MX346312B - Tratamientos oftalmicos. - Google Patents

Tratamientos oftalmicos.

Info

Publication number
MX346312B
MX346312B MX2013011314A MX2013011314A MX346312B MX 346312 B MX346312 B MX 346312B MX 2013011314 A MX2013011314 A MX 2013011314A MX 2013011314 A MX2013011314 A MX 2013011314A MX 346312 B MX346312 B MX 346312B
Authority
MX
Mexico
Prior art keywords
eye
compositions
pharmaceuticals
tramadol
analgesic
Prior art date
Application number
MX2013011314A
Other languages
English (en)
Other versions
MX2013011314A (es
Inventor
Sharma Anant
Original Assignee
Optosolve Res & Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1105732.0A external-priority patent/GB201105732D0/en
Priority claimed from GBGB1105731.2A external-priority patent/GB201105731D0/en
Application filed by Optosolve Res & Dev Ltd filed Critical Optosolve Res & Dev Ltd
Publication of MX2013011314A publication Critical patent/MX2013011314A/es
Publication of MX346312B publication Critical patent/MX346312B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La presente invención se relaciona con composiciones acuosas apropiadas para la administración tópica al ojo humano o animal, que contiene por lo menos un lubricante oftálmico polimérico, soluble en agua, tal como hialuronato, gel de carbómero o hipromelosa, junto con un analgésico soluble en agua. El analgésico puede ser un opioide, particularmente un opioide que tiene una afinidad para los receptores de 5-HT, tal como tramadol. Los niveles de tramadol típicos estarían en el intervalo de 0.5% a 1.0 p/v. Por ejemplo, las composiciones acuosas pueden usarse como lágrimas artificiales, y como lubricantes oftálmicos generales para el tratamiento de las afecciones, tales como ojo seco o blefaritis. Las composiciones adicionales combinan los agentes oftalmológicamente activos, tales como farmacéuticos, con opioides, en particular, tal como tramadol. Estas composiciones pueden usarse para tratar el ojo, mientras que reducen el dolor o el malestar que sería producido normalmente por la administración de estos farmacéuticos particulares al ojo, y aumentar la eficacia de los farmacéuticos. También se describen composiciones, que contienen opioides con actividad del receptor de 5-HT, los cuales son de uso general para aliviar el dolor en, o alrededor del ojo.
MX2013011314A 2011-04-05 2012-04-05 Tratamientos oftalmicos. MX346312B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1105732.0A GB201105732D0 (en) 2011-04-05 2011-04-05 Ophthalmic lubricants
GBGB1105731.2A GB201105731D0 (en) 2011-04-05 2011-04-05 Topical analgesics
PCT/GB2012/000330 WO2012136969A2 (en) 2011-04-05 2012-04-05 Ophthalmic treatments

Publications (2)

Publication Number Publication Date
MX2013011314A MX2013011314A (es) 2014-03-27
MX346312B true MX346312B (es) 2017-03-15

Family

ID=46086008

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013011314A MX346312B (es) 2011-04-05 2012-04-05 Tratamientos oftalmicos.

Country Status (12)

Country Link
US (2) US20140088199A1 (es)
EP (2) EP2694048B1 (es)
JP (2) JP6148664B2 (es)
KR (2) KR102165246B1 (es)
CN (2) CN107982211A (es)
BR (1) BR112013025493A2 (es)
CA (1) CA2869280C (es)
ES (1) ES2836808T3 (es)
HK (1) HK1254720A1 (es)
MA (1) MA35070B1 (es)
MX (1) MX346312B (es)
WO (1) WO2012136969A2 (es)

