ATE396993T1 - Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität - Google Patents

Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität

Info

Publication number
ATE396993T1
ATE396993T1 AT03724241T AT03724241T ATE396993T1 AT E396993 T1 ATE396993 T1 AT E396993T1 AT 03724241 T AT03724241 T AT 03724241T AT 03724241 T AT03724241 T AT 03724241T AT E396993 T1 ATE396993 T1 AT E396993T1
Authority
AT
Austria
Prior art keywords
chemokine receptor
tetrahydropyranyl
cyclopentyl
receptor activity
modulators
Prior art date
Application number
AT03724241T
Other languages
English (en)
Inventor
Richard Jiao
Gregori Morriello
Lihu Yang
Stephen Goble
Sander Mills
Alexander Pasternak
Changyou Zhou
Gabor Butora
Shankaran Kothandaraman
Deodialsingh Guiadeen
Cheng Tang
Christopher Moyes
Original Assignee
Merck & Co Inc
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Merck Sharp & Dohme filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE396993T1 publication Critical patent/ATE396993T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03724241T 2002-04-29 2003-04-25 Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität ATE396993T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37618002P 2002-04-29 2002-04-29

Publications (1)

Publication Number Publication Date
ATE396993T1 true ATE396993T1 (de) 2008-06-15

Family

ID=29401316

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03724241T ATE396993T1 (de) 2002-04-29 2003-04-25 Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität

Country Status (15)

Country Link
US (1) US6812234B2 (de)
EP (1) EP1501507B1 (de)
JP (1) JP3780291B2 (de)
AT (1) ATE396993T1 (de)
AU (1) AU2003231114B8 (de)
CA (1) CA2483752C (de)
CY (1) CY1110399T1 (de)
DE (1) DE60321333D1 (de)
DK (1) DK1501507T3 (de)
ES (1) ES2306867T3 (de)
NZ (1) NZ536477A (de)
PT (1) PT1501507E (de)
SI (1) SI1501507T1 (de)
WO (1) WO2003092586A2 (de)
ZA (1) ZA200407940B (de)

