MX2012000275A - Antagonista de bomba de acido para el tratamiento de enfermedades involucradas en la motilidad gastrointestinal anormal. - Google Patents

Antagonista de bomba de acido para el tratamiento de enfermedades involucradas en la motilidad gastrointestinal anormal.

Info

Publication number
MX2012000275A
MX2012000275A MX2012000275A MX2012000275A MX2012000275A MX 2012000275 A MX2012000275 A MX 2012000275A MX 2012000275 A MX2012000275 A MX 2012000275A MX 2012000275 A MX2012000275 A MX 2012000275A MX 2012000275 A MX2012000275 A MX 2012000275A
Authority
MX
Mexico
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
acid pump
treatment
Prior art date
Application number
MX2012000275A
Other languages
English (en)
Inventor
Shinichi Koizumi
Nobuyuki Takahashi
Original Assignee
Raqualia Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Raqualia Pharma Inc filed Critical Raqualia Pharma Inc
Publication of MX2012000275A publication Critical patent/MX2012000275A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La presente invención se refiere a un uso de un compuesto que tiene una actividad antagonista de bomba de ácido, una sal farmacéuticamente aceptable de éste o una composición farmacéutica de éste para la manufactura de un medicamento para la prevención o tratamiento de enfermedades en las cuales está involucrada motilidad gastrointestinal anormal. Además, la presente invención se relaciona con el método de prevención o tratamiento, el cual incluye la administración a un ser humano o animal. El compuesto, la sal farmacéuticamente aceptable de éste, o composiciones farmacéuticas que los contienen, pueden usarse en combinación con uno o más segundos agentes activos. Adicionalmente, la presente invención se refiere a composiciones farmacéuticas y kits que comprenden un compuesto que tiene actividad antagonista de bomba de ácido o una sal de éste farmacéuticamente aceptable para la prevención o tratamiento de dichas enfermedades.
MX2012000275A 2009-07-09 2010-07-09 Antagonista de bomba de acido para el tratamiento de enfermedades involucradas en la motilidad gastrointestinal anormal. MX2012000275A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009163182 2009-07-09
JP2009188464 2009-08-17
PCT/JP2010/061660 WO2011004882A1 (ja) 2009-07-09 2010-07-09 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤

Publications (1)

Publication Number Publication Date
MX2012000275A true MX2012000275A (es) 2012-02-08

Family

ID=43429307

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012000275A MX2012000275A (es) 2009-07-09 2010-07-09 Antagonista de bomba de acido para el tratamiento de enfermedades involucradas en la motilidad gastrointestinal anormal.

Country Status (12)

Country Link
US (1) US8648080B2 (es)
EP (1) EP2452680B1 (es)
JP (4) JP5802898B2 (es)
KR (1) KR101605063B1 (es)
CN (2) CN102470126A (es)
BR (1) BRPI1013288A2 (es)
CA (1) CA2765529C (es)
ES (1) ES2767251T3 (es)
HK (1) HK1225608A1 (es)
MX (1) MX2012000275A (es)
RU (1) RU2586276C2 (es)
WO (1) WO2011004882A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10709714B2 (en) 2013-11-22 2020-07-14 Clifton Life Sciences LLC Gastrin antagonists for treatment and prevention of osteoporosis
CN105708812A (zh) * 2014-12-02 2016-06-29 江苏柯菲平医药股份有限公司 一种5-（2-氟苯基）-n-甲基-1-（3-吡啶基磺酰基）-1h-吡咯-3-甲氨冻干粉针及其制备方法
KR101684053B1 (ko) * 2015-01-20 2016-12-08 씨제이헬스케어 주식회사 벤즈이미다졸 유도체의 신규 결정형 및 이의 제조방법
MA41850A (fr) 2015-03-31 2018-02-06 Takeda Pharmaceuticals Co Nouvelles utilisations pharmaceutiques
DK3305291T3 (da) * 2015-06-08 2021-06-28 Hk Inno N Corp Anvendelser af benzimidazolderivat mod natligt syregennembrud
CN105078891B (zh) * 2015-08-20 2018-04-24 寿光富康制药有限公司 一种tak-438脂质体及其制备方法和应用
CN105168131B (zh) * 2015-09-17 2018-04-24 寿光富康制药有限公司 一种tak-438纳米乳的制备方法
CN106913859B (zh) * 2015-12-25 2021-05-11 中美华世通生物医药科技(武汉)股份有限公司 药物组合物及制备方法
CN105663096B (zh) * 2016-01-25 2019-06-14 南京济群医药科技股份有限公司 一种沃诺拉赞口腔速溶膜剂及其制备方法
KR101829706B1 (ko) * 2016-09-21 2018-02-19 씨제이헬스케어 주식회사 벤즈이미다졸 유도체의 산부가염
JOP20190060A1 (ar) * 2016-09-26 2019-03-26 Chugai Pharmaceutical Co Ltd مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1
CN112933091B (zh) * 2020-09-07 2023-01-06 天地恒一制药股份有限公司 一种抗胃酸类疾病的药物组合物及应用
CN116507318A (zh) * 2020-10-23 2023-07-28 怡诺安有限公司 包含苯并咪唑衍生物化合物的口服崩解片剂及其制备方法
KR102648314B1 (ko) * 2021-12-08 2024-03-15 (주) 팜젠사이언스 벤즈이미다졸 유도체 화합물 및 이의 용도

