MX2018009773A - Heteroarilos inhibidores de peptidilarginina desiminasa 4 (pad4). - Google Patents

Heteroarilos inhibidores de peptidilarginina desiminasa 4 (pad4).

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Publication number
MX2018009773A
MX2018009773A MX2018009773A MX2018009773A MX2018009773A MX 2018009773 A MX2018009773 A MX 2018009773A MX 2018009773 A MX2018009773 A MX 2018009773A MX 2018009773 A MX2018009773 A MX 2018009773A MX 2018009773 A MX2018009773 A MX 2018009773A
Authority
MX
Mexico
Prior art keywords
pad4
inhibitors
heteroaryl inhibitors
heteroaryl
compositions
Prior art date
Application number
MX2018009773A
Other languages
English (en)
Inventor
Tye Heather
Kumaravel Gnanasambandam
Devraj Rajesh
Beaumont Edward
Gleave Laura
Lecci Cristina
Monck Nat
Palfrey Jordan
Atton Holly
Gadouleau Elise
Meniconi Mirco
Papadopoulos Kostas
A Woods Philip
Stephen KERRY Phillip
Original Assignee
Padlock Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Padlock Therapeutics Inc filed Critical Padlock Therapeutics Inc
Publication of MX2018009773A publication Critical patent/MX2018009773A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Abstract

La presente invención proporciona compuestos útiles como inhibidores de PAD4, composiciones de los mismos y métodos para tratar los trastornos relacionados con PAD4.
MX2018009773A 2016-02-23 2017-02-22 Heteroarilos inhibidores de peptidilarginina desiminasa 4 (pad4). MX2018009773A (es)

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US201662298726P 2016-02-23 2016-02-23
PCT/US2017/018790 WO2017147102A1 (en) 2016-02-23 2017-02-22 Heteroaryl inhibitors of pad4

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CN110248934B (zh) 2016-09-12 2022-05-24 帕德罗科治疗公司 杂芳基pad4抑制剂

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US11198681B2 (en) 2021-12-14
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CA3015482A1 (en) 2017-08-31
EP3419969A1 (en) 2019-01-02
BR112018016433A2 (pt) 2018-12-26
CN109071497B (zh) 2021-10-22
US20210188810A1 (en) 2021-06-24
US20220081418A1 (en) 2022-03-17
ES2770102T3 (es) 2020-06-30
UY37134A (es) 2017-08-31
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