ATE396993T1 - Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität - Google Patents
Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivitätInfo
- Publication number
- ATE396993T1 ATE396993T1 AT03724241T AT03724241T ATE396993T1 AT E396993 T1 ATE396993 T1 AT E396993T1 AT 03724241 T AT03724241 T AT 03724241T AT 03724241 T AT03724241 T AT 03724241T AT E396993 T1 ATE396993 T1 AT E396993T1
- Authority
- AT
- Austria
- Prior art keywords
- chemokine receptor
- tetrahydropyranyl
- cyclopentyl
- receptor activity
- modulators
- Prior art date
Links
- 102000009410 Chemokine receptor Human genes 0.000 title abstract 2
- 108050000299 Chemokine receptor Proteins 0.000 title abstract 2
- WBUHGSNIYBJEDA-UHFFFAOYSA-N 1-cyclopentyl-2-(oxan-2-yl)-3,4-dihydro-2h-1,5-naphthyridine Chemical compound C1CCCC1N1C2=CC=CN=C2CCC1C1OCCCC1 WBUHGSNIYBJEDA-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 abstract 1
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37618002P | 2002-04-29 | 2002-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE396993T1 true ATE396993T1 (de) | 2008-06-15 |
Family
ID=29401316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03724241T ATE396993T1 (de) | 2002-04-29 | 2003-04-25 | Tetrahydropyranyl-cyclopentyl- tetrahydropyridopyridin-modulatoren der chemokin- rezeptor-aktivität |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6812234B2 (de) |
| EP (1) | EP1501507B1 (de) |
| JP (1) | JP3780291B2 (de) |
| AT (1) | ATE396993T1 (de) |
| AU (1) | AU2003231114B8 (de) |
| CA (1) | CA2483752C (de) |
| CY (1) | CY1110399T1 (de) |
| DE (1) | DE60321333D1 (de) |
| DK (1) | DK1501507T3 (de) |
| ES (1) | ES2306867T3 (de) |
| NZ (1) | NZ536477A (de) |
| PT (1) | PT1501507E (de) |
| SI (1) | SI1501507T1 (de) |
| WO (1) | WO2003092586A2 (de) |
| ZA (1) | ZA200407940B (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060030582A1 (en) * | 2002-04-29 | 2006-02-09 | Demartino Julie | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| JO2479B1 (en) | 2002-04-29 | 2009-01-20 | ميرك شارب اند دوم ليمتد | Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine |
| GEP20115290B (en) | 2002-11-27 | 2011-09-26 | Incyte Corp | 3-aminopyrrolidine derivatives as modulators of chemokine receptors |
| WO2004082616A2 (en) * | 2003-03-18 | 2004-09-30 | Merck & Co. Inc. | Tetrahydropyranyl cyclopentyl heterocylic amide modulators of chemokine receptor activity |
| CA2521950C (en) * | 2003-04-15 | 2009-11-17 | Merck & Co., Inc. | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors |
| AU2004232939A1 (en) * | 2003-04-17 | 2004-11-04 | Merck Sharp & Dohme Corp. | Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity |
| US20060205761A1 (en) * | 2003-06-06 | 2006-09-14 | Catherine Abbadie | Ccr-2 antagonists for treatment of neuropathic pain |
| UA81365C2 (en) * | 2003-10-27 | 2007-12-25 | Merck & Co Inc | Ccr-2 antagonist salt, method for modulation of chemokine receptor activity, method for treating (variants) and pharmaceutical composition |
| AR045875A1 (es) | 2003-10-27 | 2005-11-16 | Merck & Co Inc | Procedimiento para la preparacion del antagonista ccr-2 |
| JP4740151B2 (ja) | 2003-12-18 | 2011-08-03 | インサイト コーポレイション | ケモカイン受容体のモジュレーターとしての3‐シクロアルキルアミノピロリジン誘導体 |
| US20070117797A1 (en) * | 2004-01-02 | 2007-05-24 | Goble Stephen D | Alkylamino, arylamino, and sulfonamido cyclopentyl amide modulators of chemokine receptor activity |
| EP1718152A4 (de) * | 2004-01-28 | 2009-09-16 | Merck & Co Inc | Aminocyclopentylpyridopyrazinon-modulatoren der chemokinrezeptoraktivität |
