ATE396993T1 - Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität - Google Patents

Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität

Info

Publication number
ATE396993T1
ATE396993T1 AT03724241T AT03724241T ATE396993T1 AT E396993 T1 ATE396993 T1 AT E396993T1 AT 03724241 T AT03724241 T AT 03724241T AT 03724241 T AT03724241 T AT 03724241T AT E396993 T1 ATE396993 T1 AT E396993T1
Authority
AT
Austria
Prior art keywords
chemokine receptor
tetrahydropyranyl
cyclopentyl
receptor activity
modulators
Prior art date
Application number
AT03724241T
Other languages
English (en)
Inventor
Richard Jiao
Gregori Morriello
Lihu Yang
Stephen Goble
Sander Mills
Alexander Pasternak
Changyou Zhou
Gabor Butora
Shankaran Kothandaraman
Deodialsingh Guiadeen
Cheng Tang
Christopher Moyes
Original Assignee
Merck & Co Inc
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Merck Sharp & Dohme filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE396993T1 publication Critical patent/ATE396993T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03724241T 2002-04-29 2003-04-25 Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität ATE396993T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37618002P 2002-04-29 2002-04-29

Publications (1)

Publication Number Publication Date
ATE396993T1 true ATE396993T1 (de) 2008-06-15

Family

ID=29401316

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03724241T ATE396993T1 (de) 2002-04-29 2003-04-25 Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität

Country Status (15)

Country Link
US (1) US6812234B2 (de)
EP (1) EP1501507B1 (de)
JP (1) JP3780291B2 (de)
AT (1) ATE396993T1 (de)
AU (1) AU2003231114B8 (de)
CA (1) CA2483752C (de)
CY (1) CY1110399T1 (de)
DE (1) DE60321333D1 (de)
DK (1) DK1501507T3 (de)
ES (1) ES2306867T3 (de)
NZ (1) NZ536477A (de)
PT (1) PT1501507E (de)
SI (1) SI1501507T1 (de)
WO (1) WO2003092586A2 (de)
ZA (1) ZA200407940B (de)

