MX2013011314A - Tratamientos oftalmicos. - Google Patents
Tratamientos oftalmicos.Info
- Publication number
- MX2013011314A MX2013011314A MX2013011314A MX2013011314A MX2013011314A MX 2013011314 A MX2013011314 A MX 2013011314A MX 2013011314 A MX2013011314 A MX 2013011314A MX 2013011314 A MX2013011314 A MX 2013011314A MX 2013011314 A MX2013011314 A MX 2013011314A
- Authority
- MX
- Mexico
- Prior art keywords
- eye
- compositions
- pharmaceuticals
- tramadol
- analgesic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se relaciona con composiciones acuosas apropiadas para la administración tópica al ojo humano o animal, que contiene por lo menos un lubricante oftálmico polimérico, soluble en agua, tal como hialuronato, gel de carbómero o hipromelosa, junto con un analgésico soluble en agua. El analgésico puede ser un opioide, particularmente un opioide que tiene una afinidad para los receptores de 5-HT, tal como tramadol. Los niveles de tramadol típicos estarían en el intervalo de 0.5% a 1.0 p/v. Por ejemplo, las composiciones acuosas pueden usarse como lágrimas artificiales, y como lubricantes oftálmicos generales para el tratamiento de las afecciones, tales como ojo seco o blefaritis. Las composiciones adicionales combinan los agentes oftalmológicamente activos, tales como farmacéuticos, con opioides, en particular, tal como tramadol. Estas composiciones pueden usarse para tratar el ojo, mientras que reducen el dolor o el malestar que sería producido normalmente por la administración de estos farmacéuticos particulares al ojo, y aumentar la eficacia de los farmacéuticos. También se describen composiciones, que contienen opioides con actividad del receptor de 5-HT, los cuales son de uso general para aliviar el dolor en, o alrededor del ojo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1105732.0A GB201105732D0 (en) | 2011-04-05 | 2011-04-05 | Ophthalmic lubricants |
| GBGB1105731.2A GB201105731D0 (en) | 2011-04-05 | 2011-04-05 | Topical analgesics |
| PCT/GB2012/000330 WO2012136969A2 (en) | 2011-04-05 | 2012-04-05 | Ophthalmic treatments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013011314A true MX2013011314A (es) | 2014-03-27 |
| MX346312B MX346312B (es) | 2017-03-15 |
Family
ID=46086008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013011314A MX346312B (es) | 2011-04-05 | 2012-04-05 | Tratamientos oftalmicos. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20140088199A1 (es) |
| EP (2) | EP3799866A1 (es) |
| JP (2) | JP6148664B2 (es) |
| KR (2) | KR102165246B1 (es) |
| CN (2) | CN103687594A (es) |
| BR (1) | BR112013025493A2 (es) |
| CA (1) | CA2869280C (es) |
| ES (1) | ES2836808T3 (es) |
| HK (1) | HK1254720A1 (es) |
| MA (1) | MA35070B1 (es) |
| MX (1) | MX346312B (es) |
| WO (1) | WO2012136969A2 (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140088199A1 (en) * | 2011-04-05 | 2014-03-27 | Optosolve Llp | Ophthalmic treatments |
| GB201217522D0 (en) * | 2012-10-01 | 2012-11-14 | Sharma Anant | ophthalmic therapy |
| RU2015145135A (ru) * | 2013-04-09 | 2017-05-12 | Крессет Биомолекьюлар Дискавери Лтд | Лечение воспалительных расстройств |
| ES2540151B1 (es) * | 2013-10-11 | 2016-02-29 | Farmalider S.A. | Composición farmacéutica de ibuprofeno y tramadol para uso oftálmico |
| RU2549472C1 (ru) * | 2013-12-26 | 2015-04-27 | Илья Александрович Марков | Фармацевтическая композиция в форме капель для профилактики и лечения аллергических заболеваний глаз |
