HK1190393A1 - 作為抗寄生物劑的螺環異噁唑啉衍生物 - Google Patents
作為抗寄生物劑的螺環異噁唑啉衍生物Info
- Publication number
- HK1190393A1 HK1190393A1 HK14103441.3A HK14103441A HK1190393A1 HK 1190393 A1 HK1190393 A1 HK 1190393A1 HK 14103441 A HK14103441 A HK 14103441A HK 1190393 A1 HK1190393 A1 HK 1190393A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- antiparasitic agents
- isoxazoline derivatives
- spirocyclic isoxazoline
- spirocyclic
- derivatives
- Prior art date
Links
- 239000003096 antiparasitic agent Substances 0.000 title 1
- 229940125687 antiparasitic agent Drugs 0.000 title 1
- 150000002547 isoxazolines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161451256P | 2011-03-10 | 2011-03-10 | |
US201161489913P | 2011-05-25 | 2011-05-25 | |
US201161490804P | 2011-05-27 | 2011-05-27 | |
PCT/IB2012/050842 WO2012120399A1 (en) | 2011-03-10 | 2012-02-23 | Spirocyclic isoxazoline derivatives as antiparasitic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1190393A1 true HK1190393A1 (zh) | 2014-07-04 |
Family
ID=45852624
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK14103441.3A HK1190393A1 (zh) | 2011-03-10 | 2014-04-10 | 作為抗寄生物劑的螺環異噁唑啉衍生物 |
Country Status (26)
Country | Link |
---|---|
US (1) | US8466115B2 (zh) |
EP (1) | EP2683723B1 (zh) |
JP (1) | JP5806743B2 (zh) |
KR (1) | KR101565853B1 (zh) |
CN (1) | CN103517907B (zh) |
AR (1) | AR085649A1 (zh) |
AU (1) | AU2012226475C1 (zh) |
BR (1) | BR112013023068B8 (zh) |
CA (1) | CA2828397C (zh) |
CL (1) | CL2013002516A1 (zh) |
CO (1) | CO6761337A2 (zh) |
CY (1) | CY1117987T1 (zh) |
ES (1) | ES2585555T3 (zh) |
HK (1) | HK1190393A1 (zh) |
HR (1) | HRP20160601T1 (zh) |
HU (1) | HUE029810T2 (zh) |
ME (1) | ME02412B (zh) |
MX (1) | MX2013010336A (zh) |
PL (1) | PL2683723T3 (zh) |
PT (1) | PT2683723T (zh) |
RS (1) | RS54860B1 (zh) |
RU (1) | RU2566083C3 (zh) |
SI (1) | SI2683723T1 (zh) |
UY (1) | UY33943A (zh) |
WO (1) | WO2012120399A1 (zh) |
ZA (1) | ZA201306817B (zh) |
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MY167560A (en) | 2012-02-06 | 2018-09-14 | Merial Inc | Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof |
JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
WO2014036056A1 (en) * | 2012-08-31 | 2014-03-06 | Zoetis Llc | Crystalline forms of 1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'h-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone |
WO2014039422A1 (en) | 2012-09-04 | 2014-03-13 | Zoetis Llc | Spirocyclic isoxazoline derivatives for treatment of sea lice |
BR112015004698B8 (pt) * | 2012-09-07 | 2022-11-22 | Zoetis Llc | Composições sinérgicas parasitícidas e seus usos |
AU2013312896A1 (en) | 2012-09-07 | 2015-02-26 | Zoetis Services Llc | Spirocyclic derivatives as antiparasitic agents |
AU2013312891A1 (en) * | 2012-09-07 | 2015-02-26 | Zoetis Services Llc | Spirocyclic isoxazolines as antiparasitic agents |
EP2922854B1 (en) | 2012-11-21 | 2022-05-04 | Zoetis Services LLC | Synthesis of spirocyclic isoxazoline derivatives |
EA028858B9 (ru) | 2013-02-06 | 2018-06-29 | Байер Кропсайенс Акциенгезельшафт | Галогензамещенные производные пиразола в качестве средств борьбы с вредителями |