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5996272A (ja) 1982-11-26 1984-06-02 Isuzu Motors Ltd 金属表面の強化層形成方法
TW282460B (es) 1993-12-28 1996-08-01 Yamanouchi Pharma Co Ltd
CN1102144C (zh) * 1994-08-13 2003-02-26 株式会社柳韩洋行 新的嘧啶衍生物及其制备方法
SE9801526D0 (sv) * 1998-04-29 1998-04-29 Astra Ab New compounds
SE9802793D0 (sv) 1998-08-21 1998-08-21 Astra Ab New compounds
SE9802794D0 (sv) 1998-08-21 1998-08-21 Astra Ab New compounds
IL142063A0 (en) * 1998-09-23 2002-03-10 Byk Gulden Lomberg Chem Fab Tetrahydropyridoether derivatives and pharmaceutical compositions containing the same
ATE386742T1 (de) 1998-11-03 2008-03-15 Nycomed Gmbh Imidazonaphthyridine
KR100272471B1 (ko) 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
TWI287014B (en) 1999-06-15 2007-09-21 Sankyo Co Optically active pyrrolopyridazine compound
AU783633B2 (en) 2000-03-29 2005-11-17 Altana Pharma Ag Prodrugs of imidazopyridine derivatives
AU2001294228A1 (en) 2000-10-12 2002-04-22 Takeda Chemical Industries Ltd. Benzimidazole compounds, process for producing the same and use thereof
EP1419163B9 (en) 2001-08-10 2005-11-09 ALTANA Pharma AG Tricyclic imidazopyridines
SE0102808D0 (sv) 2001-08-22 2001-08-22 Astrazeneca Ab New compounds
CA2506027A1 (en) 2002-11-19 2004-06-03 Altana Pharma Ag 8-substituted imidazopyridines
AR043063A1 (es) 2002-12-13 2005-07-13 Altana Pharma Ag Bencimidazoles 6-sustituidos y su uso como inhibidores de secreciones gastricas
NZ542177A (en) 2003-04-04 2009-02-28 Altana Pharma Ag Cyclic benzimidazoles for use against gastrointestinal disorders
EP1644043A1 (en) * 2003-05-27 2006-04-12 ALTANA Pharma AG Pharmaceutical combinations of a proton pump inhibitor and a compound which modifies gastrointestinal motility
SE0301905D0 (sv) 2003-06-26 2003-06-26 Astrazeneca Ab Novel imidazopyridine compound I with therapeutic effect
MXPA06002139A (es) 2003-08-29 2006-05-31 Dynogen Pharmaceuticals Inc Composiciones utiles para tratar trastornos de la motilidad gastrointestinal.
WO2005026164A1 (en) 2003-09-18 2005-03-24 Altana Pharma Ag Pharmacologically active imidazo[4,5-c]pyridines
AR046893A1 (es) 2003-12-16 2005-12-28 Altana Pharma Ag Bencimidazoles triciclicos
AR046941A1 (es) 2003-12-19 2006-01-04 Altana Pharma Ag Imidazopiridinas triciclicas y su uso como inhibidores de secrecion de acido gastrico
US20080033006A1 (en) 2004-01-26 2008-02-07 Altana Pharma Ag 1,2,4-Triazolo[ 1,5-A] Pyridines as Gastric Acid Secretion Inhibitors
US20070167427A1 (en) 2004-02-18 2007-07-19 Altana Pharma Ag 1,2,4-Triazolo[4,3-a]pyridines useful in the treatment of gastrointestinal disorders
AU2005223389A1 (en) 2004-03-17 2005-09-29 Altana Pharma Ag 7H-8,9-dihydro-pyrano (2,3-C) imidazo (1,2a) pyridine derivatives and their use as gastric acid secretion inhibitors
AR048869A1 (es) 2004-04-26 2006-06-07 Altana Pharma Ag Bencimidazoles triciclicos
AU2005251943A1 (en) 2004-06-09 2005-12-22 Altana Pharma Ag Substituted tricyclic benzimidazoles
US7662832B2 (en) 2004-09-03 2010-02-16 Yuhan Corporation Pyrrolo[2,3-c]pyridine derivatives and processes for the preparation thereof
AU2005280739B2 (en) 2004-09-03 2010-11-11 Yuhan Corporation Pyrrolo[3,2-c]pyridine derivatives and processes for the preparation thereof
PL1784402T3 (pl) 2004-09-03 2011-12-30 Yuhan Corp Pochodne pirolo[3,2-c]pirydyny oraz sposoby ich wytwarzania
CA2582256A1 (en) 2004-10-01 2006-04-13 Altana Pharma Ag Substituted tricyclic benzimidazoles
