ATE413884T1 - Beta-secretase-substrat und seine verwendung - Google Patents
Beta-secretase-substrat und seine verwendungInfo
- Publication number
- ATE413884T1 ATE413884T1 AT02729238T AT02729238T ATE413884T1 AT E413884 T1 ATE413884 T1 AT E413884T1 AT 02729238 T AT02729238 T AT 02729238T AT 02729238 T AT02729238 T AT 02729238T AT E413884 T1 ATE413884 T1 AT E413884T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- secretase
- antibodies
- disclosed
- various assays
- Prior art date
Links
- 239000000758 substrate Substances 0.000 title abstract 5
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 title 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 title 1
- 238000003556 assay Methods 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29259101P | 2001-05-22 | 2001-05-22 | |
| US31611501P | 2001-08-30 | 2001-08-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE413884T1 true ATE413884T1 (de) | 2008-11-15 |
Family
ID=26967437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02729238T ATE413884T1 (de) | 2001-05-22 | 2002-05-17 | Beta-secretase-substrat und seine verwendung |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7132401B2 (de) |
| EP (2) | EP1395275B1 (de) |
| JP (1) | JP4454230B2 (de) |
| AT (1) | ATE413884T1 (de) |
| CA (1) | CA2448142A1 (de) |
| DE (1) | DE60229846D1 (de) |
| WO (1) | WO2002094985A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200628612A (en) | 2000-07-19 | 2006-08-16 | Pharmacia & Up John Company | Substrates and assays for β-secretase activity |
| US7196163B2 (en) * | 2001-05-22 | 2007-03-27 | Merk & Co., Inc. | Assays using amyloid precursor proteins with modified β-secretase cleavage sites to monitor β-secretase activity |
| CA2477002A1 (en) * | 2002-02-27 | 2003-09-04 | Merck & Co., Inc. | Assays to monitor amyloid precursor protein processing |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| AU2004233347A1 (en) | 2003-04-23 | 2004-11-04 | Darrell H. Reneker | Sequestered reactive materials |
| WO2004111189A2 (en) * | 2003-05-30 | 2004-12-23 | Merck & Co., Inc. | Transgenic animal having an amyloid precursor protein with a modified beta secretase cleavage site |
| JP2005145837A (ja) * | 2003-11-12 | 2005-06-09 | Institute Of Physical & Chemical Research | アルツハイマー病の診断方法 |
| JP2008519988A (ja) * | 2004-11-12 | 2008-06-12 | ファイザー・インク | アミロイド−ベータペプチドを測定する方法 |
| BRPI0619249A2 (pt) | 2005-11-30 | 2011-09-20 | Abbott Lab | anticorpos anti-globulÈmeros-aß, frações que se ligam a antìgeno destes, hibridomas correspondentes, ácidos nucléicos, vetores, células hospedeiras, métodos de produzir os ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos de usar os ditos anticorpos |
| PT1976877E (pt) | 2005-11-30 | 2014-04-29 | Abbvie Inc | Anticorpos monoclonais contra proteína beta-amilóide e suas utilizações |
| US20070292895A1 (en) * | 2006-05-19 | 2007-12-20 | Xiao-Ping Shi | Assays and methods to detect beta-secretase and its activity in body fluids and tissue extracts |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| EP2124952A2 (de) | 2007-02-27 | 2009-12-02 | Abbott GmbH & Co. KG | Verfahren zur behandlung von amyloidosen |
| EP2558494B1 (de) | 2010-04-15 | 2018-05-23 | AbbVie Inc. | Amyloid-beta-bindende proteine |
| CN105348387B (zh) | 2010-08-14 | 2020-08-25 | Abbvie 公司 | β淀粉样蛋白结合蛋白 |
| TW201300417A (zh) | 2010-11-10 | 2013-01-01 | Genentech Inc | 用於神經疾病免疫療法之方法及組合物 |
| WO2012154272A1 (en) * | 2011-02-25 | 2012-11-15 | Wellstat Diagnostics, Llc | Assays for detecting enzymatic activity |
| JP2013158281A (ja) * | 2012-02-03 | 2013-08-19 | Shionogi & Co Ltd | 新規ｂａｃｅ１活性測定方法 |
| CN107108745B (zh) | 2014-11-19 | 2021-01-12 | 基因泰克公司 | 抗bace1的抗体和其用于神经疾病免疫疗法的用途 |
| WO2016081640A1 (en) | 2014-11-19 | 2016-05-26 | Genentech, Inc. | Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4272149A (en) | 1979-09-28 | 1981-06-09 | The Bendix Corporation | One piece socket type electrical contacts |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| ATE255131T1 (de) | 1991-06-14 | 2003-12-15 | Genentech Inc | Humanisierter heregulin antikörper |