EP2999339B1 (en) * | 2013-05-20 | 2019-06-19 | Zoetis Services LLC | Long-acting spiro-isoxazoline antiparasitic compositions |
US10350196B2 (en) | 2013-09-30 | 2019-07-16 | Zoetis Services Llc | Long-acting spiro-isoxazoline formulations |
US9371293B2 (en) | 2013-10-25 | 2016-06-21 | Sumitomo Chemical Company, Limited | Isoxazoline compound composition |
SG11201603430XA (en) | 2013-11-01 | 2016-05-30 | Merial Ltd | Antiparasitic and pesticidal isoxazoline compounds |
JP6581586B2 (ja) | 2013-12-20 | 2019-09-25 | インターベット インターナショナル ベー. フェー. | イソオキサゾリン組成物および動物における寄生虫侵襲の予防または処置におけるその使用 |
TW201540705A (zh) | 2014-01-03 | 2015-11-01 | 拜耳作物科學股份有限公司 | 做為殺蟲劑之新穎吡唑基雜芳基醯胺類 |
US10857121B2 (en) | 2014-04-17 | 2020-12-08 | Merial Inc. | Use of malononitrile compounds for protecting animals from parasites |
JP2017521441A (ja) | 2014-07-15 | 2017-08-03 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Animal Health Gmbh | 有害生物防除剤としてのアリール−トリアゾリルピリジン類 |
ES2887302T3 (es) | 2014-10-31 | 2021-12-22 | Boehringer Ingelheim Animal Health Usa Inc | Composiciones parasiticidas que comprenden fipronil |
CN106999475B (zh) * | 2014-12-22 | 2022-10-25 | 英特维特国际股份有限公司 | 异噁唑啉化合物用于治疗蠕形螨病的用途 |
CA2973974A1 (en) * | 2015-01-16 | 2016-07-21 | Avista Pharma Solutions, Inc. | Antiparasitic compounds |
UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
EA202090762A1 (ru) | 2015-04-08 | 2020-09-08 | Мериал, Инк. | Инъецируемые препараты замедленного высвобождения, содержащие изоксазолиновое действующее вещество, способы и применение |
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EP3426660A1 (en) | 2016-03-09 | 2019-01-16 | Basf Se | Spirocyclic derivatives |
BR112018068042A2 (pt) | 2016-03-11 | 2019-01-08 | Basf Se | métodos para controlar pragas de plantas, material de propagação de planta e uso de um ou mais compostos de fórmula i |
CN114805234A (zh) | 2016-04-06 | 2022-07-29 | 勃林格殷格翰动物保健美国公司 | 用于制备对映异构地富集的异噁唑啉化合物-(S)-afoxolaner的结晶甲苯溶剂化物的方法 |
US10556909B2 (en) | 2016-05-20 | 2020-02-11 | Avista Pharma Solutions, Inc. | Synthetic process and intermediates |
US20200181134A1 (en) * | 2016-07-08 | 2020-06-11 | Avista Phama Solutions, Inc. | Antiparasitic Compounds |
WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
CA3040278A1 (en) | 2016-10-14 | 2018-04-19 | Boehringer Ingelheim Animal Health USA Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
CN110167921A (zh) | 2016-11-16 | 2019-08-23 | 勃林格殷格翰动物保健美国公司 | 驱蠕虫缩肽化合物 |
WO2018162312A1 (en) * | 2017-03-10 | 2018-09-13 | Basf Se | Spirocyclic derivatives |
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EP3668866B1 (en) | 2017-08-14 | 2023-01-18 | Boehringer Ingelheim Animal Health USA Inc. | Pesticidal and parasiticidal pyrazole-isoxazoline compounds |
AU2018329158A1 (en) | 2017-09-06 | 2020-03-05 | Bayer Animal Health Gmbh | Topically administrable formulation for the control and prevention of animal parasites |
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IL275339B2 (en) | 2017-12-15 | 2024-03-01 | Tarsus Pharmaceuticals Inc | Parasitic formulations containing isoxazoline and methods for treating blepharitis |
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CN113260419A (zh) | 2018-11-20 | 2021-08-13 | 勃林格殷格翰动物保健美国公司 | 吲唑基氰基乙基氨基化合物、其组合物、其制备方法和其使用方法 |
