AR085649A1 - Derivados espirociclicos de isoxazolina como agentes antiparasitarios - Google Patents
Derivados espirociclicos de isoxazolina como agentes antiparasitariosInfo
- Publication number
- AR085649A1 AR085649A1 ARP120100780A ARP120100780A AR085649A1 AR 085649 A1 AR085649 A1 AR 085649A1 AR P120100780 A ARP120100780 A AR P120100780A AR P120100780 A ARP120100780 A AR P120100780A AR 085649 A1 AR085649 A1 AR 085649A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cyano
- halo
- haloalkyl
- alkoxy
- Prior art date
Links
- 150000002547 isoxazolines Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 13
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 10
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 8
- 125000005843 halogen group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 7
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 6
- 229910003827 NRaRb Inorganic materials 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000005213 alkyl heteroaryl group Chemical group 0.000 abstract 5
- 125000005037 alkyl phenyl group Chemical group 0.000 abstract 5
- 125000001424 substituent group Chemical group 0.000 abstract 5
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004043 oxo group Chemical group O=* 0.000 abstract 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000000262 haloalkenyl group Chemical group 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000000232 haloalkynyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- YMEHWISYYMKMFO-WOMRJYOTSA-N methyl N-[(12E,15S)-15-[(4S)-4-(3-chlorophenyl)-2-oxopiperidin-1-yl]-9-oxo-8,17,19-triazatricyclo[14.2.1.02,7]nonadeca-1(18),2(7),3,5,12,16-hexaen-5-yl]carbamate Chemical compound COC(=O)Nc1ccc2-c3cnc([nH]3)[C@H](C\C=C\CCC(=O)Nc2c1)N1CC[C@@H](CC1=O)c1cccc(Cl)c1 YMEHWISYYMKMFO-WOMRJYOTSA-N 0.000 abstract 1
- -1 nitro, hydroxy Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Reivindicación 1: Un compuesto caracterizado por la fórmula (1) o fórmula (2), en las que cada uno de Y y Z es independientemente C o N; cada uno de W1, W2 y W3 es independientemente C o N; V es C, N, O, o S; A, tomado junto con Y y Z o V, Y y Z es un anillo heterocíclico o carbocíclico, parcialmente saturado o saturado, de 5 a 7 miembros, en el que el que el anillo heterocíclico contiene al menos 1 a 3 heteroátomos seleccionados entre N, O ó S, y en el que el anillo A está opcionalmente sustituido con al menos un sustituyente seleccionado entre oxo, =S, =NR7, halo, hidroxilo, ciano, alquilo C1-6, haloalquilo C1-6 y alcoxi C1-6; cada uno de R1a, R1b y R1c es independientemente hidrógeno, halo, hidroxilo, ciano, nitro, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, alquil C0-3-cicloalquilo C3-6, haloalcoxi C1-6, -C(O)NH2, -SF5 o -S(O)pR; R2 es halo, ciano, alquilo C1-6, haloalquilo C1-6, nitro, hidroxilo, C(O)NRaRb, alquenilo C2-6, alquinilo C2-6, -S(O)pR o -OR; R3 es ciano, alquilo C1-6, haloalquilo C1-6, C(O)NRaRb, alquenilo C2-6, alquinilo C2-6, haloalquenilo C2-6 o haloalquinilo C2-6; R4 es hidrógeno, alquilo C1-6, alquil C0-6-cicloalquilo C3-6, -C(O)R5, -C(S)R5, C(O)NRaR5, C(O)C(O)NRaR5, -S(O)pRc, S(O)2NRaR5, -C(NR7)R5, C(NR7)NRaR5, alquilfenilo C0-6, alquilheteroarilo C0-6 o alquilheterociclo C0-6; R5 es hidrógeno, alquilo C1-6, alquenilo C2-6, alquil C0-6-cicloalquilo C3-6, alquilfenilo C0-6, alquilheteroarilo C0-6 o alquilheterociclo C0-6; R6 es hidrógeno, alquilo C1-6, hidroxilo o alcoxi C1-6; R7 es hidrógeno, alquilo