RU2566083C3 - Спироциклические производные изоксазолина в качестве противопаразитарных агентов - Google Patents
Спироциклические производные изоксазолина в качестве противопаразитарных агентовInfo
- Publication number
- RU2566083C3 RU2566083C3 RU2013139630A RU2013139630A RU2566083C3 RU 2566083 C3 RU2566083 C3 RU 2566083C3 RU 2013139630 A RU2013139630 A RU 2013139630A RU 2013139630 A RU2013139630 A RU 2013139630A RU 2566083 C3 RU2566083 C3 RU 2566083C3
- Authority
- RU
- Russia
- Prior art keywords
- isoxazoline
- antiparasitic agents
- spirocyclic derivatives
- spirocyclic
- derivatives
- Prior art date
Links
- 239000003096 antiparasitic agent Substances 0.000 title 1
- 229940125687 antiparasitic agent Drugs 0.000 title 1
- 150000002547 isoxazolines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161451256P | 2011-03-10 | 2011-03-10 | |
| US61/451,256 | 2011-03-10 | ||
| US201161489913P | 2011-05-25 | 2011-05-25 | |
| US61/489,913 | 2011-05-25 | ||
| US201161490804P | 2011-05-27 | 2011-05-27 | |
| US61/490,804 | 2011-05-27 | ||
| PCT/IB2012/050842 WO2012120399A1 (en) | 2011-03-10 | 2012-02-23 | Spirocyclic isoxazoline derivatives as antiparasitic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2013139630A RU2013139630A (ru) | 2015-04-20 |
| RU2566083C2 RU2566083C2 (ru) | 2015-10-20 |
| RU2566083C3 true RU2566083C3 (ru) | 2017-11-09 |
Family
ID=45852624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013139630A RU2566083C3 (ru) | 2011-03-10 | 2012-02-23 | Спироциклические производные изоксазолина в качестве противопаразитарных агентов |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8466115B2 (ru) |
| EP (1) | EP2683723B1 (ru) |
| JP (1) | JP5806743B2 (ru) |
| KR (1) | KR101565853B1 (ru) |
| CN (1) | CN103517907B (ru) |
| AR (1) | AR085649A1 (ru) |
| AU (1) | AU2012226475C1 (ru) |
| BR (1) | BR112013023068B8 (ru) |
| CA (1) | CA2828397C (ru) |
| CL (1) | CL2013002516A1 (ru) |
| CO (1) | CO6761337A2 (ru) |
| CY (1) | CY1117987T1 (ru) |
| ES (1) | ES2585555T3 (ru) |
| HK (1) | HK1190393A1 (ru) |
| HR (1) | HRP20160601T1 (ru) |
| HU (1) | HUE029810T2 (ru) |
| ME (1) | ME02412B (ru) |
| MX (1) | MX2013010336A (ru) |
| PL (1) | PL2683723T3 (ru) |
| PT (1) | PT2683723T (ru) |
| RS (1) | RS54860B1 (ru) |
| RU (1) | RU2566083C3 (ru) |
| SI (1) | SI2683723T1 (ru) |
| UY (1) | UY33943A (ru) |
| WO (1) | WO2012120399A1 (ru) |
| ZA (1) | ZA201306817B (ru) |
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| EP2890699B1 (en) | 2012-08-31 | 2018-04-11 | Zoetis Services LLC | Crystalline forms of 1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'h-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone |
| CA2882199A1 (en) | 2012-09-04 | 2014-03-13 | Zoetis Llc | Spirocyclic isoxazoline derivatives for treatment of sea lice |
| BR112015004826A2 (pt) | 2012-09-07 | 2017-07-04 | Zoetis Llc | derivados espirocíclicos como agentes antiparasíticos |
| CN104603140A (zh) * | 2012-09-07 | 2015-05-06 | 佐蒂斯有限责任公司 | 作为抗寄生虫剂的螺环异噁唑啉 |
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| EP4056572A1 (en) | 2012-11-21 | 2022-09-14 | Zoetis Services LLC | Synthesis of spirocyclic isoxazoline derivatives |
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| CA2924537C (en) | 2013-09-30 | 2018-01-16 | Todd P. Foster | Long-acting spiro-isoxazoline formulations |
| US9371293B2 (en) | 2013-10-25 | 2016-06-21 | Sumitomo Chemical Company, Limited | Isoxazoline compound composition |
| WO2015066277A1 (en) | 2013-11-01 | 2015-05-07 | Merial Limited | Antiparisitic and pesticidal isoxazoline compounds |
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| MX2012009707A (es) | 2010-02-25 | 2012-09-12 | Syngenta Ltd | Proceso para preparar derivados isoxazolinicos. |
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