MX2020006309A - Fórmulaciones de parasiticida de isoxazolina y métodos para el tratamiento de la blefaritis. - Google Patents

Fórmulaciones de parasiticida de isoxazolina y métodos para el tratamiento de la blefaritis.

Info

Publication number
MX2020006309A
MX2020006309A MX2020006309A MX2020006309A MX2020006309A MX 2020006309 A MX2020006309 A MX 2020006309A MX 2020006309 A MX2020006309 A MX 2020006309A MX 2020006309 A MX2020006309 A MX 2020006309A MX 2020006309 A MX2020006309 A MX 2020006309A
Authority
MX
Mexico
Prior art keywords
methods
isoxazoline parasiticide
patient
blepharitis
disclosed
Prior art date
Application number
MX2020006309A
Other languages
English (en)
Inventor
Joseph G Vehige
Douglas Michael Ackermann
Shawn D Hickok
Bobak Robert Azamian
Original Assignee
Tarsus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tarsus Pharmaceuticals Inc filed Critical Tarsus Pharmaceuticals Inc
Publication of MX2020006309A publication Critical patent/MX2020006309A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

En la presente invención se describen métodos para tratar o prevenir afecciones oftálmicas y dermatológicas en un paciente, incluidas afecciones de la superficie ocular tales como blefaritis. Los métodos pueden incluir administrar directamente de forma tópica a la superficie ocular de uno o más ojos de un paciente que necesite tratamiento de una cantidad efectiva de un parasiticida de isoxazolina, parasiticida de formamidina u otros ingredientes activos, formulados en una composición oftálmica, la composición oftálmica además comprende un vehículo farmacéuticamente aceptable. También se describen las composiciones.
MX2020006309A 2017-12-15 2018-12-14 Fórmulaciones de parasiticida de isoxazolina y métodos para el tratamiento de la blefaritis. MX2020006309A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762599213P 2017-12-15 2017-12-15
US201862615855P 2018-01-10 2018-01-10
US201862626612P 2018-02-05 2018-02-05
US201862689787P 2018-06-25 2018-06-25
US201862746498P 2018-10-16 2018-10-16
PCT/US2018/065849 WO2019118928A1 (en) 2017-12-15 2018-12-14 Isoxazoline parasiticide formulations and methods for treating blepharitis

Publications (1)

Publication Number Publication Date
MX2020006309A true MX2020006309A (es) 2021-01-29

Family

ID=66814591

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020006309A MX2020006309A (es) 2017-12-15 2018-12-14 Fórmulaciones de parasiticida de isoxazolina y métodos para el tratamiento de la blefaritis.

Country Status (15)

Country Link
US (10) US10835517B2 (es)
EP (1) EP3723739B1 (es)
JP (2) JP2021506971A (es)
KR (1) KR20200111177A (es)
CN (1) CN111655241A (es)
AU (2) AU2018385766B2 (es)
BR (1) BR112020012018A2 (es)
CA (1) CA3085787A1 (es)
DK (1) DK3723739T3 (es)
IL (2) IL275339B2 (es)
MX (1) MX2020006309A (es)
NZ (1) NZ766141A (es)
RU (1) RU2020122841A (es)
WO (1) WO2019118928A1 (es)
ZA (1) ZA202004155B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112020012018A2 (pt) * 2017-12-15 2020-11-24 Tarsus Pharmaceuticals, Inc. formulações de parasiticida de isoxazolina e métodos para tratar blefarite
JP2021532152A (ja) 2018-07-27 2021-11-25 アペルタ バイオサイエンシズ，エルエルシー デモデックスにより誘発される眼の異常および顔面の異常を治療するためのスピノシン配合
CN114269324A (zh) * 2019-06-19 2022-04-01 塔苏斯制药有限公司 用于治疗睑炎的异恶唑啉驱虫剂制剂和方法
WO2023205459A1 (en) * 2022-04-22 2023-10-26 Attillaps Holdings Inc. Anticholinergic agents and muscarinic agonists for the treatment of demodex related conditions