C1-6, hidroxilo, ciano, nitro, S(O)pRc o alcoxi C1-6; R es alquilo C1-6 o cicloalquilo C3-6 opcionalmente sustituido con al menos un sustituyente halo; Ra es hidrógeno, alquilo C1-6 o alquil C0-3-cicloalquilo C3-6; en el que el alquilo y alquilcicloalquilo están opcionalmente sustituidos con ciano o al menos un sustituyente halo; Rb es hidrógeno, alquilo C1-6, cicloalquilo C3-8, alquilfenilo C0-3, alquilheteroarilo C0-3 o alquilheterociclo C0-3, cada uno opcionalmente sustituido, cuando sea químicamente posible, con al menos un sustituyente seleccionado entre hidroxilo, ciano, halo o -S(O)pR; Rc es alquilo C1-6, haloalquilo C1-6, haloalquil C1-6-cicloalquilo C3-6, alquil C0-3-cicloalquilo C3-6, alquilfenilo C0-3, alquilheteroarilo C0-3 o alquilheterociclo C0-3, cada uno opcionalmente sustituido con al menos un sustituyente seleccionado entre ciano, halo, hidroxilo, oxo, alcoxi C1-6, haloalcoxi C1-6, haloalquilo C1-6, S(O)pR, -SH, -S(O)pNRaRb, -NRaRb, -NRaC(O)Rb, -SC(O)R, -SCN o_C(O)NRaRb; cada uno de los restos alquilo C1-6 o alquil C0-6-cicloalquilo C3-6 de R4 y R5 puede estar opcional e independientemente sustituido con al menos un sustituyente seleccionado entre ciano, halo, hidroxilo, oxo, alcoxi C1-6, haloalcoxi C1-6, haloalquilo C1-6, alquilo C1-6, hidroxilalquil C1-6-, -S(O)pRc, -SH, -S(O)pNRaRb, -NRaRb, -NRaC(O)Rb, -SC(O)R, -SCN o -C(O)NRaRb; y en el que cada uno de los restos alquilfenilo C0-6, alquilheteroarilo C0-6, o alquilheterociclo C0-6 de R4 y R5 puede estar opcionalmente sustituido adicionalmente con al menos un sustituyente seleccionado entre ciano, halo, oxo, =S, =NR7, hidroxilo, alcoxi C1-6, hidroxilalquil C1-6-, alquilo C1-6, haloalquilo C1-6, -SH, -S(O)pR y haloalcoxi C1-6; n es el número entero 0, 1 ó 2, y cuando n es 2, cada R2 puede ser igual o diferente de cada uno de los demás; p es el número entero 0, 1 ó 2; y - - - - - es un enlace simple o doble; estereoisómeros del mismo y sales veterinariamente aceptables del mismo.Reivindicación 2: Una composición farmacéutica o veterinaria caracterizada porque comprende una cantidad terapéuticamente eficaz de un compuesto de fórmula (1) o fórmula (2) de la reivindicación 1.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161451256P | 2011-03-10 | 2011-03-10 | |
| US201161489913P | 2011-05-25 | 2011-05-25 | |
| US201161490804P | 2011-05-27 | 2011-05-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR085649A1 true AR085649A1 (es) | 2013-10-16 |
Family
ID=45852624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120100780A AR085649A1 (es) | 2011-03-10 | 2012-03-09 | Derivados espirociclicos de isoxazolina como agentes antiparasitarios |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8466115B2 (es) |
| EP (1) | EP2683723B1 (es) |
| JP (1) | JP5806743B2 (es) |
| KR (1) | KR101565853B1 (es) |
| CN (1) | CN103517907B (es) |
| AR (1) | AR085649A1 (es) |
| AU (1) | AU2012226475C1 (es) |
| BR (1) | BR112013023068B8 (es) |
| CA (1) | CA2828397C (es) |
| CL (1) | CL2013002516A1 (es) |
| CO (1) | CO6761337A2 (es) |
| CY (1) | CY1117987T1 (es) |
| ES (1) | ES2585555T3 (es) |
| HK (1) | HK1190393A1 (es) |
| HR (1) | HRP20160601T1 (es) |
| HU (1) | HUE029810T2 (es) |
| ME (1) | ME02412B (es) |
| MX (1) | MX2013010336A (es) |
| PL (1) | PL2683723T3 (es) |
| PT (1) | PT2683723T (es) |
| RS (1) | RS54860B1 (es) |
| RU (1) | RU2566083C3 (es) |
| SI (1) | SI2683723T1 (es) |
| UY (1) | UY33943A (es) |
| WO (1) | WO2012120399A1 (es) |
| ZA (1) | ZA201306817B (es) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3216448B8 (en) | 2012-02-06 | 2019-06-05 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| RS57284B1 (sr) * | 2012-08-31 | 2018-08-31 | Zoetis Services Llc | Kristalne forme 1-(5’-(5-(3,5-dihlor-4-fluorfenil)-5-(trifluormetil)-4,5-dihidroizoksazol-3-il)-3’h-spiro[azetidin-3,1’-izobenzofuran]-1-il)-2-(metilsulfonil)etanona |
| CA2882199A1 (en) | 2012-09-04 | 2014-03-13 | Zoetis Llc | Spirocyclic isoxazoline derivatives for treatment of sea lice |
| WO2014039484A1 (en) * | 2012-09-07 | 2014-03-13 | Zoetis Llc | Spirocyclic isoxazolines as antiparasitic agents |
| CA2881844A1 (en) * | 2012-09-07 | 2014-03-13 | Zoetis Llc | Spirocyclic derivatives as antiparasitic agents |
| HUE045577T2 (hu) * | 2012-09-07 | 2020-01-28 | Zoetis Services Llc | Spirociklusos izoxazolint tartalmazó parazitaellenes kombinációk |
| CA2892344C (en) | 2012-11-21 | 2017-06-06 | Zoetis Services Llc | Synthesis of spirocyclic isoxazoline derivatives |
| SI2953942T1 (en) | 2013-02-06 | 2018-03-30 | Bayer Cropscience Ag | Halogen-substituted pyrazole derivatives such as pesticides |
| WO2014189837A1 (en) * | 2013-05-20 | 2014-11-27 | Zoetis Llc | Long-acting spiro-isoxazoline antiparasitic compositions |
| WO2015048371A1 (en) | 2013-09-30 | 2015-04-02 | Zoetis Llc | Long-acting spiro-isoxazoline formulations |
| US9371293B2 (en) | 2013-10-25 | 2016-06-21 | Sumitomo Chemical Company, Limited | Isoxazoline compound composition |
| CN105873925B (zh) | 2013-11-01 | 2019-09-10 | 勃林格殷格翰动物保健美国公司 | 抗寄生物的和杀虫的异噁唑啉化合物 |
| HUE066811T2 (hu) | 2013-12-20 | 2024-09-28 | Intervet Int Bv | Izoxazolin kompozíciók és azok felhasználása parazitafertõzések megelõzésében és kezelésében állatokban |
| EP3089972B1 (de) | 2014-01-03 | 2018-05-16 | Bayer Animal Health GmbH | Neue pyrazolyl-heteroarylamide als schädlingsbekämpfungsmittel |
| ES2765405T3 (es) | 2014-04-17 | 2020-06-09 | Boehringer Ingelheim Animal Health Usa Inc | Utilización de compuestos de malononitrilo para proteger animales de parásitos |
| CA2955153A1 (en) | 2014-07-15 | 2016-01-21 | Bayer Animal Health Gmbh | Aryl-triazolyl pyridines as pest control agents |
| AU2015339096B2 (en) | 2014-10-31 | 2018-08-02 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal composition comprising fipronil |
| EP3236960A1 (en) * | 2014-12-22 | 2017-11-01 | Intervet International B.V. | Use of isoxazoline compounds for treating demodicosis |
| BR112017015137A2 (pt) * | 2015-01-16 | 2018-01-30 | Avista Pharma Solutions, Inc. | compostos antiparasíticos |
| UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| KR102593069B1 (ko) | 2015-04-08 | 2023-10-23 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 이속사졸린 활성제를 포함하는 서방형 주사 제형, 이의 방법 및 용도 |
| ES2916216T3 (es) | 2015-05-20 | 2022-06-29 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de depsipéptidos antihelmínticos |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| US20190077809A1 (en) | 2016-03-09 | 2019-03-14 | Basf Se | Spirocyclic Derivatives |
| BR112018068042A2 (pt) * | 2016-03-11 | 2019-01-08 | Basf Se | métodos para controlar pragas de plantas, material de propagação de planta e uso de um ou mais compostos de fórmula i |
| MX2020013754A (es) | 2016-04-06 | 2022-07-25 | Boehringer Ingelheim Animal Health Usa Inc | Proceso para preparar compuestos de isoxazolina. |
| WO2017201134A1 (en) * | 2016-05-20 | 2017-11-23 | Avista Pharma Solutions, Inc. | Synthetic process and novel intermediates |
| WO2018009751A1 (en) * | 2016-07-08 | 2018-01-11 | Avista Pharma Solutions, Inc. | Antiparasitic compounds |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| AU2017344097A1 (en) | 2016-10-14 | 2019-05-02 | Boehringer Ingelheim Animal Health USA Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
| EP3541789A1 (en) | 2016-11-16 | 2019-09-25 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| WO2018162312A1 (en) * | 2017-03-10 | 2018-09-13 | Basf Se | Spirocyclic derivatives |
| WO2018166855A1 (en) | 2017-03-16 | 2018-09-20 | Basf Se | Heterobicyclic substituted dihydroisoxazoles |
| JP2020530850A (ja) * | 2017-08-14 | 2020-10-29 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | 殺有害生物および殺寄生生物ピラゾール−イソキサゾリン化合物 |
| MX2020002496A (es) | 2017-09-06 | 2020-07-20 | Bayer Animal Health Gmbh | Formulacion de uso topico para el control y la prevencion de parasitos en animales. |
| JP2021503465A (ja) * | 2017-11-16 | 2021-02-12 | アビスタ ファーマ ソリューションズ，インコーポレーテッド | 単一エナンチオマーの抗寄生生物化合物 |
| IL275339B2 (en) | 2017-12-15 | 2024-03-01 | Tarsus Pharmaceuticals Inc | Parasitic formulations containing isoxazoline and methods for treating blepharitis |
| US11583545B2 (en) | 2018-02-08 | 2023-02-21 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof |
| AU2019282274A1 (en) | 2018-06-07 | 2021-01-28 | Idorsia Pharmaceuticals Ltd | Alkoxy-substituted pyridinyl derivatives as LPA1 receptor antagonists and their use in the treatment of fibrosis |
| EP3820870A1 (en) | 2018-07-09 | 2021-05-19 | Boehringer Ingelheim Animal Health USA Inc. | Anthelminthic heterocyclic compounds |
| BR112021006053A2 (pt) | 2018-10-29 | 2021-07-20 | Basf Se | processo de preparação de compostos, oximas z e compostos da fórmula vi |
| CN112969690A (zh) | 2018-11-06 | 2021-06-15 | 巴斯夫欧洲公司 | 制备光学富集异噁唑啉类的方法 |
| US11773066B2 (en) | 2018-11-20 | 2023-10-03 | Boehringer Ingelheim Animal Health USA Inc. | Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof |
| CA3120221A1 (en) | 2018-12-04 | 2020-06-11 | Basf Se | Process for preparation of 5-bromo-1,3-dichloro-2-fluoro-benzene |
| WO2020150032A1 (en) | 2019-01-16 | 2020-07-23 | Boehringer Ingelheim Animal Health USA Inc. | Topical compositions comprising a neonicotinoid and a macrocyclic lactone, methods and uses thereof |
| PE20220281A1 (es) | 2019-03-19 | 2022-02-25 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de aza-benzotiofeno y aza-benzofurano como antihelminticos |
| AR119162A1 (es) | 2019-06-18 | 2021-12-01 | Idorsia Pharmaceuticals Ltd | Derivados de piridin-3-ilo |
| BR112022012269A2 (pt) | 2019-12-18 | 2022-08-30 | Elanco Tiergesundheit Ag | Derivados de isoxazolina como pesticidas |
| CN111253331B (zh) * | 2020-03-17 | 2022-03-08 | 南京林业大学 | 一种以二氢查尔酮为原料合成螺异噁唑啉的方法 |
| WO2021242481A1 (en) | 2020-05-28 | 2021-12-02 | Boehringer Ingelheim Animal Health USA Inc. | Bi-modal release intra-ruminal capsule device and methods of use thereof |
| JP2023528822A (ja) | 2020-05-29 | 2023-07-06 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | 駆虫性複素環式化合物 |
| CN111675668B (zh) * | 2020-06-28 | 2022-09-13 | 南京林业大学 | 一种tempo催化的以肟类化合物为原料合成螺异噁唑啉的反应方法 |
| US20220201983A1 (en) | 2020-12-21 | 2022-06-30 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal collar comprising isoxazoline compounds |
| US20240116854A1 (en) | 2021-01-27 | 2024-04-11 | Intervet Inc. | Cyclopropylamide compounds against parasites in fish |
