CO2018004803A2 - Compuestos oxa-diazaspiro que tienen actividad contra el dolor - Google Patents

Compuestos oxa-diazaspiro que tienen actividad contra el dolor

Info

Publication number
CO2018004803A2
CO2018004803A2 CONC2018/0004803A CO2018004803A CO2018004803A2 CO 2018004803 A2 CO2018004803 A2 CO 2018004803A2 CO 2018004803 A CO2018004803 A CO 2018004803A CO 2018004803 A2 CO2018004803 A2 CO 2018004803A2
Authority
CO
Colombia
Prior art keywords
activity against
oxa
compounds
against pain
diazaspiro compounds
Prior art date
Application number
CONC2018/0004803A
Other languages
English (en)
Inventor
Carmen Almansa-Rosales
Carlos Alegret-Molina
Marina Virgili-Bernado
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of CO2018004803A2 publication Critical patent/CO2018004803A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La presente invención se refiere a compuestos oxadiazaespíricos con actividad farmacológica contra el receptor sigma (), a procesos de preparación de tales compuestos, a composiciones farmacéuticas que los comprenden y a su uso en terapia, en particular para el tratamiento del dolor.
CONC2018/0004803A 2015-10-23 2018-05-04 Compuestos oxa-diazaspiro que tienen actividad contra el dolor CO2018004803A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15382523 2015-10-23
PCT/EP2016/001742 WO2017067664A1 (en) 2015-10-23 2016-10-21 Oxa-diazaspiro compounds having activity against pain

Publications (1)

Publication Number Publication Date
CO2018004803A2 true CO2018004803A2 (es) 2018-07-19

Family

ID=54364221

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2018/0004803A CO2018004803A2 (es) 2015-10-23 2018-05-04 Compuestos oxa-diazaspiro que tienen actividad contra el dolor

Country Status (30)

Country Link
US (1) US10689398B2 (es)
EP (1) EP3365346B1 (es)
JP (1) JP6884973B2 (es)
KR (1) KR20180073638A (es)
CN (1) CN108349998B (es)
AR (1) AR106448A1 (es)
AU (1) AU2016343551A1 (es)
BR (1) BR112018007269A2 (es)
CA (1) CA2999925A1 (es)
CO (1) CO2018004803A2 (es)
CY (1) CY1122708T1 (es)
DK (1) DK3365346T3 (es)
ES (1) ES2775522T3 (es)
HR (1) HRP20200309T1 (es)
HU (1) HUE047997T2 (es)
IL (1) IL258370A (es)
LT (1) LT3365346T (es)
MA (1) MA43158B1 (es)
ME (1) ME03636B (es)
MX (1) MX2018004777A (es)
PH (1) PH12018500682A1 (es)
PL (1) PL3365346T3 (es)
PT (1) PT3365346T (es)
RS (1) RS59956B1 (es)
RU (1) RU2018118399A (es)
SG (1) SG11201802988XA (es)
SI (1) SI3365346T1 (es)
TN (1) TN2018000091A1 (es)
TW (1) TW201731853A (es)
WO (1) WO2017067664A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201615643A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物
TN2018000091A1 (en) 2015-10-23 2019-07-08 Esteve Labor Dr Oxa-diazaspiro compounds having activity against pain

