WO2009090624A3 - Gel de quitosano para aplicaciones dermatológicas, proceso de obtención y uso del mismo - Google Patents

Gel de quitosano para aplicaciones dermatológicas, proceso de obtención y uso del mismo Download PDF

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Publication number
WO2009090624A3
WO2009090624A3 PCT/IB2009/050228 IB2009050228W WO2009090624A3 WO 2009090624 A3 WO2009090624 A3 WO 2009090624A3 IB 2009050228 W IB2009050228 W IB 2009050228W WO 2009090624 A3 WO2009090624 A3 WO 2009090624A3
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WO
WIPO (PCT)
Prior art keywords
gel
skin
chitosan
same
production method
Prior art date
Application number
PCT/IB2009/050228
Other languages
English (en)
French (fr)
Other versions
WO2009090624A2 (es
Inventor
Ariel Shaul Hasson Nisis
Original Assignee
Gynopharm S.A.
Igloo Zone Chile S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gynopharm S.A., Igloo Zone Chile S.A. filed Critical Gynopharm S.A.
Priority to MX2010007902A priority Critical patent/MX2010007902A/es
Priority to EP09702300.6A priority patent/EP2452673B1/en
Priority to US12/863,551 priority patent/US20100316739A1/en
Priority to ES201050012A priority patent/ES2361459B1/es
Priority to CN200980109724.7A priority patent/CN101977589B/zh
Priority to BRPI0906932-1A priority patent/BRPI0906932A2/pt
Priority to JP2010542731A priority patent/JP5615717B2/ja
Priority to CA2712527A priority patent/CA2712527C/en
Publication of WO2009090624A2 publication Critical patent/WO2009090624A2/es
Publication of WO2009090624A3 publication Critical patent/WO2009090624A3/es
Priority to EC2010010352A priority patent/ECSP10010352A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se protegen composiciones farmacéuticas que son apropiadas para dej ar una película protectora sobre Ia piel, en base a quitosano y agentes que Ie confieren propiedades curativas, calmantes e hidratantes en pieles irritadas. Este gel se caracteriza por incorporar quitosano en un porcentaje que va entre 2 y un 8% y otros componentes, también en proporción def inida como Ia Portulaca, entre 0, 1 y 90% y Pantenol en proporción entre 0, 1 y 45 % que Ie confieren mejores características terapéuticas al producto y otros componentes que Ie dan sus características propias al gel y Ie confieren una estabilidad adecuada y prolongada en el tiempo. Este gel es de aplicación externa y puede ser usado en pieles irritadas, quemaduras superficiales, dermo abrasiones, post-peeling, post- laser y en general en pieles erosionadas.
PCT/IB2009/050228 2008-01-18 2009-01-21 Gel de quitosano para aplicaciones dermatológicas, proceso de obtención y uso del mismo WO2009090624A2 (es)

Priority Applications (9)

Application Number Priority Date Filing Date Title
MX2010007902A MX2010007902A (es) 2008-01-18 2009-01-21 Gel de quitosano para aplicaciones dermatologicas, proceso de obtencion y uso del mismo.
EP09702300.6A EP2452673B1 (en) 2008-01-18 2009-01-21 Chitosan gel for dermatological use, production method therefor and use of same
US12/863,551 US20100316739A1 (en) 2008-01-18 2009-01-21 Chitosan gel for dermatological use, production method therefor and use of same
ES201050012A ES2361459B1 (es) 2008-01-18 2009-01-21 Gel de quitosano para aplicaciones dermatológicas, proceso de obtención y uso del mismo.
CN200980109724.7A CN101977589B (zh) 2008-01-18 2009-01-21 皮肤病学使用的壳聚糖凝胶、其制备方法及其用途
BRPI0906932-1A BRPI0906932A2 (pt) 2008-01-18 2009-01-21 Gel hidrofílico estável, baseado em um polímero para aplicação tópica, processo para obeter o mesmo e uso do mesmo
JP2010542731A JP5615717B2 (ja) 2008-01-18 2009-01-21 皮膚科利用のためのキトサンゲル、その製造方法および使用
CA2712527A CA2712527C (en) 2008-01-18 2009-01-21 Chitosan gel for dermatological use, production method and use of same
EC2010010352A ECSP10010352A (es) 2008-01-18 2010-07-16 Gel de quitosano para aplicaciones dermatologicas, proceso de obtencion y uso del mismo

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CL200800156A CL2008000156A1 (es) 2008-01-18 2008-01-18 Gel estable hidrofilo en base a un polimero para aplicacion topica porque comprende quitosano disuelto en un solvente; proceso para obtener el gel para uso topico antes mencionado; uso del gel.
CL0156-2008 2008-01-18

Publications (2)

Publication Number Publication Date
WO2009090624A2 WO2009090624A2 (es) 2009-07-23
WO2009090624A3 true WO2009090624A3 (es) 2009-09-11