AR051041A1 (es) 2004-10-04 2006-12-13 Altana Pharma Ag Bencimidazoles triciclicos condensados
AR051375A1 (es) 2004-10-15 2007-01-10 Altana Pharma Ag Imidazopiridinas difluoro substituidas
WO2006061380A2 (en) 2004-12-09 2006-06-15 Altana Pharma Ag SUBSTITUTED IMIDAZO[4,5-b]PYRIDINES AS INHIBITORS OF GASTRIC ACID SECRETION
KR101122376B1 (ko) 2005-03-09 2012-03-26 주식회사유한양행 신규의 5,6-다이메틸피리미딘 유도체 및 그의 제조방법
KR101137168B1 (ko) 2005-03-09 2012-04-19 주식회사유한양행 피롤로［２,３-ｄ］피리다진 유도체 및 그의 제조방법
EP1910313A1 (en) 2005-03-24 2008-04-16 Nycomed GmbH 6-thioamide substituted benzimidazoles
US20080255358A1 (en) 2005-03-24 2008-10-16 Mark James Bamford Derivatives of Imidazo [1,2-A] Pyridine Useful as Medicaments For Treating Gastrointestinal Diseases
EP1863820A1 (en) 2005-03-24 2007-12-12 Nycomed GmbH Thioamide-substituted tricyclic benzimidazoles useful for the treatment of gastrointestinal diseases
AU2006243255A1 (en) 2005-04-29 2006-11-09 Nycomed Gmbh Mutual prodrug compounds for use us antiinflammatory agents with gastrointestinal protective activity
AR057061A1 (es) 2005-06-16 2007-11-14 Altana Pharma Ag Espiro-bencimidazoles farmaceuticamente activos y su uso en la fabricacion de medicamentos
JP2008546736A (ja) 2005-06-22 2008-12-25 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 三環式ベンゾイミダゾールの製造のための中間体の製造方法
GB0513423D0 (en) 2005-06-30 2005-08-03 Glaxo Group Ltd Novel compounds
JP2009504798A (ja) 2005-08-22 2009-02-05 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 同位体置換されたベンゾイミダゾール誘導体
EP1919865B1 (en) * 2005-08-30 2011-04-06 Takeda Pharmaceutical Company Limited 1-heterocyclylsulfonyl, 2-aminomethyl, 5- (hetero-) aryl substituted 1-h-pyrrole derivatives as acid secretion inhibitors
US7776873B2 (en) 2005-12-01 2010-08-17 Yuhan Corporation Method for treating damage to gastric mucosa
CN101341149B (zh) 2005-12-19 2011-06-08 拉夸里亚创药株式会社 经色原烷取代的苯并咪唑类和它们作为酸泵抑制剂的用途
EP2005957B1 (en) 2006-03-31 2012-05-30 Takeda Pharmaceutical Company Limited Acid secretion inhibitor
WO2008015196A1 (en) 2006-07-31 2008-02-07 Nycomed Gmbh 5-,7-bis-substituted imidazo[1,2-a]pyridines
MX2009000080A (es) * 2006-09-21 2009-01-23 Raqualia Pharma Inc Derivados de bencimidazol como inhibidores selectivos de la bomba de acido.
WO2008058990A1 (en) 2006-11-16 2008-05-22 Nycomed Gmbh 7,7-disubstituted pyrano-[2,3-c]-imidazo-[1,2-a]-pyridine derivatives and their use as gastric acid secretion inhibitors
WO2008071765A1 (en) 2006-12-14 2008-06-19 Nycomed Gmbh Pharmaceutically active spiro-substituted benzimidazole derivatives
WO2008071766A2 (en) 2006-12-14 2008-06-19 Nycomed Gmbh Spiro-indene substituted imidazonaphythyridine and pyranoimidazopyridine derivatives as inhibitors of gastric acid secretion
WO2008084067A2 (en) 2007-01-12 2008-07-17 Nycomed Gmbh Pharmaceutically active dihydrobenzofurane-substituted benzimidazole derivatives
WO2008095912A2 (en) 2007-02-06 2008-08-14 Nycomed Gmbh Enantiopure pharmacologically active tricyclic benzimidazoles
US8933105B2 (en) 2007-02-28 2015-01-13 Takeda Pharmaceutical Company Limited Pyrrole compounds
WO2008151927A2 (en) 2007-06-15 2008-12-18 Nycomed Gmbh 6-n-substituted benz imidazole derivatives as acid pump antagonists
WO2009041447A1 (ja) 2007-09-28 2009-04-02 Takeda Pharmaceutical Company Limited ５員複素環化合物
EP2190822B1 (en) 2007-09-28 2014-12-31 Takeda Pharmaceutical Company Limited 5-membered heterocyclic compounds as proton pump inhibitors

