DK1711530T3 - Nogo-A-neutraliserende immunoglobuliner til behandling af neurologiske sygdomme - Google Patents

Nogo-A-neutraliserende immunoglobuliner til behandling af neurologiske sygdomme

Info

Publication number
DK1711530T3
DK1711530T3 DK04806128T DK04806128T DK1711530T3 DK 1711530 T3 DK1711530 T3 DK 1711530T3 DK 04806128 T DK04806128 T DK 04806128T DK 04806128 T DK04806128 T DK 04806128T DK 1711530 T3 DK1711530 T3 DK 1711530T3
Authority
DK
Denmark
Prior art keywords
nogo
treatment
neurological disorders
neutralizing immunoglobulins
immunoglobulins
Prior art date
Application number
DK04806128T
Other languages
English (en)
Inventor
Jonathan Henry Ellis
Farhana Hussain
Ruth Mcadam
Christopher Plumpton
Rabinder Kumar Prinjha
Paul Alexander Wilson
Alexandre Eon-Duval
Robert Ian Grundy
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0329684A external-priority patent/GB0329684D0/en
Priority claimed from GB0329711A external-priority patent/GB0329711D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of DK1711530T3 publication Critical patent/DK1711530T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK04806128T 2003-12-22 2004-12-20 Nogo-A-neutraliserende immunoglobuliner til behandling af neurologiske sygdomme DK1711530T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0329684A GB0329684D0 (en) 2003-12-22 2003-12-22 Method
GB0329711A GB0329711D0 (en) 2003-12-22 2003-12-22 Antibodies
PCT/GB2004/005325 WO2005061544A2 (en) 2003-12-22 2004-12-20 Nogo-a neutralising immunoglobulins for treatment of neurological diseases

Publications (1)

Publication Number Publication Date
DK1711530T3 true DK1711530T3 (da) 2009-12-14

Family

ID=34712703

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04806128T DK1711530T3 (da) 2003-12-22 2004-12-20 Nogo-A-neutraliserende immunoglobuliner til behandling af neurologiske sygdomme

Country Status (28)

Country Link
US (4) US7988964B2 (da)
EP (3) EP2213684A3 (da)
JP (2) JP4901480B2 (da)
KR (1) KR101150548B1 (da)
AR (1) AR048912A1 (da)
AT (1) ATE440866T1 (da)
AU (1) AU2004303585B2 (da)
BR (1) BRPI0417959A (da)
CA (1) CA2549956C (da)
CY (1) CY1110530T1 (da)
DE (1) DE602004022871D1 (da)
DK (1) DK1711530T3 (da)
ES (1) ES2330444T3 (da)
HK (1) HK1100144A1 (da)
HR (1) HRP20090527T1 (da)
IL (1) IL176206A (da)
IS (1) IS2739B (da)
MA (1) MA28289A1 (da)
MX (1) MXPA06007190A (da)
MY (1) MY144612A (da)
NO (1) NO20062767L (da)
NZ (1) NZ548013A (da)
PL (1) PL1711530T3 (da)
PT (1) PT1711530E (da)
RU (1) RU2362780C2 (da)
SI (1) SI1711530T1 (da)
TW (1) TWI329649B (da)
WO (2) WO2005061545A2 (da)

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CA2631195C (en) * 2005-11-30 2016-04-05 Abbott Laboratories Monoclonal antibodies against amyloid beta protein and uses thereof
GB0525662D0 (en) 2005-12-16 2006-01-25 Glaxo Group Ltd Immunoglobulins
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MX358739B (es) 2010-08-14 2018-09-03 Abbvie Inc Star Proteinas de union a amiloide beta.
JP5828901B2 (ja) * 2010-10-29 2015-12-09 イミュノジェン， インコーポレイテッド 新規ｅｇｆｒ結合分子およびその免疫抱合体
CN105399831A (zh) 2010-10-29 2016-03-16 伊缪诺金公司 非拮抗性egfr结合分子及其免疫偶联物
MX2014006087A (es) 2011-11-21 2014-08-01 Immunogen Inc Metodo de tratamiento de tumores que son resistentes a terapias contra el receptor del factor de crecimiento epidermico (egfr) con agentes citotoxicos conjugados con anticuerpos dirigidos contra el receptor del factor de crecimiento epidermico.
CN104520321A (zh) 2012-01-09 2015-04-15 斯克利普斯研究所 超长互补决定区及其用途
NZ714482A (en) 2012-01-27 2017-08-25 Abbvie Inc Composition and method for diagnosis and treatment of diseases associated with neurite degeneration
EP2870177A1 (en) 2012-07-05 2015-05-13 Glaxo Group Limited Optimum dose regime of an anti-nogo-a antibody in the treatment of amyotrophic lateral sclerosis
JP7028648B2 (ja) 2015-05-04 2022-03-02 サイトメックス セラピューティクス インコーポレイテッド 抗ｃｄ１６６抗体、活性化可能抗ｃｄ１６６抗体、およびその使用方法
US20180362660A1 (en) * 2016-05-09 2018-12-20 Schickwann Tsai Anti-penumbra monoclonal antibodies for detection and therapy of normal and abnormal B lymphocytes
EA202090247A1 (ru) * 2017-07-14 2020-05-12 Цитомкс Терапьютикс, Инк. Антитела против cd166 и их применения
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Also Published As

Publication number Publication date
WO2005061544A3 (en) 2005-08-18
KR20060129290A (ko) 2006-12-15
IL176206A0 (en) 2006-10-05
US20110054149A1 (en) 2011-03-03
MA28289A1 (fr) 2006-11-01
NZ548013A (en) 2009-04-30
EP1706426A2 (en) 2006-10-04
ATE440866T1 (de) 2009-09-15
HRP20090527T1 (en) 2009-11-30
PT1711530E (pt) 2009-10-22
AU2004303585A1 (en) 2005-07-07
IS8506A (is) 2006-06-12
EP2213684A3 (en) 2011-05-18
JP2007537145A (ja) 2007-12-20
JP4901480B2 (ja) 2012-03-21
US20070065430A1 (en) 2007-03-22
CA2549956C (en) 2016-04-12
WO2005061544A2 (en) 2005-07-07
NO20062767L (no) 2006-09-20
TWI329649B (en) 2010-09-01
JP2008504220A (ja) 2008-02-14
EP2213684A2 (en) 2010-08-04
MXPA06007190A (es) 2006-08-23
MY144612A (en) 2011-10-14
KR101150548B1 (ko) 2012-07-06
RU2006123481A (ru) 2008-01-27
WO2005061545A2 (en) 2005-07-07
PL1711530T3 (pl) 2010-01-29
DE602004022871D1 (de) 2009-10-08
US20140147435A1 (en) 2014-05-29
CY1110530T1 (el) 2015-04-29
ES2330444T3 (es) 2009-12-10
RU2362780C2 (ru) 2009-07-27
HK1100144A1 (en) 2007-09-07
EP1711530A2 (en) 2006-10-18
IS2739B (is) 2011-06-15
SI1711530T1 (sl) 2010-01-29
AR048912A1 (es) 2006-06-14
US7780964B2 (en) 2010-08-24
TW200533680A (en) 2005-10-16
US20060029603A1 (en) 2006-02-09
BRPI0417959A (pt) 2007-03-27
AU2004303585B2 (en) 2010-12-23
EP1711530B1 (en) 2009-08-26
US7988964B2 (en) 2011-08-02
IL176206A (en) 2012-02-29
WO2005061545A3 (en) 2005-08-18
CA2549956A1 (en) 2005-07-07

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