PE20210455A1 - Moduladores del receptor nmda espiro-lactama y usos de los mismos - Google Patents

Moduladores del receptor nmda espiro-lactama y usos de los mismos

Info

Publication number
PE20210455A1
PE20210455A1 PE2020001137A PE2020001137A PE20210455A1 PE 20210455 A1 PE20210455 A1 PE 20210455A1 PE 2020001137 A PE2020001137 A PE 2020001137A PE 2020001137 A PE2020001137 A PE 2020001137A PE 20210455 A1 PE20210455 A1 PE 20210455A1
Authority
PE
Peru
Prior art keywords
lactama
spiro
receiver modulators
nmda
nmda receiver
Prior art date
Application number
PE2020001137A
Other languages
English (en)
Inventor
M Amin Khan
Original Assignee
Aptinyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aptinyx Inc filed Critical Aptinyx Inc
Publication of PE20210455A1 publication Critical patent/PE20210455A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Se describen compuestos que tienen potencia en la modulacion de actividad del receptor NMDA. Tales compuestos se pueden usar en el tratamiento de afecciones tal como depresion y trastornos relacionados asi como otros trastornos
PE2020001137A 2018-01-31 2019-01-31 Moduladores del receptor nmda espiro-lactama y usos de los mismos PE20210455A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862624218P 2018-01-31 2018-01-31
US201862718067P 2018-08-13 2018-08-13
PCT/US2019/016112 WO2019152687A1 (en) 2018-01-31 2019-01-31 Spiro-lactam nmda receptor modulators and uses thereof

Publications (1)

Publication Number Publication Date
PE20210455A1 true PE20210455A1 (es) 2021-03-08

Family

ID=65444348

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2020001137A PE20210455A1 (es) 2018-01-31 2019-01-31 Moduladores del receptor nmda espiro-lactama y usos de los mismos

Country Status (15)

Country Link
US (1) US11578072B2 (es)
EP (1) EP3746447A1 (es)
JP (1) JP7210599B2 (es)
KR (1) KR20200115611A (es)
CN (1) CN112204031A (es)
AU (1) AU2019215058A1 (es)
BR (1) BR112020015710A2 (es)
CA (1) CA3089561A1 (es)
CL (1) CL2020001991A1 (es)
IL (1) IL276332A (es)
MX (1) MX2020008107A (es)
PE (1) PE20210455A1 (es)
PH (1) PH12020551144A1 (es)
SG (1) SG11202007256PA (es)
WO (1) WO2019152687A1 (es)

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MX2020008107A (es) 2018-01-31 2020-09-25 Aptinyx Inc Moduladores del receptor nmda espiro-lactama y usos de los mismos.
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Publication number Publication date
CA3089561A1 (en) 2019-08-08
BR112020015710A2 (pt) 2020-12-08
KR20200115611A (ko) 2020-10-07
US20210040095A1 (en) 2021-02-11
EP3746447A1 (en) 2020-12-09
MX2020008107A (es) 2020-09-25
SG11202007256PA (en) 2020-08-28
AU2019215058A1 (en) 2020-09-17
IL276332A (en) 2020-09-30
CL2020001991A1 (es) 2021-03-26
JP2021512098A (ja) 2021-05-13
PH12020551144A1 (en) 2021-05-31
CN112204031A (zh) 2021-01-08
JP7210599B2 (ja) 2023-01-23
US11578072B2 (en) 2023-02-14
WO2019152687A1 (en) 2019-08-08

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