DE60321333D1 - Tetrahydropyranyl-cyclopentyl-tetrahydropyridopyridin-modulatoren der chemokin-rezeptor-aktivität - Google Patents
Tetrahydropyranyl-cyclopentyl-tetrahydropyridopyridin-modulatoren der chemokin-rezeptor-aktivitätInfo
- Publication number
- DE60321333D1 DE60321333D1 DE60321333T DE60321333T DE60321333D1 DE 60321333 D1 DE60321333 D1 DE 60321333D1 DE 60321333 T DE60321333 T DE 60321333T DE 60321333 T DE60321333 T DE 60321333T DE 60321333 D1 DE60321333 D1 DE 60321333D1
- Authority
- DE
- Germany
- Prior art keywords
- receptor activity
- modulators
- chemokin receptor
- tetrahydropyranyl cyclopentyl
- tetrahydropyranyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- WBUHGSNIYBJEDA-UHFFFAOYSA-N 1-cyclopentyl-2-(oxan-2-yl)-3,4-dihydro-2h-1,5-naphthyridine Chemical compound C1CCCC1N1C2=CC=CN=C2CCC1C1OCCCC1 WBUHGSNIYBJEDA-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 abstract 1
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 abstract 1
- 102000009410 Chemokine receptor Human genes 0.000 abstract 1
- 108050000299 Chemokine receptor Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37618002P | 2002-04-29 | 2002-04-29 | |
PCT/US2003/012929 WO2003092586A2 (en) | 2002-04-29 | 2003-04-25 | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60321333D1 true DE60321333D1 (de) | 2008-07-10 |
Family
ID=29401316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60321333T Expired - Lifetime DE60321333D1 (de) | 2002-04-29 | 2003-04-25 | Tetrahydropyranyl-cyclopentyl-tetrahydropyridopyridin-modulatoren der chemokin-rezeptor-aktivität |
Country Status (15)
Country | Link |
---|---|
US (1) | US6812234B2 (de) |
EP (1) | EP1501507B1 (de) |
JP (1) | JP3780291B2 (de) |
AT (1) | ATE396993T1 (de) |
AU (1) | AU2003231114B8 (de) |
CA (1) | CA2483752C (de) |
CY (1) | CY1110399T1 (de) |
DE (1) | DE60321333D1 (de) |
DK (1) | DK1501507T3 (de) |
ES (1) | ES2306867T3 (de) |
NZ (1) | NZ536477A (de) |
PT (1) | PT1501507E (de) |
SI (1) | SI1501507T1 (de) |
WO (1) | WO2003092586A2 (de) |
ZA (1) | ZA200407940B (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060030582A1 (en) * | 2002-04-29 | 2006-02-09 | Demartino Julie | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
MY129850A (en) | 2002-04-29 | 2007-05-31 | Merck Sharp & Dohme | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
JP4828829B2 (ja) | 2002-11-27 | 2011-11-30 | インサイト・コーポレイション | ケモカイン受容体のモジュレーターとしての3−アミノピロリジン誘導体 |
CA2519297A1 (en) * | 2003-03-18 | 2004-09-30 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity |
RU2301802C2 (ru) * | 2003-04-15 | 2007-06-27 | Мерк Энд Ко., Инк. | Бензоксазинил-амидоциклопентил-гетероциклические модуляторы хемокиновых рецепторов |
EP1622916A4 (de) * | 2003-04-17 | 2008-11-05 | Merck & Co Inc | Heterocyclische cyclopentyltetrahydroisochinolin- und -tetrahydropyridopyridinmodulatoren der chemokinrezeptoraktivität |
WO2004110376A2 (en) * | 2003-06-06 | 2004-12-23 | Merck & Co., Inc. | Ccr-2 antagonists for treatment of neuropathic pain |
AR045875A1 (es) * | 2003-10-27 | 2005-11-16 | Merck & Co Inc | Procedimiento para la preparacion del antagonista ccr-2 |
ATE517622T1 (de) * | 2003-10-27 | 2011-08-15 | Merck Sharp & Dohme | Salz eines tetrahydropyranylcyclopentyltetrahydropyridopyr diderivats als ccr-2 antagonisten |
CN102344398B (zh) | 2003-12-18 | 2015-02-25 | 因赛特公司 | 作为趋化因子受体调控剂的3-环烷基氨基吡咯烷衍生物 |
