MX2009004561A - Derivados de pirazolilo con actividad analgesica y utiles en el tratamiento o profilaxis del dolor. - Google Patents

Derivados de pirazolilo con actividad analgesica y utiles en el tratamiento o profilaxis del dolor.

Info

Publication number
MX2009004561A
MX2009004561A MX2009004561A MX2009004561A MX2009004561A MX 2009004561 A MX2009004561 A MX 2009004561A MX 2009004561 A MX2009004561 A MX 2009004561A MX 2009004561 A MX2009004561 A MX 2009004561A MX 2009004561 A MX2009004561 A MX 2009004561A
Authority
MX
Mexico
Prior art keywords
treatment
pain
prophylaxis
analgesic activity
useful
Prior art date
Application number
MX2009004561A
Other languages
English (en)
Inventor
Alf Claesson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX2009004561A publication Critical patent/MX2009004561A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invención se relaciona con el uso novedoso de derivados de pirazolilo y sales farmacéuticamente aceptables de estas, las cuales se ha encontrado que poseen actividad analgésica y por consiguiente son útiles en el tratamiento o profilaxis de padecimientos de dolor en el cuerpo humano o animal, por ejemplo, en la elaboración de medicamentos para el tratamiento o prevención en un animal de sangre caliente como el hombre.
MX2009004561A 2006-11-01 2007-10-31 Derivados de pirazolilo con actividad analgesica y utiles en el tratamiento o profilaxis del dolor. MX2009004561A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86383906P 2006-11-01 2006-11-01
PCT/SE2007/000966 WO2008054291A1 (en) 2006-11-01 2007-10-31 Pyrazolyl derivatives with analgesic activity and therefore useful in the treatment or prophylaxis of pain.

Publications (1)

Publication Number Publication Date
MX2009004561A true MX2009004561A (es) 2009-05-11

Family

ID=39344535

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004561A MX2009004561A (es) 2006-11-01 2007-10-31 Derivados de pirazolilo con actividad analgesica y utiles en el tratamiento o profilaxis del dolor.

Country Status (12)

Country Link
US (1) US20080108633A1 (es)
EP (1) EP2091540A4 (es)
JP (1) JP2010508345A (es)
KR (1) KR20090077063A (es)
CN (1) CN101534830A (es)
AU (1) AU2007314657A1 (es)
BR (1) BRPI0718003A2 (es)
CA (1) CA2668321A1 (es)
MX (1) MX2009004561A (es)
RU (1) RU2009112013A (es)
TW (1) TW200823196A (es)
WO (1) WO2008054291A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0104140D0 (sv) * 2001-12-07 2001-12-07 Astrazeneca Ab Novel Compounds
ES2375735T3 (es) * 2005-02-04 2012-03-05 Astrazeneca Ab Derivados de pirazolilaminopiridina útiles como inhibidores de quinasas.
AU2006215386B2 (en) * 2005-02-16 2009-06-11 Astrazeneca Ab Chemical compounds
BRPI0610184A2 (pt) * 2005-05-16 2012-09-25 Astrazeneca Ab composto, sal farmaceuticamente aceitável de um composto, processo para preparar um composto ou um sal farmaceuticamente aceitável do mesmo, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, métodos para a inibição da atividade de trk, para o tratamento ou profilaxia de cáncer e para a produção de um efeito anti-proliferativo em um animal de sanque quente, e, composição farmacêutica
EP2388259A1 (en) * 2005-10-28 2011-11-23 AstraZeneca AB 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer
WO2008129255A1 (en) * 2007-04-18 2008-10-30 Astrazeneca Ab 5-aminopyrazol-3-yl-3h-imidazo [4,5-b] pyridine derivatives and their use for the treatment of cancer
UA99459C2 (en) * 2007-05-04 2012-08-27 Астразенека Аб 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer
CA2727073A1 (en) * 2008-06-11 2009-12-17 Astrazeneca Ab Tricyclic 2,4-diamin0-l,3,5-triazine derivatives useful for the treatment of cancer and myeloproliferative disorders
KR20110071098A (ko) * 2008-09-30 2011-06-28 아스트라제네카 아베 복소환 ｊａｋ 키나제 억제제
CN105979942B (zh) * 2013-12-12 2018-12-07 比皮艾思药物研发有限公司 用于治疗或缓解疼痛的氨基磺酸酯衍生物
ES2706184T3 (es) 2013-12-12 2019-03-27 Bio Pharm Solutions Co Ltd Compuesto derivado de sulfamato para su uso en la prevención o el tratamiento de la epilepsia
KR101792998B1 (ko) * 2013-12-12 2017-11-02 (주)바이오팜솔루션즈 통증을 치료 또는 완화하기 위한 설파메이트 유도체 화합물
JP6427039B2 (ja) * 2015-03-04 2018-11-21 株式会社浜松ファーマリサーチ 非ヒト霊長類の二足歩行時の体動痛の評価方法
KR20220008828A (ko) * 2019-05-15 2022-01-21 클라에스 툴린 동물에서 통증의 예방 및/또는 치료에 사용하기 위한 4-[5-[(rac)-1-[5-(3-클로로페닐)-3-이속사졸릴]에톡시]-4-메틸-4H-1,2,4-트리아졸-3-일]피리딘
US11987582B2 (en) * 2021-01-27 2024-05-21 Abion Inc. Maleate salts of triazolopyrazine derivatives, compositions, methods of use, and processes of manufacturing the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1339680A1 (en) * 2000-09-01 2003-09-03 Glaxo Group Limited Substituted oxindole derivatives as tyrosine kinase inhibitors
MY141220A (en) * 2003-11-17 2010-03-31 Astrazeneca Ab Pyrazole derivatives as inhibitors of receptor tyrosine kinases
MXPA06014637A (es) * 2004-06-25 2007-02-12 Amgen Inc Triazoles e indazoles condensados utiles en el tratamiento de enfermedades mediadas por citocinas y otras enfermedades.
US20060069110A1 (en) * 2004-09-27 2006-03-30 Andersen Denise L Substituted heterocyclic compounds and methods of use
CN101208093A (zh) * 2005-04-27 2008-06-25 阿斯利康(瑞典)有限公司 吡唑-嘧啶衍生物在治疗疼痛中的用途
BRPI0610184A2 (pt) * 2005-05-16 2012-09-25 Astrazeneca Ab composto, sal farmaceuticamente aceitável de um composto, processo para preparar um composto ou um sal farmaceuticamente aceitável do mesmo, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, métodos para a inibição da atividade de trk, para o tratamento ou profilaxia de cáncer e para a produção de um efeito anti-proliferativo em um animal de sanque quente, e, composição farmacêutica

