CO2018004803A2 - Compuestos oxa-diazaspiro que tienen actividad contra el dolor - Google Patents
Compuestos oxa-diazaspiro que tienen actividad contra el dolorInfo
- Publication number
- CO2018004803A2 CO2018004803A2 CONC2018/0004803A CO2018004803A CO2018004803A2 CO 2018004803 A2 CO2018004803 A2 CO 2018004803A2 CO 2018004803 A CO2018004803 A CO 2018004803A CO 2018004803 A2 CO2018004803 A2 CO 2018004803A2
- Authority
- CO
- Colombia
- Prior art keywords
- activity against
- oxa
- compounds
- against pain
- diazaspiro compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se refiere a compuestos oxadiazaespíricos con actividad farmacológica contra el receptor sigma (), a procesos de preparación de tales compuestos, a composiciones farmacéuticas que los comprenden y a su uso en terapia, en particular para el tratamiento del dolor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15382523 | 2015-10-23 | ||
PCT/EP2016/001742 WO2017067664A1 (en) | 2015-10-23 | 2016-10-21 | Oxa-diazaspiro compounds having activity against pain |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2018004803A2 true CO2018004803A2 (es) | 2018-07-19 |
Family
ID=54364221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2018/0004803A CO2018004803A2 (es) | 2015-10-23 | 2018-05-04 | Compuestos oxa-diazaspiro que tienen actividad contra el dolor |
Country Status (30)
Country | Link |
---|---|
US (1) | US10689398B2 (es) |
EP (1) | EP3365346B1 (es) |
JP (1) | JP6884973B2 (es) |
KR (1) | KR20180073638A (es) |
CN (1) | CN108349998B (es) |
AR (1) | AR106448A1 (es) |
AU (1) | AU2016343551A1 (es) |
BR (1) | BR112018007269A2 (es) |
CA (1) | CA2999925A1 (es) |
CO (1) | CO2018004803A2 (es) |
CY (1) | CY1122708T1 (es) |
DK (1) | DK3365346T3 (es) |
ES (1) | ES2775522T3 (es) |
HR (1) | HRP20200309T1 (es) |
HU (1) | HUE047997T2 (es) |
IL (1) | IL258370A (es) |
LT (1) | LT3365346T (es) |
MA (1) | MA43158B1 (es) |
ME (1) | ME03636B (es) |
MX (1) | MX2018004777A (es) |
PH (1) | PH12018500682A1 (es) |
PL (1) | PL3365346T3 (es) |
PT (1) | PT3365346T (es) |
RS (1) | RS59956B1 (es) |
RU (1) | RU2018118399A (es) |
SG (1) | SG11201802988XA (es) |
SI (1) | SI3365346T1 (es) |
TN (1) | TN2018000091A1 (es) |
TW (1) | TW201731853A (es) |
WO (1) | WO2017067664A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201615643A (zh) | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | 具有多重模式抗疼痛活性之1-氧雜-4,9-二氮雜螺十一烷化合物之烷基與芳基衍生物 |
LT3365346T (lt) | 2015-10-23 | 2020-04-10 | Esteve Pharmaceuticals, S.A. | Oksa-diazaspiro junginiai, pasižymintys aktyvumu prieš skausmą |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3481942A (en) | 1968-09-06 | 1969-12-02 | Smithkline Corp | Oxa-diazaspiro(4.5)decane compounds |
US4353900A (en) | 1981-10-19 | 1982-10-12 | Syntex (U.S.A.) Inc. | 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones |
WO1993013101A1 (en) * | 1991-12-27 | 1993-07-08 | Yoshitomi Pharmaceutical Industries, Ltd. | Pyridonecarboxylate compound, pharmaceutical use thereof, and spiro compound |
US6114541A (en) | 1997-03-10 | 2000-09-05 | Hoffmann-La Roche Inc. | Method for the preparation of α-Bromo-Lactam derivatives |
US6911452B2 (en) | 2001-12-28 | 2005-06-28 | Acadia Pharmaceuticals Inc. | Spiroazacyclic compounds as monoamine receptor modulators |
JP4890255B2 (ja) * | 2003-11-07 | 2012-03-07 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 改良された薬物特性を有するキノリノン化合物の薬学的に受容可能な塩 |
EP1634873A1 (en) | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Sigma receptor inhibitors |
DE102005030051A1 (de) | 2005-06-27 | 2006-12-28 | Grünenthal GmbH | Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
ES2407115T3 (es) | 2005-11-18 | 2013-06-11 | Ono Pharmaceutical Co., Ltd. | Compuesto que contiene un grupo básico y uso del mismo |
EP1829869A1 (en) | 2006-03-02 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | 4,5,6,7-Tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands |
WO2007124136A1 (en) | 2006-04-19 | 2007-11-01 | Acadia Pharmaceuticals, Inc. | Use of 4-amino-piperidines for treating sleep disorders |
EP1847542A1 (en) | 2006-04-21 | 2007-10-24 | Laboratorios del Dr. Esteve S.A. | Spiro[benzopyran] or spiro[benzofuran] derivatives which inhibit the sigma receptor |
