AR082562A1 - Derivados de isoxazolina como agentes antiparasitarios - Google Patents
Derivados de isoxazolina como agentes antiparasitariosInfo
- Publication number
- AR082562A1 AR082562A1 ARP110102823A ARP110102823A AR082562A1 AR 082562 A1 AR082562 A1 AR 082562A1 AR P110102823 A ARP110102823 A AR P110102823A AR P110102823 A ARP110102823 A AR P110102823A AR 082562 A1 AR082562 A1 AR 082562A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cyano
- halo
- haloalkyl
- cycloalkyl
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Composiciones de los mismos y su uso como un parasiticida en mamíferos y aves.Reivindicación 1: Un compuesto de fórmula (1) en la que A es fenilo, naftilo o heteroarilo en donde dicho heteroarilo contiene de 1 a 4 heteroátomos seleccionados cada uno de ellos independientemente entre N, O y S; cada uno de R1a, R1b y R1c es independientemente hidrógeno, halo, hidroxilo, ciano, nitro, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, alquil C0-3-cicloalquilo C3-6, haloalcoxi C1-6, -C(O)NH2, -SF5 o -S(O)pR; R2 es halo, ciano, alquilo C1-6, haloalquilo C1-6, nitro, hidroxilo, -C(O)NRaRb, alquenilo C2-6, alquinilo C2-6, -S(O)pR u -OR; R3 es hidrógeno, halo, hidroxilo, ciano, alquilo C1-6, haloalquilo C1-6, alquil C0-3-cicloalquilo C3-6, -C(O)NH2, nitro, -SC(O)R, -C(O)NRaRb, alquil C0-3NRaR4, -NRaNRbR4, -NRaORb, -ONRaRb, N3, -NHR4, -OR o -S(O)pR; R4 es hidrógeno, alquilo C1-6, alquil C0-6-cicloalquilo C3-6, -C(O)R5, -C(S)R5, -C(O)NRaR5, -C(O)C(O)NRaR5, -S(O)pRc, -S(O)2NRaR5, -C(NR7)R5, -C(NR7)NRaR5, fenilalquilo C0-6, heteroarilalquilo C0-6 o heterocicloalquilo C0-6; R5 es hidrógeno, alquilo C1-6, alquenilo C2-6, alquil C0-6-cicloalquilo C3-6, fenilalquilo C0-6, heteroarilalquilo C0-6 o heterocicloalquilo C0-6; R6 es ciano, alquilo C1-6, haloalquilo C1-6, -C(O)NRaRb, alquenilo C2-6, alquinilo C2-6, haloalquenilo C2-6 o haloalquinilo C2-6; R7 es hidrógeno, alquilo C1-6, hidroxilo, ciano, nitro, S(O)pRc o alcoxi C1-6; R es alquilo C1-6 o cicloalquilo C3-6, cada uno opcionalmente sustituido con al menos un halo; Ra es hidrógeno, alquilo C1-6 o alquil C0-3-cicloalquilo C3-6 en donde el alquilo y el alquilcicloalquilo están opcionalmente sustituidos con ciano o al menos un sustituyente halo; Rb es hidrógeno, alquilo C1-6, cicloalquilo C3-6, fenilalquilo C0-3, heteroarilalquilo C0-3 o heterocicloalquilo C0-3, cada uno opcionalmente sustituido, cuando sea químicamente posible, con al menos un sustituyente seleccionado entre hidroxilo, ciano, halo o -S(O)pR; Rc es alquilo C1-6, haloalquilo C1-6, haloalquil C1-6-cicloalquilo C3-6, alquil C0-3-cicloalquilo C3-6, fenilalquilo C0-3, heteroarilalquilo C0-3 o heterocicloalquilo C0-3, cada uno opcionalmente sustituido con al menos un sustituyente seleccionado entre ciano, halo, hidroxilo, oxo, alcoxi C1-6, haloalcoxi C1-6, haloalquilo C1-6, -S(O)pR, -SH, S(O)pNRaRb, NRaRb, -NRaC(O)Rb, -SC(O)Rb, -SCN o -C(O)NRaRb; cada uno de R4 y R5 alquilo C1-6 o alquil C0-6-cicloalquilo C3-6 puede estar opcional e independientemente sustituido con al menos un sustituyente seleccionado entre ciano, halo, hidroxilo, oxo, alcoxi C1-6, haloalcoxi C1-6, haloalquilo