Also Published As

Publication number Publication date
TW200823196A (en) 2008-06-01
EP2091540A1 (en) 2009-08-26
US20080108633A1 (en) 2008-05-08
WO2008054291A1 (en) 2008-05-08
AU2007314657A1 (en) 2008-05-08
BRPI0718003A2 (pt) 2013-11-19
KR20090077063A (ko) 2009-07-14
CN101534830A (zh) 2009-09-16
EP2091540A4 (en) 2010-11-17
JP2010508345A (ja) 2010-03-18
CA2668321A1 (en) 2008-05-08
RU2009112013A (ru) 2010-12-10

Similar Documents

Publication Publication Date Title
MX2009004561A (es) Derivados de pirazolilo con actividad analgesica y utiles en el tratamiento o profilaxis del dolor.
SG150531A1 (en) Use of meloxicam for the treatment of respiratory diseases in pigs
MX2008013212A (es) 4-anilinquinolina-3-carboxamidas como inhibidores de la cinsa csf-1r.
MX2009004908A (es) Compuestos quimicos.
WO2011014255A8 (en) Treatment of crohn's disease with laquinimod
SG135192A1 (en) Substituted pyrazoline compounds, their preparation and use as medicaments
MX2020008616A (es) Rocio de fentanilo sublingual.
UA92000C2 (en) 1-benzylindole-2-carboxamide derivatives
MY148108A (en) Medicaments for the treatment or prevention of fibrotic diseases
TW200719882A (en) Treatment of connective tissue diseases of the skin
WO2006067445A3 (en) Csf-1r kinase inhibitors
GEP20125624B (en) Pyridazine derivatives as smo inhibitors
TW200621730A (en) Chemical compounds
IL201479A (en) Use of tapentadol for the preparation of pain medication
MX2007008924A (es) Compuestos quimicos.
NZ605469A (en) Nalbuphine-based formulations and uses thereof
TW200745043A (en) Substituted pyrazoline compounds, their preparation and use as medicaments
MX2009010407A (es) Derivados fluorados de deferiprona.
MX2012000275A (es) Antagonista de bomba de acido para el tratamiento de enfermedades involucradas en la motilidad gastrointestinal anormal.
TW200738699A (en) 4-Substituted pyrazoline compounds, their preparation and use as medicaments
TW200635595A (en) Medicaments for the treatment of prevention of fibrotic diseases
MX2010009624A (es) Derivados de 1-bencil-3-hidroximetilindazol y uso de los mismos en el tratamiento de enfermedades basadas en la expresion de mcp-1 y cx3cr1.
TNSN07263A1 (en) Substituted 4-phenyl tetrahydroisoquinolines, methods for producing them, their use as drug, and drug containing them
MY150931A (en) Substituted oxazolidinones and their use
WO2007023072A3 (en) Use of ambroxol for the treatment of rhinovirus infections