SI2683723T1 - Spirociklični izoksazolinski derivati kot antiparazitiki - Google Patents
Spirociklični izoksazolinski derivati kot antiparazitikiInfo
- Publication number
- SI2683723T1 SI2683723T1 SI201230583A SI201230583A SI2683723T1 SI 2683723 T1 SI2683723 T1 SI 2683723T1 SI 201230583 A SI201230583 A SI 201230583A SI 201230583 A SI201230583 A SI 201230583A SI 2683723 T1 SI2683723 T1 SI 2683723T1
- Authority
- SI
- Slovenia
- Prior art keywords
- antiparasitic agents
- isoxazoline derivatives
- spirocyclic isoxazoline
- spirocyclic
- derivatives
- Prior art date
Links
- 239000003096 antiparasitic agent Substances 0.000 title 1
- 229940125687 antiparasitic agent Drugs 0.000 title 1
- 150000002547 isoxazolines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161451256P | 2011-03-10 | 2011-03-10 | |
| US201161489913P | 2011-05-25 | 2011-05-25 | |
| US201161490804P | 2011-05-27 | 2011-05-27 | |
| EP12709376.3A EP2683723B1 (en) | 2011-03-10 | 2012-02-23 | Spirocyclic isoxazoline derivatives as antiparasitic agents |
| PCT/IB2012/050842 WO2012120399A1 (en) | 2011-03-10 | 2012-02-23 | Spirocyclic isoxazoline derivatives as antiparasitic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2683723T1 true SI2683723T1 (sl) | 2016-07-29 |
Family
ID=45852624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201230583A SI2683723T1 (sl) | 2011-03-10 | 2012-02-23 | Spirociklični izoksazolinski derivati kot antiparazitiki |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8466115B2 (sl) |
| EP (1) | EP2683723B1 (sl) |
| JP (1) | JP5806743B2 (sl) |
| KR (1) | KR101565853B1 (sl) |
| CN (1) | CN103517907B (sl) |
| AR (1) | AR085649A1 (sl) |
| AU (1) | AU2012226475C1 (sl) |
| BR (1) | BR112013023068B8 (sl) |
| CA (1) | CA2828397C (sl) |
| CL (1) | CL2013002516A1 (sl) |
| CO (1) | CO6761337A2 (sl) |
| CY (1) | CY1117987T1 (sl) |
| ES (1) | ES2585555T3 (sl) |
| HK (1) | HK1190393A1 (sl) |
| HR (1) | HRP20160601T1 (sl) |
| HU (1) | HUE029810T2 (sl) |
| ME (1) | ME02412B (sl) |
| MX (1) | MX2013010336A (sl) |
| PL (1) | PL2683723T3 (sl) |
| PT (1) | PT2683723T (sl) |
| RS (1) | RS54860B1 (sl) |
| RU (1) | RU2566083C3 (sl) |
| SI (1) | SI2683723T1 (sl) |
| UY (1) | UY33943A (sl) |
| WO (1) | WO2012120399A1 (sl) |
| ZA (1) | ZA201306817B (sl) |
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| NZ719079A (en) | 2012-02-06 | 2017-09-29 | Merial Inc | Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| MX351463B (es) * | 2012-08-31 | 2017-10-16 | Zoetis Services Llc | Formas cristalinas de 1-(5'-(5-(3,5-dicloro-4-fluorofenil)-5-(trif luorometil)-4,5-dihidroisoxazol-3-il)-3'h-espiro[azetidin-3,1'-is obenzofuran]-1-il)-2-(metilsulfonil)etanona. |
| EP2900065A1 (en) | 2012-09-04 | 2015-08-05 | Zoetis LLC | Spirocyclic isoxazoline derivatives for treatment of sea lice |
| US9221835B2 (en) | 2012-09-07 | 2015-12-29 | Zoetis Services Llc | Spirocyclic derivatives as antiparasitic agents |
| AU2013312882B2 (en) * | 2012-09-07 | 2015-11-05 | Zoetis Services Llc | Spirocyclic isoxazoline parasiticidal combinations |
| CN104603140A (zh) | 2012-09-07 | 2015-05-06 | 佐蒂斯有限责任公司 | 作为抗寄生虫剂的螺环异噁唑啉 |
| CA2892344C (en) | 2012-11-21 | 2017-06-06 | Zoetis Services Llc | Synthesis of spirocyclic isoxazoline derivatives |
| CN105073735B (zh) | 2013-02-06 | 2018-08-14 | 拜耳作物科学股份公司 | 作为害虫防治剂的卤素取代的吡唑衍生物 |
| WO2014189837A1 (en) * | 2013-05-20 | 2014-11-27 | Zoetis Llc | Long-acting spiro-isoxazoline antiparasitic compositions |