CA2679530C (en) | 2007-03-01 | 2012-09-25 | Mitsubishi Tanabe Pharma Corporation | Benzimidazole compound and pharmaceutical use thereof |
EP1982714A1 (en) | 2007-04-16 | 2008-10-22 | Laboratorios del Dr. Esteve S.A. | Pyrano-pyrazole-amines |
EP2020414A1 (en) | 2007-06-20 | 2009-02-04 | Laboratorios del Dr. Esteve S.A. | spiro[piperidine-4,4'-thieno[3,2-c]pyran] derivatives and related compounds as inhibitors of the sigma receptor for the treatment of psychosis |
US20110190280A1 (en) | 2007-08-29 | 2011-08-04 | George Adjabeng | Thiazole And Oxazole Kinase Inhibitors |
EP2070933A1 (en) | 2007-12-07 | 2009-06-17 | Laboratorios del Dr. Esteve S.A. | Tricyclic triazolic compounds |
PL2242759T3 (pl) | 2008-02-06 | 2013-06-28 | Astrazeneca Ab | Związki |
KR101691836B1 (ko) | 2009-10-25 | 2017-01-02 | 엘지전자 주식회사 | 프로그램 정보 처리 방법 및 방송 수신기 |
MX347982B (es) * | 2011-03-14 | 2017-05-22 | Vertex Pharma | Morfolina-piperidina espirociclica-amidas como moduladores de canales ionicos. |
TWI623330B (zh) | 2011-03-16 | 2018-05-11 | 通路實業集團國際公司 | 具紫外線消毒之增濕器及其方法 |
JP5964426B2 (ja) | 2011-08-19 | 2016-08-03 | グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー2、リミテッドGlaxosmithkline Intellectual Property No.2 Limited | 脂肪酸シンターゼ阻害剤 |
US9751881B2 (en) | 2013-07-31 | 2017-09-05 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
JP2017100951A (ja) | 2014-04-04 | 2017-06-08 | 大正製薬株式会社 | オキサゾリジノン及びオキサジナノン誘導体 |
TWI685497B (zh) | 2014-06-02 | 2020-02-21 | 西班牙商伊史帝夫製藥公司 | 具有多重模式抗疼痛活性的1-氧雜-4,9-二氮雜螺十一烷化合物之烷基衍生物 |
TW201615642A (zh) | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | 具有多重模式抗疼痛活性的1-氧雜-4,9-二氮雜螺十一烷化合物之醯胺衍生物 |
TW201615643A (zh) * | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | 具有多重模式抗疼痛活性之1-氧雜-4,9-二氮雜螺十一烷化合物之烷基與芳基衍生物 |
JP2017535566A (ja) | 2014-11-21 | 2017-11-30 | ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ | 疼痛に対する多様な活性を有する1,9−ジアザスピロウンデカン化合物 |
LT3365346T (lt) | 2015-10-23 | 2020-04-10 | Esteve Pharmaceuticals, S.A. | Oksa-diazaspiro junginiai, pasižymintys aktyvumu prieš skausmą |
-
2016
- 2016-10-21 LT LTEP16784795.3T patent/LT3365346T/lt unknown
- 2016-10-21 HU HUE16784795A patent/HUE047997T2/hu unknown
- 2016-10-21 RS RS20200216A patent/RS59956B1/sr unknown
- 2016-10-21 RU RU2018118399A patent/RU2018118399A/ru not_active Application Discontinuation
- 2016-10-21 EP EP16784795.3A patent/EP3365346B1/en active Active
- 2016-10-21 AR ARP160103229A patent/AR106448A1/es unknown
- 2016-10-21 TW TW105134203A patent/TW201731853A/zh unknown
- 2016-10-21 AU AU2016343551A patent/AU2016343551A1/en not_active Abandoned
- 2016-10-21 JP JP2018519862A patent/JP6884973B2/ja active Active
- 2016-10-21 KR KR1020187014463A patent/KR20180073638A/ko unknown
- 2016-10-21 PL PL16784795T patent/PL3365346T3/pl unknown
- 2016-10-21 ME MEP-2020-39A patent/ME03636B/me unknown
- 2016-10-21 US US15/769,754 patent/US10689398B2/en active Active
- 2016-10-21 TN TNP/2018/000091A patent/TN2018000091A1/en unknown
- 2016-10-21 CN CN201680061752.6A patent/CN108349998B/zh active Active
- 2016-10-21 SI SI201630655T patent/SI3365346T1/sl unknown
- 2016-10-21 CA CA2999925A patent/CA2999925A1/en not_active Abandoned
- 2016-10-21 BR BR112018007269-9A patent/BR112018007269A2/pt not_active Application Discontinuation
- 2016-10-21 MA MA43158A patent/MA43158B1/fr unknown
- 2016-10-21 MX MX2018004777A patent/MX2018004777A/es unknown
- 2016-10-21 SG SG11201802988XA patent/SG11201802988XA/en unknown
- 2016-10-21 PT PT167847953T patent/PT3365346T/pt unknown
- 2016-10-21 ES ES16784795T patent/ES2775522T3/es active Active
- 2016-10-21 WO PCT/EP2016/001742 patent/WO2017067664A1/en active Application Filing
- 2016-10-21 DK DK16784795.3T patent/DK3365346T3/da active
-
2018
- 2018-03-26 IL IL258370A patent/IL258370A/en unknown
- 2018-03-27 PH PH12018500682A patent/PH12018500682A1/en unknown
- 2018-05-04 CO CONC2018/0004803A patent/CO2018004803A2/es unknown
-
2020
- 2020-02-24 HR HRP20200309TT patent/HRP20200309T1/hr unknown
- 2020-02-27 CY CY20201100183T patent/CY1122708T1/el unknown
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