DE60121225D1 - Tetrapeptidische tryptase substrate und ihre verwendung zur tryptase aktivitätbestimmung - Google Patents

Tetrapeptidische tryptase substrate und ihre verwendung zur tryptase aktivitätbestimmung

Info

Publication number
DE60121225D1
DE60121225D1 DE60121225T DE60121225T DE60121225D1 DE 60121225 D1 DE60121225 D1 DE 60121225D1 DE 60121225 T DE60121225 T DE 60121225T DE 60121225 T DE60121225 T DE 60121225T DE 60121225 D1 DE60121225 D1 DE 60121225D1
Authority
DE
Germany
Prior art keywords
tryptase
substrates
seq
tetrapeptidic
activity determination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60121225T
Other languages
English (en)
Other versions
DE60121225T2 (de
Inventor
L Niles
Mary Haak-Frendscho
L Harris
S Craik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Promega Corp
Original Assignee
Promega Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Promega Corp filed Critical Promega Corp
Application granted granted Critical
Publication of DE60121225D1 publication Critical patent/DE60121225D1/de
Publication of DE60121225T2 publication Critical patent/DE60121225T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
DE60121225T 2000-10-27 2001-10-03 Tetrapeptidische tryptase substrate und ihre verwendung zur tryptase aktivitätsbestimmung Expired - Fee Related DE60121225T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US955639 1997-10-23
US24401300P 2000-10-27 2000-10-27
US244013P 2000-10-27
US09/955,639 US6797461B2 (en) 2000-10-27 2001-09-19 Tryptase substrates and assay for tryptase activity using same
PCT/US2001/030984 WO2002034765A2 (en) 2000-10-27 2001-10-03 us0130034IDIC TRYPTASE SUBSTRATES AND ASSAY FOR TRYPTASE ACTIVITY USING SAME

Publications (2)

Publication Number Publication Date
DE60121225D1 true DE60121225D1 (de) 2006-08-10
DE60121225T2 DE60121225T2 (de) 2007-05-31

Family

ID=26936256

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60121225T Expired - Fee Related DE60121225T2 (de) 2000-10-27 2001-10-03 Tetrapeptidische tryptase substrate und ihre verwendung zur tryptase aktivitätsbestimmung

Country Status (6)

Country Link
US (1) US6797461B2 (de)
EP (1) EP1358205B1 (de)
AT (1) ATE331729T1 (de)
AU (1) AU2002216613A1 (de)
DE (1) DE60121225T2 (de)
WO (1) WO2002034765A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101124484A (zh) * 2002-10-02 2008-02-13 催化剂生物科学有限公司 制备与筛选改变特异性蛋白酶的方法
AU2010266028B2 (en) * 2009-06-25 2015-04-30 Société des Produits Nestlé S.A. Methods for diagnosing irritable bowel syndrome
TW202122798A (zh) * 2019-09-05 2021-06-16 國立大學法人東京農工大學 類胰蛋白酶活性測定用基質

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL60888A (en) * 1978-06-16 1984-07-31 Yeda Res & Dev Substrates and process for the quantitative assay of enzymes
DE2945239A1 (de) * 1979-11-09 1981-05-21 Troponwerke GmbH & Co KG, 5000 Köln Oligopeptide, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
SE453510B (sv) * 1980-12-29 1988-02-08 Toyo Jozo Kk Peptid for analys av humant paratyroidhormon
US4390528A (en) 1981-11-16 1983-06-28 Research Corporation Tuftsinyl-tuftsin
US5391705A (en) 1991-03-15 1995-02-21 Merrell Dow Pharmaceuticals Inc. Polyfluorinated tripeptide thrombin inhibitors
US5589458A (en) * 1992-11-13 1996-12-31 Thomas Jefferson University Compounds that inhibit T cell proliferation and methods for using the same
GB2324529A (en) 1997-02-21 1998-10-28 Merck & Co Inc A combinatorial library based on a tetrapeptide substituted with aminomethylcoumarin for characterizing proteases
EP0980440B1 (de) * 1997-05-01 2007-08-01 Minnesota Mining And Manufacturing Company Fluorogene protease-substrate basierend auf farbstoffdimerisierung
EE200100391A (et) * 1999-01-27 2002-10-15 Ortho-Mcneil Pharmaceutical, Inc. Peptidüül-heterotsüklilised ketoonid, nende kasutamine ja farmatseutiline kompositsioon
CA2261326A1 (en) 1999-02-09 2000-08-09 Jean-Pascal Viola Laboratory cap and well for hanging-drop crystallization methods
US6680178B2 (en) 2000-06-02 2004-01-20 The Regents Of The University Of California Profiling of protease specificity using combinatorial fluorogenic substrate libraries

Also Published As

Publication number Publication date
WO2002034765A3 (en) 2003-08-28
WO2002034765A9 (en) 2004-04-22
DE60121225T2 (de) 2007-05-31
EP1358205B1 (de) 2006-06-28
US20020197661A1 (en) 2002-12-26
WO2002034765A2 (en) 2002-05-02
EP1358205A2 (de) 2003-11-05
ATE331729T1 (de) 2006-07-15
US6797461B2 (en) 2004-09-28
AU2002216613A1 (en) 2002-05-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee