BR112015001158A2 - formulação oftálmica e respectivo uso e método para melhorar, reduzir ou tratar presbiopia - Google Patents

formulação oftálmica e respectivo uso e método para melhorar, reduzir ou tratar presbiopia

Info

Publication number
BR112015001158A2
BR112015001158A2 BR112015001158A BR112015001158A BR112015001158A2 BR 112015001158 A2 BR112015001158 A2 BR 112015001158A2 BR 112015001158 A BR112015001158 A BR 112015001158A BR 112015001158 A BR112015001158 A BR 112015001158A BR 112015001158 A2 BR112015001158 A2 BR 112015001158A2
Authority
BR
Brazil
Prior art keywords
reducing
ophthalmic formulation
presbyopia
improving
treating presbyopia
Prior art date
Application number
BR112015001158A
Other languages
English (en)
Other versions
BR112015001158B1 (pt
Inventor
Felipe Vejarano Restrepo Luis
Original Assignee
Felipe Vejarano Restrepo Luis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Felipe Vejarano Restrepo Luis filed Critical Felipe Vejarano Restrepo Luis
Publication of BR112015001158A2 publication Critical patent/BR112015001158A2/pt
Publication of BR112015001158B1 publication Critical patent/BR112015001158B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

“formulação oftálmica e respectivo uso e método para melhorar, reduzir ou tratar presbiopia” resumo uma formulação farmacêutica tendo uma quantidade eficaz de um agente parassimpaticomimético compreendendo pilocarpina, ou um sal farmaceuticamente aceitável do mesmo e um ou mais de agonistas ou antagonistas ?1 adrenérgicos é revelada. a formulação farmacêutica pode permitir o tratamento de condições que afetam adversamente a acuidade visual de um paciente, incluindo presbiopia. um método de uso da formulação oftálmica revelada para tratar ou melhorar sintomas de presbiopia é também revelado. 1/1
BR112015001158-6A 2012-07-19 2013-07-18 Formulação oftálmica e respectivo uso e método para melhorar, reduzir ou tratar presbiopia BR112015001158B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/553,615 2012-07-19
US13/553,615 US10507245B2 (en) 2012-07-19 2012-07-19 Ophthalmic formulation and method for ameliorating presbyopia
PCT/US2013/051153 WO2014015183A1 (en) 2012-07-19 2013-07-18 Ophthalmic formulation and method for ameliorating presbyopia

Publications (2)

Publication Number Publication Date
BR112015001158A2 true BR112015001158A2 (pt) 2017-06-27
BR112015001158B1 BR112015001158B1 (pt) 2020-12-15

Family

ID=48917698

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015001158-6A BR112015001158B1 (pt) 2012-07-19 2013-07-18 Formulação oftálmica e respectivo uso e método para melhorar, reduzir ou tratar presbiopia

Country Status (15)

Country Link
US (2) US10507245B2 (pt)
EP (1) EP2874660B1 (pt)
CN (2) CN104717981A (pt)
AR (2) AR092860A1 (pt)
BR (1) BR112015001158B1 (pt)
CO (1) CO7250451A2 (pt)
DK (1) DK2874660T3 (pt)
ES (1) ES2719250T3 (pt)
HR (1) HRP20190627T1 (pt)
MX (1) MX351230B (pt)
PL (1) PL2874660T3 (pt)
PT (1) PT2874660T (pt)
RU (1) RU2657514C2 (pt)
TR (1) TR201905683T4 (pt)
WO (1) WO2014015183A1 (pt)