| JP2017502089A (ja) * | 2014-01-10 | 2017-01-19 | マニスティー パートナーズ エルエルシーＭａｎｉｓｔｅｅ Ｐａｒｔｎｅｒｓ Ｌｌｃ | 偏頭痛の処置 |
| WO2016172712A2 (en) | 2015-04-23 | 2016-10-27 | Sydnexis, Inc. | Ophthalmic composition |
| US9421199B2 (en) | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| US11382909B2 (en) | 2014-09-05 | 2022-07-12 | Sydnexis, Inc. | Ophthalmic composition |
| RU2691412C2 (ru) * | 2015-02-24 | 2019-06-13 | Дзе Боард Оф Трастис Оф Дзе Юниверсити Оф Иллинойс | Способы и композиции для лечения болезни сухого глаза и других глазных заболеваний |
| US9877964B2 (en) | 2015-02-24 | 2018-01-30 | Ocugen, Inc. | Methods and compositions for treating dry eye disease and other eye disorders |
| WO2016196367A1 (en) | 2015-05-29 | 2016-12-08 | Sydnexis, Inc. | D2o stabilized pharmaceutical formulations |
| ES2604816B1 (es) * | 2015-09-09 | 2018-01-29 | Farmalider, S.A. | Composición farmacéutica de tramadol para uso oftálmico |
| CN108135926A (zh) * | 2015-09-24 | 2018-06-08 | 基质生物研究所 | 高弹性透明质酸组合物及其使用方法 |
| EP3355874A4 (en) * | 2015-09-30 | 2019-06-12 | George Edward Hoag | TOPICAL ANALGETIC FORMULATIONS, MANUFACTURE AND METHOD FOR USE THEREOF |
| CN105232449B (zh) * | 2015-10-30 | 2019-04-09 | 上海昊海生物科技股份有限公司 | 盐酸莫西沙星透明质酸钠缓释纳米凝胶及其制备方法 |
| EP3525885B1 (en) | 2016-10-12 | 2022-01-26 | PS Therapy Ltd. | Artificial tear, contact lens and drug vehicle compositions and methods of use thereof |
| JP2020523406A (ja) | 2017-05-19 | 2020-08-06 | オクジェン アイエヌシー． | 眼科用組成物および使用方法 |
| SG11201911750RA (en) * | 2017-06-08 | 2020-01-30 | Eye Therapies Llc | Low-dose brimonidine combinations and uses thereof |
| WO2019122982A1 (en) | 2017-12-21 | 2019-06-27 | Grünenthal GmbH | Pharmaceutical combination in a bilayer tablet form comprising ketorolac tromethamine and tramadol hydrochloride, and its use in pain treatment |
| WO2019176946A1 (ja) * | 2018-03-13 | 2019-09-19 | 参天製薬株式会社 | 点眼型洗眼薬用組成物 |
| CA3143071A1 (en) | 2019-07-26 | 2021-02-04 | Proqr Therapeutics Ii B.V. | Ophthalmic compositions comprising viscosifying polymers and nucleic acids |
| US11504269B2 (en) | 2019-11-19 | 2022-11-22 | Jennifer L. Fabian | Therapeutic bra |
| CN112007028A (zh) * | 2020-09-03 | 2020-12-01 | 北京博纳致恒科技有限责任公司 | 一种复合睫状肌松弛剂的人工泪液及用途 |
| CN116887823A (zh) * | 2021-02-26 | 2023-10-13 | 卫璐玛股份有限公司 | 用于外用施用加巴喷丁类药物的方法和制剂 |
| WO2023285878A1 (en) * | 2021-07-13 | 2023-01-19 | Aviation-Ophthalmology | Methods for detecting, treating, and preventing gpr68-mediated ocular diseases, disorders, and conditions |
| TW202408467A (zh) * | 2022-07-06 | 2024-03-01 | 日商樂敦製藥股份有限公司 | 眼科組成物 |
| TW202408474A (zh) * | 2022-07-06 | 2024-03-01 | 學校法人金澤醫科大學 | 疼痛抑制劑 |
| TW202408468A (zh) * | 2022-07-06 | 2024-03-01 | 日商樂敦製藥股份有限公司 | 眼科組成物 |
| WO2024010039A1 (ja) * | 2022-07-06 | 2024-01-11 | ロート製薬株式会社 | 眼科組成物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6384043B1 (en) | 1993-02-01 | 2002-05-07 | Gholam A. Peyman | Methods of alleviating pain sensations of the denuded eye with opioid analgesics |
| US6017963A (en) * | 1995-11-14 | 2000-01-25 | Euro-Celtique, S.A. | Formulation for intranasal administration |
| PT946157E (pt) * | 1996-12-16 | 2002-07-31 | Alcon Lab Inc | Utilizacao topica de agonistas kapa-opioides para o tratamento da dor ocular |
| US6174878B1 (en) * | 1999-08-31 | 2001-01-16 | Alcon Laboratories, Inc. | Topical use of kappa opioid agonists to treat otic pain |
| JP2004143157A (ja) * | 2002-10-01 | 2004-05-20 | Taisho Pharmaceut Co Ltd | 点眼剤 |