| WO2005110409A2 (en) * | 2004-04-26 | 2005-11-24 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl 1-substituted and 1,1-disubstituted tetrahydroisoquinoline modulators of chemokine receptor activity |
| JP2007534756A (ja) * | 2004-04-26 | 2007-11-29 | メルク エンド カムパニー インコーポレーテッド | ケモカイン受容体活性のテトラヒドロピラニルシクロペンチルテトラヒドロピリドピリジンモジュレーター |
| US7566726B2 (en) | 2004-04-28 | 2009-07-28 | Merck & Co. Inc. | 3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity |
| CN1950085A (zh) * | 2004-05-11 | 2007-04-18 | 因赛特公司 | 作为趋化因子受体调节剂的3-(4-杂芳基环己基氨基)环戊烷羧酰胺 |
| WO2006004741A2 (en) | 2004-06-28 | 2006-01-12 | Incyte Corporation | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors |
| TW200608966A (en) | 2004-06-28 | 2006-03-16 | Incyte Corp | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors |
| US20070238723A1 (en) * | 2004-10-15 | 2007-10-11 | Goble Stephen D | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors |
| US20080194548A1 (en) * | 2005-01-06 | 2008-08-14 | Forrest Michael J | Drug Combination Therapy and Pharmaceutical Compositions for Treating Inflammatory Disorders |
| US20080138866A1 (en) * | 2005-03-11 | 2008-06-12 | Moore Jeffrey C | Process for the Preparation of (R)-4,4-Dialkoxy-Pyran-3-Ols Such as (R)-4,4-Dimethoxy-Pyran-3-Ol |
| WO2007053499A2 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
| US8067457B2 (en) | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
| US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
| AP3113A (en) * | 2008-11-26 | 2015-01-31 | Pfizer | 3-Aminocyclopentanecarboxamides as chemokine receptor modulators |
| KR101754698B1 (ko) | 2008-12-19 | 2017-07-26 | 센트렉시온 테라퓨틱스 코포레이션 | 염증, 천식 및 copd 치료용 ccr2 수용체 길항제로서의 사이클릭 피리미딘-4-카복스아미드 |
| HRP20141143T1 (hr) | 2009-12-17 | 2015-01-02 | Boehringer Ingelheim International Gmbh | Novi antagonisti receptora ccr2 i njihove uporabe |
| ES2539382T3 (es) | 2009-12-22 | 2015-06-30 | Cephalon, Inc. | Derivados tricíclicos y su uso farmacéutico y composiciones |
| WO2011100227A1 (en) * | 2010-02-09 | 2011-08-18 | Bristol-Myers Squibb Company | Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity |
| EP2576542B1 (de) * | 2010-05-25 | 2015-04-22 | Boehringer Ingelheim International GmbH | Zur Behandlung von Atemwegs-, Schmerz,- Immun- und cardoivaskulären Erkrankungen geeignete cyclische Amidderivate von Pyridazin-3-carbonsäuren |
| US20130345254A1 (en) * | 2011-03-17 | 2013-12-26 | Anilkumar G. Nair | Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists |
| US8822460B2 (en) * | 2012-04-06 | 2014-09-02 | Janssen Pharmaceutica Nv | Fused cyclopentyl antagonists of CCR2 |
| US9579309B2 (en) | 2013-02-28 | 2017-02-28 | Santen Pharmaceutical Co., Ltd. | Prophylactic or therapeutic agent for posterior ocular disease containing tetrahydropyranylaminocyclopentylcarbonyltetrahydropyridopyridine derivative as effective ingredient |
| SI3297438T1 (sl) | 2015-05-21 | 2022-03-31 | Chemocentryx, Inc. | CCR2 modulatorji |
| BR112017028492B1 (pt) | 2015-07-02 | 2023-12-26 | Centrexion Therapeutics Corporation | Citrato de (4-((3r,4r)-3-metoxitetra-hidro-piran-4- ilamino)piperidin-1-il) (5- metil-6-(((2r, 6s)-6-(p-tolil) tetra-hidro-2h-piran-2-il)metilamino)pirimidin-4-il) metanona, seu uso e seu método de preparação, e composição farmacêutica |
| EP3570893A1 (de) | 2017-01-17 | 2019-11-27 | GlaxoSmithKline Intellectual Property Development Ltd | Nicht-peptidische heterobivalente moleküle zur behandlung von entzündlichen erkrankungen |
| EP3687525B1 (de) | 2017-09-25 | 2025-10-29 | ChemoCentryx, Inc. | Kombinationstherapie mit einem chemokinrezeptor-2 (ccr2)-antagonist und einem pd-1/pd-l1-inhibitor |