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BRPI0316732B8 (pt) 2002-11-27 2021-05-25 Incyte Corp composto derivado de 3-aminopirrolidina e sua composição farmacêutica
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AU2004232939A1 (en) * 2003-04-17 2004-11-04 Merck Sharp & Dohme Corp. Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity
US20060205761A1 (en) * 2003-06-06 2006-09-14 Catherine Abbadie Ccr-2 antagonists for treatment of neuropathic pain
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EP1682135B1 (de) * 2003-10-27 2011-07-27 Merck Sharp & Dohme Corp. Salz eines Tetrahydropyranylcyclopentyltetrahydropyridopyridin-Derivats als CCR-2 Antagonisten
JP4740151B2 (ja) 2003-12-18 2011-08-03 インサイト コーポレイション ケモカイン受容体のモジュレーターとしての３‐シクロアルキルアミノピロリジン誘導体
WO2005067502A2 (en) * 2004-01-02 2005-07-28 Merck & Co., Inc. Alkylamino, arylamino, and sulfonamido cyclopentyl amide modulators of chemokine receptor activity
CN1913778A (zh) * 2004-01-28 2007-02-14 默克公司 趋化因子受体活性的氨基环戊基吡啶并吡嗪酮调节剂
WO2005120505A2 (en) * 2004-04-26 2005-12-22 Merck & Co., Inc Tetrahydropyranyl cyclopentyl tetrahy-dropyridopyridine modulators of chemokine receptor activity
JP2007534758A (ja) * 2004-04-26 2007-11-29 メルク　エンド　カムパニー　インコーポレーテッド ケモカイン受容体活性調節物質であるテトラヒドロピラニルシクロペンチル１−置換及び１，１−二置換テトラヒドロイソキノリン
EP1755603A4 (de) * 2004-04-28 2009-03-11 Merck & Co Inc 3,3-disubstituierte tetrahydropyranyl cyclopentyl amide modulatoren der chemokin-rezeptor-aktivität
EP1746997A4 (de) * 2004-05-11 2010-12-29 Incyte Corp 3-(4-heteroarylcyclohexylamin) cyclopentancarboxamid als modulatoren von chemokinrezeptoren
WO2006004684A2 (en) 2004-06-28 2006-01-12 Incyte Corporation 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
GEP20094844B (en) 2004-06-28 2009-11-25 Incyte Corp 3-aminocyclopentane carboxamides as modulators of chemokine receptors
US20070238723A1 (en) * 2004-10-15 2007-10-11 Goble Stephen D Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors
WO2006074265A2 (en) * 2005-01-06 2006-07-13 Merck & Co., Inc. Drug combination therapy and pharmaceutical compositions for treating inflammatory disorders
US20080138866A1 (en) * 2005-03-11 2008-06-12 Moore Jeffrey C Process for the Preparation of (R)-4,4-Dialkoxy-Pyran-3-Ols Such as (R)-4,4-Dimethoxy-Pyran-3-Ol
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
WO2007053499A2 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
PT2370442E (pt) * 2008-11-26 2013-06-27 Pfizer 3-aminociclopentanocarboxamidas como moduladores de receptor de quimiocina
EA020548B1 (ru) 2008-12-19 2014-12-30 Бёрингер Ингельхайм Интернациональ Гмбх Циклические пиримидин-4-карбоксамиды в качестве антагонистов рецептора ccr2, предназначенные для лечения воспаления, астмы и хозл
ME01908B (me) 2009-12-17 2014-12-20 Boehringer Ingelheim Int Novi antagonisti ccr2 receptora i njihova primjena
EP2516445B1 (de) 2009-12-22 2015-03-11 Cephalon, Inc. Tricyclische derivate, ihre pharmazeutische verwendung und zusammensetzungen
WO2011100227A1 (en) * 2010-02-09 2011-08-18 Bristol-Myers Squibb Company Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity
WO2011147772A1 (en) * 2010-05-25 2011-12-01 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists
EP2685978A2 (de) * 2011-03-17 2014-01-22 Merck Sharp & Dohme Corp. Cyclohexan-substituierte amino-cyclopentan-derivate als nützliche ccr2-antagonisten
US8822460B2 (en) * 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
TW201442706A (zh) 2013-02-28 2014-11-16 參天製藥股份有限公司 含有四氫吡喃基胺基環戊基羰基四氫吡啶并吡啶衍生物作爲有效成分之後眼部疾病之預防或治療劑
PT3297438T (pt) 2015-05-21 2022-01-25 Chemocentryx Inc Moduladores de ccr2
AU2016287584B2 (en) 2015-07-02 2020-03-26 Centrexion Therapeutics Corporation (4-((3R,4R)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate
EP3570893A1 (de) 2017-01-17 2019-11-27 GlaxoSmithKline Intellectual Property Development Ltd Nicht-peptidische heterobivalente moleküle zur behandlung von entzündlichen erkrankungen
IL273188B2 (en) 2017-09-25 2023-03-01 Chemocentryx Inc Treatment with a combination of chemokine receptor 2 (ccr2) inhibitors and a pd-1/pd-l1 inhibitor
MA50423A (fr) 2018-01-08 2020-08-26 Chemocentryx Inc Procédés de traitement de tumeurs solides au moyen d'antagonistes du ccr2
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
CN119925562B (zh) * 2023-11-03 2025-11-28 中国科学院上海药物研究所 趋化因子受体2拮抗剂在制备治疗糖尿病并发焦虑症的应用

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US3772308A (en) * 1972-06-02 1973-11-13 Lilly Co Eli Cyclopentanecetamides and cyclopentaneacetonitriles
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WO2000076512A1 (en) * 1999-06-11 2000-12-21 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
DE60122753T2 (de) * 2000-08-17 2007-08-16 Merck & Co., Inc. Cyclopentylmodulatoren der chemokin-rezeptor-aktivität
WO2002070523A1 (en) 2001-03-07 2002-09-12 Pfizer Products Inc. Modulators of chemokine receptor activity
MY129850A (en) * 2002-04-29 2007-05-31 Merck Sharp & Dohme Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity

Also Published As

Publication number Publication date
AU2003231114B8 (en) 2008-08-14
CA2483752A1 (en) 2003-11-13
JP2005523929A (ja) 2005-08-11
US6812234B2 (en) 2004-11-02
CY1110399T1 (el) 2014-04-09
DE60321333D1 (de) 2008-07-10
US20040167156A1 (en) 2004-08-26
EP1501507B1 (de) 2008-05-28
AU2003231114A1 (en) 2003-11-17
WO2003092586A2 (en) 2003-11-13
DK1501507T3 (da) 2008-09-29
ES2306867T3 (es) 2008-11-16
JP3780291B2 (ja) 2006-05-31
ZA200407940B (en) 2006-06-28
NZ536477A (en) 2005-05-27
CA2483752C (en) 2011-03-29
EP1501507A2 (de) 2005-02-02
AU2003231114B2 (en) 2008-07-24
WO2003092586A3 (en) 2004-09-16
EP1501507A4 (de) 2006-05-17
PT1501507E (pt) 2008-08-12
SI1501507T1 (sl) 2008-12-31

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