JP7442141B2 - Ccr2アンタゴニストによる固形腫瘍の治療方法 - Google Patents

Ccr2アンタゴニストによる固形腫瘍の治療方法 Download PDF

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JP7442141B2
JP7442141B2 JP2020537565A JP2020537565A JP7442141B2 JP 7442141 B2 JP7442141 B2 JP 7442141B2 JP 2020537565 A JP2020537565 A JP 2020537565A JP 2020537565 A JP2020537565 A JP 2020537565A JP 7442141 B2 JP7442141 B2 JP 7442141B2
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alkyl
group
compound
tumor
heteroaryl
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JP2021509678A (ja
JPWO2019136368A5 (fr
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ジェイ.キャンベル ジェイムズ
シン ラジンダー
ファン サミュエル
ウー シュエソン
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University of California
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020537565A 2018-01-08 2019-01-07 Ccr2アンタゴニストによる固形腫瘍の治療方法 Active JP7442141B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862614923P 2018-01-08 2018-01-08
US62/614,923 2018-01-08
PCT/US2019/012515 WO2019136368A2 (fr) 2018-01-08 2019-01-07 Procédés de traitement de tumeurs solides au moyen d'antagonistes du ccr2

Publications (3)

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JP2021509678A JP2021509678A (ja) 2021-04-01
JPWO2019136368A5 JPWO2019136368A5 (fr) 2022-01-18
JP7442141B2 true JP7442141B2 (ja) 2024-03-04

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US (2) US11154556B2 (fr)
EP (1) EP3737367A4 (fr)
JP (1) JP7442141B2 (fr)
CN (1) CN112105353B (fr)
AU (1) AU2019205784A1 (fr)
CA (1) CA3087765A1 (fr)
IL (1) IL275898A (fr)
MA (1) MA50423A (fr)
TW (1) TW201938160A (fr)
WO (1) WO2019136368A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR112831A1 (es) 2017-09-25 2019-12-18 Chemocentryx Inc Terapia de combinación usando un antagonista del receptor 2 de quimiocina (ccr2) y un inhibidor de pd-1 / pd-l1
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists

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JP2016523259A (ja) 2013-06-21 2016-08-08 ゼニス・エピジェネティクス・コーポレイションZenith Epigenetics Corp. 新規の二環式ブロモドメイン阻害剤
WO2016187393A1 (fr) 2015-05-21 2016-11-24 Chemocentryx, Inc. Modulateurs du ccr2
WO2017165125A1 (fr) 2016-03-24 2017-09-28 Millennium Pharmaceuticals, Inc. Utilisation d'un antagoniste de pd-1 et d'un anticorps anti-ccr2 dans le traitement du cancer

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Also Published As

Publication number Publication date
US11154556B2 (en) 2021-10-26
US20220241290A1 (en) 2022-08-04
EP3737367A4 (fr) 2022-11-09
JP2021509678A (ja) 2021-04-01
IL275898A (en) 2020-08-31
AU2019205784A1 (en) 2020-07-30
TW201938160A (zh) 2019-10-01
CA3087765A1 (fr) 2019-07-11
CN112105353A (zh) 2020-12-18
MA50423A (fr) 2020-08-26
EP3737367A2 (fr) 2020-11-18
US20190209573A1 (en) 2019-07-11
WO2019136368A2 (fr) 2019-07-11
CN112105353B (zh) 2024-04-19
WO2019136368A3 (fr) 2020-04-16

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