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EP2694048B1 (en) * 2011-04-05 2020-10-07 Optosolve Research & Development Ltd Ophthalmic treatments
GB201217522D0 (en) * 2012-10-01 2012-11-14 Sharma Anant ophthalmic therapy
CA2909117A1 (en) * 2013-04-09 2014-10-16 Cresset Biomolecular Discovery Ltd The treatment of inflammatory disorders
ES2540151B1 (es) * 2013-10-11 2016-02-29 Farmalider S.A. Composición farmacéutica de ibuprofeno y tramadol para uso oftálmico
RU2549472C1 (ru) * 2013-12-26 2015-04-27 Илья Александрович Марков Фармацевтическая композиция в форме капель для профилактики и лечения аллергических заболеваний глаз
EP3091985B1 (en) * 2014-01-10 2024-05-08 Manistee Therapeutics, Inc. Prostanglandins for topical use in the treatment of migraines.
US9421199B2 (en) 2014-06-24 2016-08-23 Sydnexis, Inc. Ophthalmic composition
WO2016172712A2 (en) 2015-04-23 2016-10-27 Sydnexis, Inc. Ophthalmic composition
US11382909B2 (en) 2014-09-05 2022-07-12 Sydnexis, Inc. Ophthalmic composition
MX2017010544A (es) * 2015-02-24 2018-06-18 Univ Illinois Metodos y composiciones para tratar la enfermedad del ojo seco y otros trastornos del ojo.
US9877964B2 (en) 2015-02-24 2018-01-30 Ocugen, Inc. Methods and compositions for treating dry eye disease and other eye disorders
EP3302426A4 (en) 2015-05-29 2018-12-05 Sydnexis, Inc. D2o stabilized pharmaceutical formulations
ES2604816B1 (es) 2015-09-09 2018-01-29 Farmalider, S.A. Composición farmacéutica de tramadol para uso oftálmico
US20180344676A1 (en) * 2015-09-30 2018-12-06 George Edward Hoag Topical analgesic pain relief formulations, manufacture and methods of use thereof
CN105232449B (zh) * 2015-10-30 2019-04-09 上海昊海生物科技股份有限公司 盐酸莫西沙星透明质酸钠缓释纳米凝胶及其制备方法
CN110114119B (zh) 2016-10-12 2022-05-31 Ps治疗有限公司 人工泪液、隐形眼镜和药物载体组合物及其使用方法
EP3624773A4 (en) 2017-05-19 2021-04-07 Ocugen, Inc. OPHTHALMIC COMPOSITIONS AND METHOD OF USE
US20180353504A1 (en) * 2017-06-08 2018-12-13 Eye Therapies, Llc Low-dose brimonidine combinations and uses thereof
MX2018003456A (es) 2017-12-21 2019-09-06 Gruenenthal Gmbh Combinacion farmaceutica en la forma de comprimidos en bicapa que comprende ketorolaco trometamina y tramadol clorhidrato, y su uso para el tratamiento del dolor.
TW201945011A (zh) * 2018-03-13 2019-12-01 日商參天製藥股份有限公司 點眼型洗眼藥用組合物
AU2020321466A1 (en) 2019-07-26 2022-02-17 Proqr Therapeutics Ii B.V. Ophthalmic compositions comprising viscosifying polymers and nucleic acids
US11504269B2 (en) 2019-11-19 2022-11-22 Jennifer L. Fabian Therapeutic bra
CN112007028A (zh) * 2020-09-03 2020-12-01 北京博纳致恒科技有限责任公司 一种复合睫状肌松弛剂的人工泪液及用途
WO2022183051A1 (en) * 2021-02-26 2022-09-01 Vyluma Inc. Methods and formulations for topical administration of gabapentinoids
WO2023285878A1 (en) * 2021-07-13 2023-01-19 Aviation-Ophthalmology Methods for detecting, treating, and preventing gpr68-mediated ocular diseases, disorders, and conditions
WO2024010039A1 (ja) * 2022-07-06 2024-01-11 ロート製薬株式会社 眼科組成物
WO2024010040A1 (ja) * 2022-07-06 2024-01-11 ロート製薬株式会社 眼科組成物
WO2024010044A1 (ja) * 2022-07-06 2024-01-11 ロート製薬株式会社 眼科組成物
WO2024010045A1 (ja) * 2022-07-06 2024-01-11 学校法人金沢医科大学 疼痛抑制剤

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Publication number Priority date Publication date Assignee Title
US6384043B1 (en) 1993-02-01 2002-05-07 Gholam A. Peyman Methods of alleviating pain sensations of the denuded eye with opioid analgesics
US6017963A (en) * 1995-11-14 2000-01-25 Euro-Celtique, S.A. Formulation for intranasal administration
EP0946157B1 (en) * 1996-12-16 2002-03-13 Alcon Laboratories, Inc. The topical use of kappa opioid agonists to treat ocular pain
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US20060172972A1 (en) * 2002-12-20 2006-08-03 Chakshu Research Inc Formulation and method for administration of ophthalmologically active agents
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EP1611877A1 (en) * 2004-06-28 2006-01-04 Universidade de Coimbra Method for preparing sustained-release therapeutic ophthalmic articles using compressed fluids for impregnation of drugs
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EP1981491A4 (en) * 2006-01-25 2009-09-23 Aciex Inc COMPOSITIONS AND METHODS FOR TREATING OPHTHALMIC DROUGHT
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Also Published As

Publication number Publication date
EP3799866A1 (en) 2021-04-07
CN107982211A (zh) 2018-05-04
EP2694048A2 (en) 2014-02-12
ES2836808T3 (es) 2021-06-28
EP2694048B1 (en) 2020-10-07
BR112013025493A2 (pt) 2017-03-01
HK1254720A1 (zh) 2019-07-26
JP2017141243A (ja) 2017-08-17
JP6419876B2 (ja) 2018-11-07
KR20140145948A (ko) 2014-12-24
KR102165246B1 (ko) 2020-10-13
US9913813B2 (en) 2018-03-13
US20160199320A1 (en) 2016-07-14
CA2869280C (en) 2020-03-10
CN103687594A (zh) 2014-03-26
JP2014513073A (ja) 2014-05-29
MX2013011314A (es) 2014-03-27
MA35070B1 (fr) 2014-04-03
US20140088199A1 (en) 2014-03-27
WO2012136969A3 (en) 2013-01-03
KR20190004815A (ko) 2019-01-14
JP6148664B2 (ja) 2017-06-14
CA2869280A1 (en) 2012-10-11
WO2012136969A2 (en) 2012-10-11

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Owner name: OPTOSOLVE RESEARCH & DEVELOPMENT LIMITED

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