US20070117797A1 (en) * | 2004-01-02 | 2007-05-24 | Goble Stephen D | Alkylamino, arylamino, and sulfonamido cyclopentyl amide modulators of chemokine receptor activity |
AU2005208887B2 (en) * | 2004-01-28 | 2010-02-25 | Merck Sharp & Dohme Corp. | Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity |
CN1946696A (zh) * | 2004-04-26 | 2007-04-11 | 默克公司 | 四氢吡喃基环戊基1-取代的和1,1-二取代的四氢异喹啉趋化因子受体活性调节剂 |
AU2005251678A1 (en) | 2004-04-26 | 2005-12-22 | Merck Sharp & Dohme Corp. | Tetrahydropyranyl cyclopentyl tetrahy-dropyridopyridine modulators of chemokine receptor activity |
AU2005237500A1 (en) * | 2004-04-28 | 2005-11-10 | Merck Sharp & Dohme Corp. | 3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity |
WO2005115392A2 (en) * | 2004-05-11 | 2005-12-08 | Incyte Corporation | 3-(4-heteroarylcyclohexylamino) cyclopentanecarboxamides as modulators of chemokine receptors |
KR100856155B1 (ko) | 2004-06-28 | 2008-09-03 | 인사이트 코포레이션 | 케모카인 수용체의 조절자로서의3-아미노사이클로펜탄카복스아마이드 |
JP4116670B2 (ja) | 2004-06-28 | 2008-07-09 | インサイト コーポレイション | ケモカイン受容体の調節剤としての3−アミノシクロペンタンカルボキサミド |
US20070238723A1 (en) * | 2004-10-15 | 2007-10-11 | Goble Stephen D | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors |
JP2008526861A (ja) * | 2005-01-06 | 2008-07-24 | メルク エンド カムパニー インコーポレーテッド | 炎症性障害を治療するための薬剤併用療法および医薬組成物 |
AU2006223459A1 (en) * | 2005-03-11 | 2006-09-21 | Merck & Co., Inc. | Process for the preparation of (R)-4,4-dialkoxy-pyran-3-ols such as (R)-4,4-dimethoxy-pyran-3-ol |
WO2007053498A1 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
US8067415B2 (en) | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
PE20110831A1 (es) * | 2008-11-26 | 2011-11-20 | Pfizer | 3-aminociclopentanocarboxamidas como moduladores del receptor de quimiocina |
EA020548B1 (ru) | 2008-12-19 | 2014-12-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Циклические пиримидин-4-карбоксамиды в качестве антагонистов рецептора ccr2, предназначенные для лечения воспаления, астмы и хозл |
ES2524829T3 (es) | 2009-12-17 | 2014-12-12 | Boehringer Ingelheim International Gmbh | Nuevos antagonistas del receptor CCR2 y usos de los mismos |
MX2012007253A (es) | 2009-12-22 | 2012-07-17 | Cephalon Inc | Derivados triciclicos y sus usos y composiciones farmaceuticas. |
EP2534158B1 (de) | 2010-02-09 | 2014-01-08 | Bristol-Myers Squibb Company | Benzylpyrrolidinonderivate als modulatoren der chemokin-rezeptoraktivität |
US9018212B2 (en) * | 2010-05-25 | 2015-04-28 | Boehringer Ingelheim International Gmbh | Pyridazine carboxamides as CCR2 receptor antagonists |
WO2012125663A2 (en) * | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists |
US8822460B2 (en) * | 2012-04-06 | 2014-09-02 | Janssen Pharmaceutica Nv | Fused cyclopentyl antagonists of CCR2 |
WO2014133072A1 (ja) | 2013-02-28 | 2014-09-04 | 参天製薬株式会社 | テトラヒドロピラニルアミノシクロペンチルカルボニルテトラヒドロピリドピリジン誘導体を有効成分として含有する後眼部疾患の予防または治療剤 |
EP3297438B1 (de) * | 2015-05-21 | 2021-10-20 | ChemoCentryx, Inc. | Ccr2-modulatoren |
JP6917910B2 (ja) | 2015-07-02 | 2021-08-11 | セントレクシオン セラピューティクス コーポレイション | (4−((3r,4r)−3−メトキシテトラヒドロ−ピラン−4−イルアミノ)ピペリジン−1−イル)(5−メチル−6−(((2r,6s)−6−(p−トリル)テトラヒドロ−2h−ピラン−2−イル)メチルアミノ)ピリミジン−4イル)メタノンクエン酸塩 |
EP3570893A1 (de) | 2017-01-17 | 2019-11-27 | GlaxoSmithKline Intellectual Property Development Ltd | Nicht-peptidische heterobivalente moleküle zur behandlung von entzündlichen erkrankungen |