Family Cites Families (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2361974A (en) 1940-02-07 1944-11-07 John A Rietmann Electrolytic cell
US3781355A (en) 1969-12-12 1973-12-25 Boots Pure Drug Co Ltd Pesticidal compounds and compositions
US3864497A (en) 1970-12-01 1975-02-04 Boots Pure Drug Co Ltd Acaricidal and insecticidal 1,5-diphenyl-3-methyl-1,3,5-triazapenta-1,4-diener
US4389397A (en) 1980-08-04 1983-06-21 Merck & Co., Inc. Solubilization of ivermectin in water
US5019392A (en) 1988-03-03 1991-05-28 Micro-Pak, Inc. Encapsulation of parasiticides
US4957918A (en) 1988-06-09 1990-09-18 Leonard Bloom Topical treatment of blepharitis
US5614545A (en) 1988-06-09 1997-03-25 Leonard Bloom Topical composition for treatment of blepharitis
US6001822A (en) 1989-04-11 1999-12-14 Pfizer Inc. Antiparasitic formulations
FR2656526B1 (fr) 1990-01-02 1994-10-28 Virbac Sa Laboratoires Dispositif a liberation controlee et procede de preparation.
AU6021794A (en) 1993-01-11 1994-08-15 Allergan, Inc. Ophthalmic compositions comprising benzyllauryldimethylammonium chloride
US5632999A (en) 1993-08-18 1997-05-27 Virbac, Inc. Sustained release pyriproxifen compositions for parasite control
US5981500A (en) 1994-01-12 1999-11-09 Pfizer Inc. Antiparasitic agents related to the milbemycins and avermectins
FR2729539B1 (fr) 1995-01-23 1997-04-11 Virbac Lab Dispositif a liberation controlee de substances chimiques, destine a etre fixe sur un animal et procede de preparation dudit dispositif
DE19613972A1 (de) 1996-04-09 1997-10-16 Bayer Ag Injektionsformulierungen von Avermectinen und Milbemycinen auf Basis von Rizinusöl
RU2126668C1 (ru) 1996-10-17 1999-02-27 Багров Сергей Николаевич Мазь для лечения блефаритов "демалон"
FR2761886B1 (fr) 1997-04-14 2000-05-05 Virbac Sa Compositions contenant au moins un polymere cationique et au moins une molecule active contenue dans au moins un vecteur micro ou nanoparticulaire, et leur utilisation pour le traitement de surfaces vivantes ou inertes
US6255350B1 (en) 1997-10-14 2001-07-03 Isp Investments Inc. Stabilized concentrates of water unstable AZA compounds and o/w miniemulsions thereof
US5968990A (en) 1997-10-14 1999-10-19 Isp Investments Inc. Water-dilutable, microemulsion concentrate and pour-on formulations thereof
PT1676579E (pt) 1998-05-08 2009-03-24 Univ Miami Utilização de tetraciclinas sub-antimicrobianas para o tratamento de rosácea ocular
US5952372A (en) 1998-09-17 1999-09-14 Mcdaniel; William Robert Method for treating rosacea using oral or topical ivermectin
GB9825402D0 (en) 1998-11-19 1999-01-13 Pfizer Ltd Antiparasitic formulations
US7897559B2 (en) 2000-06-29 2011-03-01 Parks L Dean Dermatological composition and kit containing avermectin compound for treating dermatological conditions
US6696067B2 (en) 2001-04-12 2004-02-24 Ondeo Nalco Company Cosmetic compositions containing dispersion polymers
US6881726B2 (en) 2001-12-24 2005-04-19 Dow Pharmaceutical Sciences Aqueous compositions containing metronidazole
IL147921A0 (en) 2002-01-31 2002-08-14 Abdulrazik Mohammad A method for treating central nervous system disorders by ocular dosing
EP1476121A4 (en) 2002-02-08 2010-10-27 Merck Sharp & Dohme TOPICAL IVERMECTIN COMPOSITION