| US5702905A (en) * | 1994-09-28 | 1997-12-30 | Spectral Diagnostics | Monoclonal antibody to human ventricular myosin light chains |
| US6203979B1 (en) | 1998-01-16 | 2001-03-20 | Incyte Pharmaceuticals, Inc. | Human protease molecules |
| US7115410B1 (en) * | 1999-02-10 | 2006-10-03 | Elan Pharmaceuticals, Inc. | β-secretase enzyme compositions and methods |
| WO2000058479A1 (en) * | 1999-03-26 | 2000-10-05 | Amgen Inc. | Beta secretase genes and polypeptides |
-
2002
- 2002-05-17 CA CA002448142A patent/CA2448142A1/en not_active Abandoned
- 2002-05-17 DE DE60229846T patent/DE60229846D1/de not_active Expired - Fee Related
- 2002-05-17 AT AT02729238T patent/ATE413884T1/de not_active IP Right Cessation
- 2002-05-17 EP EP02729238A patent/EP1395275B1/de not_active Expired - Lifetime
- 2002-05-17 WO PCT/US2002/015590 patent/WO2002094985A2/en not_active Ceased
- 2002-05-17 EP EP08104739A patent/EP1990057A1/de not_active Withdrawn
- 2002-05-17 US US10/480,954 patent/US7132401B2/en not_active Expired - Fee Related
- 2002-05-17 JP JP2002592448A patent/JP4454230B2/ja not_active Expired - Fee Related
-
2006
- 2006-09-19 US US11/523,507 patent/US7479372B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002094985A3 (en) | 2003-04-17 |
| EP1990057A1 (de) | 2008-11-12 |
| US20070184488A1 (en) | 2007-08-09 |
| CA2448142A1 (en) | 2002-11-28 |
| DE60229846D1 (de) | 2008-12-24 |
| EP1395275A2 (de) | 2004-03-10 |
| JP2004530704A (ja) | 2004-10-07 |
| EP1395275A4 (de) | 2006-05-31 |
| US7479372B2 (en) | 2009-01-20 |
| WO2002094985A2 (en) | 2002-11-28 |
| US20050032190A1 (en) | 2005-02-10 |
| EP1395275B1 (de) | 2008-11-12 |
| JP4454230B2 (ja) | 2010-04-21 |
| US7132401B2 (en) | 2006-11-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60229846D1 (de) | Beta-secretase-substrat und seine verwendung | |
| DE60305634D1 (de) | Anaplastisches Lymphoma Kinase Testverfahren, Reagenzien und Kompositionen davon | |
| ATE423216T1 (de) | Neue fructosylpeptidoxidase und deren nutzung | |
| ATE520466T1 (de) | Apparat und verfahren zur modifizierung von magnetisch inmmobilizierte biomolekulen | |
| NO20043419L (no) | Nytt cytokin, zcytor17-ligand | |
| ATE427499T1 (de) | Zusammensetzungen und verfahren zur quantifizierung von serumglykoproteinen | |
| EP2158319A4 (de) | Auf knochen als ziel gerichtete alkalische phosphatase, kits und verwendungsverfahren dafür | |
| EP1540015A4 (de) | Assays und zusammensetzungen zur identifizierung von die aktivität deubiquitinierender agentien modulierenden agentien | |
| MA29135B1 (fr) | Potentialisateurs de recepteurs du glutamate | |
| DK1576112T3 (da) | Cytokin-receptor zcytor17-multimerer | |
| CY1111126T1 (el) | Σκευασμα οφθαλμικων σταγονων που περιεχει κετοτιφαινη | |
| MA31138B1 (fr) | Anticorps humains de haute affinite diriges contre le recepteur humain de l'il-4 | |
| ATE310955T1 (de) | Zusammensetzungen und verfahren zum nachweis und zur behandlung von mit chemokinrezeptoren verbundenen krankheiten | |
| ATE462006T1 (de) | Isoform des vegfs | |
| EA200601029A1 (ru) | Способ очистки фсг | |
| ATE466009T1 (de) | Ccr5 antagonisten verwendbar für die behandlung von aids | |
| DE60322613D1 (de) | Frostschutzproteine aus Basidiomyceten | |
| ATE366045T1 (de) | Verwendung von 4-aminopyrimidinen zur antimikrobiellen behandlung von oberflächen | |
| DE50211985D1 (de) | Verwendung von pyridin-2,4-dicarbons urediamiden und pyrimid in-4,6-dicarbons urediamiden zur selektiven inhibierung von kollagenasen | |
| DE60210970D1 (de) | Mutante formen von etxb und ctxb und ihre verwendung als träger | |
| FI20010582A0 (fi) | Menetelmä piianturin valmistamiseksi sekä piianturi | |
| ATE465173T1 (de) | Verändertes vp-1capsidprotein von parvovirus b19 | |
| DE60316476D1 (de) | Vorrichtung zur verhinderung des mitlaufens von feinpartikeln | |
| ATE448308T1 (de) | Fructosylamin-oxidase | |
| DE50212649D1 (de) | Verwendung von desoxypeganin zur behandlung der klinischen depression |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |