AR074583A1 - 4-azetidinil-1-heteroaril-ciclohexanol antagonistas del ccr2 - Google Patents

4-azetidinil-1-heteroaril-ciclohexanol antagonistas del ccr2

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Publication number
AR074583A1
AR074583A1 ARP090104791A ARP090104791A AR074583A1 AR 074583 A1 AR074583 A1 AR 074583A1 AR P090104791 A ARP090104791 A AR P090104791A AR P090104791 A ARP090104791 A AR P090104791A AR 074583 A1 AR074583 A1 AR 074583A1
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AR
Argentina
Prior art keywords
alkyl
optionally substituted
group
pyridyl
onyl
Prior art date
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ARP090104791A
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English (en)
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Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR074583A1 publication Critical patent/AR074583A1/es

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
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  • Physical Education & Sports Medicine (AREA)

Abstract

Composiciones farmacéuticas que comprenden los compuestos con la fórmula (1) y su uso para prevenir, tratar o aminorar síndromes, trastornos o enfermedades mediados por CCR2, por ejemplo, diabetes tipo II, obesidad o asma. Reivindicación 1: Un compuesto de fórmula (1) en donde R1 es como uno cualquiera de los grupos de fórmulas (2), piridil, óxido de N-piridil, 1H-pirid1n-2-onil, indolil, pirazinil, 3-H-tiazol-2-onil, pirimidil, benzooxazolil, oxazolil, tiazolil, isotiazolil, pirazolil, imidazolil, tiofenil, furil, [1,2,4]oxadiazolil o [1,3,4]tiadiazolil; en donde el piridil, óxido de N-piridil, pirimidil, pirazolil, imidazolil, tiofenil, o tiazolil se sustituye opcionalmente con un sustituyente seleccionado del grupo consistente de O-alquil C1-4, O-cicloalquil C3-6, OCH2CF3, OCH2Ph, F, CN, CH2CN, alquil C1-4, CH2CF3, N(alquil C1-4)2, alquil C1-4OH, Si(CH3)3, -C:::CH, SCH3, S(O)CH3, SO2CH3, pirrolidinil, OH, NH2, NHCN, CO2H, CONH2, NHCO2-alquil C1-4, N(SO2CH3)2, NHSO2CH3, NHC(O)CF3, NHalquil C1-4, NHCO2H, NHCO2alquil C1-4, NHCOalquil C1-4, NHCONH2, NHCONHalquil C1-4 y Br o el piridil puede sustituirse con un grupo OCH3 y un CH3; o en donde el pirimidil se sustituye opcionalmente con un grupo N(C1-4 alquil)2 o uno o dos grupos OCH3; o en donde el tiazolil se sustituye opcionalmente en dos átomos de carbono adyacentes para formar sistema bicíclico fusionado de benzotiazol-2-il, o en donde el benzotiazol-2-iI se sustituye opcionalmente con Br o OCH3; o en donde el 1H-piridin-2-onil se sustituye opcionalmente con un sustituyente seleccionado del grupo consistente de CH2CN, alquil C1-4, CH2CF3, y CH2CH2OH, o el 1H-piridin-2-onil puede sustituirse opcionalmente con hasta 2 grupos metilo; o en donde el [1,2,4)oxadiazolil se sustituye opcionalmente con cualquier átomo de carbono con CCl3, o pirrolidinil o, de forma alternativa, ambos hidrógenos en el átomo de carbono del [1,2,4]oxadiazolil pueden reemplazarse con un grupo oxo; R2 es alquil C1-4, NH2, NO2, NHCH2CH2OH, N(alquil C1-4)2, N(SO2CH3)2, CN, F, CI, Br, CF3, cicloalquil C3-6, heterociclil, OCF3, OCF2H, CF2H, o O-alquil C1-4; R3 es H, F, CI, CF3, o O-alquil C1-4, de forma alternativa, R2 y R3 pueden tomarse juntos con su fenil adjunto para formar un benzo[1,3]dioxolil, 2,3-dihidro-benzofuranil, o un grupo 2,3-dihidro-benzo[1,4]dioxinil; R4 es H, O-alquil C1-4 o F; y solvatos, hidratos, tautómeros, profármacos y sales farmacéuticamente o aceptables de éstos.
ARP090104791A 2008-12-10 2009-12-10 4-azetidinil-1-heteroaril-ciclohexanol antagonistas del ccr2 AR074583A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12127208P 2008-12-10 2008-12-10
US16729509P 2009-04-07 2009-04-07

Publications (1)

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AR074583A1 true AR074583A1 (es) 2011-01-26

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ARP090104791A AR074583A1 (es) 2008-12-10 2009-12-10 4-azetidinil-1-heteroaril-ciclohexanol antagonistas del ccr2

