inc Aktiválható anti-CD166 antitestek, illetve azok alkalmazási módszerei
US20180362660A1 (en) * 2016-05-09 2018-12-20 Schickwann Tsai Anti-penumbra monoclonal antibodies for detection and therapy of normal and abnormal B lymphocytes
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WO2020068058A1 (en) * 2018-09-25 2020-04-02 Academia Sinica Anti-siglec antibody, pharmaceutical composition comprising the same, and uses thereof
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DK1711530T3 (da) 2003-12-22 2009-12-14 Glaxo Group Ltd Nogo-A-neutraliserende immunoglobuliner til behandling af neurologiske sygdomme

Also Published As

Publication number Publication date
BRPI0417959A (pt) 2007-03-27
AR048912A1 (es) 2006-06-14
US20110054149A1 (en) 2011-03-03
WO2005061544A3 (en) 2005-08-18
US20140147435A1 (en) 2014-05-29
RU2362780C2 (ru) 2009-07-27
MY144612A (en) 2011-10-14
MXPA06007190A (es) 2006-08-23
US20060029603A1 (en) 2006-02-09
WO2005061544A2 (en) 2005-07-07
KR101150548B1 (ko) 2012-07-06
HK1100144A1 (en) 2007-09-07
US7780964B2 (en) 2010-08-24
US20070065430A1 (en) 2007-03-22
PT1711530E (pt) 2009-10-22
IL176206A (en) 2012-02-29
JP4901480B2 (ja) 2012-03-21
IS2739B (is) 2011-06-15
EP1711530B1 (en) 2009-08-26
JP2008504220A (ja) 2008-02-14
KR20060129290A (ko) 2006-12-15
RU2006123481A (ru) 2008-01-27
EP1711530A2 (en) 2006-10-18
JP2007537145A (ja) 2007-12-20
MA28289A1 (fr) 2006-11-01
WO2005061545A3 (en) 2005-08-18
DK1711530T3 (da) 2009-12-14
ES2330444T3 (es) 2009-12-10
IS8506A (is) 2006-06-12
WO2005061545A2 (en) 2005-07-07
EP2213684A2 (en) 2010-08-04
ATE440866T1 (de) 2009-09-15
PL1711530T3 (pl) 2010-01-29
CA2549956A1 (en) 2005-07-07
AU2004303585A1 (en) 2005-07-07
CY1110530T1 (el) 2015-04-29
HRP20090527T1 (en) 2009-11-30
IL176206A0 (en) 2006-10-05
TW200533680A (en) 2005-10-16
EP2213684A3 (en) 2011-05-18
AU2004303585B2 (en) 2010-12-23
NO20062767L (no) 2006-09-20
TWI329649B (en) 2010-09-01
CA2549956C (en) 2016-04-12
EP1706426A2 (en) 2006-10-04
DE602004022871D1 (de) 2009-10-08
US7988964B2 (en) 2011-08-02
NZ548013A (en) 2009-04-30

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