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AR119162A1 (es) | 2019-06-18 | 2021-12-01 | Idorsia Pharmaceuticals Ltd | Derivados de piridin-3-ilo |
AU2020408351A1 (en) | 2019-12-18 | 2022-08-11 | Elanco Tiergesundheit Ag | Isoxazoline derivatives as pesticides |
CN111253331B (zh) * | 2020-03-17 | 2022-03-08 | 南京林业大学 | 一种以二氢查尔酮为原料合成螺异噁唑啉的方法 |
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CN111675668B (zh) * | 2020-06-28 | 2022-09-13 | 南京林业大学 | 一种tempo催化的以肟类化合物为原料合成螺异噁唑啉的反应方法 |
EP4262789A1 (en) | 2020-12-21 | 2023-10-25 | Boehringer Ingelheim Vetmedica GmbH | Parasiticidal collar comprising isoxazoline compounds |
US20240116854A1 (en) | 2021-01-27 | 2024-04-11 | Intervet Inc. | Cyclopropylamide compounds against parasites in fish |
BR112023015168A2 (pt) | 2021-01-27 | 2023-10-03 | Corteva Agriscience Llc | Compostos de ciclopropilamida contra parasitas em peixes |
JP2024516912A (ja) | 2021-05-14 | 2024-04-17 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 昆虫、ダニ目及び線虫有害生物の防除 |
CN117529473A (zh) | 2021-06-16 | 2024-02-06 | 礼蓝动物保健有限公司 | 异噁唑啉杀虫剂 |
CN117500800A (zh) | 2021-06-16 | 2024-02-02 | 礼蓝动物保健有限公司 | (硫)噁唑啉杀虫剂 |
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2012
- 2012-02-23 CN CN201280022404.XA patent/CN103517907B/zh active Active
- 2012-02-23 PT PT127093763T patent/PT2683723T/pt unknown
- 2012-02-23 ME MEP-2016-125A patent/ME02412B/me unknown
- 2012-02-23 KR KR1020137026527A patent/KR101565853B1/ko active Protection Beyond IP Right Term
- 2012-02-23 JP JP2013557191A patent/JP5806743B2/ja active Active
- 2012-02-23 AU AU2012226475A patent/AU2012226475C1/en active Active
- 2012-02-23 HU HUE12709376A patent/HUE029810T2/en unknown
- 2012-02-23 ES ES12709376.3T patent/ES2585555T3/es active Active
- 2012-02-23 RU RU2013139630A patent/RU2566083C3/ru active
- 2012-02-23 MX MX2013010336A patent/MX2013010336A/es active IP Right Grant
- 2012-02-23 WO PCT/IB2012/050842 patent/WO2012120399A1/en active Application Filing
- 2012-02-23 EP EP12709376.3A patent/EP2683723B1/en active Active
- 2012-02-23 RS RS20160432A patent/RS54860B1/sr unknown
- 2012-02-23 BR BR112013023068A patent/BR112013023068B8/pt active IP Right Grant
- 2012-02-23 PL PL12709376T patent/PL2683723T3/pl unknown
- 2012-02-23 CA CA2828397A patent/CA2828397C/en active Active
- 2012-02-23 SI SI201230583A patent/SI2683723T1/sl unknown
- 2012-03-08 US US13/414,764 patent/US8466115B2/en active Active
- 2012-03-09 AR ARP120100780A patent/AR085649A1/es active IP Right Grant
- 2012-03-09 UY UY0001033943A patent/UY33943A/es active IP Right Grant
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2013
- 2013-08-30 CL CL2013002516A patent/CL2013002516A1/es unknown
- 2013-09-06 CO CO13211877A patent/CO6761337A2/es unknown
- 2013-09-10 ZA ZA2013/06817A patent/ZA201306817B/en unknown
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2014
- 2014-04-10 HK HK14103441.3A patent/HK1190393A1/zh unknown
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2016
- 2016-06-03 HR HRP20160601TT patent/HRP20160601T1/hr unknown
- 2016-07-22 CY CY20161100723T patent/CY1117987T1/el unknown
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