UY37589A - COMPUESTOS MODULADORES DEL RECEPTOR DE HIDROCARBUROS ARÍLICOS (AhR) - Google Patents

COMPUESTOS MODULADORES DEL RECEPTOR DE HIDROCARBUROS ARÍLICOS (AhR)

Info

Publication number
UY37589A
UY37589A UY0001037589A UY37589A UY37589A UY 37589 A UY37589 A UY 37589A UY 0001037589 A UY0001037589 A UY 0001037589A UY 37589 A UY37589 A UY 37589A UY 37589 A UY37589 A UY 37589A
Authority
UY
Uruguay
Prior art keywords
ahr
arylic
modulating compounds
compounds
hydrocarbon
Prior art date
Application number
UY0001037589A
Other languages
English (en)
Inventor
Ulrich Deuschle
Michael Albers
Christoph Steeneck
Thomas Hoffmann
Original Assignee
Phenex Pharmaceuticals Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phenex Pharmaceuticals Ag filed Critical Phenex Pharmaceuticals Ag
Publication of UY37589A publication Critical patent/UY37589A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Compuestos que pueden actuar como moduladores del receptor de hidrocarburo arílico (AhR) y, en particular, como antagonistas de AhR. La invención además se relaciona con el uso de los compuestos para el tratamiento y/o la profilaxis de enfermedades y/o condiciones a través de la unión a dicho receptor de hidrocarburo arílico por parte de dichos compuestos.
UY0001037589A 2017-02-01 2018-01-31 COMPUESTOS MODULADORES DEL RECEPTOR DE HIDROCARBUROS ARÍLICOS (AhR) UY37589A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17000158 2017-02-01

Publications (1)

Publication Number Publication Date
UY37589A true UY37589A (es) 2018-02-28

Family

ID=57960223

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001037589A UY37589A (es) 2017-02-01 2018-01-31 COMPUESTOS MODULADORES DEL RECEPTOR DE HIDROCARBUROS ARÍLICOS (AhR)

Country Status (28)

Country Link
US (1) US10981908B2 (es)
EP (1) EP3577112B1 (es)
JP (1) JP6849823B2 (es)
KR (1) KR102320516B1 (es)
CN (1) CN110248940B (es)
AR (1) AR110789A1 (es)
AU (1) AU2018216957B2 (es)
BR (1) BR112019015716A2 (es)
CA (1) CA3050827C (es)
CL (1) CL2019002108A1 (es)
CO (1) CO2019007881A2 (es)
CR (1) CR20190392A (es)
CU (1) CU20190069A7 (es)
EA (1) EA038318B1 (es)
EC (1) ECSP19055169A (es)
ES (1) ES2858329T3 (es)
IL (1) IL268080B (es)
MX (1) MX2019008994A (es)
MY (1) MY196831A (es)
NI (1) NI201900076A (es)
PE (1) PE20191478A1 (es)
PH (1) PH12019550135A1 (es)
SG (1) SG11201906958TA (es)
TW (1) TWI752155B (es)
UA (1) UA122745C2 (es)
UY (1) UY37589A (es)
WO (1) WO2018141857A1 (es)
ZA (1) ZA201904771B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI752155B (zh) 2017-02-01 2022-01-11 德商菲尼克斯製藥股份有限公司 芳香烴受體(AhR)調節劑化合物
TWI674260B (zh) * 2017-02-01 2019-10-11 德商菲尼克斯製藥股份有限公司 芳基烴受體(AhR)調節劑化合物
US10815250B2 (en) 2018-02-06 2020-10-27 Ideaya Biosciences, Inc. AhR modulators
WO2020021024A1 (en) * 2018-07-26 2020-01-30 Phenex Pharmaceuticals Ag Substituted bicyclic compounds as modulators of the aryl hydrocarbon receptor (ahr)
SG11202105213XA (en) * 2018-11-30 2021-06-29 Celularity Inc Expansion of natural killer cells and ilc3 cells with novel aromatic compounds
EP4093739A1 (en) * 2020-01-23 2022-11-30 Phenex Pharmaceuticals AG Oxalamide substituted heterocyclic compounds as modulators of the aryl hydrocarbon receptor (ahr)
EP4110778A1 (en) 2020-02-26 2023-01-04 Jaguahr Therapeutics Pte Ltd Pyridopyrimidine derivatives useful in modulation of ahr signalling
US20230234967A1 (en) * 2020-05-28 2023-07-27 Senda Biosciences, Inc. Fused Azole Heterocycles as AHR Antagonists
CN114181212B (zh) * 2020-09-15 2023-06-06 山东轩竹医药科技有限公司 哒嗪酮类AhR抑制剂
CN114835687B (zh) * 2021-04-02 2023-09-05 北京华森英诺生物科技有限公司 AhR抑制剂
CN115572282A (zh) * 2021-07-05 2023-01-06 华东理工大学 含芳杂环结构的吡唑酰胺类化合物及其制备方法和应用
WO2024076300A1 (en) 2022-10-03 2024-04-11 Jaguahr Therapeutics Pte Ltd Compounds useful in modulation of ahr signalling