| ES2991280T3 (es) | 2018-01-08 | 2024-12-03 | Chemocentryx Inc | Antagonistas de CCR2 para el tratamiento del linfoma cutáneo de linfocitos T |
| US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
| CN119925562B (zh) * | 2023-11-03 | 2025-11-28 | 中国科学院上海药物研究所 | 趋化因子受体2拮抗剂在制备治疗糖尿病并发焦虑症的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2002A (en) * | 1841-03-12 | Tor and planter for plowing | ||
| US3647804A (en) | 1970-02-27 | 1972-03-07 | Upjohn Co | Cycloalkanecarboxamides |
| US3772308A (en) | 1972-06-02 | 1973-11-13 | Lilly Co Eli | Cyclopentanecetamides and cyclopentaneacetonitriles |
| CA2143143A1 (en) * | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | 3-phenylpyrrolidine derivatives |
| JPH09291034A (ja) * | 1996-02-27 | 1997-11-11 | Yoshitomi Pharmaceut Ind Ltd | 縮合ピリジン化合物およびその医薬としての用途 |
| GB9812037D0 (en) | 1998-06-04 | 1998-07-29 | Pfizer Ltd | Piperidones |
| US6312689B1 (en) | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
| AU5473400A (en) * | 1999-06-11 | 2001-01-02 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| CA2419194C (en) * | 2000-08-17 | 2007-10-16 | Lihu Yang | Cyclopentyl modulators of chemokine receptor activity |
| MXPA03008109A (es) | 2001-03-07 | 2003-12-12 | Pfizer Prod Inc | Moduladores de la actividad de receptores de quimiocinas. |
| JO2479B1 (en) * | 2002-04-29 | 2009-01-20 | ميرك شارب اند دوم ليمتد | Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine |
-
2003
- 2003-04-25 NZ NZ536477A patent/NZ536477A/en not_active IP Right Cessation
- 2003-04-25 EP EP03724241A patent/EP1501507B1/de not_active Expired - Lifetime
- 2003-04-25 DE DE60321333T patent/DE60321333D1/de not_active Expired - Lifetime
- 2003-04-25 WO PCT/US2003/012929 patent/WO2003092586A2/en not_active Ceased
- 2003-04-25 SI SI200331285T patent/SI1501507T1/sl unknown
- 2003-04-25 CA CA2483752A patent/CA2483752C/en not_active Expired - Lifetime
- 2003-04-25 ES ES03724241T patent/ES2306867T3/es not_active Expired - Lifetime
- 2003-04-25 JP JP2004500771A patent/JP3780291B2/ja not_active Expired - Fee Related
- 2003-04-25 AT AT03724241T patent/ATE396993T1/de active
- 2003-04-25 AU AU2003231114A patent/AU2003231114B8/en not_active Ceased
- 2003-04-25 DK DK03724241T patent/DK1501507T3/da active
- 2003-04-25 PT PT03724241T patent/PT1501507E/pt unknown
- 2003-04-29 US US10/425,167 patent/US6812234B2/en not_active Expired - Lifetime
-
2004
- 2004-10-01 ZA ZA200407940A patent/ZA200407940B/en unknown
-
2008
- 2008-08-26 CY CY20081100915T patent/CY1110399T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2306867T3 (es) | 2008-11-16 |
| ZA200407940B (en) | 2006-06-28 |
| CY1110399T1 (el) | 2014-04-09 |
| EP1501507A2 (de) | 2005-02-02 |
| EP1501507B1 (de) | 2008-05-28 |
| AU2003231114B8 (en) | 2008-08-14 |
| EP1501507A4 (de) | 2006-05-17 |
| CA2483752C (en) | 2011-03-29 |
| DK1501507T3 (da) | 2008-09-29 |
| US20040167156A1 (en) | 2004-08-26 |
| CA2483752A1 (en) | 2003-11-13 |
| PT1501507E (pt) | 2008-08-12 |
| DE60321333D1 (de) | 2008-07-10 |
| NZ536477A (en) | 2005-05-27 |
| AU2003231114A1 (en) | 2003-11-17 |
| AU2003231114B2 (en) | 2008-07-24 |
| SI1501507T1 (sl) | 2008-12-31 |
| US6812234B2 (en) | 2004-11-02 |
| WO2003092586A2 (en) | 2003-11-13 |
| JP2005523929A (ja) | 2005-08-11 |
| WO2003092586A3 (en) | 2004-09-16 |
| JP3780291B2 (ja) | 2006-05-31 |
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Legal Events
| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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