| BR112016006182B1 (pt) * | 2013-09-30 | 2023-01-10 | Zoetis Services Llc | Composição veterinária de longa duração e seus usos |
| US9371293B2 (en) | 2013-10-25 | 2016-06-21 | Sumitomo Chemical Company, Limited | Isoxazoline compound composition |
| US9447084B2 (en) | 2013-11-01 | 2016-09-20 | Merial, Inc. | Antiparisitic and pesticidal isoxazoline compounds |
| CN110327468B (zh) | 2013-12-20 | 2023-04-28 | 英特维特国际股份有限公司 | 异噁唑啉组合物及其在预防或治疗动物的寄生虫侵袭中的用途 |
| TW201540705A (zh) | 2014-01-03 | 2015-11-01 | 拜耳作物科學股份有限公司 | 做為殺蟲劑之新穎吡唑基雜芳基醯胺類 |
| EP3131398B1 (en) | 2014-04-17 | 2019-10-23 | Boehringer Ingelheim Animal Health USA Inc. | Use of malononitrile compounds for protecting animals from parasites |
| AU2015289246B2 (en) | 2014-07-15 | 2019-07-25 | Bayer Animal Health Gmbh | Aryl-triazolyl pyridines as pest control agents |
| US10864193B2 (en) | 2014-10-31 | 2020-12-15 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising fipronil at high concentrations |
| CA2971296A1 (en) * | 2014-12-22 | 2016-06-30 | Intervet International B.V. | Use of isoxazoline compounds for treating demodicosis |
| AU2016206748B9 (en) | 2015-01-16 | 2020-01-16 | Avista Pharma Solutions, Inc. | Antiparasitic compounds |
| UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| JP6824900B2 (ja) | 2015-04-08 | 2021-02-03 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | イソオキサゾリン活性薬剤を含む延長放出注射製剤、方法及びその使用 |
| BR112017024773A2 (pt) | 2015-05-20 | 2018-11-06 | Merial, Inc. | compostos depsipeptídeos anti-helmínticos |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| BR112018068034A2 (pt) | 2016-03-09 | 2019-01-08 | Basf Se | compostos espiro da fórmula i, composição, composição agrícola para combater pragas animais, método de combate ou controle de pragas invertebradas, método de proteção de plantas, semente e uso dos compostos |
| EP3426042A1 (en) * | 2016-03-11 | 2019-01-16 | Basf Se | Method for controlling pests of plants |
| KR102438541B1 (ko) | 2016-04-06 | 2022-08-30 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 거울상 이성질체적으로 풍부한 이속사졸린 화합물의 제조 방법 및 (s)-아폭솔라너의 결정질 톨루엔 용매화물 |
| WO2017201134A1 (en) * | 2016-05-20 | 2017-11-23 | Avista Pharma Solutions, Inc. | Synthetic process and novel intermediates |
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| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| US10653144B2 (en) | 2016-10-14 | 2020-05-19 | Boehringer Ingelheim Animal Health USA Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
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| WO2018166855A1 (en) | 2017-03-16 | 2018-09-20 | Basf Se | Heterobicyclic substituted dihydroisoxazoles |
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| JP2021506971A (ja) | 2017-12-15 | 2021-02-22 | ターサス ファーマシューティカルズ， インコーポレイテッド | イソキサゾリン系寄生虫駆除剤及び眼瞼炎を治療する方法 |
| WO2019157241A1 (en) | 2018-02-08 | 2019-08-15 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof |
| CN112236424B (zh) | 2018-06-07 | 2024-03-15 | 爱杜西亚药品有限公司 | 经烷氧基取代的吡啶基衍生物 |
| SG11202012922VA (en) | 2018-07-09 | 2021-01-28 | Boehringer Ingelheim Animal Health Usa Inc | Anthelminthic heterocyclic compounds |
| MX2021004995A (es) | 2018-10-29 | 2021-06-15 | Basf Se | Proceso para la preparacion de compuestos de aldol opticamente enriquecidos. |
| US20210380569A1 (en) | 2018-11-06 | 2021-12-09 | Basf Se | Process for Preparation of Optically Enriched Isoxazolines |
| WO2020112374A1 (en) | 2018-11-20 | 2020-06-04 | Boehringer Ingelheim Animal Health USA Inc. | Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof |
| US11440861B2 (en) | 2018-12-04 | 2022-09-13 | Basf Se | Process for preparation of 5-bromo-1,3-dichloro-2-fluoro-benzene |
| NZ776819A (en) | 2019-01-16 | 2023-04-28 | Boehringer Ingelheim Animal Health Usa Inc | Topical compositions comprising a neonicotinoid and a macrocyclic lactone, methods and uses thereof |
| SG11202109786UA (en) | 2019-03-19 | 2021-10-28 | Boehringer Ingelheim Animal Health Usa Inc | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
| AR119162A1 (es) | 2019-06-18 | 2021-12-01 | Idorsia Pharmaceuticals Ltd | Derivados de piridin-3-ilo |
| EP4077286A1 (en) * | 2019-12-18 | 2022-10-26 | Elanco Tiergesundheit AG | Isoxazoline derivatives as pesticides |
| CN111253331B (zh) * | 2020-03-17 | 2022-03-08 | 南京林业大学 | 一种以二氢查尔酮为原料合成螺异噁唑啉的方法 |
| AU2021278871A1 (en) | 2020-05-28 | 2023-01-19 | Boehringer Ingelheim Animal Health USA Inc. | Bi-modal release intra-ruminal capsule device and methods of use thereof |
| AU2021278889A1 (en) | 2020-05-29 | 2023-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelmintic heterocyclic compounds |
| CN111675668B (zh) * | 2020-06-28 | 2022-09-13 | 南京林业大学 | 一种tempo催化的以肟类化合物为原料合成螺异噁唑啉的反应方法 |
| WO2022140728A1 (en) | 2020-12-21 | 2022-06-30 | Boehringer Ingelheim Animam Health Usa Inc. | Parasiticidal collar comprising isoxazoline compounds |
| US20240116854A1 (en) | 2021-01-27 | 2024-04-11 | Intervet Inc. | Cyclopropylamide compounds against parasites in fish |
| JP2024511258A (ja) | 2021-01-27 | 2024-03-13 | コルテバ アグリサイエンス エルエルシー | 魚における寄生生物に対するシクロプロピルアミド化合物 |
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-
2012
- 2012-02-23 RS RS20160432A patent/RS54860B1/sr unknown
- 2012-02-23 HU HUE12709376A patent/HUE029810T2/en unknown
- 2012-02-23 WO PCT/IB2012/050842 patent/WO2012120399A1/en active Application Filing
- 2012-02-23 MX MX2013010336A patent/MX2013010336A/es active IP Right Grant
- 2012-02-23 ES ES12709376.3T patent/ES2585555T3/es active Active
- 2012-02-23 PT PT127093763T patent/PT2683723T/pt unknown
- 2012-02-23 AU AU2012226475A patent/AU2012226475C1/en active Active
- 2012-02-23 CA CA2828397A patent/CA2828397C/en active Active
- 2012-02-23 EP EP12709376.3A patent/EP2683723B1/en active Active
- 2012-02-23 CN CN201280022404.XA patent/CN103517907B/zh active Active
- 2012-02-23 KR KR1020137026527A patent/KR101565853B1/ko active Protection Beyond IP Right Term
- 2012-02-23 RU RU2013139630A patent/RU2566083C3/ru active
- 2012-02-23 ME MEP-2016-125A patent/ME02412B/me unknown
- 2012-02-23 SI SI201230583A patent/SI2683723T1/sl unknown
- 2012-02-23 BR BR112013023068A patent/BR112013023068B8/pt active IP Right Grant
- 2012-02-23 PL PL12709376T patent/PL2683723T3/pl unknown
- 2012-02-23 JP JP2013557191A patent/JP5806743B2/ja active Active
- 2012-03-08 US US13/414,764 patent/US8466115B2/en active Active
- 2012-03-09 UY UY0001033943A patent/UY33943A/es active IP Right Grant
- 2012-03-09 AR ARP120100780A patent/AR085649A1/es active IP Right Grant
-
2013
- 2013-08-30 CL CL2013002516A patent/CL2013002516A1/es unknown
- 2013-09-06 CO CO13211877A patent/CO6761337A2/es unknown
- 2013-09-10 ZA ZA2013/06817A patent/ZA201306817B/en unknown
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2014
- 2014-04-10 HK HK14103441.3A patent/HK1190393A1/zh unknown
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2016
- 2016-06-03 HR HRP20160601TT patent/HRP20160601T1/hr unknown
- 2016-07-22 CY CY20161100723T patent/CY1117987T1/el unknown
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