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WO2004110376A2 (en) * 2003-06-06 2004-12-23 Merck & Co., Inc. Ccr-2 antagonists for treatment of neuropathic pain
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US20070117797A1 (en) * 2004-01-02 2007-05-24 Goble Stephen D Alkylamino, arylamino, and sulfonamido cyclopentyl amide modulators of chemokine receptor activity
CA2554387A1 (en) * 2004-01-28 2005-08-11 Merck & Co., Inc. Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity
EP1742919A4 (de) * 2004-04-26 2010-04-28 Merck Sharp & Dohme Tetrahydropyranyl-cyclopentyl-1-substituierte und 1,1-disubstituierte tetrahydroisochinoline-modulatoren der chemokinrezeptoraktivität
JP2007534756A (ja) * 2004-04-26 2007-11-29 メルク　エンド　カムパニー　インコーポレーテッド ケモカイン受容体活性のテトラヒドロピラニルシクロペンチルテトラヒドロピリドピリジンモジュレーター
EP1755603A4 (de) * 2004-04-28 2009-03-11 Merck & Co Inc 3,3-disubstituierte tetrahydropyranyl cyclopentyl amide modulatoren der chemokin-rezeptor-aktivität
BRPI0510665A (pt) * 2004-05-11 2007-12-04 Incyte Corp 3-(4-heteroarilcicloexilamino) ciclopentano-carboxiamidas como moduladores de receptores de quimiocinas
MXPA06014672A (es) 2004-06-28 2007-03-26 Incyte Corp 3-aminociclopentanocarboxamidas como moduladores de receptores de quimioquinas.
WO2006004741A2 (en) 2004-06-28 2006-01-12 Incyte Corporation 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
US20070238723A1 (en) * 2004-10-15 2007-10-11 Goble Stephen D Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors
WO2006074265A2 (en) * 2005-01-06 2006-07-13 Merck & Co., Inc. Drug combination therapy and pharmaceutical compositions for treating inflammatory disorders
JP2008536484A (ja) * 2005-03-11 2008-09-11 メルク エンド カムパニー インコーポレーテッド （ｒ）−４，４−ジメトキシ−ピラン−３−オールなどの（ｒ）−４，４−ジアルコキシ−ピラン−３−オールの調製方法
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
WO2007053499A2 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
EP2370442B9 (de) * 2008-11-26 2013-09-04 Pfizer Inc. 3-Aminocyclopentancarbonsäureamide als Modulatoren des Chemokinrezeptors
CN102256963B (zh) 2008-12-19 2014-06-11 贝林格尔.英格海姆国际有限公司 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺
ES2674275T3 (es) 2009-12-17 2018-06-28 Centrexion Therapeutics Corporation Antagonistas del receptor CCR2 y usos de los mismos
CA2785058A1 (en) 2009-12-22 2011-07-21 Cephalon, Inc. Tricyclic derivatives and their pharmaceutical use and compositions
US9040526B2 (en) 2010-02-09 2015-05-26 Bristol-Myers Squibb Company Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity
WO2011147772A1 (en) * 2010-05-25 2011-12-01 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists
WO2012125663A2 (en) * 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists
US8822460B2 (en) * 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
HK1216233A1 (zh) 2013-02-28 2016-10-28 参天制药株式会社 含有四氢吡喃基氨基环戊基羰基四氢吡啶并吡啶衍生物作为有效成分的眼後段疾病的预防或治疗剂
DK3297438T3 (da) 2015-05-21 2022-01-17 Chemocentryx Inc Ccr2-modulatorer
PT3317270T (pt) 2015-07-02 2020-08-24 Centrexion Therapeutics Corp (4-((3r,4r)-3-metoxitetrahidro-pirano-4-ilamino)piperidina-1-il)(5-metil-6-(((2r,6s)-6-(p-tolil)tetrahidro-2h-pirano-2-il)metilamino)pirimidina-4-il)citrato de metanona
US20190336489A1 (en) 2017-01-17 2019-11-07 Glaxosmithkline Intellectual Property Development Limited Non peptide heterobivalent molecules for treating inflammatory diseases
CA3293051A1 (en) 2017-09-25 2026-03-02 Chemocentryx, Inc. Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor
CN112105353B (zh) 2018-01-08 2024-04-19 凯莫森特里克斯股份有限公司 Ccr2拮抗剂治疗实体瘤的方法
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
CN119925562B (zh) * 2023-11-03 2025-11-28 中国科学院上海药物研究所 趋化因子受体2拮抗剂在制备治疗糖尿病并发焦虑症的应用

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US3647804A (en) * 1970-02-27 1972-03-07 Upjohn Co Cycloalkanecarboxamides
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EP1318811B1 (de) * 2000-08-17 2006-08-30 Merck & Co., Inc. Cyclopentylmodulatoren der chemokin-rezeptor-aktivität
EP1368354A1 (de) 2001-03-07 2003-12-10 Pfizer Products Inc. Modulatoren der aktivität von chemokin-rezeptoren
JO2479B1 (en) * 2002-04-29 2009-01-20 ميرك شارب اند دوم ليمتد Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine

Also Published As

Publication number Publication date
ZA200407940B (en) 2006-06-28
JP2005523929A (ja) 2005-08-11
AU2003231114B2 (en) 2008-07-24
US20040167156A1 (en) 2004-08-26
DE60321333D1 (de) 2008-07-10
ES2306867T3 (es) 2008-11-16
PT1501507E (pt) 2008-08-12
WO2003092586A2 (en) 2003-11-13
EP1501507A4 (de) 2006-05-17
EP1501507B1 (de) 2008-05-28
CY1110399T1 (el) 2014-04-09
WO2003092586A3 (en) 2004-09-16
EP1501507A2 (de) 2005-02-02
DK1501507T3 (da) 2008-09-29
US6812234B2 (en) 2004-11-02
AU2003231114B8 (en) 2008-08-14
AU2003231114A1 (en) 2003-11-17
SI1501507T1 (sl) 2008-12-31
JP3780291B2 (ja) 2006-05-31
NZ536477A (en) 2005-05-27
CA2483752A1 (en) 2003-11-13
CA2483752C (en) 2011-03-29

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