C1-6, S(O)pRc, -SH, -S(O)pNRaRb, -NRaRb, -NRaC(O)Rb, -SC(O)Rc, -SCN o -C(O)NRaRb; y donde los restos R4 y R5 fenilalquilo C0-6, heteroarilalquilo C0-6 o heterocicloalquilo C0-6 pueden estar además opcionalmente sustituidos con al menos un sustituyente seleccionado entre ciano, halo, oxo, =S, =NR7, hidroxilo, alcoxi C1-6, alquilo C1-6, haloalquilo C1-6, -SH, -S(O)pR y haloalcoxi C1-6; n es el número entero 0, 1 ó 2, y cuando n es 2, cada R2 puede ser idéntico o diferente entre sí; y p es el número entero 0, 1 ó 2; y sales farmacéutica o veterinariamente aceptables de los mismos.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37101410P | 2010-08-05 | 2010-08-05 | |
US201161445221P | 2011-02-22 | 2011-02-22 | |
US201161451888P | 2011-03-11 | 2011-03-11 | |
US201161486831P | 2011-05-17 | 2011-05-17 | |
US201161490811P | 2011-05-27 | 2011-05-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR082562A1 true AR082562A1 (es) | 2012-12-19 |
Family
ID=45556573
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110102823A AR082562A1 (es) | 2010-08-05 | 2011-08-04 | Derivados de isoxazolina como agentes antiparasitarios |
Country Status (18)
Country | Link |
---|---|
US (1) | US8415310B2 (es) |
EP (1) | EP2601190B1 (es) |
JP (1) | JP5409968B2 (es) |
KR (1) | KR101508862B1 (es) |
CN (1) | CN103270036B (es) |
AR (1) | AR082562A1 (es) |
AU (1) | AU2011287323B2 (es) |
BR (1) | BR112013002871B1 (es) |
CA (1) | CA2807005C (es) |
CL (1) | CL2013000352A1 (es) |
CO (1) | CO6680631A2 (es) |
ES (1) | ES2682303T3 (es) |
HK (1) | HK1184780A1 (es) |
MX (1) | MX2013001437A (es) |
NZ (1) | NZ606194A (es) |
RU (1) | RU2551354C2 (es) |
UY (1) | UY33545A (es) |
WO (1) | WO2012017359A1 (es) |
Families Citing this family (49)
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TWI487486B (zh) | 2009-12-01 | 2015-06-11 | Syngenta Participations Ag | 以異唑啉衍生物為主之殺蟲化合物 |
CN103562190A (zh) * | 2011-03-22 | 2014-02-05 | 佐蒂斯有限责任公司 | 作为抗寄生虫药的异噁唑啉衍生物 |
WO2012155352A1 (en) | 2011-05-19 | 2012-11-22 | Eli Lilly And Company | Dihydroisoxazole compounds, parasiticidal uses and formulations thereof |
KR102081036B1 (ko) | 2011-09-12 | 2020-02-24 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 이속사졸 활성화제를 포함하는 구충 조성물, 이의 용도 및 구충 방법 |
WO2013116236A1 (en) | 2012-02-03 | 2013-08-08 | Zoetis Llc | Process for the preparation of chiral isoxazoline azetidine derivatives as antiparasitic agents |
PL2814825T3 (pl) * | 2012-02-03 | 2016-08-31 | Zoetis Services Llc | Dihydrofuranowe pochodne azetydyny jako środki przeciwpasożytnicze |
US9233100B2 (en) | 2012-02-06 | 2016-01-12 | Merial, Inc. | Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof |
JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
AU2013245011B2 (en) | 2012-04-04 | 2017-11-23 | Intervet International B.V. | Solid oral pharmaceutical compositions for isoxazoline compounds |
JP6049866B2 (ja) * | 2012-05-09 | 2016-12-21 | ゾエティス・サービシーズ・エルエルシー | 駆虫剤としてのアゼチジン誘導体 |
TR201807735T4 (tr) * | 2012-08-31 | 2018-06-21 | Zoetis Services Llc | 1-(5'-(5-(3,5-Dikloro-4-florofenil)-5-(triflorometil)-4,5-dihidroizoksazol-3-il)-3'h-spiro[azetidin-3,1'-izobenzofuran]-1-il)-2-(metilsülfonil)etanonun kristal formları. |