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US (1) US8450304B2 (es)
EP (1) EP2376475B1 (es)
JP (1) JP5782381B2 (es)
KR (1) KR20110094325A (es)
CN (1) CN102317278B (es)
AR (1) AR074583A1 (es)
AU (1) AU2009324723B2 (es)
BR (1) BRPI0923237A2 (es)
CA (1) CA2745969C (es)
CL (1) CL2011001427A1 (es)
CO (1) CO6331470A2 (es)
CR (1) CR20110381A (es)
EA (1) EA018997B1 (es)
EC (1) ECSP11011124A (es)
ES (1) ES2555004T3 (es)
HN (1) HN2011001606A (es)
IL (1) IL213250A0 (es)
MX (1) MX2011006226A (es)
NI (1) NI201100117A (es)
NZ (1) NZ593172A (es)
PA (1) PA8853001A1 (es)
PE (1) PE20110928A1 (es)
SG (1) SG171998A1 (es)
SV (1) SV2011003944A (es)
TW (1) TW201033204A (es)
UY (1) UY32312A (es)
WO (1) WO2010068663A1 (es)
ZA (1) ZA201105056B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5782381B2 (ja) 2008-12-10 2015-09-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ Ｃｃｒ２の４−アゼチジニル−１−ヘテロアリール−シクロヘキサノールアンタゴニスト
KR20120061060A (ko) * 2009-04-16 2012-06-12 얀센 파마슈티카 엔.브이. Ｃｃｒ2의 4-아제티디닐-1-헤테로아릴-사이클로헥산 길항제
EP2419419B1 (en) * 2009-04-17 2014-12-03 Janssen Pharmaceutica NV 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2
BRPI1016205A2 (pt) * 2009-04-17 2016-04-19 Janssen Pharmaceutica Nv compostos de cicloexano ligado a 4-azetidinil-1-heteroátomo antagonistas de ccr2
TW201211027A (en) * 2010-06-09 2012-03-16 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of CCR2
MX2012014934A (es) * 2010-06-17 2013-05-20 Janssen Pharmaceutica Nv Antagonistas de ciclohexilacetindinilo del receptor de la citocina quimioatrayente 2.
CA2852160A1 (en) 2011-10-28 2013-05-02 Galderma Research & Development New leukocyte infiltrate markers for rosacea and uses thereof
CN108135168B (zh) 2015-05-21 2021-07-20 凯莫森特里克斯股份有限公司 Ccr2调节剂
MX2020003192A (es) 2017-09-25 2020-07-29 Chemocentryx Inc Terapia de combinacion usando un antagonista del receptor de quimiocina tipo 2 (ccr2) y un inhibidor de pd-1/pd-l1.
CN107793404A (zh) * 2017-11-07 2018-03-13 全椒先奇医药科技有限公司 一种治疗缺血性脑损伤药物组合物及其应用
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
JP7442141B2 (ja) 2018-01-08 2024-03-04 ケモセントリックス，インコーポレイティド Ｃｃｒ２アンタゴニストによる固形腫瘍の治療方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998057641A1 (en) 1997-06-18 1998-12-23 Merck & Co., Inc. ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS
US6037354A (en) * 1997-06-18 2000-03-14 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
CA2378499A1 (en) * 1999-08-04 2001-02-15 Teijin Limited Cyclic amine ccr3 antagonists
BR0015401A (pt) 1999-11-08 2002-07-02 Wyeth Corp [(indol-3-il)-cicloalquil]-3-azetidinas substituìdas para o tratamento de distúrbios do sistema nervoso central
US6245799B1 (en) * 1999-11-08 2001-06-12 American Home Products Corp [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders
EP1343751A2 (en) * 2000-12-20 2003-09-17 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
UA87449C2 (ru) * 2002-11-27 2009-07-27 Инсайт Корпорейшн Производные 3-аминопиролидина как модуляторы рецепторов хемокина
ATE555087T1 (de) * 2002-11-27 2012-05-15 Incyte Corp 3-aminopyrrolidinderivate als modulatoren von chemokinrezeptoren
US7576089B2 (en) 2003-12-18 2009-08-18 Incyte Corporation 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
CA2582225A1 (en) * 2004-09-28 2006-04-06 Mingde Xia Substituted dipiperdine ccr2 antagonists
US20060073592A1 (en) * 2004-10-06 2006-04-06 Wendell Sun Methods of storing tissue matrices
PA8653301A1 (es) * 2004-11-22 2006-11-09 Incyte Corp Incyte Corp Sales de la n-[2-({(3r)-1-[trans-4-hidroxi-4-(6-metoxipiridin-3-il) ciclohexil)pirrolidin
GB0513747D0 (en) 2005-07-06 2005-08-10 Merck Sharp & Dohme Therapeutic compounds
WO2007053498A1 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
US20070197590A1 (en) 2006-01-31 2007-08-23 Demong Duane E Substituted dipiperidine ccr2 antagonists
JP5782381B2 (ja) 2008-12-10 2015-09-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ Ｃｃｒ２の４−アゼチジニル−１−ヘテロアリール−シクロヘキサノールアンタゴニスト
KR20120061060A (ko) * 2009-04-16 2012-06-12 얀센 파마슈티카 엔.브이. Ｃｃｒ2의 4-아제티디닐-1-헤테로아릴-사이클로헥산 길항제
EP2419419B1 (en) * 2009-04-17 2014-12-03 Janssen Pharmaceutica NV 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2
BRPI1016205A2 (pt) 2009-04-17 2016-04-19 Janssen Pharmaceutica Nv compostos de cicloexano ligado a 4-azetidinil-1-heteroátomo antagonistas de ccr2

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