Family

ID=40261146

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/050228 WO2009090624A2 (es) 2008-01-18 2009-01-21 Gel de quitosano para aplicaciones dermatológicas, proceso de obtención y uso del mismo

Country Status (14)

Country Link
US (1) US20100316739A1 (es)
EP (1) EP2452673B1 (es)
JP (1) JP5615717B2 (es)
CN (1) CN101977589B (es)
AR (1) AR071334A1 (es)
BR (1) BRPI0906932A2 (es)
CA (1) CA2712527C (es)
CL (1) CL2008000156A1 (es)
CO (1) CO6331421A2 (es)
EC (1) ECSP10010352A (es)
ES (1) ES2361459B1 (es)
MX (1) MX2010007902A (es)
PE (1) PE20091363A1 (es)
WO (1) WO2009090624A2 (es)

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CN103919689A (zh) * 2014-03-20 2014-07-16 金红叶纸业集团有限公司 湿巾乳液、湿巾及湿巾的制备方法
GB201501333D0 (en) 2015-01-27 2015-03-11 Medtrade Products Ltd Composition for a wound dressing
GB201501330D0 (en) * 2015-01-27 2015-03-11 Medtrade Products Ltd Composition for a wound dressing
EA026104B1 (ru) * 2015-04-02 2017-03-31 Общество С Ограниченной Ответственностью "Тектум" Кровоостанавливающее и ранозаживляющее средство
US10660945B2 (en) 2015-08-07 2020-05-26 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
US10751444B2 (en) 2015-08-07 2020-08-25 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
CN105055582B (zh) * 2015-08-18 2018-09-04 云南同方科技有限公司 一种用于皮肤轻度烧烫伤的配方精油
WO2018005145A1 (en) * 2016-06-28 2018-01-04 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
CA3066321A1 (en) 2017-07-19 2019-01-24 Universidade Da Beira Interior Film for topical application in the treatment of skin lesions and method of obtaining and applying it
CN108514546B (zh) * 2018-05-14 2020-09-29 山东师范大学 一种二氢杨梅素的壳聚糖水凝胶制剂及制备方法
CN109731021A (zh) * 2019-03-20 2019-05-10 武汉市思泰利医疗器械发展有限公司 一种用于治疗修复造口皮肤的壳聚糖水凝胶及其制备方法
WO2020207844A1 (en) * 2019-04-08 2020-10-15 Medoderm Gmbh Liquid composition for influencing the microbiota on a subject's skin comprising chitosan
EP3996914A4 (en) * 2019-07-11 2023-08-02 Stenco, LLC BIODEGRADABLE MATERIAL
CN111920742A (zh) * 2020-09-18 2020-11-13 微著生物科技(东营)有限责任公司 一种壳聚糖多效修复面膜及制备方法
US20230381217A1 (en) * 2020-10-14 2023-11-30 Medoderm Gmbh Liquid composition for use in the prevention or reduction of skin irritation, allergy and/or an infectious disease
DE102021109834A1 (de) * 2021-04-19 2022-10-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Zusammensetzung zur Desinfektion und für kosmetische Anwendungen
WO2023233299A1 (en) 2022-05-31 2023-12-07 Instituto Politécnico Da Guarda Wound dressing comprising a ph sensor composition and method of producing the same
US11845859B1 (en) 2023-03-28 2023-12-19 King Faisal University Biopolymer derived from algae

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EP0460385A2 (en) * 1990-05-10 1991-12-11 H.B. FULLER LICENSING & FINANCING, INC. Polymeric biocidal agents
WO1992009636A1 (en) * 1990-11-30 1992-06-11 Baker Cummins Dermatologicals, Inc. Skin protective compositions and method of inhibiting skin irritation
WO2001000246A2 (en) * 1999-06-11 2001-01-04 Shearwater Corporation Hydrogels derived from chitosan and poly(ethylene glycol)
KR20010016482A (ko) * 2000-12-14 2001-03-05 손태원 키토산과 젤라틴으로 조성된 연질 겔
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CO6331421A2 (es) 2011-10-20
ES2361459A1 (es) 2011-06-17
CA2712527A1 (en) 2009-07-23
CL2008000156A1 (es) 2008-08-01
WO2009090624A2 (es) 2009-07-23
BRPI0906932A2 (pt) 2015-07-28
JP2012515710A (ja) 2012-07-12
ES2361459B1 (es) 2012-04-24
ECSP10010352A (es) 2010-11-30
AR071334A1 (es) 2010-06-16
US20100316739A1 (en) 2010-12-16
EP2452673A4 (en) 2013-04-03
EP2452673A2 (en) 2012-05-16
PE20091363A1 (es) 2009-10-15
JP5615717B2 (ja) 2014-10-29
CN101977589B (zh) 2014-12-10
CN101977589A (zh) 2011-02-16
MX2010007902A (es) 2010-11-25
CA2712527C (en) 2017-02-28
EP2452673B1 (en) 2017-04-26
ES2361459A8 (es) 2011-07-21

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