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HUE045577T2 (hu) * | 2012-09-07 | 2020-01-28 | Zoetis Services Llc | Spirociklusos izoxazolint tartalmazó parazitaellenes kombinációk |
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WO2023248871A1 (ja) * | 2022-06-20 | 2023-12-28 | 日本曹達株式会社 | ヘテロアリール化合物および有害生物防除剤 |
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ATE227277T1 (de) * | 1996-08-21 | 2002-11-15 | Upjohn Co | Isoxazoline derivate und ihre verwendung als antimikroben |
TW524667B (en) | 1996-12-05 | 2003-03-21 | Pfizer | Parasiticidal pyrazoles |
GB0329314D0 (en) | 2003-12-18 | 2004-01-21 | Pfizer Ltd | Substituted arylpyrazoles |
KR20070121013A (ko) * | 2005-04-22 | 2007-12-26 | 다이이찌 산쿄 가부시키가이샤 | 헤테로 고리 화합물 |
TW200803740A (en) * | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
EP1997813B1 (en) | 2006-03-10 | 2010-05-05 | Nissan Chemical Industries, Ltd. | Substituted isoxazoline compound and pest control agent |
JP2008044880A (ja) * | 2006-08-15 | 2008-02-28 | Bayer Cropscience Ag | 殺虫性イソオキサゾリン類 |
JP2008260691A (ja) * | 2007-04-10 | 2008-10-30 | Bayer Cropscience Ag | 殺虫性アリールイソオキサゾリン誘導体 |
NZ580241A (en) | 2007-04-10 | 2011-02-25 | Bayer Cropscience Ag | Insecticidal aryl isoxazoline derivatives |
US8053452B2 (en) | 2007-06-29 | 2011-11-08 | Nissan Chemical Industries, Ltd. | Substituted isoxazoline or enone oxime compound, and pest control agent |
EP2199287A4 (en) | 2007-09-10 | 2011-04-27 | Nissan Chemical Ind Ltd | SUBSTITUTED ISOXAZOLINE COMPOUND AND AGENT FOR CONTROLLING PESTS |
WO2009051956A2 (en) | 2007-10-16 | 2009-04-23 | E. I. Du Pont De Nemours And Company | Pyrazole-substituted isoxazoline insecticides |
TWI411395B (zh) * | 2007-12-24 | 2013-10-11 | Syngenta Participations Ag | 殺蟲化合物 |
KR20110044873A (ko) * | 2008-08-22 | 2011-05-02 | 신젠타 파티서페이션즈 아게 | 살충성 화합물 |
EP2331536B1 (en) * | 2008-08-22 | 2013-08-21 | Syngenta Participations AG | Insecticidal compounds |
WO2010079077A1 (en) | 2008-12-18 | 2010-07-15 | Novartis Ag | Isoxazolines derivatives and their use as pesticide |
MX2011006568A (es) * | 2008-12-19 | 2011-08-03 | Novartis Ag | Compuestos organicos. |
KR20110099139A (ko) | 2008-12-23 | 2011-09-06 | 바스프 에스이 | 동물 해충의 퇴치를 위한 치환된 아미딘 화합물 |
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JP5409968B2 (ja) | 2014-02-05 |
CN103270036A (zh) | 2013-08-28 |
RU2013104027A (ru) | 2014-09-10 |
CL2013000352A1 (es) | 2013-09-23 |
MX2013001437A (es) | 2013-06-05 |
AU2011287323A1 (en) | 2013-03-07 |
AU2011287323B2 (en) | 2015-12-17 |
KR20130062333A (ko) | 2013-06-12 |
RU2551354C2 (ru) | 2015-05-20 |
US20120035122A1 (en) | 2012-02-09 |
JP2013532719A (ja) | 2013-08-19 |
KR101508862B1 (ko) | 2015-04-07 |
CN103270036B (zh) | 2015-11-25 |
US8415310B2 (en) | 2013-04-09 |
BR112013002871B1 (pt) | 2018-11-21 |
UY33545A (es) | 2012-02-29 |
HK1184780A1 (en) | 2014-01-30 |
CA2807005A1 (en) | 2012-02-09 |
WO2012017359A1 (en) | 2012-02-09 |
NZ606194A (en) | 2013-12-20 |
CO6680631A2 (es) | 2013-05-31 |
EP2601190B1 (en) | 2018-07-04 |
ES2682303T3 (es) | 2018-09-19 |
EP2601190A1 (en) | 2013-06-12 |
CA2807005C (en) | 2015-04-07 |
BR112013002871A2 (pt) | 2017-04-04 |
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