UY37134A - Compuestos heteroarilos y composiciones que los contienen útiles como inhibidores de pad4 - Google Patents

Compuestos heteroarilos y composiciones que los contienen útiles como inhibidores de pad4

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Publication number
UY37134A
UY37134A UY0001037134A UY37134A UY37134A UY 37134 A UY37134 A UY 37134A UY 0001037134 A UY0001037134 A UY 0001037134A UY 37134 A UY37134 A UY 37134A UY 37134 A UY37134 A UY 37134A
Authority
UY
Uruguay
Prior art keywords
compositions
heteroarile
compounds
contain useful
pad4 inhibitors
Prior art date
Application number
UY0001037134A
Other languages
English (en)
Inventor
Edward Beaumont
Laura Gleave
Gnanasambandam Kumaravel
Heather Tye
Rajesh Devraj
Holly Atton
Elise Gadouleau
Philip Stephen Kerry
Cristina Lecci
Mirco Meniconi
Nat Monck
Jordan Palfrey
Kostas Papadopoulos
Philip A Woods
Original Assignee
Padlock Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Padlock Therapeutics Inc filed Critical Padlock Therapeutics Inc
Publication of UY37134A publication Critical patent/UY37134A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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Abstract

La presente invención proporciona compuestos útiles como inhibidores de PAD4, composiciones de estos que son útiles para tratar trastornos relacionados con PAD4.
UY0001037134A 2016-02-23 2017-02-22 Compuestos heteroarilos y composiciones que los contienen útiles como inhibidores de pad4 UY37134A (es)

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AU (1) AU2017223416A1 (es)
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EP3490989B1 (en) 2016-07-27 2020-09-09 Padlock Therapeutics, Inc. Covalent inhibitors of pad4
ES2924522T3 (es) 2016-09-12 2022-10-07 Padlock Therapeutics Inc Inhibidores heteroarilo de PAD4
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CA3073656C (en) * 2017-09-22 2024-03-05 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
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BR112020010322A2 (pt) 2017-11-24 2020-11-17 Jubilant Episcribe Llc composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer
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KR20210042935A (ko) * 2018-08-08 2021-04-20 브리스톨-마이어스 스큅 컴퍼니 Pad4 억제제로서의 치환된 티에노피롤
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CN113248507A (zh) * 2020-02-09 2021-08-13 上海茂晟康慧科技有限公司 瑞德西韦关键中间体7-卤代吡咯并[1,2-f][1,2,4]三嗪-4-胺的合成方法
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KR20220122879A (ko) * 2021-02-26 2022-09-05 주식회사 티에스디라이프사이언스 이미다조피리딘 유도체 및 이를 유효성분으로 함유하는 약학적 조성물

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US20210188810A1 (en) 2021-06-24
US11897866B2 (en) 2024-02-13
US20220081418A1 (en) 2022-03-17
WO2017147102A1 (en) 2017-08-31
JP6926126B2 (ja) 2021-08-25
AU2017223416A1 (en) 2018-10-11
BR112018016433A2 (pt) 2018-12-26
IL261167A (en) 2018-10-31
EA201891910A1 (ru) 2019-02-28
SG11201807021UA (en) 2018-09-27
JP2019505597A (ja) 2019-02-28
MX2018009773A (es) 2018-11-29
TW201825476A (zh) 2018-07-16
US11198681B2 (en) 2021-12-14
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KR20180110160A (ko) 2018-10-08
EP3419969A1 (en) 2019-01-02
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