| US20060172972A1 (en) * | 2002-12-20 | 2006-08-03 | Chakshu Research Inc | Formulation and method for administration of ophthalmologically active agents |
| EP1768650B1 (en) | 2004-06-04 | 2008-07-16 | Camurus Ab | Liquid depot formulations |
| EP1611877A1 (en) * | 2004-06-28 | 2006-01-04 | Universidade de Coimbra | Method for preparing sustained-release therapeutic ophthalmic articles using compressed fluids for impregnation of drugs |
| WO2007057508A2 (en) | 2005-11-18 | 2007-05-24 | Orion Corporation | Treatment of pain with a combination of an alpha2 -adrenoceptor antagonist such as atipemezole or fipamezoiie and an opioid receptor agonist, such as tramadol |
| CA2636646A1 (en) * | 2006-01-25 | 2007-08-02 | Aciex, Inc. | Formulations and methods for treating dry eye |
| MX2009012645A (es) | 2007-05-24 | 2010-03-08 | Aciex Therapeutics Inc | Formulaciones y metodos para tratar el ojo seco. |
| EP2311446A1 (en) * | 2009-10-16 | 2011-04-20 | Laboratorios Del. Dr. Esteve, S.A. | Compositions comprising Tramadol and Celecoxib in the treatment of pain |
| US20140088199A1 (en) * | 2011-04-05 | 2014-03-27 | Optosolve Llp | Ophthalmic treatments |
-
2012
- 2012-04-05 US US14/009,397 patent/US20140088199A1/en not_active Abandoned
- 2012-04-05 EP EP20200285.3A patent/EP3799866A1/en active Pending
- 2012-04-05 ES ES12721571T patent/ES2836808T3/es active Active
- 2012-04-05 CN CN201280025096.6A patent/CN103687594A/zh active Pending
- 2012-04-05 MA MA36378A patent/MA35070B1/fr unknown
- 2012-04-05 CA CA2869280A patent/CA2869280C/en active Active
- 2012-04-05 KR KR1020187038197A patent/KR102165246B1/ko active IP Right Grant
- 2012-04-05 CN CN201711200533.4A patent/CN107982211A/zh active Pending
- 2012-04-05 BR BR112013025493A patent/BR112013025493A2/pt not_active Application Discontinuation
- 2012-04-05 MX MX2013011314A patent/MX346312B/es active IP Right Grant
- 2012-04-05 KR KR1020137029016A patent/KR20140145948A/ko active Application Filing
- 2012-04-05 EP EP12721571.3A patent/EP2694048B1/en active Active
- 2012-04-05 JP JP2014503208A patent/JP6148664B2/ja active Active
- 2012-04-05 WO PCT/GB2012/000330 patent/WO2012136969A2/en active Application Filing
-
2016
- 2016-03-21 US US15/076,098 patent/US9913813B2/en active Active
-
2017
- 2017-03-07 JP JP2017043172A patent/JP6419876B2/ja active Active
-
2018
- 2018-10-26 HK HK18113731.7A patent/HK1254720A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012136969A2 (en) | 2012-10-11 |
| JP2014513073A (ja) | 2014-05-29 |
| JP6148664B2 (ja) | 2017-06-14 |
| MA35070B1 (fr) | 2014-04-03 |
| WO2012136969A3 (en) | 2013-01-03 |
| EP2694048A2 (en) | 2014-02-12 |
| EP3799866A1 (en) | 2021-04-07 |
| KR20190004815A (ko) | 2019-01-14 |
| KR102165246B1 (ko) | 2020-10-13 |
| MX346312B (es) | 2017-03-15 |
| KR20140145948A (ko) | 2014-12-24 |
| CN103687594A (zh) | 2014-03-26 |
| JP2017141243A (ja) | 2017-08-17 |
| CA2869280C (en) | 2020-03-10 |
| BR112013025493A2 (pt) | 2017-03-01 |
| EP2694048B1 (en) | 2020-10-07 |
| CA2869280A1 (en) | 2012-10-11 |
| CN107982211A (zh) | 2018-05-04 |
| US20140088199A1 (en) | 2014-03-27 |
| US9913813B2 (en) | 2018-03-13 |
| JP6419876B2 (ja) | 2018-11-07 |
| US20160199320A1 (en) | 2016-07-14 |
| ES2836808T3 (es) | 2021-06-28 |
| HK1254720A1 (zh) | 2019-07-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or rights |
Owner name: OPTOSOLVE RESEARCH & DEVELOPMENT LIMITED |
|
| FG | Grant or registration |