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8225991A (en) 1990-07-31 1992-03-02 Teikoku Hormone Mfg. Co., Ltd. 2-phenylindole derivative
DE69728688T2 (de) * 1996-11-19 2004-08-19 Amgen Inc., Thousand Oaks Aryl und heteroaryl substituierte kondensierte pyrrole als entzündunghemmende mittel
AU2003270426A1 (en) 2002-09-12 2004-04-30 Avanir Pharmaceuticals PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION
US20050032869A1 (en) 2003-07-08 2005-02-10 Pharmacia Italia S.P.A. Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
KR101007489B1 (ko) 2005-11-18 2011-01-12 에프. 호프만-라 로슈 아게 아자인돌-2-카복스아마이드 유도체
US8563573B2 (en) * 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
ES2749504T3 (es) 2009-10-13 2020-03-20 Ligand Pharm Inc Compuestos de moléculas pequeñas miméticos del factor de crecimiento hematopoyético y sus usos
US20130338201A1 (en) * 2009-11-02 2013-12-19 Ahr Pharmaceuticals, Inc. Method of Cancer Treatment with 2-(1H-Indole-3-Carbonyl)-Thiazole-4-Carboxylic Acid Methyl Ester
JP5598775B2 (ja) * 2009-11-02 2014-10-01 ソン，ジャシェン 癌の介入治療および根絶のためのｉｔｅとその類似体を含む医薬組成物
WO2011097079A1 (en) 2010-02-03 2011-08-11 Takeda Pharmaceutical Company Limited Apoptosis signal-regulating kinase 1 inhibitors
US8410117B2 (en) * 2010-03-26 2013-04-02 Hoffmann-La Roche Inc. Imidazopyrimidine derivatives
TWI619713B (zh) 2010-04-21 2018-04-01 普雷辛肯公司 用於激酶調節的化合物和方法及其適應症
WO2012015914A2 (en) 2010-07-27 2012-02-02 Trustees Of Boston University Aryl hydrocarbon receptor (ahr) modifiers as novel cancer therapeutics
GB201104267D0 (en) 2011-03-14 2011-04-27 Cancer Rec Tech Ltd Pyrrolopyridineamino derivatives
KR20150070290A (ko) 2012-10-17 2015-06-24 에프. 호프만-라 로슈 아게 Trp 채널 길항제로서의 6-아미노인돌 유도체
KR102212923B1 (ko) 2012-12-21 2021-02-04 플렉시콘 인코퍼레이티드 키나제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증
TWI752155B (zh) 2017-02-01 2022-01-11 德商菲尼克斯製藥股份有限公司 芳香烴受體(AhR)調節劑化合物
TWI674260B (zh) 2017-02-01 2019-10-11 德商菲尼克斯製藥股份有限公司 芳基烴受體(AhR)調節劑化合物
TW201835070A (zh) 2017-02-21 2018-10-01 德商菲尼克斯製藥股份有限公司 芳香烴受體(AhR)調節劑化合物

