EP1622916A4 - Heterocyclische cyclopentyltetrahydroisochinolin- und -tetrahydropyridopyridinmodulatoren der chemokinrezeptoraktivität - Google Patents
Heterocyclische cyclopentyltetrahydroisochinolin- und -tetrahydropyridopyridinmodulatoren der chemokinrezeptoraktivitätInfo
- Publication number
- EP1622916A4 EP1622916A4 EP04750112A EP04750112A EP1622916A4 EP 1622916 A4 EP1622916 A4 EP 1622916A4 EP 04750112 A EP04750112 A EP 04750112A EP 04750112 A EP04750112 A EP 04750112A EP 1622916 A4 EP1622916 A4 EP 1622916A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- tetrahydroisoquinoline
- chemokine receptor
- receptor activity
- tetrahydropyridopyridine
- modulators
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- OALXTMWCXNPUKJ-UHFFFAOYSA-N 1,2,3,4-tetrahydro-1,5-naphthyridine Chemical compound C1=CN=C2CCCNC2=C1 OALXTMWCXNPUKJ-UHFFFAOYSA-N 0.000 title 1
- GARMUJFIZOPCTN-UHFFFAOYSA-N 1-cyclopentyl-1,2,3,4-tetrahydroisoquinoline Chemical compound C1CCCC1C1C2=CC=CC=C2CCN1 GARMUJFIZOPCTN-UHFFFAOYSA-N 0.000 title 1
- 102000009410 Chemokine receptor Human genes 0.000 title 1
- 108050000299 Chemokine receptor Proteins 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Biotechnology (AREA)
- Otolaryngology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Transplantation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46367303P | 2003-04-17 | 2003-04-17 | |
PCT/US2004/011463 WO2004094371A2 (en) | 2003-04-17 | 2004-04-14 | Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1622916A2 EP1622916A2 (de) | 2006-02-08 |
EP1622916A4 true EP1622916A4 (de) | 2008-11-05 |
Family
ID=33310806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04750112A Withdrawn EP1622916A4 (de) | 2003-04-17 | 2004-04-14 | Heterocyclische cyclopentyltetrahydroisochinolin- und -tetrahydropyridopyridinmodulatoren der chemokinrezeptoraktivität |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1622916A4 (de) |
JP (1) | JP2006523704A (de) |
CN (1) | CN100384856C (de) |
AU (1) | AU2004232939A1 (de) |
CA (1) | CA2521625A1 (de) |
WO (1) | WO2004094371A2 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006523704A (ja) * | 2003-04-17 | 2006-10-19 | メルク エンド カムパニー インコーポレーテッド | ケモカイン受容体活性ヘテロサイクリックシクロペンチルテトラヒドロイソキノリンおよびテトラヒドロピリドピリジンのモジュレーター |
US7598243B2 (en) | 2003-04-17 | 2009-10-06 | Merck & Co., Inc. | Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity |
TWI350168B (en) | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
WO2007053498A1 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
US8067415B2 (en) | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
EP2010506B1 (de) * | 2006-04-20 | 2010-08-04 | F. Hoffmann-La Roche AG | Diazepanderivate als modulatoren von chemokinrezeptoren |
JP5497429B2 (ja) | 2007-03-07 | 2014-05-21 | 武田薬品工業株式会社 | ベンゾオキサゼピン誘導体およびその用途 |
EA025824B1 (ru) | 2009-07-27 | 2017-02-28 | Джилид Сайэнс, Инк. | Конденсированные гетероциклические соединения в качестве модуляторов ионных каналов |
AR080375A1 (es) | 2010-03-05 | 2012-04-04 | Sanofi Aventis | Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida |
CA2802288C (en) | 2010-07-02 | 2018-08-21 | Gilead Sciences, Inc. | Triazolopyridinone compounds as ion channel modulators |
CA2834164A1 (en) | 2011-05-10 | 2012-11-15 | Gilead Sciences, Inc. | Fused benzoxazinones as ion channel modulators |
NO3175985T3 (de) | 2011-07-01 | 2018-04-28 | ||
TWI549944B (zh) | 2011-07-01 | 2016-09-21 | 吉李德科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
MX2017014375A (es) | 2015-05-21 | 2018-06-20 | Chemocentryx Inc | Moduladores del ccr2. |
CA3031537A1 (en) | 2016-08-01 | 2018-02-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
PE20190501A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores nmda espiro-lactam y metodos de uso de los mismos |
EP3490974B1 (de) | 2016-08-01 | 2023-12-06 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spirolactam-nmda-modulatoren und verfahren zu deren verwendung |
EP3687525A4 (de) | 2017-09-25 | 2021-10-13 | ChemoCentryx, Inc. | Kombinationstherapie mit einem chemokinrezeptor-2 (ccr2)-antagonist und einem pd-1/pd-l1-inhibitor |
CA3087765A1 (en) | 2018-01-08 | 2019-07-11 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
PE20210455A1 (es) * | 2018-01-31 | 2021-03-08 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos |
CN111056955B (zh) * | 2019-12-16 | 2021-05-25 | 中国科学院大连化学物理研究所 | 一种环己烯制备己二胺的方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002013824A1 (en) * | 2000-08-17 | 2002-02-21 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
WO2003093231A2 (en) * | 2002-04-29 | 2003-11-13 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1501507E (pt) * | 2002-04-29 | 2008-08-12 | Merck Sharp & Dohme | Tetrahidropiranil ciclopentil tetrahidropiridopiridinas moduladoras da actividade dos receptores de quimioquinas |
JP2006523704A (ja) * | 2003-04-17 | 2006-10-19 | メルク エンド カムパニー インコーポレーテッド | ケモカイン受容体活性ヘテロサイクリックシクロペンチルテトラヒドロイソキノリンおよびテトラヒドロピリドピリジンのモジュレーター |
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2004
- 2004-04-14 JP JP2006510018A patent/JP2006523704A/ja active Pending
- 2004-04-14 WO PCT/US2004/011463 patent/WO2004094371A2/en active Application Filing
- 2004-04-14 CA CA002521625A patent/CA2521625A1/en not_active Abandoned
- 2004-04-14 EP EP04750112A patent/EP1622916A4/de not_active Withdrawn
- 2004-04-14 CN CNB2004800165371A patent/CN100384856C/zh not_active Expired - Fee Related
- 2004-04-14 AU AU2004232939A patent/AU2004232939A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002013824A1 (en) * | 2000-08-17 | 2002-02-21 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
WO2003093231A2 (en) * | 2002-04-29 | 2003-11-13 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity |
Also Published As
Publication number | Publication date |
---|---|
CA2521625A1 (en) | 2004-11-04 |
CN1805965A (zh) | 2006-07-19 |
AU2004232939A1 (en) | 2004-11-04 |
WO2004094371A2 (en) | 2004-11-04 |
JP2006523704A (ja) | 2006-10-19 |
WO2004094371A3 (en) | 2005-03-24 |
EP1622916A2 (de) | 2006-02-08 |
CN100384856C (zh) | 2008-04-30 |
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