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3481942A (en) 1968-09-06 1969-12-02 Smithkline Corp Oxa-diazaspiro(4.5)decane compounds
US4353900A (en) * 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones
WO1993013101A1 (en) * 1991-12-27 1993-07-08 Yoshitomi Pharmaceutical Industries, Ltd. Pyridonecarboxylate compound, pharmaceutical use thereof, and spiro compound
US6114541A (en) 1997-03-10 2000-09-05 Hoffmann-La Roche Inc. Method for the preparation of α-Bromo-Lactam derivatives
MXPA04006280A (es) 2001-12-28 2004-09-27 Acadia Pharm Inc Compuestos espiroazaciclicos como moduladores de receptor de monoamina.
JP4823914B2 (ja) * 2003-11-07 2011-11-24 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Ｆｇｆｒ３の阻害および多発性骨髄腫の治療
EP1634873A1 (en) 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
DE102005030051A1 (de) 2005-06-27 2006-12-28 Grünenthal GmbH Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
JP5217438B2 (ja) 2005-11-18 2013-06-19 小野薬品工業株式会社 塩基性基を含有する化合物およびその用途
EP1829869A1 (en) 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. 4,5,6,7-Tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands
WO2007124136A1 (en) 2006-04-19 2007-11-01 Acadia Pharmaceuticals, Inc. Use of 4-amino-piperidines for treating sleep disorders
EP1847542A1 (en) 2006-04-21 2007-10-24 Laboratorios del Dr. Esteve S.A. Spiro[benzopyran] or spiro[benzofuran] derivatives which inhibit the sigma receptor
EP2128154B1 (en) 2007-03-01 2015-04-08 Mitsubishi Tanabe Pharma Corporation Benzimidazole compound and pharmaceutical use thereof
EP1982714A1 (en) 2007-04-16 2008-10-22 Laboratorios del Dr. Esteve S.A. Pyrano-pyrazole-amines
EP2020414A1 (en) 2007-06-20 2009-02-04 Laboratorios del Dr. Esteve S.A. spiro[piperidine-4,4'-thieno[3,2-c]pyran] derivatives and related compounds as inhibitors of the sigma receptor for the treatment of psychosis
EP2197876A1 (en) 2007-08-29 2010-06-23 Glaxosmithkline LLC Thiazole and oxazole kinase inhibitors
EP2070933A1 (en) 2007-12-07 2009-06-17 Laboratorios del Dr. Esteve S.A. Tricyclic triazolic compounds
MY149731A (en) 2008-02-06 2013-10-14 Astrazeneca Ab Compounds
CN102668581A (zh) 2009-10-25 2012-09-12 Lg电子株式会社 用于处理广播节目信息的方法及广播接收器
CA2829803A1 (en) * 2011-03-14 2012-09-20 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels
TWI623330B (zh) 2011-03-16 2018-05-11 通路實業集團國際公司 具紫外線消毒之增濕器及其方法
JP5964426B2 (ja) 2011-08-19 2016-08-03 グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー２、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｎｏ．２ Ｌｉｍｉｔｅｄ 脂肪酸シンターゼ阻害剤
US9751881B2 (en) 2013-07-31 2017-09-05 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
JP2017100951A (ja) 2014-04-04 2017-06-08 大正製薬株式会社 オキサゾリジノン及びオキサジナノン誘導体
TWI685497B (zh) 2014-06-02 2020-02-21 西班牙商伊史帝夫製藥公司 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物
TW201615642A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性的１－氧雜－４，９－二氮雜螺十一烷化合物之醯胺衍生物
TW201615643A (zh) * 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物
JP2017535566A (ja) 2014-11-21 2017-11-30 ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ 疼痛に対する多様な活性を有する１，９−ジアザスピロウンデカン化合物
TN2018000091A1 (en) 2015-10-23 2019-07-08 Esteve Labor Dr Oxa-diazaspiro compounds having activity against pain

