MA50423A - Procédés de traitement de tumeurs solides au moyen d'antagonistes du ccr2 - Google Patents
Procédés de traitement de tumeurs solides au moyen d'antagonistes du ccr2Info
- Publication number
- MA50423A MA50423A MA050423A MA50423A MA50423A MA 50423 A MA50423 A MA 50423A MA 050423 A MA050423 A MA 050423A MA 50423 A MA50423 A MA 50423A MA 50423 A MA50423 A MA 50423A
- Authority
- MA
- Morocco
- Prior art keywords
- solid tumor
- treatment methods
- tumor treatment
- ccr2 antagonists
- ccr2
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862614923P | 2018-01-08 | 2018-01-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA50423A true MA50423A (fr) | 2020-08-26 |
Family
ID=67139234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA050423A MA50423A (fr) | 2018-01-08 | 2019-01-07 | Procédés de traitement de tumeurs solides au moyen d'antagonistes du ccr2 |
Country Status (10)
Country | Link |
---|---|
US (2) | US11154556B2 (fr) |
EP (1) | EP3737367A4 (fr) |
JP (1) | JP7442141B2 (fr) |
CN (1) | CN112105353B (fr) |
AU (1) | AU2019205784A1 (fr) |
CA (1) | CA3087765A1 (fr) |
IL (1) | IL275898A (fr) |
MA (1) | MA50423A (fr) |
TW (1) | TW201938160A (fr) |
WO (1) | WO2019136368A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2020003192A (es) | 2017-09-25 | 2020-07-29 | Chemocentryx Inc | Terapia de combinacion usando un antagonista del receptor de quimiocina tipo 2 (ccr2) y un inhibidor de pd-1/pd-l1. |
US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
Family Cites Families (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1296978A2 (fr) | 2000-06-30 | 2003-04-02 | Bristol-Myers Squibb Company | N-ureidoheterocycloaklyl-piperidines utilises comme modulateurs de l'activite du recepteur de la chimiokine |
CA2419194C (fr) | 2000-08-17 | 2007-10-16 | Lihu Yang | Modulateurs cyclopentyles de l'activite du recepteur de la chimiokine |
ATE319703T1 (de) | 2001-07-02 | 2006-03-15 | Piperidinverbindungen, die sich als modulatoren der chemokinrezeptoraktivität eignen | |
US20060030582A1 (en) | 2002-04-29 | 2006-02-09 | Demartino Julie | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
PT1501507E (pt) | 2002-04-29 | 2008-08-12 | Merck Sharp & Dohme | Tetrahidropiranil ciclopentil tetrahidropiridopiridinas moduladoras da actividade dos receptores de quimioquinas |
WO2003093231A2 (fr) | 2002-04-29 | 2003-11-13 | Merck & Co., Inc. | Modulateurs de l'activite des recepteurs des chimiokines a base de tetrahydropyranyl cyclopentyl tetrahydroisoquinoline |
MY129850A (en) | 2002-04-29 | 2007-05-31 | Merck Sharp & Dohme | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
US7491737B2 (en) | 2002-10-30 | 2009-02-17 | Merck & Co., Inc. | Heterarylpiperidine modulators of chemokine receptor activity |
WO2004076411A2 (fr) | 2003-02-24 | 2004-09-10 | Merck & Co., Inc. | Modulateurs d'heterotricylicamide fusionne avec un aminocyclopentyl de l'activite des recepteurs de la chimiokine |
CA2519220A1 (fr) | 2003-03-18 | 2004-09-30 | Merck & Co., Inc. | Modulateurs amino cyclobutylamide de l'activite du recepteur de chimiokine |
AU2004231087B2 (en) | 2003-04-15 | 2007-01-04 | Merck Sharp & Dohme Corp. | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors |
JP2006523704A (ja) | 2003-04-17 | 2006-10-19 | メルク エンド カムパニー インコーポレーテッド | ケモカイン受容体活性ヘテロサイクリックシクロペンチルテトラヒドロイソキノリンおよびテトラヒドロピリドピリジンのモジュレーター |
US20060205761A1 (en) | 2003-06-06 | 2006-09-14 | Catherine Abbadie | Ccr-2 antagonists for treatment of neuropathic pain |
BRPI0415836A (pt) | 2003-10-27 | 2007-01-02 | Merck & Co Inc | composto, métodos para a modulação da atividade de receptor de quimocina em um mamìfero, e para o tratamento, a melhoria, o controle ou a redução do risco de uma doença ou distúrbio inflamatório e imunorregulatório, e de artrite reumatóide, composição farmacêutica |