Also Published As

Publication number Publication date
CN102470126A (zh) 2012-05-23
CA2765529A1 (en) 2011-01-13
JP2016166255A (ja) 2016-09-15
KR20120052269A (ko) 2012-05-23
US8648080B2 (en) 2014-02-11
JP2015038140A (ja) 2015-02-26
EP2452680A4 (en) 2013-12-04
CA2765529C (en) 2017-02-07
CN105919998B (zh) 2021-08-24
EP2452680A1 (en) 2012-05-16
EP2452680B1 (en) 2019-12-18
HK1225608A1 (zh) 2017-09-15
JP5802898B2 (ja) 2015-11-04
RU2012104533A (ru) 2013-08-20
CN105919998A (zh) 2016-09-07
JP5978447B2 (ja) 2016-08-24
ES2767251T3 (es) 2020-06-17
RU2586276C2 (ru) 2016-06-10
JP6212765B2 (ja) 2017-10-18
KR101605063B1 (ko) 2016-03-21
WO2011004882A1 (ja) 2011-01-13
US20120115820A1 (en) 2012-05-10
BRPI1013288A2 (pt) 2016-03-29
JP5699309B2 (ja) 2015-04-08
JP2013144719A (ja) 2013-07-25
JPWO2011004882A1 (ja) 2012-12-20

Similar Documents

Publication Publication Date Title
MX2012000275A (es) Antagonista de bomba de acido para el tratamiento de enfermedades involucradas en la motilidad gastrointestinal anormal.
WO2011014255A8 (en) Treatment of crohn's disease with laquinimod
WO2008131056A3 (en) Sustained release monoeximic formulations of opioid and nonopioid analgesics
MX2014002171A (es) Tratamientos de combinacion para hepatitis c.
MX2010002392A (es) Composiciones de brimonidina mejoradas para tratar eritema.
WO2012007159A3 (en) Novel gastro-retentive dosage forms
WO2010088000A3 (en) Antifibrotic compounds and uses thereof
PE20142319A1 (es) Tratamiento de esclerosis multiple con combinacion de laquinimod y acetato de glatiramero
NZ602510A (en) Treatment of lupus nephritis using laquinimod
MX348705B (es) Composiciones farmacéuticas y métodos de administración relacionados.
EA201270144A1 (ru) Комбинированная терапия при лечении диабета
WO2008131057A3 (en) Sustained release formulations of opioid and nonopioid analgesics
NZ605469A (en) Nalbuphine-based formulations and uses thereof
MX2011013201A (es) Composiciones para tratar adiccion a drogas y para mejorar comportamiento relacionado a la adiccion.
EA200700214A1 (ru) Мемантин в качестве дополнительной терапии к атипичным антипсихотическим средствам у больных шизофренией
MX2009004561A (es) Derivados de pirazolilo con actividad analgesica y utiles en el tratamiento o profilaxis del dolor.
BR112014015482A8 (pt) compostos carbamato de fenila para uso no alívio ou tratamento de dor e dor neuropática
WO2011116139A3 (en) Improved pharmaceutical compositions comprising cck- 8 and methods of delivery
MX345032B (es) Antagonistas del receptor ep4 para el tratamiento de cáncer.
MX2011009709A (es) Compuestos para el tratamiento de la inflamacion y del dolor.
MX2009011900A (es) Curacion de herida diabetica.
NZ599265A (en) A skin external composition comprising a salt and sugar as active ingredients for preventing and treating vaginosis and the use thereof
WO2011151722A3 (en) Methods and compositions for oral pharmaceutical therapy
MX341660B (es) Agonista del receptor de ghrelina para el tratamiento de caquexia.
WO2012044783A3 (en) Method of achieving a thymosin beta 4 concentration in a human patient

Legal Events

Date Code Title Description
FG Grant or registration