BRPI0923237A2 - compostos de 4-azetidinil-1-heteroaril-ciclohexanol antagonistas de ccr2 - Google Patents
compostos de 4-azetidinil-1-heteroaril-ciclohexanol antagonistas de ccr2Info
- Publication number
- BRPI0923237A2 BRPI0923237A2 BRPI0923237A BRPI0923237A BRPI0923237A2 BR PI0923237 A2 BRPI0923237 A2 BR PI0923237A2 BR PI0923237 A BRPI0923237 A BR PI0923237A BR PI0923237 A BRPI0923237 A BR PI0923237A BR PI0923237 A2 BRPI0923237 A2 BR PI0923237A2
- Authority
- BR
- Brazil
- Prior art keywords
- azetidinyl
- heteroaryl
- ccr2 antagonist
- cyclohexanol compounds
- cyclohexanol
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12127208P | 2008-12-10 | 2008-12-10 | |
US16729509P | 2009-04-07 | 2009-04-07 | |
PCT/US2009/067307 WO2010068663A1 (en) | 2008-12-10 | 2009-12-09 | 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2 |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0923237A2 true BRPI0923237A2 (pt) | 2019-09-24 |
Family
ID=41510894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0923237A BRPI0923237A2 (pt) | 2008-12-10 | 2009-12-09 | compostos de 4-azetidinil-1-heteroaril-ciclohexanol antagonistas de ccr2 |
Country Status (28)
Country | Link |
---|---|
US (1) | US8450304B2 (pt) |
EP (1) | EP2376475B1 (pt) |
JP (1) | JP5782381B2 (pt) |
KR (1) | KR20110094325A (pt) |
CN (1) | CN102317278B (pt) |
AR (1) | AR074583A1 (pt) |
AU (1) | AU2009324723B2 (pt) |
BR (1) | BRPI0923237A2 (pt) |
CA (1) | CA2745969C (pt) |
CL (1) | CL2011001427A1 (pt) |
CO (1) | CO6331470A2 (pt) |
CR (1) | CR20110381A (pt) |
EA (1) | EA018997B1 (pt) |
EC (1) | ECSP11011124A (pt) |
ES (1) | ES2555004T3 (pt) |
HN (1) | HN2011001606A (pt) |
IL (1) | IL213250A0 (pt) |
MX (1) | MX2011006226A (pt) |
NI (1) | NI201100117A (pt) |
NZ (1) | NZ593172A (pt) |
PA (1) | PA8853001A1 (pt) |
PE (1) | PE20110928A1 (pt) |
SG (1) | SG171998A1 (pt) |
SV (1) | SV2011003944A (pt) |
TW (1) | TW201033204A (pt) |
UY (1) | UY32312A (pt) |
WO (1) | WO2010068663A1 (pt) |
ZA (1) | ZA201105056B (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5782381B2 (ja) | 2008-12-10 | 2015-09-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプJanssen Pharmaceutica Naamloze Vennootschap | Ccr2の4−アゼチジニル−1−ヘテロアリール−シクロヘキサノールアンタゴニスト |
KR20120061060A (ko) * | 2009-04-16 | 2012-06-12 | 얀센 파마슈티카 엔.브이. | Ccr2의 4-아제티디닐-1-헤테로아릴-사이클로헥산 길항제 |
EP2419419B1 (en) * | 2009-04-17 | 2014-12-03 | Janssen Pharmaceutica NV | 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2 |
BRPI1016205A2 (pt) * | 2009-04-17 | 2016-04-19 | Janssen Pharmaceutica Nv | compostos de cicloexano ligado a 4-azetidinil-1-heteroátomo antagonistas de ccr2 |
TW201211027A (en) * | 2010-06-09 | 2012-03-16 | Janssen Pharmaceutica Nv | Cyclohexyl-azetidinyl antagonists of CCR2 |
MX2012014934A (es) * | 2010-06-17 | 2013-05-20 | Janssen Pharmaceutica Nv | Antagonistas de ciclohexilacetindinilo del receptor de la citocina quimioatrayente 2. |
CA2852160A1 (en) | 2011-10-28 | 2013-05-02 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