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ES2715296T3 (es) 2011-09-20 2019-06-03 Allergan Inc Composiciones y métodos para tratar presbicia, hipermetropía leve y astigmatismo irregular
ES2538551B1 (es) * 2013-12-20 2016-01-13 Eurocanarias Oftalmológica, Sl Composición Oftálmica para la corrección de la presbicia
EP3104851A1 (en) * 2014-02-11 2016-12-21 Orasis Pharmaceuticals Ltd. Pharmacological ophthalmic composition for use in the correction of presbyopia and its administration
CN104856990A (zh) * 2015-05-07 2015-08-26 武汉武药科技有限公司 去氧肾上腺素酮咯酸溶液及制备方法
US20190000808A1 (en) * 2015-07-13 2019-01-03 Allergan, Inc. Composition and methods for the treatment of blephopharoptosis
CH711969A2 (it) * 2015-12-29 2017-06-30 Pinelli Roberto Composizione per il trattamento della presbiopia.
PT3500255T (pt) * 2016-08-19 2023-01-10 Orasis Pharmaceuticals Ltd Composições farmacêuticas oftálmicas e utilizações relacionadas com estas
US20180318319A1 (en) 2017-05-04 2018-11-08 Ocular Science, Inc. Compositions and Methods for Treating Eyes and Methods of Preparation
BR112020015436A2 (pt) * 2018-02-05 2020-12-22 Cellix Bio Private Limited Composição farmacêutica, mistura física e uso de uma composição
WO2019204401A1 (en) * 2018-04-19 2019-10-24 Presbyopia Therapies Llc Compositions and methods for the treatment of presbyopia
MX2020011301A (es) 2018-04-24 2021-01-29 Allergan Inc Uso de clorhidrato de pilocarpina para el tratamiento de afecciones oculares.
US11077053B2 (en) 2018-08-21 2021-08-03 Allergan, Inc. Alpha-2-adrenergic receptor agonists for treatment of presbyopia, visual glare, visual starbursts, visual halos and night myopia
US20210205273A1 (en) * 2018-08-21 2021-07-08 Allergan, Inc. The use of alpha-2-adrenergic receptor agonists for improving vision
EP3870170A4 (en) 2018-10-26 2022-07-20 Ocuphire Pharma, Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF PRESBYOPIA, MYDRIASIS AND OTHER EYE DISEASES
US11071724B2 (en) * 2019-05-17 2021-07-27 Ocular Science, Inc. Compositions and methods for treating presbyopia
CN114585365A (zh) * 2019-06-10 2022-06-03 视觉治疗股份有限公司 在假晶状体患者中使用拟副交感神经药物单独或与一种或多种α激动剂组合以产生多焦点
MX2020012116A (es) * 2020-11-12 2022-08-09 Cesar Alejandro Sanchez Galeana Composicion oftalmologica sinergica en dosis de baja concentracion eficaz en la prevencion, control y erradicacion de la presbicia.
CN115368310A (zh) 2021-05-18 2022-11-22 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法
CN116350790A (zh) * 2021-12-28 2023-06-30 沈阳兴齐眼药股份有限公司 组合物及其在制备用于治疗老花眼的药物中的用途

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Also Published As

Publication number Publication date
US20200237916A1 (en) 2020-07-30
PL2874660T3 (pl) 2019-07-31
BR112015001158B1 (pt) 2020-12-15
DK2874660T3 (en) 2019-04-15
CO7250451A2 (es) 2015-04-30
RU2657514C2 (ru) 2018-06-14
MX351230B (es) 2017-10-06
HRP20190627T1 (hr) 2019-06-14
ES2719250T3 (es) 2019-07-09
AR092860A1 (es) 2015-05-06
PT2874660T (pt) 2019-05-14
CN104717981A (zh) 2015-06-17
EP2874660B1 (en) 2019-01-23
MX2015000806A (es) 2015-08-10
US20140024642A1 (en) 2014-01-23
WO2014015183A1 (en) 2014-01-23
AR121843A2 (es) 2022-07-13
US10507245B2 (en) 2019-12-17
CN113425715A (zh) 2021-09-24
EP2874660A1 (en) 2015-05-27
RU2015102531A (ru) 2016-09-10
TR201905683T4 (tr) 2019-05-21

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