NI201100117A - Antagonistas de 4 -- azetidinil - 1 - heteroaril - ciclohexanol del ccr2. - Google Patents

Antagonistas de 4 -- azetidinil - 1 - heteroaril - ciclohexanol del ccr2.

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Publication number
NI201100117A
NI201100117A NI201100117A NI201100117A NI201100117A NI 201100117 A NI201100117 A NI 201100117A NI 201100117 A NI201100117 A NI 201100117A NI 201100117 A NI201100117 A NI 201100117A NI 201100117 A NI201100117 A NI 201100117A
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NI
Nicaragua
Prior art keywords
ccr2
azetidinyl
cyclohexanol
antagonists
heteroaryl
Prior art date
Application number
NI201100117A
Other languages
English (en)
Inventor
Zhang Xuqing
Rae Hufnagel Heather
Hou Cuifen
L Johnson Dana
Sui Zhihua
Fegely Barry
Breslin David
Original Assignee
Janssen Pharmaceutica Nv
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41510894&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NI201100117(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NI201100117A publication Critical patent/NI201100117A/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

La presente invención comprende los compuestos de la fórmula (I) en donde: R1, R2, R3, y R4 son como se definió en la descripción. La invención comprende, además, las composiciones farmacéuticas que comprenden los compuestos de la fórmula (I) y los métodos para prevenir, tratar o mejorar un síndrome, trastorno o enfermedad mediada por el CCR2, por ejemplo, la diabetes tipo II, la obesidad o asma, al administrar los compuestos de la fórmula (I).
NI201100117A 2008-12-10 2011-06-09 Antagonistas de 4 -- azetidinil - 1 - heteroaril - ciclohexanol del ccr2. NI201100117A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12127208P 2008-12-10 2008-12-10
US16729509P 2009-04-07 2009-04-07

Publications (1)

Publication Number Publication Date
NI201100117A true NI201100117A (es) 2012-06-13

Family

ID=41510894

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201100117A NI201100117A (es) 2008-12-10 2011-06-09 Antagonistas de 4 -- azetidinil - 1 - heteroaril - ciclohexanol del ccr2.

Country Status (28)

Country Link
US (1) US8450304B2 (es)
EP (1) EP2376475B1 (es)
JP (1) JP5782381B2 (es)
KR (1) KR20110094325A (es)
CN (1) CN102317278B (es)
AR (1) AR074583A1 (es)
AU (1) AU2009324723B2 (es)
BR (1) BRPI0923237A2 (es)
CA (1) CA2745969C (es)
CL (1) CL2011001427A1 (es)
CO (1) CO6331470A2 (es)
CR (1) CR20110381A (es)
EA (1) EA018997B1 (es)
EC (1) ECSP11011124A (es)
ES (1) ES2555004T3 (es)
HN (1) HN2011001606A (es)
IL (1) IL213250A0 (es)
MX (1) MX2011006226A (es)
NI (1) NI201100117A (es)
NZ (1) NZ593172A (es)
PA (1) PA8853001A1 (es)
PE (1) PE20110928A1 (es)
SG (1) SG171998A1 (es)
SV (1) SV2011003944A (es)
TW (1) TW201033204A (es)
UY (1) UY32312A (es)
WO (1) WO2010068663A1 (es)
ZA (1) ZA201105056B (es)

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AU2010236393B2 (en) * 2009-04-16 2014-11-13 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of CCR2
EP2419418B1 (en) * 2009-04-17 2015-04-15 Janssen Pharmaceutica NV 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2
MX2011010964A (es) * 2009-04-17 2011-11-02 Janssen Pharmaceutica Nv Antagonistas del receptor 2 de citocina quimioatrayente de 4- azetidinil-1-fenil-ciclohexano.
TW201211027A (en) * 2010-06-09 2012-03-16 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of CCR2
WO2011159854A1 (en) 2010-06-17 2011-12-22 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of ccr2
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CN108135168B (zh) 2015-05-21 2021-07-20 凯莫森特里克斯股份有限公司 Ccr2调节剂
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AU2010236393B2 (en) * 2009-04-16 2014-11-13 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of CCR2
MX2011010964A (es) * 2009-04-17 2011-11-02 Janssen Pharmaceutica Nv Antagonistas del receptor 2 de citocina quimioatrayente de 4- azetidinil-1-fenil-ciclohexano.
EP2419418B1 (en) 2009-04-17 2015-04-15 Janssen Pharmaceutica NV 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2

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AU2009324723A1 (en) 2010-06-17
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CN102317278B (zh) 2016-01-06
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US8450304B2 (en) 2013-05-28
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