CN108135168B (zh) | 2015-05-21 | 2021-07-20 | 凯莫森特里克斯股份有限公司 | Ccr2调节剂 |
MX2020003192A (es) | 2017-09-25 | 2020-07-29 | Chemocentryx Inc | Terapia de combinacion usando un antagonista del receptor de quimiocina tipo 2 (ccr2) y un inhibidor de pd-1/pd-l1. |
CN107793404A (zh) * | 2017-11-07 | 2018-03-13 | 全椒先奇医药科技有限公司 | 一种治疗缺血性脑损伤药物组合物及其应用 |
US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
JP7442141B2 (ja) | 2018-01-08 | 2024-03-04 | ケモセントリックス,インコーポレイティド | Ccr2アンタゴニストによる固形腫瘍の治療方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998057641A1 (en) | 1997-06-18 | 1998-12-23 | Merck & Co., Inc. | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS |
US6037354A (en) * | 1997-06-18 | 2000-03-14 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonists |
CA2378499A1 (en) * | 1999-08-04 | 2001-02-15 | Teijin Limited | Cyclic amine ccr3 antagonists |
BR0015401A (pt) | 1999-11-08 | 2002-07-02 | Wyeth Corp | [(indol-3-il)-cicloalquil]-3-azetidinas substituìdas para o tratamento de distúrbios do sistema nervoso central |
US6245799B1 (en) * | 1999-11-08 | 2001-06-12 | American Home Products Corp | [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders |
EP1343751A2 (en) * | 2000-12-20 | 2003-09-17 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
UA87449C2 (ru) * | 2002-11-27 | 2009-07-27 | Инсайт Корпорейшн | Производные 3-аминопиролидина как модуляторы рецепторов хемокина |
ATE555087T1 (de) * | 2002-11-27 | 2012-05-15 | Incyte Corp | 3-aminopyrrolidinderivate als modulatoren von chemokinrezeptoren |
US7576089B2 (en) | 2003-12-18 | 2009-08-18 | Incyte Corporation | 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors |
CA2582225A1 (en) * | 2004-09-28 | 2006-04-06 | Mingde Xia | Substituted dipiperdine ccr2 antagonists |
US20060073592A1 (en) * | 2004-10-06 | 2006-04-06 | Wendell Sun | Methods of storing tissue matrices |
PA8653301A1 (es) * | 2004-11-22 | 2006-11-09 | Incyte Corp Incyte Corp | Sales de la n-[2-({(3r)-1-[trans-4-hidroxi-4-(6-metoxipiridin-3-il) ciclohexil)pirrolidin |
GB0513747D0 (en) | 2005-07-06 | 2005-08-10 | Merck Sharp & Dohme | Therapeutic compounds |
WO2007053498A1 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
US20070197590A1 (en) | 2006-01-31 | 2007-08-23 | Demong Duane E | Substituted dipiperidine ccr2 antagonists |
JP5782381B2 (ja) | 2008-12-10 | 2015-09-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプJanssen Pharmaceutica Naamloze Vennootschap | Ccr2の4−アゼチジニル−1−ヘテロアリール−シクロヘキサノールアンタゴニスト |
KR20120061060A (ko) * | 2009-04-16 | 2012-06-12 | 얀센 파마슈티카 엔.브이. | Ccr2의 4-아제티디닐-1-헤테로아릴-사이클로헥산 길항제 |
EP2419419B1 (en) * | 2009-04-17 | 2014-12-03 | Janssen Pharmaceutica NV | 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2 |
BRPI1016205A2 (pt) | 2009-04-17 | 2016-04-19 | Janssen Pharmaceutica Nv | compostos de cicloexano ligado a 4-azetidinil-1-heteroátomo antagonistas de ccr2 |
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