SG11202101174RA - Indole and azaindole inhibitors of pad enzymes - Google Patents
Indole and azaindole inhibitors of pad enzymesInfo
- Publication number
- SG11202101174RA SG11202101174RA SG11202101174RA SG11202101174RA SG11202101174RA SG 11202101174R A SG11202101174R A SG 11202101174RA SG 11202101174R A SG11202101174R A SG 11202101174RA SG 11202101174R A SG11202101174R A SG 11202101174RA SG 11202101174R A SG11202101174R A SG 11202101174RA
- Authority
- SG
- Singapore
- Prior art keywords
- indole
- pad enzymes
- azaindole
- inhibitors
- azaindole inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862715850P | 2018-08-08 | 2018-08-08 | |
| PCT/US2019/045466 WO2020033520A1 (en) | 2018-08-08 | 2019-08-07 | Indole and azaindole inhibitors of pad enzymes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202101174RA true SG11202101174RA (en) | 2021-03-30 |
Family
ID=67766306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202101174RA SG11202101174RA (en) | 2018-08-08 | 2019-08-07 | Indole and azaindole inhibitors of pad enzymes |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US11524959B1 (en) |
| EP (1) | EP3833440A1 (en) |
| JP (1) | JP2021534108A (en) |
| KR (1) | KR20210042934A (en) |
| CN (1) | CN112805067A (en) |
| AR (1) | AR115920A1 (en) |
| AU (1) | AU2019319835A1 (en) |
| BR (1) | BR112021002091A2 (en) |
| CA (1) | CA3108791A1 (en) |
| CL (1) | CL2021000296A1 (en) |
| CO (1) | CO2021001217A2 (en) |
| EA (1) | EA202190462A1 (en) |
| IL (1) | IL280650A (en) |
| MX (1) | MX2021001565A (en) |
| PE (1) | PE20211068A1 (en) |
| SG (1) | SG11202101174RA (en) |
| TW (1) | TW202019415A (en) |
| WO (1) | WO2020033520A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019319835A1 (en) | 2018-08-08 | 2021-03-25 | Bristol-Myers Squibb Company | Indole and azaindole inhibitors of PAD enzymes |
| EP4143189A1 (en) * | 2020-04-30 | 2023-03-08 | Gilead Sciences, Inc. | Macrocyclic inhibitors of peptidylarginine deiminases |
| CN111943947B (en) * | 2020-07-24 | 2021-04-30 | 重庆文理学院 | 1H-pyrrole [2,3-b ] pyridine derivative and synthesis method and application thereof |
| WO2022140428A2 (en) * | 2020-12-22 | 2022-06-30 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
| US11878965B2 (en) | 2020-12-22 | 2024-01-23 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2609126T3 (en) | 2012-07-26 | 2017-04-18 | Glaxo Group Limited | 2- (Azaindol-2-yl) benzimidazoles as PAD4 inhibitors |
| JP6703553B2 (en) | 2015-05-21 | 2020-06-03 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | Benzimidazole derivatives as PAD4 inhibitors |
| AR107032A1 (en) * | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | PAD4 BICYCLIC INHIBITORS |
| AR107030A1 (en) | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | AZA-BENCIMIDAZOL INHIBITORS OF PAD4 |
| CA3007025A1 (en) | 2015-12-22 | 2017-06-29 | Kancera Ab | Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity |
| CN109071497B (en) | 2016-02-23 | 2021-10-22 | 帕德罗科治疗公司 | PAD4 heteroaryl inhibitors |
| US10703741B2 (en) | 2016-07-27 | 2020-07-07 | Padlock Therapeutics, Inc. | Covalent inhibitors of PAD4 |
| EP3510025B1 (en) | 2016-09-12 | 2022-06-29 | Padlock Therapeutics, Inc. | Heteroaryl inhibitors of pad4 |
| AU2018294054B2 (en) | 2017-06-30 | 2022-05-26 | Beijing Tide Pharmaceutical Co., Ltd. | Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof |
| CA3076476A1 (en) | 2017-10-18 | 2019-04-25 | Jubilant Epipad LLC | Imidazo-pyridine compounds as pad inhibitors |
| MX2021001471A (en) | 2018-08-08 | 2021-04-28 | Bristol Myers Squibb Co | Substituted benzimidazoles as pad4 inhibitors. |
| AU2019319835A1 (en) | 2018-08-08 | 2021-03-25 | Bristol-Myers Squibb Company | Indole and azaindole inhibitors of PAD enzymes |
| JP7447080B2 (en) | 2018-08-08 | 2024-03-11 | ブリストル－マイヤーズ スクイブ カンパニー | Substituted thienopyrroles as PAD4 inhibitors |
| US20220348562A1 (en) | 2018-08-08 | 2022-11-03 | Bristol-Myers Squibb Company | Benzimidazole inhibitors of pad enzymes |
-
2019
- 2019-08-07 AU AU2019319835A patent/AU2019319835A1/en not_active Abandoned
- 2019-08-07 MX MX2021001565A patent/MX2021001565A/en unknown
- 2019-08-07 WO PCT/US2019/045466 patent/WO2020033520A1/en unknown
- 2019-08-07 EA EA202190462A patent/EA202190462A1/en unknown
- 2019-08-07 JP JP2021506683A patent/JP2021534108A/en active Pending
- 2019-08-07 CA CA3108791A patent/CA3108791A1/en active Pending
- 2019-08-07 TW TW108128155A patent/TW202019415A/en unknown
- 2019-08-07 CN CN201980064963.9A patent/CN112805067A/en active Pending
- 2019-08-07 KR KR1020217006477A patent/KR20210042934A/en active Search and Examination
- 2019-08-07 EP EP19759141.5A patent/EP3833440A1/en active Pending
- 2019-08-07 BR BR112021002091-8A patent/BR112021002091A2/en not_active Application Discontinuation
- 2019-08-07 PE PE2021000171A patent/PE20211068A1/en unknown
- 2019-08-07 US US17/265,842 patent/US11524959B1/en active Active
- 2019-08-07 SG SG11202101174RA patent/SG11202101174RA/en unknown
- 2019-08-07 AR ARP190102237A patent/AR115920A1/en unknown
-
2021
- 2021-02-03 CL CL2021000296A patent/CL2021000296A1/en unknown
- 2021-02-03 CO CONC2021/0001217A patent/CO2021001217A2/en unknown
- 2021-02-04 IL IL280650A patent/IL280650A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020033520A1 (en) | 2020-02-13 |
| KR20210042934A (en) | 2021-04-20 |
| AR115920A1 (en) | 2021-03-10 |
| JP2021534108A (en) | 2021-12-09 |
| MX2021001565A (en) | 2021-04-19 |
| TW202019415A (en) | 2020-06-01 |
| PE20211068A1 (en) | 2021-06-09 |
| CA3108791A1 (en) | 2020-02-13 |
| EA202190462A1 (en) | 2021-06-03 |
| CL2021000296A1 (en) | 2021-06-25 |
| AU2019319835A1 (en) | 2021-03-25 |
| EP3833440A1 (en) | 2021-06-16 |
| US11524959B1 (en) | 2022-12-13 |
| IL280650A (en) | 2021-03-25 |
| CO2021001217A2 (en) | 2021-02-26 |
| BR112021002091A2 (en) | 2021-05-04 |
| CN112805067A (en) | 2021-05-14 |
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