US11304952B2 (en) | 2017-09-25 | 2022-04-19 | Chemocentryx, Inc. | Combination therapy using a chemokine receptor 2 (CCR2) antagonist and a PD-1/PD-L1 inhibitor |
MA50423A (fr) | 2018-01-08 | 2020-08-26 | Chemocentryx Inc | Procédés de traitement de tumeurs solides au moyen d'antagonistes du ccr2 |
US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2002A (en) * | 1841-03-12 | Tor and planter for plowing | ||
US3647804A (en) * | 1970-02-27 | 1972-03-07 | Upjohn Co | Cycloalkanecarboxamides |
US3772308A (en) * | 1972-06-02 | 1973-11-13 | Lilly Co Eli | Cyclopentanecetamides and cyclopentaneacetonitriles |
CA2143143A1 (en) * | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | 3-phenylpyrrolidine derivatives |
JPH09291034A (ja) * | 1996-02-27 | 1997-11-11 | Yoshitomi Pharmaceut Ind Ltd | 縮合ピリジン化合物およびその医薬としての用途 |
GB9812037D0 (en) | 1998-06-04 | 1998-07-29 | Pfizer Ltd | Piperidones |
US6312689B1 (en) | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
US6500844B1 (en) * | 1999-06-11 | 2002-12-31 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
JP2004506013A (ja) * | 2000-08-17 | 2004-02-26 | メルク エンド カムパニー インコーポレーテッド | シクロペンチル系ケモカイン受容体活性調節剤 |
EP1368354A1 (de) | 2001-03-07 | 2003-12-10 | Pfizer Products Inc. | Modulatoren der aktivität von chemokin-rezeptoren |
MY129850A (en) * | 2002-04-29 | 2007-05-31 | Merck Sharp & Dohme | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
-
2003
- 2003-04-25 WO PCT/US2003/012929 patent/WO2003092586A2/en active IP Right Grant
- 2003-04-25 DE DE60321333T patent/DE60321333D1/de not_active Expired - Lifetime
- 2003-04-25 EP EP03724241A patent/EP1501507B1/de not_active Expired - Lifetime
- 2003-04-25 DK DK03724241T patent/DK1501507T3/da active
- 2003-04-25 SI SI200331285T patent/SI1501507T1/sl unknown
- 2003-04-25 CA CA2483752A patent/CA2483752C/en not_active Expired - Lifetime
- 2003-04-25 AT AT03724241T patent/ATE396993T1/de active
- 2003-04-25 PT PT03724241T patent/PT1501507E/pt unknown
- 2003-04-25 NZ NZ536477A patent/NZ536477A/en not_active IP Right Cessation
- 2003-04-25 JP JP2004500771A patent/JP3780291B2/ja not_active Expired - Fee Related
- 2003-04-25 AU AU2003231114A patent/AU2003231114B8/en not_active Ceased
- 2003-04-25 ES ES03724241T patent/ES2306867T3/es not_active Expired - Lifetime
- 2003-04-29 US US10/425,167 patent/US6812234B2/en not_active Expired - Lifetime
-
2004
- 2004-10-01 ZA ZA200407940A patent/ZA200407940B/en unknown
-
2008
- 2008-08-26 CY CY20081100915T patent/CY1110399T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU2003231114A1 (en) | 2003-11-17 |
EP1501507A2 (de) | 2005-02-02 |
WO2003092586A2 (en) | 2003-11-13 |
EP1501507B1 (de) | 2008-05-28 |
US6812234B2 (en) | 2004-11-02 |
JP3780291B2 (ja) | 2006-05-31 |
AU2003231114B2 (en) | 2008-07-24 |
CA2483752C (en) | 2011-03-29 |
PT1501507E (pt) | 2008-08-12 |
WO2003092586A3 (en) | 2004-09-16 |
EP1501507A4 (de) | 2006-05-17 |
NZ536477A (en) | 2005-05-27 |
AU2003231114B8 (en) | 2008-08-14 |
CA2483752A1 (en) | 2003-11-13 |
ATE396993T1 (de) | 2008-06-15 |
ES2306867T3 (es) | 2008-11-16 |
CY1110399T1 (el) | 2014-04-09 |
ZA200407940B (en) | 2006-06-28 |
DK1501507T3 (da) | 2008-09-29 |
SI1501507T1 (sl) | 2008-12-31 |
US20040167156A1 (en) | 2004-08-26 |
JP2005523929A (ja) | 2005-08-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: MERCK SHARP & DOHME CORP., RAHWAY, N.J., US Owner name: MERCK SHARP & DOHME LTD., HODDESDON, HERTFORDS, GB |