UY37018A - Inhibidores bicíclicos de pad4 - Google Patents

Inhibidores bicíclicos de pad4

Info

Publication number
UY37018A
UY37018A UY0001037018A UY37018A UY37018A UY 37018 A UY37018 A UY 37018A UY 0001037018 A UY0001037018 A UY 0001037018A UY 37018 A UY37018 A UY 37018A UY 37018 A UY37018 A UY 37018A
Authority
UY
Uruguay
Prior art keywords
pad4
bicyclic inhibitors
inhibitors
bicyclic
compositions
Prior art date
Application number
UY0001037018A
Other languages
English (en)
Inventor
Edward Beaumont
Lee Bowles
Sophie Cooper
Rajesh Devraj
Elise Gadouleau
Laura Gleave
Philip Kerry
Adrian Kotey
Thomas Krulle
Gnanasambandam Kumaravel
Cristina Lecci
Pui Loke
Mirco Meniconi
Nat Monck
Carl North
Jordan Palfrey
Michael F Parker
Heather Tye
Steve Bromidge
Shelley Parrott
Mark Ridgill
Original Assignee
Padlock Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Padlock Therapeutics Inc filed Critical Padlock Therapeutics Inc
Publication of UY37018A publication Critical patent/UY37018A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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Abstract

La presente invención proporciona compuestos útiles como inhibidores de PAD4, composiciones de estos y métodos para tratar trastornos relacionados con PAD4.
UY0001037018A 2015-12-09 2016-12-09 Inhibidores bicíclicos de pad4 UY37018A (es)

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AU (1) AU2016366398A1 (es)
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CA3199601A1 (en) * 2015-05-21 2016-11-24 Glaxosmithkline Intellectual Property Development Limited Benzoimidazole derivatives as pad4 inhibitors
KR20180110160A (ko) 2016-02-23 2018-10-08 패들락 테라퓨틱스, 인코포레이티드 Pad4의 헤테로아릴 억제제
CN109790162B (zh) 2016-07-27 2022-06-28 帕德罗科治疗公司 Pad4的共价抑制剂
JP7118951B2 (ja) 2016-09-12 2022-08-16 パドロック・セラピューティクス・インコーポレイテッド Ｐａｄ４のヘテロアリール阻害剤
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AU2019318415A1 (en) * 2018-08-08 2021-03-25 Bristol-Myers Squibb Company Substituted benzimidazoles as PAD4 inhibitors
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KR20220137694A (ko) * 2020-02-06 2022-10-12 브리스톨-마이어스 스큅 컴퍼니 면역억제제로서 유용한 마크로시클릭 pad4 억제제
CR20220550A (es) 2020-04-30 2022-12-15 Gilead Sciences Inc Inhibidores macrocíclicos de las peptidilarginina deiminasas
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WO2024109945A1 (en) * 2022-11-24 2024-05-30 Helios Huaming Biopharma Co., Ltd. Selenium containing heterocycle compounds and use thereof

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US9963448B2 (en) 2018-05-08
CN109069869A (zh) 2018-12-21
EA201891251A1 (ru) 2018-12-28
US20170166565A1 (en) 2017-06-15
WO2017100594A1 (en) 2017-06-15
BR112018011709A2 (pt) 2018-12-04
IL259794A (en) 2018-08-30
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AU2016366398A1 (en) 2018-07-19
TW201726674A (zh) 2017-08-01
JP6932136B2 (ja) 2021-09-08
MX2018006632A (es) 2018-11-09
ES2877543T3 (es) 2021-11-17
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EP3386590A1 (en) 2018-10-17
CA3007639A1 (en) 2017-06-15
AR107032A1 (es) 2018-03-14
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