US7906128B2 (en) 2002-10-21 2011-03-15 Wyeth Llc Use of neuronal sodium channel antagonists for the control of ectoparasites in homeothermic animals
JP5711867B2 (ja) 2003-04-24 2015-05-07 ガルデルマ・ソシエテ・アノニム 皮膚科学的疾患の治療のためのアイバメクチンの使用
FR2854074B1 (fr) 2003-04-24 2007-11-23 Galderma Res & Dev Utilisation de l'ivermectine pour le traitement de desordres dermatologiques
US7531186B2 (en) 2003-12-17 2009-05-12 Merial Limited Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz
AU2005219788B2 (en) 2004-03-05 2010-06-03 Nissan Chemical Corporation Isoxazoline-substituted benzamide compound and noxious organism control agent
US8568794B2 (en) 2004-03-12 2013-10-29 Life Science Investments, Ltd. Topical and intravaginal microbicidal and antiparasitic compositions comprising quassinoids or quassinoid-containing plant extracts
US8541413B2 (en) 2004-10-01 2013-09-24 Ramscor, Inc. Sustained release eye drop formulations
TWI350728B (en) 2004-10-08 2011-10-21 Wyeth Corp Amitraz compositions
EP2008660A1 (en) 2004-10-12 2008-12-31 Ernir Snorrason Inhibitors of acetylcholinesterase for treating skin diseases
GB2419093A (en) 2004-10-12 2006-04-19 Ernir Snorrason Acetylcholinesterase inhibitors for the treatment of skin
DE102004053964A1 (de) 2004-11-09 2006-05-11 Bayer Healthcare Ag Mittel gegen Demodikose
AU2005304035B2 (en) 2004-11-09 2010-07-22 Santen Sas Ophthalmic oil-in-water type emulsion with stable positive zeta potential
WO2006119174A1 (en) 2005-04-30 2006-11-09 Ocular Surface Center, P.A. Method for treating ocular demodex
FR2886851B1 (fr) 2005-06-10 2007-10-05 Galderma Sa Composition a base d'une avermectine et de metronidazole notamment pour le traitement de la rosacee
ES2443690T3 (es) 2005-09-02 2014-02-20 Nissan Chemical Industries, Ltd. Compuesto de benzamida sustituido con isoxazolina y agente controlador de organismos dañinos
FR2891460B1 (fr) 2005-09-30 2010-07-30 Galderma Sa Utilisation d'au moins un compose de la famille des avermectines pour le traitement des pathologies ophtalmiques dues au demodex folliculorum.
KR20080080168A (ko) 2005-12-14 2008-09-02 이 아이 듀폰 디 네모아 앤드 캄파니 무척추 해충 방제용 이속사졸린
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
FR2900052B1 (fr) 2006-04-19 2011-02-18 Galderma Sa Composition comprenant au moins une phase aqueuse et au moins une phase grasse comprenant de l'ivermectine
KR20090005201A (ko) 2006-04-20 2009-01-12 이 아이 듀폰 디 네모아 앤드 캄파니 무척추 해충 방제용 피라졸린
JP2008044880A (ja) 2006-08-15 2008-02-28 Bayer Cropscience Ag 殺虫性イソオキサゾリン類
JP5256753B2 (ja) 2007-03-29 2013-08-07 住友化学株式会社 イソオキサゾリン化合物とその有害生物防除用途
RU2009141185A (ru) 2007-04-10 2011-05-20 Байер КропСайенс АГ (DE) Инсектицидные производные арилизоксазолина
EP2144904B1 (en) * 2007-05-09 2011-03-09 Ganial Immunotherapeutics Inc. (s,r)-3-phenyl-4,5 dihydro-5-isoxazole acetic acid-nitric oxide and use thereof as anti-cancer and antiviral agent
JP5473906B2 (ja) 2007-06-13 2014-04-16 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー イソキサゾリン殺虫剤
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
US8128968B2 (en) 2007-08-29 2012-03-06 Tissuetech, Inc. Compositions and methods for treating Demodex infestations
EP2193124B1 (en) 2007-10-03 2012-12-19 E. I. du Pont de Nemours and Company Naphthalene isoxazoline compounds for control of invertebrate pests