Also Published As

Publication number Publication date
CL2019002108A1 (es) 2019-12-20
KR20190104410A (ko) 2019-09-09
BR112019015716A2 (pt) 2020-03-24
CN110248940B (zh) 2022-07-01
PE20191478A1 (es) 2019-10-16
EP3577112B1 (en) 2020-12-30
JP6849823B2 (ja) 2021-03-31
ECSP19055169A (es) 2019-08-30
EP3577112A1 (en) 2019-12-11
AU2018216957B2 (en) 2020-09-24
TW201831480A (zh) 2018-09-01
ZA201904771B (en) 2022-05-25
IL268080B (en) 2022-03-01
EA038318B1 (ru) 2021-08-09
PH12019550135A1 (en) 2020-06-01
MX2019008994A (es) 2019-12-19
US10981908B2 (en) 2021-04-20
CN110248940A (zh) 2019-09-17
JP2020506228A (ja) 2020-02-27
NZ755709A (en) 2021-04-30
CR20190392A (es) 2019-10-21
IL268080A (en) 2019-09-26
CU20190069A7 (es) 2020-03-04
CO2019007881A2 (es) 2019-10-09
MY196831A (en) 2023-05-03
SG11201906958TA (en) 2019-08-27
CA3050827A1 (en) 2018-08-09
ES2858329T3 (es) 2021-09-30
CA3050827C (en) 2021-09-07
EA201991599A1 (ru) 2020-03-10
AU2018216957A1 (en) 2019-08-22
US20190389857A1 (en) 2019-12-26
AR110789A1 (es) 2019-05-02
NI201900076A (es) 2020-01-23
UA122745C2 (uk) 2020-12-28
KR102320516B1 (ko) 2021-11-02
WO2018141857A1 (en) 2018-08-09
TWI752155B (zh) 2022-01-11

Similar Documents

Publication Publication Date Title
UY37589A (es) COMPUESTOS MODULADORES DEL RECEPTOR DE HIDROCARBUROS ARÍLICOS (AhR)
UY37610A (es) Compuestos moduladores del receptor de hidrocarburos de arilo (ahr)
UY37590A (es) COMPUESTOS MODULADORES DEL RECEPTOR DE HIDROCARBUROS ARÍLICOS (AhR)
CL2019003015A1 (es) Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos.
CO2020016619A2 (es) Anticuerpos biespecificos anti-pvrig/anti-tigit y métodos de uso
EA201891209A1 (ru) Модуляторы хемокиновых рецепторов
UY37134A (es) Compuestos heteroarilos y composiciones que los contienen útiles como inhibidores de pad4
CL2017001289A1 (es) Compuestos bicíclicos fusionados, sus composiciones y su uso para el tratamiento de enfermedades relacionadas con la modulación del receptor x farnesoide (fxr).
CL2016002021A1 (es) Ciclopropilaminas como inhibidores lsd1.
AR102712A1 (es) Agonistas parciales del receptor de insulina
CO7160047A2 (es) Compuestos y composiciones que modulan la actividad del receptor del factor de crecimiento epidérmico (egfr)
ECSP18060342A (es) Derivados de tiohidantoína sustituidos como antagonistas del receptor de andrógenos
CL2016002084A1 (es) Compuestos derivados de ciclopentano 1,2 substituidos como antagonistas del receptor de orexina.
GT201700231A (es) Azabenzimidazoles y su uso como moduladores del receptor ampa
PE20230683A1 (es) Moduladores de receptor nuclear
CL2022001406A1 (es) Aminoquinolonas sustituidas como inhibidores de dgk alfa para la activación inmune.
CL2016003074A1 (es) Compuestos derivados de 2-oxi-2-fenil-n-5-pirrolidin-3-ilamino-1,3,4-tiadiazol-2-ilacetamida, inhibidores gls1 composición farmacéutica y su uso para tratar el cáncer.
UY36348A (es) Derivados de benzotiofenilo sustituidos como agonistas del gpr40 para el tratamiento de la diabetes tipo ii
DOP2016000212A (es) Heterociclos condensados sustituidos como moduladores de gpr119 para el tratamiento de la diabetes, obesidad, dislipidemia y trastornos relacionados
CR20160557A (es) Compuestos derivados de 1-(ciclopent-2-en-1-il)-3-(2-hidroxi-3-(arilsulfonil)fenil)urea como inhibidores cxcr2
CL2019002873A1 (es) Moduladores del receptor x del hígado (lxr).
EA202090732A1 (ru) Составы для трансдермального введения
UY36217A (es) Compuestos piridona sustituídos, composiciones farmacéuticas y métodos de uso.
ECSP16074207A (es) Pirazinas moduladoras de gpr6
CL2020002147A1 (es) 3ß-(4-metoxibenciloxi)pregn-5-en-20-ona para su uso en el tratamiento de los trastornos relacionados con los cannabinoides.

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20231026