EP1622916A4 - Modulateurs tetrahydroisoquinoline et tetrahydropyridopyridine cyclopentyles heterocycliques de l'activite des recepteurs de chimiokine - Google Patents

Modulateurs tetrahydroisoquinoline et tetrahydropyridopyridine cyclopentyles heterocycliques de l'activite des recepteurs de chimiokine

Info

Publication number
EP1622916A4
EP1622916A4 EP04750112A EP04750112A EP1622916A4 EP 1622916 A4 EP1622916 A4 EP 1622916A4 EP 04750112 A EP04750112 A EP 04750112A EP 04750112 A EP04750112 A EP 04750112A EP 1622916 A4 EP1622916 A4 EP 1622916A4
Authority
EP
European Patent Office
Prior art keywords
tetrahydroisoquinoline
chemokine receptor
receptor activity
tetrahydropyridopyridine
modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04750112A
Other languages
German (de)
English (en)
Other versions
EP1622916A2 (fr
Inventor
Gabor Butora
Stephen D Goble
Alexander Pasternak
Lihu Yang
Changyou Zhou
Christopher R Moyes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme Ltd
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd, Merck and Co Inc filed Critical Merck Sharp and Dohme Ltd
Publication of EP1622916A2 publication Critical patent/EP1622916A2/fr
Publication of EP1622916A4 publication Critical patent/EP1622916A4/fr
Withdrawn legal-status Critical Current

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
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  • Hematology (AREA)
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EP04750112A 2003-04-17 2004-04-14 Modulateurs tetrahydroisoquinoline et tetrahydropyridopyridine cyclopentyles heterocycliques de l'activite des recepteurs de chimiokine Withdrawn EP1622916A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46367303P 2003-04-17 2003-04-17
PCT/US2004/011463 WO2004094371A2 (fr) 2003-04-17 2004-04-14 Modulateurs tetrahydroisoquinoline et tetrahydropyridopyridine cyclopentyles heterocycliques de l'activite des recepteurs de chimiokine

Publications (2)

Publication Number Publication Date
EP1622916A2 EP1622916A2 (fr) 2006-02-08
EP1622916A4 true EP1622916A4 (fr) 2008-11-05

Family

ID=33310806

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04750112A Withdrawn EP1622916A4 (fr) 2003-04-17 2004-04-14 Modulateurs tetrahydroisoquinoline et tetrahydropyridopyridine cyclopentyles heterocycliques de l'activite des recepteurs de chimiokine

Country Status (6)

Country Link
EP (1) EP1622916A4 (fr)
JP (1) JP2006523704A (fr)
CN (1) CN100384856C (fr)
AU (1) AU2004232939A1 (fr)
CA (1) CA2521625A1 (fr)
WO (1) WO2004094371A2 (fr)

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AU2004232939A1 (en) * 2003-04-17 2004-11-04 Merck Sharp & Dohme Corp. Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity
US7598243B2 (en) 2003-04-17 2009-10-06 Merck & Co., Inc. Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity
TWI350168B (en) 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
WO2007053498A1 (fr) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Composés pouvant être employés en tant qu'antagonistes de ccr2
ATE476424T1 (de) * 2006-04-20 2010-08-15 Hoffmann La Roche Diazepanderivate als modulatoren von chemokinrezeptoren
WO2008108445A1 (fr) 2007-03-07 2008-09-12 Takeda Pharmaceutical Company Limited Dérivés de benzodiazépine et utilisation de ces derniers
LT2464645T (lt) 2009-07-27 2017-10-25 Gilead Sciences, Inc. Kondensuoti heterocikliniai junginiai, kaip jonų kanalų moduliatoriai
AR080374A1 (es) 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparcion de 2-(ciclohexilmetil)-n-(2-((2s)-1-metilpirrolidin-2-il) etil)- 1,2,3,4-tetrahidroisoquinolin-7- sulfonamida
BR112012033402A2 (pt) 2010-07-02 2017-01-24 Gilead Sciences Inc moduladores de canais de íons conforme os compostos heterocíclicos fundidos
PT2707361T (pt) * 2011-05-10 2017-11-28 Gilead Sciences Inc Compostos heterocíclicos fusionados como moduladores do canal de sódio
NO3175985T3 (fr) 2011-07-01 2018-04-28
TWI622583B (zh) 2011-07-01 2018-05-01 基利科學股份有限公司 作為離子通道調節劑之稠合雜環化合物
BR112017024555A2 (pt) 2015-05-21 2018-07-24 Chemocentryx Inc moduladores de ccr2
PE20190501A1 (es) 2016-08-01 2019-04-10 Aptinyx Inc Moduladores nmda espiro-lactam y metodos de uso de los mismos
PE20190503A1 (es) 2016-08-01 2019-04-10 Aptinyx Inc Moduladores del receptor nmda espiro-lactam y uso de los mismos
PE20190500A1 (es) 2016-08-01 2019-04-10 Aptinyx Inc Moduladores del receptor nmda spiro-lactam y uso de los mismos
CN111712242B (zh) 2017-09-25 2023-11-24 凯莫森特里克斯股份有限公司 使用趋化因子受体2(ccr2)拮抗剂和pd-1/pd-l1抑制剂的联合治疗
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
WO2019136368A2 (fr) 2018-01-08 2019-07-11 Chemocentryx, Inc. Procédés de traitement de tumeurs solides au moyen d'antagonistes du ccr2
US11578072B2 (en) * 2018-01-31 2023-02-14 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
CN111056955B (zh) * 2019-12-16 2021-05-25 中国科学院大连化学物理研究所 一种环己烯制备己二胺的方法

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2002013824A1 (fr) * 2000-08-17 2002-02-21 Merck & Co., Inc. Modulateurs cyclopentyles de l'activite du recepteur de la chimiokine
WO2003093231A2 (fr) * 2002-04-29 2003-11-13 Merck & Co., Inc. Modulateurs de l'activite des recepteurs des chimiokines a base de tetrahydropyranyl cyclopentyl tetrahydroisoquinoline

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SI1501507T1 (sl) * 2002-04-29 2008-12-31 Merck & Co Inc Tetrahidropiranil ciklopentil tetrahidropiridopiridin modulatorji s kemokinsko receptorsko aktivnostjo
AU2004232939A1 (en) * 2003-04-17 2004-11-04 Merck Sharp & Dohme Corp. Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2002013824A1 (fr) * 2000-08-17 2002-02-21 Merck & Co., Inc. Modulateurs cyclopentyles de l'activite du recepteur de la chimiokine
WO2003093231A2 (fr) * 2002-04-29 2003-11-13 Merck & Co., Inc. Modulateurs de l'activite des recepteurs des chimiokines a base de tetrahydropyranyl cyclopentyl tetrahydroisoquinoline

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CN100384856C (zh) 2008-04-30
AU2004232939A1 (en) 2004-11-04
EP1622916A2 (fr) 2006-02-08
JP2006523704A (ja) 2006-10-19
WO2004094371A2 (fr) 2004-11-04
WO2004094371A3 (fr) 2005-03-24
CA2521625A1 (fr) 2004-11-04
CN1805965A (zh) 2006-07-19

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