Also Published As

Publication number Publication date
JP2018531263A (ja) 2018-10-25
CY1122708T1 (el) 2021-03-12
IL258370A (en) 2018-05-31
HRP20200309T1 (hr) 2020-06-12
AU2016343551A1 (en) 2018-04-19
WO2017067664A9 (en) 2017-06-29
MX2018004777A (es) 2018-06-19
PL3365346T3 (pl) 2020-06-01
PH12018500682A1 (en) 2018-10-01
CA2999925A1 (en) 2017-04-27
JP6884973B2 (ja) 2021-06-09
RU2018118399A (ru) 2019-11-25
TW201731853A (zh) 2017-09-16
SI3365346T1 (sl) 2020-04-30
DK3365346T3 (da) 2020-03-09
RU2018118399A3 (es) 2020-01-31
EP3365346A1 (en) 2018-08-29
WO2017067664A1 (en) 2017-04-27
HUE047997T2 (hu) 2020-05-28
PT3365346T (pt) 2020-03-05
CN108349998A (zh) 2018-07-31
BR112018007269A2 (pt) 2018-10-30
AR106448A1 (es) 2018-01-17
ME03636B (me) 2020-07-20
SG11201802988XA (en) 2018-05-30
CN108349998B (zh) 2021-10-29
EP3365346B1 (en) 2019-12-04
US10689398B2 (en) 2020-06-23
RS59956B1 (sr) 2020-03-31
US20190002475A1 (en) 2019-01-03
MA43158B1 (fr) 2020-03-31
ES2775522T3 (es) 2020-07-27
LT3365346T (lt) 2020-04-10
TN2018000091A1 (en) 2019-07-08
KR20180073638A (ko) 2018-07-02

Similar Documents

Publication Publication Date Title
IL264413B (en) Preparations containing fibers obtained electrohydrodynamically for delivering specific doses of active substance to the skin or mucous membrane
MX2020004467A (es) Metodos para el tratamiento o la prevencion del asma mediante la administracion de antagonista de il-4r.
SV2017005461A (es) Benzamidas sustituidas con 1,3-tiazol-2-ilo
CO2018013747A2 (es) Moduladores del receptor espiro-lactama n-metil-d-aspartato y usos de los mismos
BR112017027132A2 (pt) reguladores do nrf2
PE20151416A1 (es) Moduladores de receptores nmda de espiro-lactama y sus usos
DOP2016000226A (es) Compuestos de isoindolinona como moduladores de gpr119 para el tratamiento de diabetes, obesidad, dislipidemia y trastornos relacionados
CL2014001853A1 (es) Compuestos derivados de pirrol sustituido; procedimiento de preparacion; composicion farmaceutica que los contiene; combinacion farmaceutica; uso para tratar enfermedades tales como canceres y enfermedades del sistema inmunitario.
CL2014001865A1 (es) Compuestos derivados de fosfatos; procedimiento de preparacion; composiciones farmaceuticas que los contienen y uso en el tratamiento del cancer.
CL2020000747A1 (es) Formulaciones de niraparib.
PH12017500239A1 (en) Abiraterone acetate formulation and methods of use
MX2018000419A (es) Derivados de amida sustituida que tienen actividad multimodal contra el dolor.
PH12016500978A1 (en) Piperazine derivatives having multimodal activity against pain
GT201600027A (es) Inhibidores de rorc2 y sus métodos de uso
MX2017006437A (es) Compuestos espiroisoquinolin-1,4'-piperidinicos con actividad multimodal contra el dolor.
ECSP16086247A (es) (s)-pirlindole y sus sales farmacéuticamente aceptables para uso en medicina
CR20170090A (es) Derivados de terahidroquinolina como inhibidores del bromodominio
BR112018069682A2 (pt) métodos de tratamento para doenças colestáticas e fibróticas
CR20160529A (es) Composiciones farmacéuticas para tratar enfermedades infecciosas
CO2018004665A2 (es) Compuestos oxadiazoespíricos
ECSP16086232A (es) (r) -pirlindole y sus sales farmacéuticamente aceptables para uso en medicina
CO2018004803A2 (es) Compuestos oxa-diazaspiro que tienen actividad contra el dolor
MX2017006513A (es) Compuestos de tipo 1,9-diazaespiroundecano con actividad multimodal contra el dolor.
CO2018011797A2 (es) Derivados de tetrahidropirano y tiopirano que tienen actividad multimodal contra el dolor
BR112019017314A2 (pt) composições farmacêuticas para terapia de combinação