FR2922108A1 (fr) 2007-10-11 2009-04-17 Virbac Sa Utilisation d'un derive de 1-n-(halo-3-pyridylmethyle)-n-methylamino-1-alkylamino -2- nitroethylene pour la preparation d'une composition pharmaceutique veterinaire pour lutter contre les puces
FR2925337B1 (fr) 2007-12-21 2010-01-15 Virbac Composition pharmaceutique contenant un derive de n-phenylpyrazole et du glycofurol, utilisation pour la preparation d'un medicament veterinaire topique pour lutter contre les puces
AU2009228205A1 (en) 2008-03-26 2009-10-01 Eric Donnenfeld Methods for improving lid margin and tear film function and treatment of lid margin disease using tetracycline family antibiotics
CN102149695B (zh) 2008-07-09 2015-02-04 日产化学工业株式会社 异*唑啉取代的苯甲酰胺化合物的制造方法
CN102088856B (zh) 2008-07-09 2015-11-25 巴斯夫欧洲公司 包含异*唑啉化合物的杀虫活性混合物i
US9173728B2 (en) 2008-11-19 2015-11-03 Merial Inc. Multi-cavity container having offset indentures for dispensing fluids
US8450357B2 (en) 2008-11-19 2013-05-28 Merial Limited Compositions comprising an aryl pyrazole and/or a formamidine, methods and uses thereof
BRPI0823302B1 (pt) 2008-12-16 2017-01-31 Virbac composição farmacêutica líquida que contém um derivado de n-fenilpirazol, e utilização para a preparação de um medicamento veterinário tópico para lutar contra pulgas
AR074790A1 (es) * 2008-12-19 2011-02-09 Novartis Ag Derivados de isooxazol sustituidos, composiciones farmaceuticas y para el control de parasitos que los comprenden y su uso en metodos para controlar parasitos en y sobre animales de sangre caliente.
US8313752B2 (en) 2009-04-14 2012-11-20 Merial Limited Macrocyclic lactone combination compositions, vaccines and methods for producing same
FR2945797B1 (fr) 2009-05-20 2015-11-06 Virbac Sa Conditionnement alimentaire,pharmaceutique ou veterinaire de securite et son procede de fabrication
CN102985091B (zh) 2010-03-03 2016-11-23 新科蒂斯公司 使用抗微生物肽螯合化合物治疗皮肤疾病和异常的组合物和方法
BR112012026364B1 (pt) 2010-04-12 2018-04-10 Exosect Limited Controle de artrópodes em ambientes de animais
US8211450B2 (en) * 2010-05-05 2012-07-03 Senju Usa, Inc. Ophthalmic composition
CN102260252A (zh) * 2010-05-24 2011-11-30 盟科医药技术(上海)有限公司 可用于治疗细菌感染的新噁唑烷酮
WO2012085683A1 (en) * 2010-12-22 2012-06-28 Entarco Sa The use of spinosyns and spinosyn compositions as local anesthetics and as antiarrhythmic agents
HUE058291T2 (hu) 2010-12-27 2022-07-28 Intervet Int Bv Topikális lokalizált izoxazolin formuláció
US20130331768A1 (en) 2010-12-29 2013-12-12 Louis D. Nichamin Eye treatment
JP2014505089A (ja) 2011-02-10 2014-02-27 ノバルティス アーゲー 無脊椎有害動物を防除するためのイソオキサゾリン誘導体
AU2012226475C1 (en) 2011-03-10 2015-08-06 Zoetis Services Llc Spirocyclic isoxazoline derivatives as antiparasitic agents
EP2755473B1 (en) * 2011-09-12 2018-12-12 Merial, Inc. Parasiticidal compositions comprising an isoxazoline active agent, methods and uses thereof
CN102552114A (zh) 2012-03-19 2012-07-11 段亚东 甲硝唑眼用凝胶及其制备方法和用途
US9345522B2 (en) 2012-05-22 2016-05-24 Matthew Songer Bone fixation screw and method
DK2890699T3 (en) 2012-08-31 2018-06-14 Zoetis Services Llc Crystalline Forms of 1- (5 '- (5- (3,5-DICHLOR-4-FLUORPHENYL) -5- (TRIFLUOROMETHYL) -4,5-DIHYDROISOXAZOL-3-YL) -3'H-SPIRO [AZETIDIN-3 , 1'-isobenzofuran] -1-yl) -2- (methylsulfonyl) ethanone
US9095566B1 (en) 2013-06-28 2015-08-04 Edward Quicksilver Yavitz Eyelash and eyelid margin infections