AR045875A1 (es) | 2003-10-27 | 2005-11-16 | Merck & Co Inc | Procedimiento para la preparacion del antagonista ccr-2 |
AU2004313486A1 (en) | 2004-01-02 | 2005-07-28 | Merck & Co., Inc. | Alkylamino, arylamino, and sulfonamido cyclopentyl amide modulators of chemokine receptor activity |
US7700772B2 (en) | 2004-02-12 | 2010-04-20 | Merck Sharp & Dohme Corp. | Amino heterocyclic modulators of chemokine receptor activity |
JP2007537264A (ja) | 2004-05-11 | 2007-12-20 | インサイト コーポレイション | ケモカインレセプタのモジュレータとしての3−(4−ヘテロアリールシクロヘキシルアミノ)シクロペンタンカルボキサミド |
PA8653301A1 (es) | 2004-11-22 | 2006-11-09 | Incyte Corp Incyte Corp | Sales de la n-[2-({(3r)-1-[trans-4-hidroxi-4-(6-metoxipiridin-3-il) ciclohexil)pirrolidin |
AU2006204038A1 (en) | 2005-01-06 | 2006-07-13 | Merck & Co., Inc. | Drug combination therapy and pharmaceutical compositions for treating inflammatory disorders |
US8519135B2 (en) | 2006-07-14 | 2013-08-27 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2/CCR9 |
US7671062B2 (en) | 2006-07-28 | 2010-03-02 | Bristol-Myers Squibb Company | Modulators of chemokine receptor activity, crystalline forms and process |
AU2008266951B2 (en) | 2007-06-18 | 2013-12-12 | Merck Sharp & Dohme B.V. | Antibodies to human programmed death receptor PD-1 |
CA2692761C (fr) | 2007-07-12 | 2013-04-30 | Chemocentryx, Inc. | Heteroaryl-pyridyl- et phenyl-benzenesulfonamides condenses en tant que modulateurs du ccr2 pour le traitement de l'inflammation |
US8168757B2 (en) | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
DK2342226T3 (en) | 2008-09-26 | 2016-09-26 | Dana Farber Cancer Inst Inc | HUMAN ANTI-PD-1, PD-L1 AND PD-L2 ANTIBODIES AND APPLICATIONS THEREOF |
BRPI0923237A2 (pt) | 2008-12-10 | 2019-09-24 | Janssen Pharmaceutica Nv | compostos de 4-azetidinil-1-heteroaril-ciclohexanol antagonistas de ccr2 |
JP5844159B2 (ja) | 2009-02-09 | 2016-01-13 | ユニヴェルシテ デクス−マルセイユUniversite D’Aix−Marseille | Pd−1抗体およびpd−l1抗体ならびにその使用 |
NZ595431A (en) | 2009-04-16 | 2013-12-20 | Janssen Pharmaceutica Nv | 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of ccr2 |
CA2758934A1 (fr) | 2009-04-17 | 2010-10-21 | Janssen Pharmaceutica Nv | Antagonistes de ccr2 a base de 4-azetidinyl-1-phenyl-cyclohexane |
EA024397B1 (ru) | 2009-12-17 | 2016-09-30 | Сентрекшн Терапьютикс Корпорейшн | Новые антагонисты рецептора ccr2 и их применение |
US9040526B2 (en) | 2010-02-09 | 2015-05-26 | Bristol-Myers Squibb Company | Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity |
EP2569298B1 (fr) | 2010-05-12 | 2015-11-25 | Boehringer Ingelheim International GmbH | Nouveaux antagonistes du récepteur ccr2, son procédé de production et utilisation associée en tant que médicaments |
US8642622B2 (en) | 2010-06-16 | 2014-02-04 | Bristol-Myers Squibb Company | Piperidinyl compound as a modulator of chemokine receptor activity |
JP5936608B2 (ja) | 2010-06-17 | 2016-06-22 | ヤンセン ファーマシューティカ エヌ.ベー. | Ccr2のシクロヘキシル−アゼチジニルアンタゴニスト |
AU2012226890B2 (en) | 2011-03-10 | 2016-10-06 | Daiichi Sankyo Company, Limited | Dispiropyrrolidine derivative |
KR101981873B1 (ko) | 2011-11-28 | 2019-05-23 | 메르크 파텐트 게엠베하 | 항-pd-l1 항체 및 그의 용도 |
US8822460B2 (en) | 2012-04-06 | 2014-09-02 | Janssen Pharmaceutica Nv | Fused cyclopentyl antagonists of CCR2 |
CN104470949A (zh) | 2012-05-15 | 2015-03-25 | 百时美施贵宝公司 | 通过破坏pd-1/pd-l1信号传输的免疫治疗 |
EP2855528B1 (fr) | 2012-05-31 | 2019-06-19 | Genentech, Inc. | Procédés de traitement du cancer au moyen d'antagonistes liant l'axe pd-1 et d'antagonistes de vegf |
EP2864358B1 (fr) | 2012-06-22 | 2019-08-07 | Sorrento Therapeutics, Inc. | Protéines de liaison à un antigène qui se lient à ccr2 |
