ATE331729T1 - Tetrapeptidische tryptase substrate und ihre verwendung zur tryptase aktivitätbestimmung - Google Patents

Tetrapeptidische tryptase substrate und ihre verwendung zur tryptase aktivitätbestimmung

Info

Publication number
ATE331729T1
ATE331729T1 AT01988724T AT01988724T ATE331729T1 AT E331729 T1 ATE331729 T1 AT E331729T1 AT 01988724 T AT01988724 T AT 01988724T AT 01988724 T AT01988724 T AT 01988724T AT E331729 T1 ATE331729 T1 AT E331729T1
Authority
AT
Austria
Prior art keywords
tryptase
substrates
seq
tetrapeptidic
determining
Prior art date
Application number
AT01988724T
Other languages
English (en)
Inventor
Andrew L Niles
Mary Haak-Frendscho
Jennifer L Harris
Charles S Craik
Original Assignee
Promega Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Promega Corp filed Critical Promega Corp
Application granted granted Critical
Publication of ATE331729T1 publication Critical patent/ATE331729T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT01988724T 2000-10-27 2001-10-03 Tetrapeptidische tryptase substrate und ihre verwendung zur tryptase aktivitätbestimmung ATE331729T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24401300P 2000-10-27 2000-10-27
US09/955,639 US6797461B2 (en) 2000-10-27 2001-09-19 Tryptase substrates and assay for tryptase activity using same

Publications (1)

Publication Number Publication Date
ATE331729T1 true ATE331729T1 (de) 2006-07-15

Family

ID=26936256

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01988724T ATE331729T1 (de) 2000-10-27 2001-10-03 Tetrapeptidische tryptase substrate und ihre verwendung zur tryptase aktivitätbestimmung

Country Status (6)

Country Link
US (1) US6797461B2 (de)
EP (1) EP1358205B1 (de)
AT (1) ATE331729T1 (de)
AU (1) AU2002216613A1 (de)
DE (1) DE60121225T2 (de)
WO (1) WO2002034765A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101132555B1 (ko) * 2002-10-02 2012-04-02 리전츠 오브 더 유니버시티 오브 캘리포니아 변경된 특이성을 갖는 프로테아제의 제조 및 선별 방법
US7416854B2 (en) * 2004-01-22 2008-08-26 Promega Corporation Luminogenic and nonluminogenic multiplex assay
ES2509616T3 (es) 2009-06-25 2014-10-17 Nestec S.A. Procedimientos de diagnóstico del síndrome del intestino irritable
WO2021045182A1 (ja) * 2019-09-05 2021-03-11 国立大学法人東京農工大学 トリプターゼ活性測定用基質

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL60888A (en) * 1978-06-16 1984-07-31 Yeda Res & Dev Substrates and process for the quantitative assay of enzymes
DE2945239A1 (de) * 1979-11-09 1981-05-21 Troponwerke GmbH & Co KG, 5000 Köln Oligopeptide, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
SE453510B (sv) 1980-12-29 1988-02-08 Toyo Jozo Kk Peptid for analys av humant paratyroidhormon
US4390528A (en) 1981-11-16 1983-06-28 Research Corporation Tuftsinyl-tuftsin
US5391705A (en) 1991-03-15 1995-02-21 Merrell Dow Pharmaceuticals Inc. Polyfluorinated tripeptide thrombin inhibitors
US5589458A (en) * 1992-11-13 1996-12-31 Thomas Jefferson University Compounds that inhibit T cell proliferation and methods for using the same
GB2324529A (en) 1997-02-21 1998-10-28 Merck & Co Inc A combinatorial library based on a tetrapeptide substituted with aminomethylcoumarin for characterizing proteases
CN1254383A (zh) * 1997-05-01 2000-05-24 美国3M公司 基于染料二聚作用的生荧光蛋白水解酶底物
SK10742001A3 (sk) * 1999-01-27 2002-08-06 Ortho-Mcneil Pharmaceutical, Inc. Peptidylové heterocyklické ketóny použiteľné ako inhibítory tryptázy
CA2261326A1 (en) 1999-02-09 2000-08-09 Jean-Pascal Viola Laboratory cap and well for hanging-drop crystallization methods
WO2001094332A1 (en) 2000-06-02 2001-12-13 Regents Of The University Of California Profiling of protease specificity using combinatorial fluorogenic substrate libraries

Also Published As

Publication number Publication date
EP1358205B1 (de) 2006-06-28
WO2002034765A2 (en) 2002-05-02
EP1358205A2 (de) 2003-11-05
WO2002034765A3 (en) 2003-08-28
DE60121225D1 (de) 2006-08-10
US6797461B2 (en) 2004-09-28
AU2002216613A1 (en) 2002-05-06
DE60121225T2 (de) 2007-05-31
WO2002034765A9 (en) 2004-04-22
US20020197661A1 (en) 2002-12-26

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