| US20240316045A1 (en) | 2021-01-27 | 2024-09-26 | Intervet Inc. | Cyclopropylamide compounds against parasites in fish |
| JP2024516912A (ja) | 2021-05-14 | 2024-04-17 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 昆虫、ダニ目及び線虫有害生物の防除 |
| EP4355735A1 (en) | 2021-06-16 | 2024-04-24 | Elanco Tiergesundheit AG | Isoxazoline pesticides |
| WO2022263530A1 (en) | 2021-06-16 | 2022-12-22 | Elanco Tiergesundheit Ag | (thi)oxazoline pesticides |
| WO2022268813A1 (en) | 2021-06-24 | 2022-12-29 | Syngenta Crop Protection Ag | Insect, acarina and nematode pest control |
| WO2022268815A1 (en) | 2021-06-24 | 2022-12-29 | Syngenta Crop Protection Ag | Insect, acarina and nematode pest control |
| WO2023046853A1 (en) | 2021-09-23 | 2023-03-30 | Syngenta Crop Protection Ag | Insect, acarina and nematode pest control |
| US20230312207A1 (en) | 2022-02-17 | 2023-10-05 | Boehringer Ingelheim Vetmedica Gmbh | Method and system for providing a fluid product mailer |
| WO2023203038A1 (en) | 2022-04-19 | 2023-10-26 | Syngenta Crop Protection Ag | Insect, acarina and nematode pest control |
| FI20225388A1 (en) | 2022-05-05 | 2023-11-06 | Equinorm Ltd | New heterocyclic compounds, preparation methods and their uses |
| DK202470076A1 (en) | 2023-03-13 | 2024-10-10 | Zoetis Services Llc | Degradation of isoxazolines in ozonated sea water |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5554753A (en) | 1993-08-25 | 1996-09-10 | Indiana University Foundation | Catalytic enantioselective synthesis of α-amino acid derivatives by phase-transfer catalysis |
| TW524667B (en) | 1996-12-05 | 2003-03-21 | Pfizer | Parasiticidal pyrazoles |
| GB0329314D0 (en) | 2003-12-18 | 2004-01-21 | Pfizer Ltd | Substituted arylpyrazoles |
| DK1731512T3 (en) * | 2004-03-05 | 2015-01-05 | Nissan Chemical Ind Ltd | Isoxazoline-substituted benzamide AND INSTRUMENTS FOR COMBATING HARMFUL ORGANISMS |
| DK1904477T3 (da) | 2005-07-14 | 2009-03-16 | Hoffmann La Roche | Indol-3-carbonyl-spiro-piperodom-derivater som V1A-receptorantagonister |
| TW200803740A (en) | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| EP1997813B1 (en) | 2006-03-10 | 2010-05-05 | Nissan Chemical Industries, Ltd. | Substituted isoxazoline compound and pest control agent |
| US8575167B2 (en) | 2007-02-06 | 2013-11-05 | Takeda Pharmaceutical Company Limited | Spiro compounds having stearoyl-CoA desaturase action |
| MY146638A (en) | 2007-04-10 | 2012-09-14 | Bayer Cropscience Ag | Insecticidal aryl isoxazoline derivatives |
| JP5184057B2 (ja) * | 2007-08-10 | 2013-04-17 | 日本曹達株式会社 | 含窒素複素環化合物および有害生物防除剤 |
| JP5365806B2 (ja) | 2007-09-10 | 2013-12-11 | 日産化学工業株式会社 | 置換イソキサゾリン化合物及び有害生物防除剤 |
| WO2009063910A1 (ja) | 2007-11-12 | 2009-05-22 | Nissan Chemical Industries, Ltd. | 光学活性イソキサゾリン化合物の触媒的不斉合成方法 |
| JP2009286773A (ja) * | 2008-03-14 | 2009-12-10 | Bayer Cropscience Ag | 殺虫性縮環式アリール類 |
| BRPI0918500A2 (pt) | 2008-09-04 | 2015-09-22 | Syngenta Participations Ag | compostos inseticidas |
| JP5488835B2 (ja) * | 2008-09-04 | 2014-05-14 | 日産化学工業株式会社 | 置換アセトフェノン化合物、その製造方法及び用途 |
| EP2332927A4 (en) | 2008-09-18 | 2012-07-18 | Nippon Soda Co | HETEROCYCLIC COMPOUND CONTAINING NITROGEN AND AGENT FOR CONTROLLING HARMFUL ANIMALS |
| BRPI1007310A2 (pt) * | 2009-01-22 | 2015-08-25 | Syngenta Participations Ag | Compostos inseticidas. |
| MX2012009707A (es) | 2010-02-25 | 2012-09-12 | Syngenta Ltd | Proceso para preparar derivados isoxazolinicos. |
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