US9233118B2 (en) 2013-07-08 2016-01-12 Galderma S.A. Treatment of papulopustular rosacea with ivermectin
WO2015195928A1 (en) 2014-06-19 2015-12-23 Attillaps Holdings Acetylcholinesterase inhibitors for treatment of dermatological conditions
WO2019126541A1 (en) 2017-12-20 2019-06-27 Attillaps Holdings Treatment of ophthalmological conditions with acetylcholinesterase inhibitors
CA2917815C (en) 2013-07-29 2022-08-30 Attillaps Holdings Organophosphates for treating afflictions of the skin
US10456358B2 (en) * 2013-12-20 2019-10-29 Intervet Inc. Isoxazoline compositions and use thereof in the prevention or treatment of parasite infestations in animals
US10172902B2 (en) 2014-05-28 2019-01-08 Lunovus Llc Ocular eyelid scrub composition for the treatment of demodex blepharitis
WO2016022066A1 (en) 2014-08-04 2016-02-11 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
US9463201B2 (en) 2014-10-19 2016-10-11 M.G. Therapeutics Ltd Compositions and methods for the treatment of meibomian gland dysfunction
US20170348286A1 (en) * 2014-12-22 2017-12-07 Intervet Inc. Use of isoxazoline compounds for treating demodicosis
BR112017017448A2 (pt) * 2015-02-24 2018-04-03 Ocugen Inc métodos e composições para o tratamento de doença do olho ressecado e outros distúrbios do olho
UY36570A (es) 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
US20160287566A1 (en) 2015-04-04 2016-10-06 Thomas Lynn Busby Anti-demodectic active agents and topical compositions for the treatment of demodicosis in humans and animals
BR112017027855B1 (pt) 2015-06-23 2022-11-16 Intervet International B.V. Composição farmacêutica, seu uso, água potável medicamentosa e método para sua preparação
US20170024748A1 (en) 2015-07-22 2017-01-26 Patient Doctor Technologies, Inc. Guided discussion platform for multiple parties
US10717756B2 (en) * 2015-09-03 2020-07-21 Agrimetis, Llc Spinosyn derivatives as insecticides
BR112018004327B8 (pt) 2015-09-10 2022-08-23 Dow Agrosciences Llc Moléculas, composição pesticida, e processos nãoterapêuticos para controlar uma praga
US10688122B2 (en) 2015-09-28 2020-06-23 Azura Ophthalmics Ltd. Thiol and disulfide-containing agents for increasing meibomian gland lipid secretion
UY37137A (es) 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
LT3440062T (lt) 2016-04-06 2021-12-10 Boehringer Ingelheim Animal Health USA Inc. Enantiomeru praturtintų izoksazolino junginių - (s)-afoksolanerio kristalinio tolueno solvato gamybos būdas
AU2017251155B2 (en) 2016-04-15 2021-08-05 Bayer Animal Health Gmbh Pyrazolopyrimidine derivatives
WO2018081733A1 (en) 2016-10-31 2018-05-03 The California Institute For Biomedical Research Methods and compositions for preventing vector-borne disease transmission
BR112020012018A2 (pt) 2017-12-15 2020-11-24 Tarsus Pharmaceuticals, Inc. formulações de parasiticida de isoxazolina e métodos para tratar blefarite
JP2021532152A (ja) 2018-07-27 2021-11-25 アペルタ バイオサイエンシズ，エルエルシー デモデックスにより誘発される眼の異常および顔面の異常を治療するためのスピノシン配合
KR20220054241A (ko) 2019-04-04 2022-05-02 타르서스 파마수티칼스, 아이엔씨. 벡터 매개 및 바이러스성 질환의 치료 또는 예방을 위한 전신 이속사졸린 구충제
US20220249445A1 (en) 2019-06-19 2022-08-11 Tarsus Pharmaceuticals, Inc. Isoxazoline parasiticide formulations and methods for treating blepharitis