US9308236B2 (en) | 2013-03-15 | 2016-04-12 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions |
BR112015031073B1 (pt) * | 2013-06-21 | 2022-11-29 | Zenith Epigenetics Ltd | Compostos inibidores bicíclicos de bromodomínio e composição farmacêutica contendo os referidos compostos |
ES2827679T3 (es) | 2013-08-20 | 2021-05-24 | Merck Sharp & Dohme | Tratamiento del cáncer con una combinación de un antagonista de PD-1 y dinaciclib |
AU2014315457B2 (en) | 2013-09-04 | 2018-05-10 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗pd-l1之人類抗體 |
US9850225B2 (en) | 2014-04-14 | 2017-12-26 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
TN2017000084A1 (en) | 2014-09-11 | 2018-07-04 | Bristol Myers Squibb Co | Macrocyclic inhibitors of the pd-1/pd-l1 and cd80 (b7-1)/pd-li protein/protein interactions |
US9732119B2 (en) | 2014-10-10 | 2017-08-15 | Bristol-Myers Squibb Company | Immunomodulators |
US9856292B2 (en) | 2014-11-14 | 2018-01-02 | Bristol-Myers Squibb Company | Immunomodulators |
US9861680B2 (en) | 2014-12-18 | 2018-01-09 | Bristol-Myers Squibb Company | Immunomodulators |
US9944678B2 (en) | 2014-12-19 | 2018-04-17 | Bristol-Myers Squibb Company | Immunomodulators |
US20160222060A1 (en) | 2015-02-04 | 2016-08-04 | Bristol-Myers Squibb Company | Immunomodulators |
US9809625B2 (en) | 2015-03-18 | 2017-11-07 | Bristol-Myers Squibb Company | Immunomodulators |
EP3297438B1 (fr) * | 2015-05-21 | 2021-10-20 | ChemoCentryx, Inc. | Modulateurs du ccr2 |
WO2017165125A1 (fr) * | 2016-03-24 | 2017-09-28 | Millennium Pharmaceuticals, Inc. | Utilisation d'un antagoniste de pd-1 et d'un anticorps anti-ccr2 dans le traitement du cancer |
US10195188B2 (en) | 2016-06-13 | 2019-02-05 | Chemocentryx, Inc. | Method of treating pancreatic cancer |
US10251888B2 (en) | 2016-06-13 | 2019-04-09 | Chemocentryx, Inc. | Method of treating pancreatic cancer |
CA3029256A1 (fr) * | 2016-06-27 | 2018-01-04 | Chemocentryx, Inc. | Composes immunomodulateurs |
MX2020003192A (es) | 2017-09-25 | 2020-07-29 | Chemocentryx Inc | Terapia de combinacion usando un antagonista del receptor de quimiocina tipo 2 (ccr2) y un inhibidor de pd-1/pd-l1. |
US20190275015A1 (en) | 2017-09-25 | 2019-09-12 | Chemocentryx, Inc. | Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor |
US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
-
2019
- 2019-01-07 EP EP19735699.1A patent/EP3737367A4/fr active Pending
- 2019-01-07 US US16/241,391 patent/US11154556B2/en active Active
- 2019-01-07 MA MA050423A patent/MA50423A/fr unknown
- 2019-01-07 CN CN201980017482.2A patent/CN112105353B/zh active Active
- 2019-01-07 JP JP2020537565A patent/JP7442141B2/ja active Active
- 2019-01-07 WO PCT/US2019/012515 patent/WO2019136368A2/fr unknown
- 2019-01-07 AU AU2019205784A patent/AU2019205784A1/en active Pending
- 2019-01-07 CA CA3087765A patent/CA3087765A1/fr active Pending
- 2019-01-08 TW TW108100692A patent/TW201938160A/zh unknown
-
2020
- 2020-07-07 IL IL275898A patent/IL275898A/en unknown
-
2021
- 2021-09-22 US US17/481,829 patent/US20220241290A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3737367A4 (fr) | 2022-11-09 |
CA3087765A1 (fr) | 2019-07-11 |
EP3737367A2 (fr) | 2020-11-18 |
US20190209573A1 (en) | 2019-07-11 |
JP7442141B2 (ja) | 2024-03-04 |
JP2021509678A (ja) | 2021-04-01 |
IL275898A (en) | 2020-08-31 |
US20220241290A1 (en) | 2022-08-04 |
CN112105353B (zh) | 2024-04-19 |
TW201938160A (zh) | 2019-10-01 |
AU2019205784A1 (en) | 2020-07-30 |
WO2019136368A3 (fr) | 2020-04-16 |
US11154556B2 (en) | 2021-10-26 |
WO2019136368A2 (fr) | 2019-07-11 |
CN112105353A (zh) | 2020-12-18 |
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