Also Published As

Publication number Publication date
US20220362218A1 (en) 2022-11-17
AU2023200843A1 (en) 2023-03-16
BR112020012018A2 (pt) 2020-11-24
US20220054457A2 (en) 2022-02-24
EP3723739B1 (en) 2024-03-27
EP3723739A4 (en) 2022-04-20
US20220354829A1 (en) 2022-11-10
EP3723739A1 (en) 2020-10-21
US11752137B2 (en) 2023-09-12
US11690827B2 (en) 2023-07-04
KR20200111177A (ko) 2020-09-28
JP2021506971A (ja) 2021-02-22
AU2018385766B2 (en) 2022-12-01
US20210077466A1 (en) 2021-03-18
DK3723739T3 (da) 2024-06-17
US20190183862A1 (en) 2019-06-20
IL275339B2 (en) 2024-03-01
WO2019118928A1 (en) 2019-06-20
IL275339A (en) 2020-07-30
JP2024038449A (ja) 2024-03-19
RU2020122841A (ru) 2022-01-18
US20220354830A1 (en) 2022-11-10
NZ766141A (en) 2024-01-26
US20210196689A1 (en) 2021-07-01
IL307992A (en) 2023-12-01
CN111655241A (zh) 2020-09-11
US20210077465A1 (en) 2021-03-18
US20230301971A1 (en) 2023-09-28
US20230190711A1 (en) 2023-06-22
IL275339B1 (en) 2023-11-01
US10835517B2 (en) 2020-11-17
US20230293496A1 (en) 2023-09-21
US11690826B2 (en) 2023-07-04
AU2018385766A1 (en) 2020-07-23
US11197847B2 (en) 2021-12-14
ZA202004155B (en) 2023-01-25
CA3085787A1 (en) 2019-06-20

Similar Documents

Publication Publication Date Title
NZ766141A (en) Isoxazoline parasiticide formulations and methods for treating blepharitis
MX2016014634A (es) Compuestos para el tratamiento de enfermedades y trastornos oftalmicos.
PH12017502092A1 (en) Topical pharmaceutical compositions
MX361590B (es) Suministro topico de composiciones para la piel que tienen ph bajo.
MX2022014313A (es) Formulaciones para administracion oral de agentes activos con perfil de absorcion controlada.
MY195002A (en) Benzoxazepin oxazolidinone compounds and methods of use
WO2017158366A3 (en) Ophthalmic delivery device and ophthalmic drug compositions
MX2020010907A (es) Mejora de suministro de agentes activos lipofilicos a traves de la barrera hematoencefalica y metodos para tratar trastornos del sistema nervioso central.
MX2020005217A (es) Composicion oftalmica y dispositivo de administracion de la misma.
MX2013011314A (es) Tratamientos oftalmicos.
MX2019012884A (es) Terapia de combinacion.
MX2015002239A (es) Formulacion oftalmica de lipido polioxilo o de acido graso polioxilo y tratamiento de padecimientos oculares.
PH12020500543A1 (en) Nonracemic mixtures and uses thereof
MX2019013799A (es) Peptido novedoso y composicion farmaceutica para tratar una enfermedad ocular que comprende el mismo como un ingrediente farmaceutico activo.
MY163235A (en) Pharmaceutical preparation containing pyridylaminoacetic acid compound
MX2020011873A (es) Nuevos derivados de quinolina.
EP4234021A3 (en) Pharmaceutical composition comprising an adenosine derivative for use in the prevention or treatment of diabetic nephropathy
MX2016016400A (es) Formulaciones de oximetazolina estabilizadas y sus usos.
WO2015048188A8 (en) Modified fibroblast growth factors for the treatment of ocular disorders
MX2020013692A (es) Compuestos de pirazol e imidazol para la inhibicion de il-17 y rorgamma.
AU2017261303A1 (en) Ophthalmic compositions
MX2021016055A (es) Formulaciones y métodos de parasiticidas de isoxazolina para el tratamiento de la blefaritis.
PH12020550722A1 (en) Ophthalmic topical composition comprising dobesilic acid for treating diseases of the posterior segment of the eye
WO2014116015A3 (ko) 자죽염을 포함하는 알츠하이머병 예방용 조성물 및 자죽염의 제조방법
WO2017152129A3 (en) Treatment of glaucoma and/or retinal diseases and formulations useful therefore